Oct 16, 2015 - Li, F., Chan, C. U. & Ohl, C. D. Rebuttal to a Comment by Richard E. Waugh on our Article 'Yield Strength of Human Erythrocyte. Membranes to ...
received: 23 June 2015 accepted: 24 September 2015 Published: 16 October 2015
Effects of Stretching Speed on Mechanical Rupture of Phospholipid/Cholesterol Bilayers: Molecular Dynamics Simulation Taiki Shigematsu, Kenichiro Koshiyama & Shigeo Wada Rupture of biological cell membrane under mechanical stresses is critical for cell viability. It is triggered by local rearrangements of membrane molecules. We investigated the effects of stretching speed on mechanical rupture of phospholipid/cholesterol bilayers using unsteady molecular dynamics simulations. We focused on pore formation, the trigger of rupture, in a 40 mol% cholesterol-including bilayer. The unsteady stretching was modeled by proportional and temporal scaling of atom positions at stretching speeds from 0.025 to 30 m/s. The effects of the stretching speed on the critical areal strain, where the pore forms, is composed of two regimes. At low speeds (