Microglandular Hyperplasia of the Uterine Cervix

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Feb 19, 1998 - Microglandular Hyperplasia of the Uterine. Cervix. Cytologic Diagnosis in Cervical Smears. Carmen Alvarez-Santín, M.D., M.I.A.C., Adela Sica, ...
Acta Cytologica

Microglandular Hyperplasia of the Uterine Cervix

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Cytologic Diagnosis in Cervical Smears

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Carmen Alvarez-Santín, M.D., M.I.A.C., Adela Sica, M.D., María Carmen Rodríguez, M.D., Alicia Feijó, M.D., and Grisel Garrido, M.D.

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ters selected and the histologic diagnosis of MGH. OBJECTIVE: To identify cytomorphologic features speCONCLUSION: Until now, no specific cytologic pacific to microglandular hyperplasia (MGH) in cervical rameters were described for cytologic smears. MGH. This study underSTUDY DESIGN: Twentyscored the value of cytomorfour cervical smears from 24 [The results of this study] should phologic parameters depatients obtained before the help avoid an overdiagnosis of scribed for typical cellular histologic diagnosis of MGH AGUS and false positives. clusters showing microlumimade on colposcopically dina or fenestrated spaces with rected biopsies during a perishared party walls and an od of two years (1995–1997) admixture of glandular cells, and immature squamous were evaluated. metaplastic and subcylindrical reserve cells in the cytoRESULTS: Of cases with MGH, 13/24 (54%) showed logic diagnosis of MGH. (Acta Cytol 1999;43:110–113) the presence of bidimensional or tridimensional cellular clusters made up of cubic or cylindrical glandular cells Keywords: cervical smears, cervix diseases, cervix with vacuolated cytoplasm; cells with dense cytoplasm, neoplasms, hyperplasia, microglandular hyperbasaloid in appearance, corresponding to immature squaplasia. mous metaplasia; and subcylindrical reserve cells with small, round nuclei and scant cytoplasm. Clusters showed microlumina or fenestrated spaces, preserved poMicroglandular hyperplasia (MGH) is characterlarity and absence of nuclear peripheral dispersion. In the ized by a benign proliferation of endocervical control group these cellular clusters were found in 6/100 glands. First described by Taylor and Norris in (6%). Statistical analysis (χ2) showed a strong, highly 1967,7 it was designated microglandular hyperplasia significant association (P