central hemodynamics, vasoactive hormones, fractional sodium excretion (FENa), free water clearance (CH2O) and GFR. Methods: 12 healthy subjects were ...
Nephrology Dialysis Transplantation 31 (Supplement 1): i3–i5, 2016 doi:10.1093/ndt/gfw118.1
MINERAL METABOLISM SO006
EFFECT OF SODIUM NITRITE ON RENAL VARIABLES, BRACHIAL AND CENTRAL BLOOD PRESSURE IN HEALTHY SUBJECTS. A RANDOMIZED, PLACEBO-CONTROLLED DOSE-RESPONSE STUDY
Jeppe B Rosenbaek, Safa Therwani, Janni M Jensen, Frank H Mose, Erling B Pedersen and Jesper N Bech Regional Hospital West Jutland and Aarhus University, University Clinic in Nephrology and Hypertension, Department of Medical Research, Holstebro, DENMARK Introduction and Aims: A growing body of evidence has shown that sodium nitrite (NaNO2) causes dilation of the human vasculature, presumably by enzymatic conversion to nitric oxide (NO). Studies based on inhibition of NO synthase indicate a natriuretic effect of NO. We aimed to examine the effects of NaNO2 on brachial and central hemodynamics, vasoactive hormones, fractional sodium excretion (FENa), free water clearance (CH2O) and GFR.
Methods: 12 healthy subjects were randomly treated with placebo (0.9% NaCl) or 40, 120 or 240 μg NaNO2/kg/hour for 2 hours, in a single-blinded, placebo-controlled, cross-over study. Examinations were preceded by standard diet. Subjects were supine and orally water-loaded throughout the day. Before, during and after drug infusion, we measured brachial and central blood pressure (BP), plasma renin, angiotensin II and aldosterone, plasma and urine osmalality, GFR by Cr-EDTA clearance, FENa and urinary excretion rate (UER) of cyclic guanosine monophosphate (cGMP), nitrite and nitrate (NOx) and aquaporin-2 (AQP2). Results: FENa was reduced 0.32% 95%CI(0.06;0.59) by the highest dose of NaNO2 compared to placebo. The highest dose reduced brachial systolic BP by 4.2 mmHg (1.7;6.7), central systolic BP by 5.6 mmHg (0.5;10.7) and CH2O ( p
