RESEARCH ARTICLE
Micronutrient Deficiencies and Plasmodium vivax Malaria among Children in the Brazilian Amazon Silvana Gomes Benzecry1, Márcia Almeida Alexandre1,2, Sheila Vítor-Silva1,2, Jorge Luis Salinas3, Gisely Cardoso de Melo1,2, Helyde Albuquerque Marinho4, Ângela Tavares Paes5, André Machado de Siqueira1,2,6, Wuelton Marcelo Monteiro1,2, Marcus Vinícius Guimarães Lacerda1,2,7*, Heitor Pons Leite8*
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1 Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, Brazil, 2 Gerência de Malária, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil, 3 Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, United States of America, 4 Laboratório de Nutrição, Instituto Nacional de Pesquisas da Amazônia, Manaus, Brazil, 5 Applied Statistics, Federal University of São Paulo, São Paulo, Brazil, 6 Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil, 7 Instituto de Pesquisas Leônidas & Maria Deane, Fundação Oswaldo Cruz, Manaus, Brazil, 8 Department of Pediatrics, Discipline of Nutrition and Metabolism, Federal University of São Paulo, São Paulo, Brazil *
[email protected] (ML);
[email protected] (HPL)
OPEN ACCESS Citation: Benzecry SG, Alexandre MA, Vítor-Silva S, Salinas JL, de Melo GC, Marinho HA, et al. (2016) Micronutrient Deficiencies and Plasmodium vivax Malaria among Children in the Brazilian Amazon. PLoS ONE 11(3): e0151019. doi:10.1371/journal. pone.0151019 Editor: Georges Snounou, Université Pierre et Marie Curie, FRANCE
Abstract Background There is a growing body of evidence linking micronutrient deficiencies and malaria incidence arising mostly from P. falciparum endemic areas. We assessed the impact of micronutrient deficiencies on malaria incidence and vice versa in the Brazilian state of Amazonas.
Received: November 13, 2015 Accepted: February 23, 2016 Published: March 10, 2016 Copyright: © 2016 Benzecry et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Due to ethical restrictions regarding patient privacy, data are available upon request. Requests for the data may be sent to the corresponding author. Funding: This study was funded by CNPq, FAPEAM (Fundação de Amparo à Pesquisa do Estado do Amazonas) and Fundació Cellex (grant 483758/ 2009-4; G64334048/2007). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Methodology/Principal Findings We evaluated children
