L.D.C. is grateful to AXA Research funds. The authors gratefully ac- knowledge the âFondation CIRFCâ (Università de Strasbourg), the. RÃgion Alsace, the ...
DOI: 10.1002/chem.201404200
Cover Profile
Multifunctional Inorganic Nanocontainers for DNA and Drug Delivery into Living Cells
From left to right: Henning Llf, Alessandro Bertucci, Dedy Septiadi, Roberto Corradini, and Luisa De Cola
Invited for the cover of this issue is the group of Luisa De Cola at the University of Strasbourg, ISIS, (France) and her collaborator, Roberto Corradini from Universit degli Studi di Parma (Italy). Their study demonstrates the use of multifunctional zeolite L nanoparticles for the simultaneous delivery of foreign DNA and organic molecules into living cells. The fate and the kinetics of the different labeled components have been followed by confocal microscopy. Read the full text of the article at 10.1002/chem.201403232.
How would you describe your research? Exciting, creative, and multidisciplinary. I also hope that it will be relevant for society.
What do you consider the exciting developments in the field? I believe that the controlled delivery of drugs and oligonucleotides is very relevant since a combined therapy could lead to a more efficient cure for several diseases. Also the combination of imaging and therapy is a very young and exciting field.
What other topics are you working on at the moment? We are working on the development of biocompatible and destroyable nanocontainers that are able to deliver desired enzymes and proteins and on the synthesis of modified PNA for therapeutic and diagnostic purposes.
Acknowledgements We kindly thank the Helmholtz Virtual Institute, NanoTracking, (grant no. VH-VI-421), ERC advanced grant award (no. 2009247365) for financial support, as well as the French Embassy in Italy and the French government for providing the MAEE grant for scientific cooperation between Italy and France (no. 778588G). L.D.C. is grateful to AXA Research funds. The authors gratefully acknowledge the “Fondation CIRFC” (Universit de Strasbourg), the Rgion Alsace, the Communaut Urbaine de Strasbourg, the Dpartement du Bas-Rhin, and the Ministre de l’Enseignement Suprieur de la Recherche (MESR) for funding the purchase of the confocal microscope.
