neuroendocrine & endocrine tumours and cup - Oxford Journals

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3Dept. of Oncology-presidio Ospedaliero, Polo Oncologico, Ospedale S. Chiara, ... 4Oncologia, Trapianti e Nuove Tecnologie In Medicina, Polo Oncologico - ...
Annals of Oncology 25 (Supplement 4): iv394–iv405, 2014 doi:10.1093/annonc/mdu345.17

neuroendocrine & endocrine tumours and cup 1148P

OCTREOTIDE LAR SUITABLE TREATMENT FOR G1-G2 THORACIC NEUROENDOCRINE TUMORS (T-NET): SINGLE CENTER EXPERIENCE

abstracts

R. Marconcini1, I. Petrini1, L. Galli1, E. Vasile1, A. Antonuzzo2, A. Farnesi1, L. Derosa1, E. Bracco1, R. Viglialoro1, A. Falcone3, S. Ricci4 1 U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero Universitaria S. Chiara, Pisa, ITALY 2 Oncologico, U.O. Oncologia Medica 1, Pisa, ITALY 3 Dept. of Oncology-presidio Ospedaliero, Polo Oncologico, Ospedale S. Chiara, AOUP, Pisa, ITALY 4 Oncologia, Trapianti e Nuove Tecnologie In Medicina, Polo Oncologico - Azienda Ospedaliero-Universitaria Pisana - Istituto Toscano Tumori, Pisa, ITALY

Aim: Somatostatin Analogs are useful for treatment of Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET) because increase patients Progression Free Survival (PFS) and Overall Survival (OS). However, limited data are available for T-NET. Therefore, we conducted a retrospective analysis of G1-G2 T-NET patients treated with Octreotide LAR at our Institution. Methods: From June 1997 to April 2012, 15 consecutive metastatic G1-G2 T-NET patients were treated with Octrotide LAR 30 mg fl i.m. every 28 days. Thirteen patients had pulmonary primary site and 2 patients thymic primary site. Nine patients were treatment naïve, 4 patients and 2 patients received one or more lines of chemotherapy, respectively. Toxicities were evaluated according to CTCAE version 4.0, and response according RECIST criteria. Results: Two (13%) patients experienced partial response, 12 (80%) stable disease, and 1 (7%) patient progressive disease. Partial response was obtained in 2 pulmonary NET. Median number of administrations was 13 (4-72). At a median follow-up of 34,7 months, median OS is not reached (9 patients are still alive). 2-year Survival is 67%. G1-G2 toxicities were diarrhea and asthenia; no G3-G4 toxicities were reported. Conclusions: In our experience, Octreotide LAR was well tolerated and showed interesting activity in T-NET patients. Despite limited data are available for Somatostatin Analogs treatment in T-NET, our analysis is in line with activity and efficacy demonstrated in prospective trials conducted in GEP-NET. Disclosure: All authors have declared no conflicts of interest.

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