Multiple Sclerosis Journal

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Multiplehttp://msj.sagepub.com/ Sclerosis Journal Functional magnetic resonance imaging correlates of cognitive performance in patients with a clinically isolated syndrome suggestive of multiple sclerosis at presentation: an activation and connectivity study C Forn, MA Rocca, P Valsasina, I Boscá, B Casanova, A Sanjuan, C Ávila and M Filippi Mult Scler published online 9 August 2011 DOI: 10.1177/1352458511417744 The online version of this article can be found at: http://msj.sagepub.com/content/early/2011/08/04/1352458511417744 Published by: http://www.sagepublications.com

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Research Paper

Functional magnetic resonance imaging correlates of cognitive performance in patients with a clinically isolated syndrome suggestive of multiple sclerosis at presentation: an activation and connectivity study

Multiple Sclerosis Journal 0(00) 1–11 ! The Author(s) 2011 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1352458511417744 msj.sagepub.com

C Forn1,2, MA Rocca1, P Valsasina1, I Bosca´3, B Casanova3, ´ vila2 and M Filippi1 A Sanjuan2, C A

Abstract Background/Objective: To assess whether abnormalities on functional magnetic resonance imaging (fMRI) are related to cognitive function in patients at presentation with clinically isolated syndrome (CIS) suggestive of multiple sclerosis. Methods: Eighteen patients with CIS and 15 healthy controls (HCs) performed an adapted fMRI version of the Paced Auditory Serial Addition Test (PASAT). According to their PASAT performance, CIS patients were divided into two groups: 10 with a low PASAT performance (