Nighttime Insulin Kinetics and Glycemic Control in ... - Diabetes Care

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Nighttime Insulin Kinetics and Glycemic. Control in Type 1 Diabetes Patients. Following Administration of an. Intermediate-Acting Lispro Preparation. MAUREEN ...
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Nighttime Insulin Kinetics and Glycemic Control in Type 1 Diabetes Patients Following Administration of an Intermediate-Acting Lispro Preparation MAUREEN M.J. JANSSEN, MD SANDRINA CASTELEIJN WALTER DEVILLE, MD

CORR1E POPP-SNIJDERS, PHD PARIS ROACH, MD ROBERT J. HEINE, MD, PHD

OBJECTIVE — To determine insulin kinetics and overnight glycemic control after bedtime administration of a new intermediate-acting insulin preparation called neutral protamine lispro (NPL). RESEARCH DESIGN AND METHODS— We studied 12 patients with well-controlled type 1 diabetes. The study had a double-blind, randomized, crossover design. After a lead-in period of 10-14 days two experiments were carried out with an interval of 2-7 days. During these experiments overnight insulin kinetics and fasting blood glucose levels were studied after evening administration of NPH insulin and NPL. Blood glucose levels