02. 56.72±0. 31. Pyruvic acid 0.71±0.0. 3. 1.64±0.0. 1. 22.96±0. 41. 22.25±0. ...... 76980 79219 78798 79219 78638 91254 89106 82867 81448 83611 81160.
Microbial dynamics and metabolite changes in Chinese Rice Wine fermentation from sorghum with different tannin content Jialiang Xu, Huijun Wu, Zhiwei Wang, Fuping Zheng, Xin Lu, Zhenpeng Li, Qing Ren Table. S1 Changes in acid，reducing sugar and alcohol found in JZ22(a) and JB3(b) Chinese Rice Wine brewed from Sorghum during fermentation. Every value is expressed as means ± standard error (n=3). a JZ22 Compounds( g/L) Acid reducing sugar alcohol
0 day
2nd day
4th day
6thday
8th day
10th day
12th day
pvalue
Correl ation coeffic ient
2.70± 0.09
3.63± 0.18
3.85± 0.09
5.09± 0.07
6.54± 0.12
7.33± 0.10
7.91± 0.07
0.0039 83
-0.91
18.29 ±0.19 2.9±0. 21
19.85 ±0.24 5.7±0. 22
17.54 ±0.34 8.9±0. 45
17.03 ±0.19 9.8±0. 14
16.68 ±0.35 10.5± 0.21
15.14 ±0.15 10.9± 0.22
14.73 ±0.27 11.1±0 .22
2.556e -05 0.0042 41
Fermentation time (days)
0.99 0.91
b
0 day
2nd day
4th day
6thday
8th day
10th day
12th day
pvalue
Correl ation coeffic ient
Acid
1.8±0. 15
2.86± 0.16
3.78± 0.31
4.93± 0.15
5.38± 0.22
6.54± 0.24
7.89± 0.30
0.0001 436
-0.98
reducing sugar
20.64 ±0.23
19.25 ±0.16
17.61 ±0.14
17.23 ±0.19
16.67 ±0.21
15.72 ±0.25
15.15 ±0.12
alcohol
3.1±0. 08
4.3±0. 14
6.5±0. 22
9.2±0. 17
9.6±0. 22
10.4± 0.08
10.8± 0.14
JB3 Compounds( g/L)
Fermentation time (days)
2.259e -06 0.0005 339
1.00 0.96
Table.S2 Changes in organic acids found in JZ22(a) and JB3(b) Chinese Rice Wine during fermentation. Every value is expressed as means ± standard error (n = 3). a JZ22
Fermentation time (days)
Organic acid (mg/L) Oxalic acid Tartaric acid Pyruvic acid Malic acid α-ketoglutar ic acid Lactic acid Citric acid Succinic acid
0 day 1.03±0 25.71±3. 68 0.71±0.0 3 22.06±0. 20 20.59±3. 12 156.44±3 3.79 3.71±0.0 2 70.26±8. 00
2nd day
4th day
6thday
8th day
10th day
12th day
4.21±0.1 3 30.65±2. 75 1.64±0.0 1 27.17±2. 09 18.44±0. 24 999.67±4 .43 17.42±0. 12
4.99±0.0 1 38.83±0. 14 22.96±0. 41 36.85±0. 01 12.03±0. 29 1350.52± 2.29 18.19±0. 14 859.81±4 .98
5.64±0.0 4 38.98±0. 12 22.25±0. 80 38.02±0. 28 8.60±0.1 3
7.09±2.0 6 51.55±0. 02 15.23±0. 07 52.41±3. 06 11.72±0. 34 1640.75± 9.42 22.90±0. 09 1771.71± 4.71
7.93±0.5 4 56.72±0. 31 14.09±0. 01
1366.41± 18.29 19.35±0. 12 1236.97± 2.86
5.79±0.0 9 48.87±0. 19 15.93±0. 34 48.70±0. 63 8.27±0.0 8 1449.45± 5.05 19.77±0. 27 1458.78± 0.28
87.05±26 .40
58.86±5. 31 9.92±0.2 8 1646.58± 10.33 26.14±0. 07 1954.38± 0.39
b JB3 Organic acid (mg/L) oxalic acid Tartaric Acid pyruvic acid malic acid α-ketoglutar ic acid
Fermentation time (days) 0 day 1.03±0 4.67±0.7 0.50±0.0 1 24.55±0. 74 1.05±0.3 1
2nd day
4th day
6thday
8th day
10th day
12th day
3.32±0.0 1 48.22±0. 96 1.38±0.0 2 32.59±1. 62 8.35±0.6 8
4.52±0.1 2 48.22±3. 21 1.72±0.0 4 46.87±0. 23 6.83±0.3 3
7.79±0.0 6 53.59±1. 40 1.59±0.0 1 48.10±0. 09 5.50±0.5 7
8.52±0.0 2 58.03±0. 73 1.28±0.0 6 50.06±8. 95 4.16±0.1 4
9.37±0.1 6 59.58±1. 88 1.29±0.0 8 58.72±0. 07 5.56±0.1 5
10.68±0. 15 70.11±1. 37 1.17±0.0 2 62.83±2. 04 5.24±0.5 6
lactic acid citric acid Succinic acid
86.69±0. 89 8.10±00. 15 150.19±1 .55
1048.63± 18.14 15.89±0. 42 182.35±0 .21
1351.92± 36.80 17.54±0. 49 634.74±5 .09
1536.10± 6.06 17.99±0. 50 687.69±0 .49
1768.18± 2.971 21.08±0. 20 863.81±1 4.62
2233.19± 47.18 21.96±0. 38 1077.04± 3.62
2084.23± 7.39 20.34±0. 20 942.43±7 0.73
Table.S3 Changes in volatile compounds in JZ22(a) and JB3(b) Chinese Rice Wine during fermentation. a Relative content of volatile compounds in Jz22 fermentation stages(mg/l) No.
Compounds
Day 0
Day 2
Day 4
Day 6
Day 8
4.76 49.86 2.08
3.13
2.79 12.68
0.11
0.57
Day 10
Day12
alkane Heneicosane Pentacosane Tetratriacontane 2,4,4-trimethyl-Hexane 2,6,10,15-tetramethyl-Hept adecane 3,7-dimethyl-Nonane 3,8-dimethyl-Decane 3-methyl-Undecane 2,6,10-trimethyl-Dodecane 2,6,10,15-tetramethyl-Hept adecane 2-ethoxy-Propane Cyclodecane 2-Bromo dodecane ethoxymethyl Oxirane 1,1'-Bicycloheptyl diethyl(decyloxy)-Borane alcohol 1-Propanol 1-Butanol
0.05 1.50 0.12
6.08
0.11
0.01 0.02
0.31 0.12
0.87
0.18
0.50
0.01
0.58 0.16
2.23 1.69
6.61
0.78 0.12 0.08 1.29 1.26 0.06
0.57
6.12 0.33
2.63 0.18
11.60 0.69
6.45 0.72
2-methyl-1-Propanol 1-Pentanol 3-methyl-1-Butanol 1-Hexanol 1-Heptanol 6-methyl-2-Heptanol 1-Octanol 1-Nonanol 1-Undecanol 2-Furanmethanol 2-ethyl-2-methyl-Tridecan ol 1-methoxy-2-Butanol 3-ethoxy-1-Propanol 2-(2-butoxyethoxy)-Ethan ol 1-(1-methylethoxy)-2-Prop anol 1,2-Propanediol Glycerin 2,3-Butanediol 1-Octen-3-ol Phenylethyl Alcohol 3-(methylthio)-1-Propanol 2-Chloroethanol
0.04 0.01 0.07 0.04
4.44
2.42
22.11
10.96
40.98
25.77
25.51 0.14 1.04
17.12 0.14
113.19 0.62
73.88 0.61
198.80 1.40
172.43 1.58
0.36 1.05
1.30 0.46 1.54
0.01
0.04
0.01 0.03
0.20 0.59
0.29 1.96 0.77
0.05 0.18 0.65 0.03 0.88 0.01 0.03
8.36 11.71
24.27 12.37
83.56 28.56
51.26 24.29
0.18
7.05
14.69
40.39 0.49
5.38 140.53 243.33
2.73 258.38 92.60
105.83 1.07 4.52
93.27 0.74
ester Formic acid ethyl ester Butanoic acid ethyl ester Pentanoic acid ethyl ester Hexanoic acid ethyl ester Heptanoic acid ethyl ester Octanoic acid ethyl ester Nonanoic acid ethyl ester
0.01
0.19 0.13
0.10 0.08 1.74 0.11 1.01 0.25
0.91 0.61 0.17
0.25 0.19 5.73 0.58 7.62 2.37
0.42 0.30 0.40 11.32 0.77 10.67 2.80
0.36 0.51 14.17 1.16 12.91 3.48
Decanoic acid ethyl ester 2-hydroxy-Propanoic acid ethyl ester Undecanoic acid ethyl ester Pentadecanoic acid ethyl ester Dodecanoic acid ethyl ester Tetradecanoic acid ethyl ester Hexadecanoic acid ethyl ester Ethyl 9-hexadecenoate Octadecanoic acid ethyl ester (E)-9-Octadecenoic acid ethyl ester 9,12-Octadecadienoic acid ethyl ester Eicosanoic acid ethyl ester Benzoic acid ethyl ester Benzeneacetic acid ethyl ester Butanedioic acid diethyl ester Octanoic acid 3-methylbutyl ester 3-methyl-1-Butanol acetate Isopentyl hexanoate Amyl Nitrite Acetic acid phenylethyl ester
0.47
1.52
0.05
0.05
2.01 0.42
15.84
17.66
23.04
0.36
2.57
1.32
5.18
5.30
6.13
2.13
2.01
1.96
48.57 0.93
50.78
81.02 1.34
0.36 3.80 0.48
1.07
0.19 0.17
3.99
14.96
1.29
5.30
0.27
1.19
2.08
6.80
15.49
17.49
38.54
0.04 0.01
0.67
1.79 0.08 0.29
6.76 0.34 1.06
10.95
12.60 1.03 4.95
29.47
3.39
9.63
0.21
0.02
0.21
0.12
0.14
0.36
1.42
2.30
0.59
0.19
0.79 0.91 0.38
2.07 0.52
2.23
0.55
1.91
0.06
5.89 0.42
0.90
1.23
Formic acid heptyl ester 2-Propenoic acid oxiranylmethyl ester Sulfurous acid ethylhexyl hexyl ester Sulfurous acid ethylhexyl isohexyl ester Sulfurous acid butyl nonyl ester ketone 2-Octanone 2-Nonanone 2-ethoxy-Propane 1-hydroxy-2-Propanone 1,3-dihydroxy-2-Propanon e 2-Hydroxy-gamma-butyrol actone 3-hydroxy-2-Butanone 4-Hydroxy-3-hexanone 2-methyl-Cyclopentanone 1,3-dihydroxy-2-Propanon e dihydro-5-propyl-2(3H)-F uranone 2,3-dihydro-3,5-dihydroxy -6-methyl-4H-Pyran-4-one aldehyde hydroxy-Acetaldehyde 3-methyl-Hexanal Nonanal Decanal Benzeneacetaldehyde
0.23 0.02 0.01
0.11 0.17 0.56
0.01
1.49
12.32
2.30 30.58
37.18
0.06 0.88 0.01 0.60 0.01 0.16
0.16
0.13
0.54
0.06 0.24
0.18 0.88
0.01 0.47 0.01
0.04
0.07
0.13
0.16
0.61
1.23
2.45 0.09
0.81
0.02 0.08 0.52
acid Acetic acid Hexanoic acid 2-methyl-Propanoic acid 3-methyl-Butanoic acid hydroxy-Acetic acid phenol Phenol 2-methoxy-Phenol 4-ethyl-2-methoxy-Phenol 2-Methoxy-4-vinylphenol other Benzothiazole 2,3-dihydro-Benzofuran 2-hydroxy-N,3,3-trimethyl -Butanamide 2-Methoxyethyl ether Acetamide N-(2-methylpropyl)-Aceta mide, Methylamine Vinylfuran
0.10 0.16 0.07 0.14
3.20
8.18 2.00
22.13 5.04
0.57 0.44
0.02 0.06 0.09 0.20 0.05 0.01
0.13 0.27 0.83
0.09 0.24 0.86
0.30 1.43
0.89 1.17 6.65
1.74 1.49 5.85 10.43
6.42
1.47
4.40
2.89
7.85
6.27
0.70 0.13
0.27
2.46 7.25 14.05
0.07 0.09 0.07
1.03
b Relative content of volatile compounds in JB3 fermentation stages(mg/l) No.
Compounds
Day 0
Day 2
Day 4
2.09
0.55 0.97
Day 6
Day 8
Day 10
Day12
alkane Heneicosane Pentacosane 2,4,4-trimethyl-Hexane 3,7-dimethylnonane 3,7-dimethyldecane
0.12
0.02
0.04
0.40
0.42 0.79 0.28
3-methylundecane 3,8-dimethyundecane, 6-methyl- Tridecane 3,4,5,6-tetramethyloctane 2,6,10,15-tetramethyl-Hept adecane cis-1-ethyl-3-methyl-Cyclo pentane 2,2'-oxybis-Pentane 2-(1-hydroxy-2-propyl)-1, 3-dimethyl-Cyclopentane ethoxymethyl-Oxirane 1-(1-methylpropoxy)Butane 1-iodo-Decane alcohol 1-Propanol 1-Butanol 2-methyl-1-Propanol 1-Pentanol 3-methyl-1-Butanol 1-Hexanol Heptanol 1-Octanol 1-Nonanol 1-Undecanol 2-ethyl-1-Hexanol 4-methyl-3-Hexanol 2-butyl-1-Octanol 6-methyl-1-Heptanol 2,3-dimethyl-1-Pentanol 3-ethoxy-1-Propanol 1-(1-methylethoxy)-2-Prop
0.03 0.03 0.17 0.05 0.40
0.17
0.01 0.01 0.09 0.07 0.29 0.30
0.01 0.21 0.05 0.02
1.23 0.06 3.90
0.67 0.05 2.45
1.29 0.10 5.11
1.49 0.11 6.74
2.56 0.29 13.83
3.00 0.25 13.40
21.76 0.15
16.56 0.13
50.89 0.44
107.59 1.06
96.68 0.81
0.13
35.04 0.24 0.07 0.08
0.19 0.35
0.49
0.28
0.09
0.17
0.72
0.02 0.14
0.58 0.35 0.17
0.01 0.08 0.85
0.69
anol 2-(1-methylethoxy)-1-Prop anol Propylene Glycol Glycerin 2,3-Butanediol 2-Dodecenal 2-(2-butoxyethoxy)-Ethan ol 2-ethyl-2-methyl-Tridecan ol 3-(methylthio)-1-Propanol, Phenylethyl Alcohol
0.28 0.04 3.60
0.38 9.87 23.32
11.00 10.19 0.06
5.19 13.97
30.00 8.36
16.66 30.24
1.67 83.00 53.88
7.64
0.41 35.25
0.73 85.10
0.37 76.53
0.02 0.05 0.06
7.32
5.45
ester (S)-2-hydroxy-Propanoic acid ethyl ester Butanoic acid ethyl ester Pentanoic acid ethyl ester Hexanoic acid ethyl ester Heptanoic acid ethyl ester Octanoic acid ethyl ester Nonanoic acid ethyl ester Decanoic acid ethyl ester 2-hydroxy-Propanoic acid ethyl ester Undecanoic acid ethyl ester Benzoic acid ethyl ester 9-oxo-Nonanoic acid ethyl ester Dodecanoic acid ethyl ester Tetradecanoic acid ethyl
0.40
0.02
0.55 0.03 0.48 0.16 0.93
0.09 0.07 1.65 0.13 0.83 0.27 0.12
0.19 0.15 2.90 0.19 1.22 0.28 1.19
0.28 0.22 6.24 0.51 4.57 1.10 5.54
0.49 0.50 12.97 1.10 9.90 2.62 13.67
0.04
0.04
0.08
0.12
0.21
0.08 0.11
0.21 0.18
1.45 0.43 3.50
1.02
0.55
2.03
3.95
0.25
1.20
3.23
0.03 0.26
1.67
0.87
2.42
ester Hexadecanoic acid ethyl ester Octadecanoic acid ethyl ester (E)-9-Octadecenoic acid ethyl ester 9,12-Octadecadienoic acid ethyl ester Eicosanoic acid, ethyl ester 2-methyl-Butanoic acid ethyl ester 3-methyl-Butanoic acid ethyl ester Butanedioic acid diethyl ester 3-methyl-1-Butanol acetate Acetic acid methylpropyl ester Acetic acid phenylethyl ester Isopentyl hexanoate Amyl Nitrite Formic acid heptyl ester Sulfurous acid butyl decyl ester Sulfurous acid hexyl octyl ester Sulfurous acid ethylhexyl isohexyl ester Oxalic acid6-ethyloct-3-yl heptyl ester Pentafluoropropionic acid
1.95
2.86
3.71
5.02
9.87
24.11
17.12
1.38
1.65
2.34
2.95
10.12
7.38
0.74
1.57
5.83
4.81
0.03 0.76
0.71
0.53 0.08
0.28
0.27
0.08
0.29
1.22
0.59
0.90
2.00
0.39
0.98
0.60
0.24 1.38
2.36
2.34 0.49
0.10
0.34
0.38
1.21
0.07 0.09
0.12
0.09
0.06
0.14
1.00
0.01 0.17 0.52 0.07
undecenyl ester 1,2-Benzenedicarboxylic acid bis(2-methylpropyl) ester aldehyde Nonanal 2-methyl-Pentanal 3-methyl-Hexanal Hydroxy Acetaldehyde Methoxy Acetaldehyde 4-methyl-Benzaldehyde ketone 2-Octanone 3-hydroxy-2-Butanone 5-hydroxy-2-Pentanone 4-Hydroxy-3-hexanone 1,3-dihydroxy-2-Propanon e 3,5-dimethyl-4H-Pyran-4one 5-ethyldihydro2(3H)-Furanone 5-hexyldihydro-2(3H)-Fur anone dihydro-5-propyl-2(3H)-F uranone acid Acetic acid Hexanoic acid 2-methyl-Propanoic acid 3-methyl- Butanoic acid phenol Phenol
0.07
0.02
3.08
0.23 0.06 0.05
0.24
0.07
0.28
0.48 0.49
0.03 0.03
0.56
1.14 0.14
0.09
1.18 0.08
12.42
0.54 29.78
6.56
0.48 0.19 0.04 0.01 0.01
0.06 1.49
3.47 0.1 0.08
0.04
0.64 0.77
0.09
0.08
1.45 0.51
2.72
0.61
0.37
1.29
2-methoxy-Phenol 4-ethyl-2-methoxy-Phenol 2-Methoxy-4-vinylphenol
0.04 0.53 1.11
2,3-dihydro- Benzofuran methoxy-phenyl-Oxime Benzothiazole 2-(2-butoxyethoxy)-Ethan ol Acetamide (E)-5-Decene N-(2-methylpropyl)-Aceta mide Phenanthrene 1,3,5,7-Cyclooctatetraene 9-methylene-9H-Fluorene
0.07 0.02 0.17
1.22 2.36
0.49 1.87
1.16 2.26
6.01 10.20
0.66 15.12 27.61
10.11 22.35
other 0.88 4.96
0.97
7.40
1.74
7.36
3.75
0.11
0.82
0.23
0.08 0.04 0.09
2.55 0.31 2.22
Table S4. Comparisons of alpha diversity indice among the two kinds of sorghum. Estimators
shannon
simpson
Pvalue(JB3_D0-JB3_D10) Pvalue(JB3_D0-JB3_D12) Pvalue(JB3_D0-JB3_D2) Pvalue(JB3_D0-JB3_D4) Pvalue(JB3_D0-JB3_D6) Pvalue(JB3_D0-JB3_D8) Pvalue(JB3_D0-JZ22_D0) Pvalue(JB3_D0-JZ22_D10) Pvalue(JB3_D0-JZ22_D12) Pvalue(JB3_D0-JZ22_D2) Pvalue(JB3_D0-JZ22_D4) Pvalue(JB3_D0-JZ22_D6) Pvalue(JB3_D0-JZ22_D8) Pvalue(JB3_D10-JB3_D12)
0.008879 0.01504 0.1906 0.0008832 0.003188 0.001705 0.1258 0.04263 0.01823 0.9167 0.001686 0.001731 0.02023 0.8957
0.104 0.009197 0.5166 0.005293 0.001154 0.000384 0.2563 0.03221 0.007066 0.363 0.001699 0.002269 0.001444 0.6109
Pvalue(JB3_D10-JB3_D2) Pvalue(JB3_D10-JB3_D4) Pvalue(JB3_D10-JB3_D6) Pvalue(JB3_D10-JB3_D8) Pvalue(JB3_D10-JZ22_D0) Pvalue(JB3_D10-JZ22_D10) Pvalue(JB3_D10-JZ22_D12) Pvalue(JB3_D10-JZ22_D2) Pvalue(JB3_D10-JZ22_D4) Pvalue(JB3_D10-JZ22_D6) Pvalue(JB3_D10-JZ22_D8) Pvalue(JB3_D12-JB3_D2) Pvalue(JB3_D12-JB3_D4) Pvalue(JB3_D12-JB3_D6) Pvalue(JB3_D12-JB3_D8) Pvalue(JB3_D12-JZ22_D0) Pvalue(JB3_D12-JZ22_D10) Pvalue(JB3_D12-JZ22_D12) Pvalue(JB3_D12-JZ22_D2) Pvalue(JB3_D12-JZ22_D4) Pvalue(JB3_D12-JZ22_D6) Pvalue(JB3_D12-JZ22_D8) Pvalue(JB3_D2-JB3_D4) Pvalue(JB3_D2-JB3_D6) Pvalue(JB3_D2-JB3_D8) Pvalue(JB3_D2-JZ22_D0) Pvalue(JB3_D2-JZ22_D10) Pvalue(JB3_D2-JZ22_D12) Pvalue(JB3_D2-JZ22_D2) Pvalue(JB3_D2-JZ22_D4) Pvalue(JB3_D2-JZ22_D6) Pvalue(JB3_D2-JZ22_D8) Pvalue(JB3_D4-JB3_D6)
0.9931 0.01753 0.4479 0.04505 0.2831 0.106 0.7653 0.1218 0.08265 0.05594 0.6279 0.9752 0.004092 0.1916 0.006498 0.2942 0.001308 0.4448 0.1403 0.02186 0.009841 0.1458 0.2435 0.7859 0.3682 0.5595 0.5048 0.9344 0.2252 0.4739 0.4057 0.8871 0.005878
0.8698 0.06244 0.2676 0.08367 0.6782 0.3669 0.6041 0.1436 0.1586 0.1226 0.5643 0.7219 0.06039 0.1352 0.02438 0.4054 0.002487 0.8701 0.1328 0.08225 0.07162 0.7632 0.3012 0.5374 0.3329 0.9541 0.8416 0.719 0.244 0.4411 0.3989 0.7006 0.1082
Pvalue(JB3_D4-JB3_D8) Pvalue(JB3_D4-JZ22_D0) Pvalue(JB3_D4-JZ22_D10) Pvalue(JB3_D4-JZ22_D12) Pvalue(JB3_D4-JZ22_D2) Pvalue(JB3_D4-JZ22_D4) Pvalue(JB3_D4-JZ22_D6) Pvalue(JB3_D4-JZ22_D8) Pvalue(JB3_D6-JB3_D8) Pvalue(JB3_D6-JZ22_D0) Pvalue(JB3_D6-JZ22_D10) Pvalue(JB3_D6-JZ22_D12) Pvalue(JB3_D6-JZ22_D2) Pvalue(JB3_D6-JZ22_D4) Pvalue(JB3_D6-JZ22_D6) Pvalue(JB3_D6-JZ22_D8) Pvalue(JB3_D8-JZ22_D0) Pvalue(JB3_D8-JZ22_D10) Pvalue(JB3_D8-JZ22_D12) Pvalue(JB3_D8-JZ22_D2) Pvalue(JB3_D8-JZ22_D4) Pvalue(JB3_D8-JZ22_D6) Pvalue(JB3_D8-JZ22_D8) Pvalue(JZ22_D0-JZ22_D10) Pvalue(JZ22_D0-JZ22_D12) Pvalue(JZ22_D0-JZ22_D2) Pvalue(JZ22_D0-JZ22_D4) Pvalue(JZ22_D0-JZ22_D6) Pvalue(JZ22_D0-JZ22_D8) Pvalue(JZ22_D10-JZ22_D12) Pvalue(JZ22_D10-JZ22_D2) Pvalue(JZ22_D10-JZ22_D4) Pvalue(JZ22_D10-JZ22_D6)
0.08525 0.03221 0.001032 0.00591 0.0397 0.02977 0.0524 0.006079 0.02472 0.1591 0.01594 0.1536 0.09773 0.0851 0.03791 0.1202 0.05376 0.00114 0.009003 0.05416 0.2741 0.625 0.009011 0.8961 0.3261 0.3042 0.071 0.05979 0.3681 0.003283 0.3104 0.00384 0.001708
0.723 0.0672 0.0216 0.05959 0.06368 0.2431 0.3782 0.049 0.05254 0.2133 0.01471 0.1342 0.103 0.3765 0.2368 0.1629 0.08993 0.005739 0.02177 0.07402 0.2267 0.4378 0.01034 0.7635 0.4016 0.1825 0.1432 0.1173 0.3785 0.0001959 0.2184 0.01625 0.01737
Pvalue(JZ22_D10-JZ22_D8) Pvalue(JZ22_D12-JZ22_D2) Pvalue(JZ22_D12-JZ22_D4) Pvalue(JZ22_D12-JZ22_D6) Pvalue(JZ22_D12-JZ22_D8) Pvalue(JZ22_D2-JZ22_D4) Pvalue(JZ22_D2-JZ22_D6) Pvalue(JZ22_D2-JZ22_D8) Pvalue(JZ22_D4-JZ22_D6) Pvalue(JZ22_D4-JZ22_D8) Pvalue(JZ22_D6-JZ22_D8)
0.005956 0.1484 0.02384 0.0125 0.2049 0.06363 0.05772 0.1582 0.489 0.02202 0.01215
0.01487 0.1323 0.08049 0.07012 0.7963 0.08807 0.08119 0.1279 0.6832 0.07227 0.05853
Table S5. Bacterial genera abundance during different fermentation stages of JZ22 and JB3. OTU ID g__[Eubacterium]_coprostanoligenes_grou p g__[Eubacterium]_eligens_group g__[Eubacterium]_hallii_group g__[Eubacterium]_rectale_group g__[Eubacterium]_ruminantium_group g__[Eubacterium]_ventriosum_group g__[Ruminococcus]_torques_group g__Acetobacter g__Achromobacter g__Acidibacter g__Acinetobacter g__Alistipes g__Alloprevotella g__Anaerococcus g__Anaerostipes g__Apibacter g__Aquabacterium
JZ22 D0
JZ22 D2
JZ22 D4
JZ22 D6
JZ22 D8
JZ22 D10
JZ22 D12
JB3 D0
JB3 D2
JB3 D4
JB3 D6
JB3 D8
JB3 D10
JB3 D12
0
0
0
0
0
0
0
0
0
0
2
1
0
0
0 1 0 0 0 0 16 1 0 4 0 0 0 0 15 3
0 0 0 0 0 0 4 0 0 1 0 0 0 0 19 1
0 0 2 0 0 0 11 3 0 17 0 0 0 0 49 7
0 0 1 0 0 0 10 4 0 6 0 0 0 0 91 4
0 1 1 0 0 1 5 4 0 6 0 0 0 1 14 5
1 1 5 0 0 1 1 7 0 10 0 0 0 1 11 7
0 0 6 1 0 2 5 3 0 68 0 0 0 3 4 7
0 0 0 0 0 0 2 0 0 5 0 0 0 1 7 1
0 0 0 0 0 0 15 1 0 4 0 0 0 0 42 2
1 1 5 0 0 0 3 7 1 11 0 1 1 3 64 10
0 1 1 0 0 0 4 5 0 7 1 0 0 1 31 5
0 2 3 0 2 5 8 7 0 15 0 0 0 2 37 8
0 0 4 0 0 3 3 5 0 9 1 0 0 1 10 8
1 2 9 0 0 1 3 7 0 9 0 0 1 3 7 7
g__Atopobium g__Azospirillum g__Bacillus g__Bacteroides g__Bdellovibrio g__Bifidobacterium g__Bilophila g__Blautia g__Bradyrhizobium g__Brevibacillus g__Brevundimonas g__Burkholderia-Paraburkholderia g__Carnimonas g__Catenibacterium g__Cellulosimicrobium g__Cetobacterium g__Chroococcidiopsis g__Chryseobacterium g__Cloacibacterium g__Clostridium_sensu_stricto_1 g__Clostridium_sensu_stricto_10 g__Clostridium_sensu_stricto_13 g__Collinsella g__Coprococcus_1 g__Coprococcus_3 g__Corynebacterium_1 g__Cupriavidus g__Deinococcus g__Desulfovibrio g__Dialister g__Dorea g__Enhydrobacter g__Enterococcus
0 0 37925 3 0 0 0 1 0 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 1
0 0 36148 1 0 2 0 1 0 0 1 1 0 0 0 0 0 0 0 1 0 0 1 0 0 2 0 0 1 0 1 0 1
0 1 33308 1 0 1 0 2 1 1 3 13 0 0 0 0 0 0 0 1 0 0 1 0 0 7 0 0 0 0 0 0 3
0 0 34736 3 1 3 0 2 1 88 1 18 1 0 0 0 0 0 0 1 0 0 0 0 0 4 0 0 0 1 1 1 1
0 0 37303 4 1 3 0 3 1 32 0 12 0 0 0 0 11 0 0 1 0 0 1 0 1 4 0 3 0 0 1 0 0
0 0 37942 4 1 8 0 8 1 7 0 15 0 0 0 0 0 1 0 1 0 0 5 0 1 3 1 0 0 0 2 3 0
22 0 37252 5 0 11 0 11 2 1 0 9 0 0 0 0 0 9 2 0 0 0 6 0 1 5 0 0 0 4 1 0 3
0 0 38918 1 0 0 0 1 1 38 0 2 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
0 0 33378 5 1 3 0 2 1 78 1 4 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 1
0 0 32132 3 0 15 0 9 2 972 2 7 0 0 0 1 0 0 1 7 0 0 2 1 0 4 2 0 1 1 2 0 0
0 0 33412 2 1 5 0 4 1 3488 0 10 1 0 0 0 0 0 0 2 1 0 2 0 0 6 0 0 0 1 1 0 1
0 0 31541 3 1 13 0 16 2 4400 1 17 0 0 0 0 0 0 0 2 0 0 7 1 1 4 2 0 0 0 3 0 0
0 0 35042 3 2 10 0 8 1 1936 0 9 0 1 0 1 0 0 0 4 0 0 2 0 0 2 1 1 0 0 1 0 1
0 0 35857 4 3 17 0 14 1 2080 0 12 0 0 1 0 0 0 0 2 0 0 5 1 1 5 1 0 0 2 0 5 1
g__Erysipelotrichaceae_UCG-003 g__Escherichia-Shigella g__Faecalibacterium g__Finegoldia g__Flavobacterium g__Fusicatenibacter g__Gardnerella g__Georgenia g__Halomonas g__Klebsiella g__Kroppenstedtia g__Lachnoclostridium g__Lachnospira g__Lachnospiraceae_ND3007_group g__Lachnospiraceae_NK4A136_group g__Lachnospiraceae_UCG-004 g__Lactobacillus g__Lactococcus g__Lentibacillus g__Leuconostoc g__Lysinibacillus g__Marmoricola g__Megamonas g__Megasphaera g__Mesorhizobium g__Methylobacterium g__Microbispora g__Moraxella g__Nafulsella g__Nitrospira g__norank_c__1-20 g__norank_c__Acidobacteria g__norank_c__Actinobacteria
0 2 2 0 0 0 0 0 0 10 14 0 0 0 0 0 42 193 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0
0 1 1 0 0 0 0 0 1 3 20 0 0 0 0 0 29 10 0 10 0 0 0 0 0 0 0 0 1 0 0 0 1
0 3 2 0 0 0 0 0 0 21 123 0 0 0 1 0 60 25 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0
0 5 2 0 0 0 0 0 1 20 178 0 0 1 0 0 72 19 3 6 0 0 1 0 1 1 1 0 0 0 0 0 0
0 4 3 1 0 1 0 0 0 13 102 0 0 0 0 0 19 15 1 7 0 3 3 0 0 0 0 0 0 0 0 1 0
0 4 10 0 0 2 0 0 0 9 129 0 2 0 2 0 9 15 0 3 0 0 1 0 0 0 0 0 1 0 0 1 0
0 8 12 0 0 1 38 0 0 75 93 0 0 0 3 0 11 7 0 0 0 0 1 19 0 0 1 0 0 0 0 1 0
0 2 1 0 0 1 0 0 0 4 8 0 0 0 0 0 25 140 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0
0 3 2 0 0 1 0 3 0 15 60 0 0 0 1 0 26 9 0 6 0 0 1 0 0 0 0 0 0 0 3 0 0
0 9 10 0 0 3 0 0 1 15 194 2 0 0 3 1 15 7 0 11 1 0 0 0 0 0 0 3 0 0 0 1 0
0 7 2 0 0 2 0 0 0 10 134 0 0 0 0 0 11 2 0 3 1 0 0 0 0 0 0 0 0 0 0 0 0
1 6 8 0 1 8 0 0 0 15 231 2 1 2 3 0 12 1 0 4 0 0 1 0 0 0 0 0 0 0 0 3 0
0 3 11 0 0 6 0 0 0 13 177 2 1 1 1 0 24 3 0 3 1 0 1 0 0 1 0 0 0 0 0 1 0
0 5 10 0 0 4 0 0 1 17 172 0 1 1 1 0 6 1 0 2 1 0 0 0 0 1 0 0 1 1 0 3 0
g__norank_c__BD7-11 g__norank_c__Cyanobacteria g__norank_c__Gemmatimonadetes g__norank_f__0319-6G20 g__norank_f__Actinopolysporaceae g__norank_f__Anaerolineaceae g__norank_f__Bacteroidales_S24-7_group g__norank_f__Cytophagaceae g__norank_f__Elev-16S-1332 g__norank_f__env.OPS_17 g__norank_f__Holophagaceae g__norank_f__Longimicrobiaceae g__norank_f__Mitochondria g__norank_f__Neisseriaceae g__norank_f__Nitrosomonadaceae g__norank_f__Porphyromonadaceae g__norank_f__Ruminococcaceae g__norank_f__Synergistaceae g__norank_f__Syntrophaceae g__norank_f__Unknown_Family g__norank_p__Saccharibacteria g__norank_p__WWE3 g__Novosphingobium g__Oceanobacillus g__Paenibacillus g__Paeniclostridium g__Pantoea g__Parabacteroides g__Paracoccus g__Parasutterella g__Pediococcus g__Pelomonas g__Perlucidibaca
0 357 0 0 0 0 2 0 0 0 0 0 102 0 0 0 0 0 0 0 0 1 0 0 940 1 1 0 1 1 38 3 0
0 753 2 0 1 0 0 0 0 0 0 1 256 0 0 0 0 0 0 0 0 0 0 3 322 0 0 0 0 0 58 1 0
1 1042 0 1 8 0 2 0 0 0 0 0 285 1 0 0 0 0 0 1 0 3 1 1 180 0 4 0 2 0 92 1 0
1 924 0 1 3 0 0 0 0 0 0 0 353 0 0 1 0 0 0 1 0 0 0 1 247 1 3 0 1 0 182 6 0
3 674 0 1 2 0 0 0 0 0 1 0 205 0 1 0 0 0 0 0 0 0 0 1 41 0 2 0 0 0 20 6 0
2 344 1 2 5 0 0 0 0 0 0 0 42 0 0 0 0 0 0 0 0 0 1 0 264 2 1 0 1 0 18 7 1
3 272 0 1 5 0 0 1 0 0 0 0 19 0 0 0 0 1 0 0 0 0 0 0 898 1 0 1 0 0 21 3 0
0 132 0 0 0 0 0 0 1 0 0 0 24 0 0 0 0 0 0 0 0 0 1 0 526 0 0 0 0 0 20 2 0
0 2378 0 1 1 0 1 0 0 0 0 0 684 0 0 0 0 0 0 0 0 16 1 0 1111 0 8 0 0 1 31 2 0
2 2728 0 0 2 0 2 0 0 0 0 0 290 0 0 0 0 0 0 0 0 1 1 1 553 0 1 0 0 0 22 14 1
2 1331 0 1 4 1 1 0 0 0 1 0 133 1 0 0 1 0 0 0 0 0 0 0 189 1 1 0 0 0 2 4 0
3 1173 0 2 7 0 0 0 0 0 0 0 181 1 0 0 1 0 1 0 1 0 1 4 635 0 1 1 1 0 8 6 0
2 1096 0 2 4 0 0 0 0 1 0 0 224 0 0 0 1 0 0 0 0 0 1 0 349 1 2 0 0 0 7 6 0
2 695 0 2 6 0 1 0 0 0 1 0 59 0 0 0 1 0 1 0 0 0 1 0 162 0 1 0 1 0 6 9 0
g__Phascolarctobacterium g__Porphyromonas g__Prevotella g__Prevotella_1 g__Prevotella_6 g__Prevotella_9 g__Propionibacterium g__Pseudomonas g__Pseudorhodoferax g__Ralstonia g__Rhizobium g__Rhizomicrobium g__Rhodococcus g__Rikenellaceae_RC9_gut_group g__Roseburia g__Roseomonas g__Rubellimicrobium g__Ruminiclostridium g__Ruminococcaceae_UCG-002 g__Ruminococcaceae_UCG-010 g__Ruminococcus_1 g__Ruminococcus_2 g__Rummeliibacillus g__Saccharopolyspora g__Sediminibacterium g__Shuttleworthia g__Sneathia g__Solibacillus g__Sorangium g__Sphingobacterium g__Sphingomonas g__Sporosarcina g__Staphylococcus
0 0 0 0 0 0 0 2 0 43 0 0 38 0 0 0 0 0 0 0 0 2 6 7 0 1 0 0 0 0 0 0 8
0 0 0 0 0 3 1 4 0 16 0 0 13 0 0 0 0 0 0 0 0 0 28 26 0 1 0 0 0 2 0 0 38
0 0 0 2 0 1 2 17 0 114 0 0 93 0 1 0 2 0 0 0 1 0 5 82 0 0 0 0 1 3 0 0 86
0 0 0 0 0 3 4 7 1 133 0 0 128 0 0 0 0 0 0 0 0 0 6 76 0 0 0 0 0 3 0 0 123
0 0 0 0 0 5 2 2 0 108 0 0 81 1 0 0 0 0 0 0 0 0 2 47 0 0 0 0 0 0 1 0 22
0 0 0 0 0 18 1 4 0 162 0 1 123 0 1 0 0 0 0 0 4 0 6 46 0 0 0 2 0 0 1 0 16
2 2 70 0 5 16 3 3 0 128 1 0 127 0 4 0 0 0 0 0 1 1 5 41 0 232 11 0 0 0 6 0 11
0 0 0 0 0 2 0 0 0 29 0 0 35 0 0 0 0 0 0 0 0 1 8 4 0 0 0 0 0 0 0 0 6
0 0 0 0 0 1 0 3 0 38 0 0 29 0 1 0 0 0 0 0 0 0 44 34 1 0 0 0 1 0 0 0 76
1 0 2 0 0 2 2 7 0 194 0 0 199 1 0 1 1 1 0 0 1 5 65 43 0 1 0 0 1 1 1 1 15
0 0 0 0 0 0 1 2 0 90 0 0 78 0 0 0 0 0 0 0 0 0 31 58 0 0 0 0 0 0 0 0 7
0 0 0 0 0 3 1 4 0 139 0 0 140 0 1 0 0 0 0 0 4 3 75 86 0 0 0 0 0 1 1 0 8
0 0 0 0 0 1 1 7 0 144 1 0 81 0 1 0 0 0 0 0 2 1 25 47 0 0 0 1 1 0 1 0 5
0 0 0 0 0 2 4 2 0 150 0 1 163 0 1 0 0 0 1 0 2 1 10 72 0 0 0 1 0 0 0 0 5
g__Stenotrophomonas g__Streptococcus g__Streptomyces g__Subdoligranulum g__Sulfuritalea g__Sva0081_sediment_group g__Terrabacter g__Terrisporobacter g__Thermoactinomyces g__Thermus g__unclassified_c__Betaproteobacteria g__unclassified_c__Gemmatimonadetes g__unclassified_f__Comamonadaceae g__unclassified_f__Corynebacteriaceae g__unclassified_f__Enterobacteriaceae g__unclassified_f__Erythrobacteraceae g__unclassified_f__Lachnospiraceae g__unclassified_f__Peptostreptococcaceae g__unclassified_f__Prevotellaceae g__unclassified_k__norank g__unclassified_o__Bacillales g__unclassified_o__Rhizobiales g__unclassified_p__Firmicutes g__unclassified_p__Proteobacteria g__Undibacterium g__Vibrio g__Virgibacillus g__Weissella
0 1 13 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 10 0 0 0 192
0 0 79 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 2 0 0 0 4 0 0 0 2134
1 0 186 0 0 0 1 0 1 0 0 1 0 1 4 0 0 0 0 4 0 0 0 26 0 0 0 4073
0 3 206 0 0 0 0 0 0 0 0 0 0 1 6 0 0 1 1 0 1 0 0 3 0 0 0 2294
1 0 88 0 0 0 0 0 0 0 0 0 3 0 4 0 0 1 0 0 0 1 0 6 0 1 0 1087
0 0 119 1 0 0 4 0 1 0 1 0 0 0 0 0 0 1 0 0 0 0 0 8 1 0 0 564
6 10 68 2 0 0 1 0 0 1 0 0 0 1 0 0 2 1 1 1 0 0 0 1 0 0 0 312
0 0 3 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 51
0 1 147 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 4 2 0 0 19 0 0 0 1702
1 4 102 5 0 0 1 1 1 1 0 0 0 1 4 0 1 2 0 5 3 0 0 13 1 1 1 2154
0 0 115 3 0 0 0 0 2 0 0 0 0 0 8 0 0 1 0 2 12 0 0 16 1 0 0 743
1 1 132 6 0 0 0 0 2 1 0 0 0 0 3 1 2 1 0 1 28 1 0 6 2 0 0 933
3 0 122 4 0 0 0 0 1 1 1 0 0 1 4 0 1 3 0 9 12 0 0 21 1 0 0 495
3 4 144 6 0 0 2 0 0 0 0 0 0 0 0 0 0 2 0 1 6 0 1 8 1 0 0 187
Table S6. Predicted gene functions related to KEGG pathways at levels 3
1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane
JZ22 D0
JZ22 D2
JZ22 D4
JZ22 D6
JZ22 D8
JZ22 D10
JZ22 D12
JB3 D0
JB3 D2
JB3 D4
JB3 D6
JB3 D8
JB3 D10
JB3 D12
34
13
89
113
83
128
112
28
30
173
74
121
100
137
(DDT) degradation ABC transporters Adherens junction Adipocytokine signaling pathway African trypanosomiasis Alanine, aspartate and glutamate metabolism Aldosterone-regulated sodium reabsorption Alzheimer's disease Amino acid metabolism Amino acid related enzymes Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Aminobenzoate degradation Amoebiasis Amyotrophic lateral sclerosis (ALS) Antigen processing and presentation Apoptosis Arachidonic acid metabolism Arginine and proline metabolism Arrhythmogenic right ventricular cardiomyopathy (ARVC) Ascorbate and aldarate metabolism Atrazine degradation Bacterial chemotaxis Bacterial invasion of epithelial cells Bacterial motility proteins
67928 7 0 10320 123 17446 4 0 10367 56996 22329 1 23958 5 15475 6 89724 13290 22104 5080 170 14484 24220 4
65210 0 0 9943 259 17041 3 0 11059 56797 22657 9 23437 6 16435 0 85786 12536 20794 5085 697 14159 23627 4
67897 0 0 10688 315 17043 6 0 11284 57012 23151 7 23731 7 17465 3 85733 11807 18887 4868 1159 13441 24080 7
67926 2 0 10885 389 17314 2 0 11665 57168 23165 0 23660 8 17109 9 87968 12111 19800 5114 884 14019 24239 3
68526 3 0 10831 235 17755 5 0 10892 59015 22986 9 24194 5 16332 2 91638 13347 22013 5009 458 14751 24713 1
68130 8 0 10801 80 17829 8 0 10256 58794 22613 4 24319 0 15644 8 93950 13725 22862 4967 208 14891 24582 0
71610 7 0 10901 86 18219 9 0 10284 57525 23204 2 25015 6 16121 5 92263 13333 22112 5216 143 14497 25187 8
66753 2 0 10001 38 17613 3 0 10001 58572 22318 0 24318 0 15139 5 93412 14052 23853 4904 51 14701 24156 8
72660 6 0 11204 697 18621 6 0 13547 62986 25696 2 25857 7 19347 3 89300 13125 21242 6113 1040 15180 26159 7
73077 1 0 11864 422 18497 8 0 11672 63327 24950 3 25023 6 18844 9 91345 12009 19119 5560 778 14992 26150 0
71016 6 0 10842 442 18023 2 0 10522 62583 23225 7 24284 2 16508 6 92258 12818 20988 5140 302 14810 24995 2
71265 0 0 10808 592 17685 9 1 10517 61926 22986 3 23675 7 16558 1 92029 12185 20552 4918 415 14580 24635 3
70313 7 0 10882 413 18033 0 1 10917 61687 23359 4 24363 1 16621 8 93290 13249 22201 5081 366 15102 25034 1
69745 2 0 11010 286 17993 9 0 10184 61042 22781 4 24147 2 15847 8 95501 13317 22382 4919 148 15029 24834 0
0 54560 2656 12879 0 181 27587
0 50349 3115 11986 1 366 26438
0 49574 4442 11313 6 512 25472
0 50534 4407 11739 6 448 26296
0 54361 2847 12536 7 341 27546
0 56019 2130 12881 7 170 27703
0 56159 2769 13750 6 145 29198
0 56564 892 13107 2 134 27523
0 51955 4641 11822 0 1237 27900
0 47896 6058 11350 1 1534 27806
0 51468 2911 12458 1 750 27943
0 49117 2736 12307 9 678 27540
0 52765 2365 12573 1 609 28019
0 53853 2166 12806 3 408 28001
Bacterial secretion system Bacterial toxins Basal transcription factors Base excision repair Benzoate degradation Betalain biosynthesis Bile secretion Biosynthesis and biodegradation of secondary metabolites Biosynthesis of 12-, 14- and 16-membered macrolides Biosynthesis of ansamycins Biosynthesis of siderophore group nonribosomal peptides Biosynthesis of type II polyketide backbone Biosynthesis of type II polyketide products Biosynthesis of unsaturated fatty acids Biosynthesis of vancomycin group antibiotics Biotin metabolism Bisphenol degradation Bladder cancer Butanoate metabolism Butirosin and neomycin biosynthesis C5-Branched dibasic acid metabolism CAM ligands Caffeine metabolism Calcium signaling pathway Caprolactam degradation Carbohydrate digestion and absorption Carbohydrate metabolism Carbon fixation in photosynthetic organisms
2 73197 14623 116 66617 71340 12 7
1 78532 14618 57 67500 69913 18 29
0 82884 15354 115 69144 73739 57 77
6 82780 14977 149 69848 75200 65 81
3 77584 15118 75 68625 73864 41 36
1 73420 14993 116 67498 75500 58 47
2 75031 15081 162 68996 74986 40 39
1 70416 15248 66 65384 71770 7 2
5 95529 16160 176 75688 70997 34 55
2 88801 17367 253 75121 79454 64 42
8 76689 16550 389 70358 76041 40 46
1 76368 16737 553 71073 78338 56 58
6 78023 16146 288 70534 75682 55 51
1 73334 15990 305 69183 78382 61 59
9751
10161
10293
10542
10220
10436
10193
9977
11442
12167
11153
11047
10816
10928
15 13598
85 12706
217 12155
231 12498
107 13559
136 14072
83 14898
2 14301
156 13609
116 12650
133 13152
164 12802
139 13666
170 13786
29198 15 4 56356 885 28214 39900 23 15754 9 5850 48767 0 310 177 16520 5075 52518 63864
28082 75 17 54543 1342 27191 37674 23 15452 4 5956 46900 0 104 365 15213 4898 49552 67007
24021 205 55 52742 2587 26961 36312 94 15817 2 7082 45519 0 600 504 18362 4841 50084 72598
25701 218 55 54638 1969 27491 37550 107 16129 3 6645 47342 0 442 442 18810 4903 50181 71191
28763 95 25 57104 1353 28632 40243 68 16178 8 6266 48462 0 334 334 17927 5196 52433 68337
30823 125 32 58528 863 28798 42326 94 16353 7 5813 49266 0 191 168 18155 5049 52702 64470
28755 85 24 57628 1589 29648 41123 86 16377 0 6796 50428 0 440 133 18844 5310 54131 67857
33226 5 2 58258 360 28894 42836 16 15838 0 5262 49367 0 36 65 15261 5023 52821 60982
29093 140 33 58960 2999 31060 38514 49 16038 5 7499 52528 0 41 1177 15155 5532 55200 85703
27265 110 28 57366 3725 30171 36669 113 16392 4 7864 51526 0 69 1340 17902 5463 52291 86719
29330 125 33 57327 2023 29315 38741 66 16223 6 6579 49544 0 47 662 16856 4918 51515 72013
27475 165 47 56294 2164 27939 37664 99 16260 8 6869 48223 0 72 581 17907 4836 49220 71287
29834 135 35 58297 1668 29092 40040 80 16245 1 6519 49552 0 56 538 17092 5197 51866 71254
30564 165 44 58706 1258 28905 41446 108 16558 8 6157 49524 0 75 342 18550 5014 51506 67043
Carbon fixation pathways in prokaryotes Cardiac muscle contraction Carotenoid biosynthesis Cell cycle Cell cycle - Caulobacter Cell cycle - yeast Cell division Cell motility and secretion Cellular antigens Chagas disease (American trypanosomiasis) Chaperones and folding catalysts Chloroalkane and chloroalkene degradation Chlorocyclohexane and chlorobenzene degradation Cholinergic synapse Chromosome Chronic myeloid leukemia Circadian rhythm - plant Citrate cycle (TCA cycle) Clavulanic acid biosynthesis Colorectal cancer Complement and coagulation cascades Cyanoamino acid metabolism Cysteine and methionine metabolism Cytochrome P450 Cytokine receptors Cytokine-cytokine receptor interaction Cytoskeleton proteins Cytosolic DNA-sensing pathway
16151 3 356 1514 0 71150 0 9290 7679 10537 117 12337 5 58709 9250 0 27107 0 0 4763 12614 8 0 108 0 56074 18332 6 15 0 0 41254 0
15991 8 770 3008 0 74239 0 9293 10115 10333 257 13133 1 58221 9480 0 27346 8 0 4464 12448 7 0 252 0 54146 17756 0 5 0 0 43243 0
16211 8 950 4299 0 76828 0 8907 12142 10422 311 13874 3 59124 9312 0 27502 3 0 4159 12578 9 0 292 0 52833 17162 5 38 0 0 45042 0
16598 9 1155 3846 0 76795 0 9267 11628 10713 379 13646 4 59648 9934 0 27683 2 0 4342 12985 0 0 351 0 53863 17789 3 51 0 0 44473 0
16587 4 721 2824 0 74796 0 9642 9629 10646 230 13148 5 60000 9856 0 27724 5 0 4639 12890 3 2 209 0 56609 18274 4 33 0 0 43439 0
16404 3 276 1534 0 71835 0 9716 7748 10468 79 12572 8 60723 10359 0 27441 7 0 4757 12714 6 0 52 0 57734 18394 1 50 0 0 41815 0
16666 4 216 1267 0 73179 0 9605 8377 10542 87 12876 0 59860 9613 0 28004 1 0 4730 12892 9 0 32 0 59857 18853 0 51 0 0 44124 0
15931 2 101 591 0 70001 0 9675 6178 10059 34 12003 8 59545 9869 0 27083 0 0 4801 12398 3 0 28 0 57993 18368 1 14 0 0 40123 0
17498 3 2070 9604 0 89560 0 11287 18145 11163 689 15985 2 61795 12075 0 30693 1 0 4195 13509 5 0 679 0 59785 18866 5 12 0 0 52041 0
17379 6 1023 10973 0 86435 0 10836 18938 11704 338 15750 9 63641 12833 0 30016 5 0 3895 13026 3 0 293 0 57118 18868 3 80 0 0 51961 0
16685 3 466 5440 0 77251 0 9982 12362 11194 150 13521 1 59940 11001 0 27859 5 0 4375 12671 2 0 131 0 56623 18528 5 31 0 0 44565 0
16692 1 670 4879 0 77077 0 9624 12749 10973 223 13348 6 59130 10633 0 27135 9 0 4273 12597 6 0 193 0 55312 18245 8 56 0 0 43986 0
16799 2 793 4470 0 77541 0 10132 11723 10821 251 13504 6 60110 10767 0 27951 7 0 4489 12825 5 0 232 0 57726 18563 5 33 0 0 44607 0
16664 3 321 2957 0 73769 0 9858 9582 10810 112 12808 5 60841 10919 0 27371 6 0 4594 12738 9 0 71 0 57559 18589 7 66 0 0 42543 0
D-Alanine metabolism D-Arginine and D-ornithine metabolism D-Glutamine and D-glutamate metabolism DNA repair and recombination proteins DNA replication DNA replication proteins Dilated cardiomyopathy (DCM) Dioxin degradation Drug metabolism - cytochrome P450 Drug metabolism - other enzymes ECM-receptor interaction Electron transfer carriers Endocrine and other factor-regulated calcium reabsorption Endocytosis Energy metabolism Epithelial cell signaling in Helicobacter pylori infection ErbB signaling pathway Ether lipid metabolism Ethylbenzene degradation Fat digestion and absorption Fatty acid biosynthesis Fatty acid elongation in mitochondria Fatty acid metabolism Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Flagellar assembly
26997 4677 25084 38058 3 82750 14063 9 0 18133 16920 47232 0 8971
26505 4455 25316 39620 3 87366 14839 7 0 18677 18374 46920 0 8650
25139 4183 26617 41425 7 92177 15700 8 0 18475 20328 46021 0 7999
25593 4357 26187 41049 7 90762 15464 2 0 18428 20115 46421 0 8349
26990 4643 25899 39765 5 87056 14778 3 0 18718 18718 47409 0 8991
27856 4733 25293 38469 9 83414 14149 7 0 19364 17716 48616 0 9307
27334 4651 26049 39368 3 85560 14624 7 0 18363 17340 48774 0 8950
28958 4886 24673 37234 7 80681 13639 1 0 19656 16163 48868 0 9491
27707 4228 28394 45780 3 99647 17135 9 0 20326 24897 47778 0 9299
26876 4214 27702 45244 4 96932 16779 7 0 21136 27706 47042 0 8821
27530 4532 25701 40399 2 85934 14780 3 0 20519 21084 47413 0 9019
26491 4391 25332 40333 7 86150 14793 1 0 20357 21149 46572 0 8579
27560 4584 25790 40517 4 87244 14894 9 0 20036 20481 47582 0 9117
27773 4705 25168 39057 2 83631 14257 4 0 20228 19393 48205 0 9207
0 8 11334 5
0 3 11122 6
0 19 11216 4
0 26 11439 9
0 16 11592 5
0 26 11634 8
0 38 11943 2
0 7 11343 7
0 6 12233 4
0 41 12186 9
0 16 11647 7
1 28 11553 2
1 17 11745 5
0 34 11719 5
10392 0 51 16578 0 11524 5 0 10150 0 0 8 15640
10247 0 39 16203 0 11282 2 0
9622 0 178 16179 0 11377 0 0 10473 4 0 19 13685
10135 0 200 16781 0 11608 2 0 10671 6 0 26 14236
10049 0 130 16333 0 11688 0 0 10596 9 0 16 15279
10211 0 178 16348 0 11621 1 0 10677 3 0 26 15686
10711 0 171 16473 0 11739 8 0 10652 9 0 38 16349
10146 0 104 16660 0 11405 9 0 10022 1 0 7 15981
11300 0 131 16405 0 12125 3 0 10489 2 0 6 13940
11524 0 415 19623 0 11964 8 0 11237 3 0 41 13305
10480 0 214 17277 0 11727 6 0 10587 5 0 16 14682
10093 0 304 17718 0 11679 3 0 10707 9 0 28 14416
10239 0 218 17068 0 11792 3 0 10614 8 0 17 15022
10233 0 284 17359 0 11729 2 0 10894 7 0 34 15364
99174 0 3 14588
5 97 5343 519 0 87744 15258 4 27921 5 0 0
0 36 5577 850 0 87705 14620 1 27378 8 0 0
7 23 5720 1589 0 87163 14940 4 28371 4 0 0
1 31 5725 1553 0 88101 14909 5 28221 5 0 0
2 7 5665 1131 0 89200 15412 4 28559 2 0 0
6 33 5297 970 0 89288 15471 3 28248 8 0 0
General function prediction only Geraniol degradation
97261 0 65181 9 45192
93254 0 64527 7 42982
96582 0 66777 7 44682
95503 0 66628 4 46636
97069 0 66783 0 46814
97794 0 65986 9 48021
0 335 5157 903 0 88914 15916 0 29045 8 0 0 10426 6 0 67775 5 47887
Germination Glioma Glutamatergic synapse Glutathione metabolism Glycan bindng proteins Glycan biosynthesis and metabolism Glycerolipid metabolism
97476 0 15046 45968 0 528 71369
90651 0 14858 49408 0 802 70658
81482 0 15772 51065 0 1241 74260
85879 0 15641 50815 0 1161 73730
92608 0 15579 49274 0 875 72504
96992 0 15246 47764 0 625 71774
Glycerophospholipid metabolism
94150 14772 1 21576 3 0
94526 14345 5 21613 3 0
95049 14542 3 22663 5 0
96273 14808 8 22429 8 0
96125 15008 0 22207 4 0
95474 15027 6 21866 2 0
Flavone and flavonol biosynthesis Flavonoid biosynthesis Fluorobenzoate degradation Focal adhesion Folate biosynthesis Fructose and mannose metabolism Function unknown G protein-coupled receptors GTP-binding proteins Galactose metabolism Gastric acid secretion
Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glycosaminoglycan biosynthesis - chondroitin
0 55 5034 258 0 88724 15455 5 27723 9 0 0
6 116 7767 2618 0 96531 16074 0 30059 3 0 0
8 63 8030 3484 0 96401 15526 3 29990 2 0 0
3 22 6679 1753 0 90414 15251 6 28746 2 0 0
3 74 6429 1837 0 87700 14811 0 28613 1 0 0
9 43 6299 1616 0 90205 15356 3 28864 6 0 0
4 27 5833 1402 0 89365 15282 9 28514 6 0 0
98112 0 72436 1 42138
93057 0 72429 1 45223
91785 0 67600 8 44871
89355 1 66757 6 45392
93659 1 67624 1 45634
93897 0 66550 6 48125
96483 0 15857 46650 0 697 74756
96769 0 64483 8 44568 10156 0 0 14707 45651 0 304 69557
90048 0 15770 52076 0 1967 71123
93260 0 15817 52357 0 1597 71507
95366 0 15489 49850 0 1212 71385
94330 14772 4 21339 5 0
82519 0 17002 62898 0 3339 76456 10175 1 15488 7 23894 0 0
92493 0 15949 52813 0 1891 72012
97782 15407 2 22438 3 0
88816 0 17297 61360 0 2628 75730 10318 0 15656 4 23755 1 0
98065 15131 0 22230 9 0
97749 14944 9 21929 7 0
98098 15160 0 22189 8 0
96929 15149 6 21923 2 0
sulfate Glycosaminoglycan degradation Glycosphingolipid biosynthesis - ganglio series Glycosphingolipid biosynthesis - globo series Glycosphingolipid biosynthesis - lacto and neolacto series Glycosylphosphatidylinositol(GPI)-anchor biosynthesis Glycosyltransferases
128 25 5411
122 66 4816
240 160 5119
271 175 5219
124 84 5125
186 115 5233
529 144 6389
70 9 5022
280 121 4815
278 100 4381
445 96 4924
620 124 5133
356 110 5010
387 135 5141
0
0
0
0
0
0
1
0
0
0
0
0
0
0
Glyoxylate and dicarboxylate metabolism GnRH signaling pathway Hedgehog signaling pathway Hematopoietic cell lineage Hepatitis C
0 45483 12640 0 8 0 0 0
0 51100 12200 8 3 0 0 0
0 53840 12259 6 19 0 0 0
0 52070 12563 2 26 0 0 0
0 49124 12861 9 16 0 0 0
0 47408 12951 5 26 0 0 0
0 46947 13192 9 38 0 0 0
0 45314 12623 1 7 0 0 0
0 64906 13017 2 6 0 0 0
0 53286 12663 6 16 0 0 0
0 51011 12364 8 28 0 0 0
0 51608 12758 6 17 0 0 0
0 48868 12852 7 34 0 0 0
Histidine metabolism
92833 99688 14726 1 3 110 24932 59653 6766 5042 93 5632 0 0 76251 13932
94870 11475 8 14394 1 31 323 25711 56091 8340 6418 167 6019 0 0 72386 13058
94686 11241 1 15164 0 35 385 26016 56561 8136 5977 118 6059 0 0 74738 13430
94691 10595 4 15353 1 16 224 25771 59868 7529 5320 231 5992 0 0 77399 13926
93597 10070 9 14796 1 21 72 26157 61238 6539 5164 129 5658 0 0 79793 14604
98312 10388 3 14404 3 12 43 26615 61212 7187 5250 154 6253 0 0 79098 14467
90894
Homologous recombination Huntington's disease Hypertrophic cardiomyopathy (HCM) Indole alkaloid biosynthesis Influenza A Inorganic ion transport and metabolism Inositol phosphate metabolism Insulin signaling pathway Ion channels Isoflavonoid biosynthesis Isoquinoline alkaloid biosynthesis Leishmaniasis Leukocyte transendothelial migration Limonene and pinene degradation Linoleic acid metabolism
90413 10755 1 14841 0 14 265 24470 55887 7396 5735 53 5344 0 0 71646 13322
98168 12674 2 18429 0 25 703 28837 58673 11878 6131 143 6568 0 0 72518 13048
0 67344 12798 0 41 0 0 0 10258 6 12452 7 16425 2 19 310 30280 53680 13252 6502 317 6674 0 0 74945 13068
95349 10670 4 15642 0 20 150 28884 56654 8956 5515 181 6012 0 0 75768 13433
95359 10660 1 15719 3 25 215 29881 54649 8690 5265 370 6392 0 0 75269 13339
95346 10713 2 16175 3 23 252 28273 58291 8468 5189 347 6218 0 0 76937 13743
94989 10178 0 15295 4 27 95 28241 58999 7459 5106 267 5985 0 0 79943 14367
96254 14832 0 1 28 25544 61654 5715 5044 128 5248 0 0 78683 14619
Lipid biosynthesis proteins Lipid metabolism Lipoic acid metabolism Lipopolysaccharide biosynthesis Lipopolysaccharide biosynthesis proteins Long-term depression Long-term potentiation Lysine biosynthesis Lysine degradation Lysosome MAPK signaling pathway MAPK signaling pathway - yeast Measles Meiosis - yeast Melanogenesis Membrane and intracellular structural molecules Metabolism of cofactors and vitamins Metabolism of xenobiotics by cytochrome P450 Methane metabolism Mineral absorption Mismatch repair N-Glycan biosynthesis NOD-like receptor signaling pathway Naphthalene degradation Neuroactive ligand-receptor interaction Neurotrophin signaling pathway Nicotinate and nicotinamide metabolism Nitrogen metabolism
14032 7 11831 15302 1760 7160 0 0 10208 3 67351 434 0 9709 0 4760 9 76070 30382 16689 15729 6 5428 10354 7 4656 5082 58732 2 0 57218 16335 0
13888 9 12306 15856 2802 9077 0 0 10219 2 63718 233 0 9336 0 5295 4 75917 29470 18296 15801 8 5628 10940 2 4945 5085 58501 13 0 58304 15715 4
14158 7 14788 16064 4555 12090 0 0 10498 7 68140 328 0 8682 0 5455 26 75437 30113 20096 16201 9 5805 11523 1 4853 4868 58268 31 0 62168 15216 8
14439 7 14384 16274 4144 10794 0 0 10573 7 69488 386 0 9062 0 5448 30 76980 30555 19892 16188 8 5840 11351 3 4888 5129 59503 34 0 60990 15613 0
14423 5 13412 15866 3373 9283 0 0 10450 3 69321 169 0 9839 0 5424 25 79219 30444 18404 16220 2 5721 10868 5 5014 5015 59529 15 0 59810 16411 5
14385 5 12206 15292 2364 7994 0 0 10259 7 69099 318 0 9889 0 5140 37 78798 30509 17456 16212 1 5393 10432 5 4899 4969 60827 20 0 58156 16767 3
14501 1 13218 14995 2696 8841 0 0 10649 9 70714 1118 0 9627 0 4688 28 79219 31224 16971 16705 3 5314 10760 8 4575 5235 59442 11 0 60621 16868 9
13892 8 10595 14962 788 6038 0 0 10007 7 64682 238 0 10272 0 4869 6 78638 30260 15915 15809 8 5142 10061 7 4825 4978 60688 0 0 55668 16929 9
15175 3 16970 19277 8773 15666 0 0 11460 5 63683 628 0 10108 0 8627 9 91254 32728 24640 17892 1 7966 12645 3 7527 6178 60733 24 0 65884 16882 6
15213 5 17839 18853 10762 18395 0 0 11310 7 66522 446 0 10636 0 8867 45 89106 34375 27068 18077 4 8372 12354 4 7421 5913 65089 17 0 68901 16336 8
14541 3 14259 16545 5362 12136 0 0 10588 0 65311 246 0 10148 0 6593 20 82867 31979 20541 16551 3 6829 10937 9 5881 5807 60756 19 0 61535 16443 5
14494 3 14836 16002 5373 12538 0 0 10589 6 65794 530 0 10309 0 6049 31 81448 31223 20231 16275 0 6651 10931 7 5416 5744 60063 22 0 61543 15966 1
14605 0 14339 16326 4947 11265 0 0 10623 1 66393 351 0 10540 0 6246 32 83611 31157 19872 16533 4 6453 10988 3 5660 5471 60514 20 0 61005 16614 9
14580 6 13265 15602 3672 9758 0 0 10408 2 68512 345 0 10381 0 5688 34 81160 31181 18811 16352 6 5981 10527 4 5232 5328 61827 24 0 59659 16700 4
Nitrotoluene degradation Non-homologous end-joining Notch signaling pathway Novobiocin biosynthesis Nucleotide excision repair Nucleotide metabolism Olfactory transduction One carbon pool by folate Oocyte meiosis Other glycan degradation Other ion-coupled transporters Other transporters Other types of O-glycan biosynthesis Others Oxidative phosphorylation PPAR signaling pathway Pancreatic cancer Pancreatic secretion Pantothenate and CoA biosynthesis Parkinson's disease Pathogenic Escherichia coli infection Pathways in cancer Penicillin and cephalosporin biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidases
956 13883 0 15587 55653 9059 0 71123 0 10733 41515 0 30610 0 27156 0 17989 6 16658 0 2
745 12960 0 15080 57227 8768 0 73268 0 9404 40935 9 31238 0 26629 9 18628 2 16840 0 13
2384 12227 0 15665 59739 9435 0 76391 0 10316 38885 9 32406 0 26502 7 19238 4 19240 0 31
2065 12824 0 15969 59057 8913 0 75810 0 10000 39654 6 32138 0 26677 8 19541 4 19379 0 34
1514 13767 0 16146 57750 9063 0 74010 0 9713 41723 3 31554 0 27560 8 19009 9 18117 0 15
1250 14378 0 15779 56489 9318 0 72321 0 10174 42762 7 30809 0 27724 3 18207 9 17852 0 20
2411 14102 0 16744 58320 9882 0 74721 0 13152 41897 2 32179 0 27733 8 18423 1 18167 0 11
240 14438 0 15145 54787 9565 0 69955 0 10100 43706 8 30043 0 28038 5 17595 4 15611 0 0
90399 464 0 10273 9573 15632 2 13213 3 32921 2
90196 1022 0 10466 8939 14748 7 13410 4 33052 4
92331 1242 0 10226 8982 14455 2 13754 5 33215 4
92770 1506 0 10755 9227 14550 8 13552 2 33476 7
92723 931 0 10449 9519 15393 9 13526 3 33855 5
91705 328 0 10061 9806 15857 1 13482 8 33489 0
94992 249 0 10222 9798 16199 8 13788 8 33985 0
89823 129 0 9938 9905 16104 7 13325 5 33044 9
1640 12825 0 17519 64242 8933 0 84060 0 11315 41804 3 37666 0 29501 7 23178 0 20183 0 24 10336 7 2749 0 12967 9933 14969 6 15040 1 37498 5
2304 12102 0 17751 62664 8674 0 83026 0 9711 39741 5 37806 0 29401 1 22581 4 22994 0 17 10451 5 1316 0 11654 9970 13613 7 14971 5 37484 9
1251 13680 0 16157 58124 9511 0 74896 0 9405 40815 0 33258 0 28442 8 20131 1 19216 0 19
1605 13755 0 16237 58453 9499 0 74580 0 9784 39285 5 32661 0 27847 6 20087 4 19585 0 23
1274 14021 0 16489 58523 9210 0 75225 0 9777 41516 2 32734 0 28419 0 20020 0 18686 0 21
1339 14416 0 16156 56984 9356 0 73021 0 9646 41861 7 31580 0 28156 6 19064 1 18950 0 24
96030 597 0 10579 10126 14296 1 13696 9 35259 1
94693 862 0 10321 10049 13577 6 13371 9 34606 5
95349 1024 0 10688 10004 14722 1 13680 4 34945 3
93582 392 0 10129 10137 14941 0 13445 7 34284 6
Phosphotransferase system (PTS)
10350 9 52200 236 0 28940 10667 8 23986 15708 9236 23201 4
10995 7 50810 396 0 27089 10309 7 22021 16857 8485 21410 0
11558 9 49485 671 0 32137 10316 2 22341 18050 7830 20700 0
11338 4 51131 611 0 32189 10577 4 22440 17559 8340 21030 6
10817 7 53207 470 0 31444 10828 3 23760 16662 8829 22832 6
10442 6 54013 351 0 30197 10757 2 24144 15843 9413 23569 3
10756 3 53285 383 0 32425 11376 7 27021 16103 9748 23503 3
10109 4 53767 100 0 26753 10523 3 24185 15196 9895 24306 0
Photosynthesis Photosynthesis - antenna proteins
51770 3013
66060 6205
76996 8568
72345 7518
63506 5670
51796 2860
52498 2261
44042 1109
Photosynthesis proteins Phototransduction Phototransduction - fly Plant-pathogen interaction Polycyclic aromatic hydrocarbon degradation Polyketide sugar unit biosynthesis Pores ion channels
59752 0 0 20186 33274 3807 24254 11587 6 51903 4169 5124 4286 5080 16347 8
77121 0 0 20163 33621 5540 27249 11890 6 54764 4299 4997 3925 5085 15605 2
90320 0 0 20655 35638 9964 29303 13007 2 56741 4353 5154 3596 4868 16004 8
84742 0 0 20752 34931 7714 29234 12938 9 56733 4282 5344 3722 5114 16392 2
74204 0 0 20335 34843 5105 26798 12536 6 54691 4355 5273 4429 5009 16698 8
59654 0 0 20191 35209 3319 24482 11614 3 52450 4681 5339 4600 4967 16815 2
59696 0 0 21705 35136 5608 25339 12216 3 52558 4805 5557 4416 5216 17036 9
50162 0 0 19761 34434 1572 21902 10750 0 50640 4673 5055 4813 4904 16255 7
Peptidoglycan biosynthesis Peroxisome Pertussis Phagosome Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Phenylpropanoid biosynthesis Phosphatidylinositol signaling system Phosphonate and phosphinate metabolism
Porphyrin and chlorophyll metabolism Prenyltransferases Primary bile acid biosynthesis Primary immunodeficiency Prion diseases Progesterone-mediated oocyte maturation Propanoate metabolism
12566 9 55430 1254 0 32327 11731 8 25859 20260 8776 20795 5 12174 7 20013 14729 0 0 0 21653 36319 11140 41461 17072 6 68463 4288 5721 4165 6113 15946 5
12506 1 54319 1574 0 36755 11928 0 24085 20267 8686 18649 2 12967 3 22780 15807 9 0 0 21137 37264 13682 46217 17618 6 68285 4094 5886 3881 5560 16205 9
11114 4 53338 785 0 32725 11061 2 23510 17632 9662 21025 8
11118 8 52484 761 0 35334 10958 5 22983 17655 9762 19849 3
11029 2 54271 704 0 33107 11136 7 24170 17306 9564 21716 9
10623 7 54414 528 0 33001 10989 0 23833 16440 9801 22235 0
82938 11250
78113 9881
75948 9146
62257 5810
99159 0 0 21008 34620 6926 33133 14389 5 58440 4155 5427 4415 5140 16345 2
92749 0 0 20939 34188 7318 31946 14277 1 57419 4036 5415 4606 4918 16388 1
90161 0 0 20552 34873 5758 30810 13850 2 57535 4258 5462 4788 5081 16530 3
73028 0 0 20439 35192 4287 27940 12815 0 54638 4493 5482 4767 4919 16887 6
Prostate cancer Proteasome Protein digestion and absorption
5080 5127 10
Protein export Protein folding and associated processing
99617 66562 15421 1 14337 9582 33181 8 24096 8 23515 7 443 62577 25734 20380 0 5085 7 11254 9 26584 15751 0 40783 30275 4 18109 4
Protein kinases Protein processing in endoplasmic reticulum Proximal tubule bicarbonate reclamation Purine metabolism Pyrimidine metabolism Pyruvate metabolism RIG-I-like receptor signaling pathway RNA degradation RNA polymerase RNA transport Regulation of actin cytoskeleton Renal cell carcinoma Renin-angiotensin system Replication, recombination and repair proteins Restriction enzyme Retinol metabolism Rheumatoid arthritis Riboflavin metabolism Ribosome Ribosome Biogenesis
5085 5173 36 10354 7 69537 14886 7 14460 8845 34178 7 25034 5 23337 2 141 65642 27573 20920 0 5129 1 10191 7 26537 16520 0 41185 32332 5 18864 5
4868 5155 91 10489 0 77524 14270 0 13942 9194 36073 8 26289 7 23646 6 633 69025 29247 22348 0 5066 2 13682 7 22910 17422 0 42961 33743 5 19491 5
5114 5433 102 10538 7 76161 14597 7 14432 9224 35403 2 25840 9 23836 0 481 68380 28527 21428 0 5290 1 12444 0 24534 17386 0 42884 33249 5 19275 4
5009 5181 49 10269 5 72812 15398 1 14706 9669 34390 3 25013 8 24112 1 346 65995 27211 20957 0 5231 4 11494 3 26480 16552 0 42329 31669 1 18746 7
4967 5205 68 10061 0 67959 15671 3 14644 9708 33538 9 24305 0 24031 5 223 63051 25981 20455 0 5042 2 10066 4 27743 16320 0 41237 30617 7 18351 2
5216 5414 98 10166 8 70439 15584 5 14390 9855 34455 5 25012 0 24173 4 570 65009 26049 21407 0 4974 4 12110 0 26911 15954 0 42279 31084 7 18871 8
4904 4940 7 99118 62128 15933 5 14474 9543 32454 9 23603 8 23664 6 160 60606 25104 19940 0 5006 1 89052 28709 15546 0 39909 29788 6 17971 4
6113 6289 69 11758 4 95083 16482 8 17657 9364 38190 2 27874 6 25272 7 211 80561 31989 22177 0 6175 1 12036 8 29203 19083 0 48718 37537 5 21434 8
5560 5840 139 11260 8 98886 15691 5 16872 9053 38154 1 27681 6 25336 9 320 80907 31197 22529 0 5801 5 12447 0 27954 20913 0 49170 36033 5 21056 8
5140 5334 347 10289 9 78502 15795 1 15408 9393 34437 9 25152 0 24333 8 154 69495 27270 20618 0 5308 1 10410 7 27699 17507 0 44157 31893 5 19172 1
4918 5199 446 10078 1 78585 15312 3 14543 9074 34017 4 25138 3 24020 4 236 68530 27122 20377 0 5210 7 10325 9 26180 17320 0 43483 31304 1 19061 2
5081 5285 226 10329 4 77731 15824 6 15220 9413 34343 8 25173 2 24370 8 165 68561 27403 20562 0 5375 5 10164 0 27852 17105 0 43638 31820 7 19129 2
4919 5229 254 10029 3 72479 15721 5 14783 9524 33517 6 24463 4 24245 1 157 65194 26103 20154 0 5139 8 96166 27868 16965 0 42353 30525 8 18549 5
Ribosome biogenesis in eukaryotes Salivary secretion Secondary bile acid biosynthesis Secretion system Selenocompound metabolism Sesquiterpenoid biosynthesis Shigellosis Signal transduction mechanisms Small cell lung cancer Sphingolipid metabolism Spliceosome Sporulation Staphylococcus aureus infection Starch and sucrose metabolism Steroid biosynthesis Steroid hormone biosynthesis Stilbenoid, diarylheptanoid and gingerol biosynthesis Streptomycin biosynthesis Styrene degradation Sulfur metabolism Sulfur relay system Synthesis and degradation of ketone bodies Systemic lupus erythematosus TGF-beta signaling pathway Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Tetracycline biosynthesis Thiamine metabolism
5203 0 4096 23653 1 72047 4 0 11234 2 108 10386 0 45398 2 29555 21104 0 4685 276
5598 0 4239 24359 8 71315 26 0 11144 8 252 9707 0 42386 5 27840 20266 8 4701 445
6040 0 4080 24658 1 73367 62 2 11251 8 292 10555 0 39115 9 24126 19714 2 4673 852
5921 0 3957 24853 3 73525 69 0 11283 0 351 10382 0 40683 6 25677 19992 9 4767 859
5591 0 4163 24581 6 72978 30 0 11471 5 209 10120 0 44399 8 28357 21075 5 4991 592
5350 0 4409 23976 5 71944 40 0 11417 7 52 10336 0 46005 9 30411 21414 2 5015 521
5536 0 4534 24317 1 74921 23 0 11545 6 32 12560 0 45956 8 28779 22128 7 4755 492
5051 0 4610 23396 1 70225 0 0 11288 7 28 9985 0 47639 3 32810 21630 2 4968 153
6604 0 4170 27873 5 76412 48 2 12363 9 679 10791 0 41073 5 27574 21877 3 6663 1331
6472 0 3711 27269 9 77172 34 0 12261 7 293 10299 0 38096 0 24417 20616 9 6714 1841
5578 0 3957 24687 7 73643 38 0 11580 8 131 10189 0 42537 3 27314 20288 7 5811 921
5619 1 3707 24309 5 73697 44 0 11301 3 193 10527 0 40875 1 24872 19397 1 5779 1023
5651 1 4048 24939 9 73334 40 0 11592 6 232 10238 0 43604 1 27909 20812 3 5765 816
5404 0 4134 24122 1 72758 48 0 11443 9 71 10316 0 44591 3 28798 20752 7 5514 806
17607 24805 9977 73119 63859 12487 0 0 28654 77518 39215 88076
16903 26423 9567 69822 62436 13089 1 0 28285 80956 38153 86953
16263 34152 9978 68025 61513 14380 3 0 27950 85562 37285 87985
16814 30668 10367 70157 63473 14724 1 0 28329 84108 38285 88149
18040 27385 10534 72488 64519 13268 2 0 29030 81051 39413 89095
18742 24548 10712 73386 64555 13089 1 0 29372 79218 39487 89049
17912 28420 10629 75146 65552 13137 1 0 29224 80753 39210 91893
18901 21418 10049 73415 64121 11267 0 0 29209 75713 39444 88333
18583 36151 10225 75418 71984 11257 1 0 29468 91174 40341 93537
17553 38457 11125 74923 72028 14491 1 0 29025 94009 40655 92846
18146 29167 11014 74769 66725 13423 0 0 28699 83397 40295 88845
17404 29682 11442 72629 64246 14713 1 0 27906 82988 39604 86570
18422 27959 11061 73691 66150 13121 2 0 28899 82372 40090 88858
18729 25742 11412 74113 65334 13958 0 0 29090 80670 40053 88371
Tight junction Toluene degradation Toxoplasmosis Transcription factors Transcription machinery Transcription related proteins Translation factors Translation proteins Transporters Tropane, piperidine and pyridine alkaloid biosynthesis Tryptophan metabolism Tuberculosis Two-component system Type I diabetes mellitus Type II diabetes mellitus Tyrosine metabolism Ubiquinone and other terpenoid-quinone biosynthesis Ubiquitin system VEGF signaling pathway Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation Various types of N-glycan biosynthesis Vascular smooth muscle contraction Vasopressin-regulated water reabsorption
0 20145 108 43012 3 14985 7 4374 52600 11983 5 14089 42
0 20178 252 41252 2 14973 9 3874 57711 12368 3 13369 44
0 20981 292 40974 4 14929 2 3775 61520 12976 3 13719 78
0 21884 351 41379 8 15200 5 3799 60147 12824 5 13749 98
0 21389 209 42749 1 15207 7 4243 55743 12462 8 14018 46
0 21009 52 43493 2 15131 0 4422 53025 12018 3 14090 10
0 20710 32 44404 0 15505 1 4393 54670 12467 2 14760 19
0 19898 28 43673 0 14893 9 4753 50587 11626 0 13997 28
0 24900 679 42176 7 16623 0 3916 69599 14290 5 14641 79
0 24128 293 40651 6 16283 4 3630 68311 14389 9 14296 18
0 21792 131 41899 1 15892 9 3977 57704 12755 7 14190 46
0 21771 193 41030 0 15947 9 3669 57080 12691 9 14125 29
0 22112 232 42264 6 15787 0 4087 56855 12702 6 14195 33
0 21656 71 42710 4 15558 0 4189 53803 12240 6 14138 62
16319 89043 17058 54393 5 5341 5445 69334
15762 84214 19706 52066 0 5933 6068 70496
16715 88073 22075 50235 9 6445 6721 76934
17112 89893 21211 51468 1 6320 6409 75357
16820 92210 19361 54353 8 5728 6013 72607
16427 93054 17301 55359 1 5434 5590 70719
17385 93474 17736 55908 7 5527 5693 72403
15495 89295 15759 56049 6 5092 5214 68180
17976 87957 29250 56334 6 7722 8318 78523
18897 90813 30280 54017 4 7734 8993 86802
16931 91044 22331 55346 4 6185 6822 75783
17165 93025 21873 53993 1 5981 6635 77212
17034 92853 21413 55555 6 5948 6533 74950
16928 94887 19068 55563 2 5596 6018 74052
59541 8661 0 11421 3 13612 6 1 0 0
62139 8143 0 11314 3 13063 2 0 0 0
60957 7786 0 11350 0 13569 4 1 0 0
63090 7958 0 11572 0 13885 2 0 0 0
62914 8791 0 11569 0 14034 0 0 0 1
61072 9079 0 11565 2 14057 0 0 0 0
58725 8786 0 11843 7 14142 5 0 0 0
60018 9446 0 11403 2 13377 6 0 0 0
80313 9179 0 12933 2 13210 7 8 0 0
79263 8552 0 12908 0 13560 1 0 0 0
67435 8916 0 11991 0 13576 4 0 0 0
65013 8542 0 11701 3 13745 4 0 0 0
67237 9092 0 11858 2 13798 9 0 0 0
63741 9090 0 11729 2 14128 3 0 0 0
Vibrio cholerae infection Vibrio cholerae pathogenic cycle Viral myocarditis Vitamin B6 metabolism Wnt signaling pathway Xylene degradation Zeatin biosynthesis alpha-Linolenic acid metabolism beta-Alanine metabolism beta-Lactam resistance mRNA surveillance pathway mTOR signaling pathway p53 signaling pathway
0 15024 108 32831 0 9598 5089 5440 60803 9043 8 0 109
0 15192 252 32272 0 10092 5520 5489 58006 8700 3 0 254
0 15014 292 30858 0 10873 5760 5446 61791 8146 19 0 293
0 15326 351 31836 0 10626 5680 5774 63022 8549 26 0 353
0 15488 209 32651 0 10247 5273 5666 63419 9066 16 0 210
0 15123 52 33668 0 10403 5112 5654 63756 9415 25 0 53
0 15331 32 33875 0 10021 5279 5571 65143 9069 25 0 33
0 14785 28 33794 0 10165 4972 5214 59598 9685 7 0 28
0 18392 679 35405 0 11896 6456 5887 61288 9510 6 0 679
0 18770 293 34583 0 13268 6208 6509 64904 9540 40 0 293
0 16569 131 33329 0 12070 5402 5665 62959 10105 16 0 131
0 15690 193 31504 0 12333 5219 5753 63882 9959 28 0 194
0 16096 232 32972 0 11426 5273 5760 63325 9821 16 0 232
0 15570 71 33213 0 11513 5066 5837 65056 9963 33 0 72
Table S7. Fungi genera abundance during different fermentation stages of JZ22 and JB3. OTU ID
JZ22 D0
JZ22 D2
JZ22 D4
JZ22 D6
JZ22 D8
JZ22 D10
JZ22 D12
JB3 D0
JB3 D2
JB3 D4
JB3 D6
JB3 D8
JB3 D10
JB3 D12
g__Cladosporium g__Cochliobolus g__Cryptosporidium g__Galactomyces g__norank_c__Agaricomycetes g__norank_k__Fungi g__norank_o__Malasseziales g__norank_o__Tremellales g__norank_p__Basidiomycota g__norank_p__Chytridiomycota g__norank_p__Glomeromycota g__Oryza g__Pichia g__Saccharomycopsis g__Symbiodinium g__Trichosporon
28 11 0 0 10 1737 4 7 3 2 8 30 13410 429 1 2
0 0 0 0 0 49 0 0 0 0 0 0 89 12 0 0
0 0 0 0 0 102 0 0 0 0 0 0 60 9 0 0
0 0 0 0 0 22 0 0 0 0 0 1 54 9 0 0
0 0 0 0 0 27 0 0 0 0 0 0 39 5 0 0
0 0 0 0 0 38 0 0 0 0 0 0 80 10 0 0
1 0 0 0 0 20 0 0 0 0 0 0 90 7 0 0
185 100 1 2 21 1917 11 4 0 0 0 48 19694 631 36 11
0 0 0 0 0 24 0 0 0 0 0 0 46 10 0 0
0 0 0 0 0 38 0 0 0 0 0 2 38 8 0 0
0 0 0 0 0 97 0 0 0 0 0 0 44 6 0 0
0 0 0 0 0 53 0 0 0 0 0 1 43 8 0 0
0 0 0 0 0 62 0 0 0 0 0 1 42 8 0 0
0 0 0 0 0 71 0 0 0 0 0 1 43 7 0 0
g__unclassified_d__Eukaryota g__unclassified_f__Colpodea g__unclassified_f__Trichocomaceae g__unclassified_o__Hypocreales g__unclassified_o__Saccharomycetales g__unclassified_p__Ascomycota
4 6 2158 94 22659 4
0 0 45 0 40411 0
0 0 22 0 40415 0
0 0 18 0 40504 0
0 0 11 0 40526 0
0 0 35 0 40444 0
0 0 26 0 40463 0
0 0 1893 36 16017 0
Microbial dynamics and metabolite changes in Chinese Rice Wine fermentation from sorghum with different tannin content Jialiang Xu, Huijun Wu, Zhiwei Wang, Fuping Zheng, Xin Lu, Zhenpeng Li, Qing Ren
Figure S1. Non-metric Multidimensional Scaling (NMDS) distribution based on Weighted Unifrac distance.
0 0 22 1 40505 0
0 0 9 0 40513 0
0 0 7 0 40453 0
0 0 13 0 40490 0
0 0 10 0 40486 0
0 0 10 0 40476 0
