Non-professional marathon running: RAGE axis and ST2 family changes in relation to openwindow effect, inflammation and renal function Christine Bekos1,2, Matthias Zimmermann1, Lukas Unger1, Stefan Janik1, Philipp Hacker1, Andreas Mitterbauer1, Michael Koller3, Robert Fritz3, Mario Kessler4, Stefanie Nickl5, Jessica Didcock1, Patrick Altmann1, Thomas Haider1,6, Georg Roth7, Walter Klepetko8, Hendrik Jan Ankersmit1,8 and Bernhard Moser1,8* 1
Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria 2
Department. of Obstetrics and Gynaecology, Division of Gynaecology and Gynecological Oncology, Medical University Vienna, Austria 3
Sportordination, Alserstraße 27/1/6, Vienna, Austria
4
Austrian Red Cross, Nottendorfer Gasse 21, 1030 Wien, Austria
5
Department of Surgery, Division of Plastic and Reconstructive Surgery, Medical University Vienna, Austria 6
Department of Trauma Surgery, Medical University Vienna, Austria
7
Department of Anesthesia, Critical Care and Pain Medicine, Medical University Vienna, Austria
8
Department of Surgery, Division of Thoracic Surgery, Medical University Vienna, Austria
*Corresponding author Bernhard Moser, MD, Assoc. Prof., FEBTS Department of Thoracic Surgery, Division of Surgery, Medical University Vienna Währinger Gürtel 18-20, 1090 Vienna, Austria FAX: +43 1 40400 69770 Tel: +43 1 40400 67770 E-mail:
[email protected]
Supplemental material Table. Red and white blood count analysis in 34 marathoners, 36 half-marathoners and 30 sedentary controls before the run (baseline), immediately after (peak) and after 2 to 7 days of recovery (recovery).
WBC RBC HGB HCT MCV MCH MCHC PLT LYM MXD NEUT RDW_S D RDW_C V PDW MPV P_LCR
M baseline
M peak
M recovery
HM baseline
HM peak
HM recovery
Sedentary subjects
6.51 (6.05) ± 1.71 (0.29) 4.96 (4.94) ± 0.35 (0.06) 14.62 (14.75) ± 1.20 (0.21) 44.58 (44.20) ± 2.77 (0.48) 90.06 (90.35) ± 4.68 (0.80) 29.54 (29.90) ± 1.98 (0.34) 32.78 (32.95) ± 1.07 (0.18) 260.21 (252.50) ± 62.29 (10.68) 30.28 (29.85) ± 7.26 (1.25) 8.28 (7.60) ± 3.30 (0.59) 61.96 (62.70) ± 8.32 (1.49)
17.08 (16.16) ± 4.10 (0.70) 5.36 (5.33) ± 0.49 (0.08) 15.50 (16.00) ± 1.41 (0.24) 44.42 (44.40) ± 3.10 (0.53) 95.84 (97.07) ± 5.19 (0.89) 31.53 (32.00) ± 2.18 (0.37) 35.01 (35.20) ± 1.16 (0.20) 334.05 (328.00) ± 68.54 (11.75) 11.34 (10.67) ± 4.44 (0.76) 7.48 (7.25) ± 2.61 (0.45) 85.08 (88.43) ± 15.91 (2.73)
6.88 (6.55) ± 1.79 (0.31) 4.81 (4.83) ± 0.37 (0.06) 14.08 (14.20) ± 1.37 (0.24) 42.87 (43.15) ± 3.35 (0.58) 89.25 (90.15) ± 5.55 (0.95) 29.30 (29.75) ± 2.35 (0.40) 32.80 (33.00) ± 1.06 (0.18)
6.44 (6.65) ± 1.40 (0.23) 4.82 (4.81) ± 0.42 (0.07) 14.08 (14.10) ± 1.10 (0.18) 43.10 (43.00) ± 2.88 (0.48) 89.61 (89.60) ± 3.75 (0.62) 29.25 (29.05) ± 1.37 (0.23) 32.64 (32.55) ± 0.71 (0.12)
6.53 (6.65) ± 1.40 (0.23) 4.61 (4.60) ± 0.42 (0.07) 13.45 (13.45) ± 1.10 (0.18) 41.14 (41.65) ± 2.86 (0.48) 89.49 (89.65) ± 3.86 (0.64) 29.23 (29.05) ± 1.53 (0.26) 32.68 (32.65) ± 0.86 (0.14)
6.71 (6.15) ± 1.88 (0.34) 4.96 (4.98) ± 0.59 (0.11) 14.37 (14.40) ± 1.53 (0.28) 43.90 (43.60) ± 4.46 (0.81) 88.76 (89.30) ± 4.95 (0.90) 29.06 (29.15) ± 2.09 (0.38) 32.73 (32.85) ± 1.14 (0.21)
