Non-invasive prediction of preterm birth in women with cervical ... - PLOS

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Jul 10, 2017 - Ha-Na Yoo, Kyo Hoon Park*, Eun Young Jung, Yu Mi Kim, Song Yi Kook, ...... Jung EY, Park KH, Han BR, Cho SH, Ryu A. Measurement of ...
RESEARCH ARTICLE

Non-invasive prediction of preterm birth in women with cervical insufficiency or an asymptomatic short cervix (25 mm) by measurement of biomarkers in the cervicovaginal fluid Ha-Na Yoo, Kyo Hoon Park*, Eun Young Jung, Yu Mi Kim, Song Yi Kook, Se Jeong Jeon

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Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea * [email protected]

Abstract OPEN ACCESS Citation: Yoo H-N, Park KH, Jung EY, Kim YM, Kook SY, Jeon SJ (2017) Non-invasive prediction of preterm birth in women with cervical insufficiency or an asymptomatic short cervix (25 mm) by measurement of biomarkers in the cervicovaginal fluid. PLoS ONE 12(7): e0180878. https://doi.org/10.1371/journal.pone.0180878 Editor: Brenda A Wilson, University of Illinois at Urbana-Champaign, UNITED STATES Received: March 2, 2017 Accepted: June 22, 2017 Published: July 10, 2017 Copyright: © 2017 Yoo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (grant no. HI 14C1798). Competing interests: The authors have declared that no competing interests exist.

Objective To determine whether various proteins in the cervicovaginal fluid (CVF) known to be involved in immune regulation, alone or in combination with clinical risk factors, can predict spontaneous preterm delivery (SPTD) in women with cervical insufficiency or a short cervix (25 mm).

Methods This retrospective cohort study included 62 asymptomatic women with cervical insufficiency (n = 27) or an asymptomatic short cervix (n = 35) at 18–27 weeks. CVF swab samples were taken for assays of vitamin D binding protein (VDBP), interleukin (IL)-8, matrix metalloproteinases (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and Dickkopf-related protein 3 (DKK3) before cervical examination, and maternal blood was collected for the determination of the C-reactive protein (CRP) level. The primary outcome measurement was SPTD at