initial period, cyclic AMP levels and the activities of phosphodlesterase and adenylatt~ vyc case in muscle tissue were i increased. The Values for these indices ...
NOTICE
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CYCTilC AMP SYSTEM IN MUSCLE TISSUE DURING PROLONGED HYPOKINESIA A. Ye. Antpenko, Yu. A. Bubeyev, B. F Korovkin, and N. P Mikhaleva
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Translation of "Sistema tsAMF v myshechnoy tkani pri dlitel:'.noy gipokinezii, R ' Voprosy meditsinskoy khimii,, Vol. 24, No. 6,
1978, pp. 765-768.
(NASA-TM-y 761'86) CYCLIC AMP SYSTEM TN
I
Musc,-LE
N81-13627
TISSUE; DUAING PROLONGED HYPOKINESIA {National Aeronautics and Space Administration) 7 p HC A02/MP A01
CSCL 06S
Unclas G3/52 29460
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} NATIONAL AERONAUTICS AND SPACE ADMINISTRATION JUNE -1980 WASHINGTON, D. C'. 205 1n6
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i -AMP SYSTEM IN MUSCLE TISSUE DURING OYCLT
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8. Performing Organisation Re or No:
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Ye. Antipenko Yu, A. Hubeyev,
10. work Unit No. B. F. K orov lcln, and N. P. Mikhaleva ICirov Military Medical Academy, LeninSrtl ,,_,_,, _ sw:rw..-.: .^ v.::,
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to homogenates of muscle tissue from the con trol rats .led to a 2.9 fold, incr ease in aden yl. c y cla se
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or thin enzyme in
while the activity
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from experimental rats tnoreased onl y 1. 4 times (P < 0.05) in the presence
of epinephrine (7.Oth day off' hypokinesi a) .
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Consequently, qualitative shifts in the IH M4
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activity (
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familiar with the fact that adenyl oyolase activity normally Increases sharply when epinephrine is added to ,t^^4 ules we a tissue homogena te C33. e) showed that p ezfo^zned ^^^^ figg ure) addition of epinephrine in concentrations
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of t he so-c all ed stim ulated
activity or adenyl eyelase during the protr acted hypoki n esia period, Il e are
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synthesis.
This fact compelled us to m ake a
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adenyl cyolase complex occur durin g
protracted hypaklnesr'here 1,s some basis for assuming that further studies ` on this subject will make ^t p ossible ^ to discover the true mechanisms of
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muscle tissue metabolic disruptions P.
OH
during protracted hypokinesia and
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find ways to correct them.
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ro
Vtig. 1. The effects Of epl ephrine on the activity of adenyl cycl.ase in muscle tissue homogenates normal aonditlQns an y during protracted hypokinesia. I .._ without addition of epinephrine. w _ in the presence of epinephrine (3 Y 10 hypokinesla (70 days) A control- B
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3
REVERUCES
1. Zhdanova, A. G.; Arkh. anat.. 12, 29 (1965). 2
Mikhaleva et al- Kosmicheskay:a biol., 2, 42 (1970)
3.
Feart;seva, M. N., Uspekhi sovr. biol., 411, 16 (1976).
4.
Tkaebulc, V. A o , et al., Biokhimiya, X11, 1704 (1976)
5.
Chagovets, R. V., mrud Uevslc. in-t;a fizkul l t;ury , Z, 105 (1957),
6.
Sutherland, Z. W., Sclenva,7., 401 (1972).
7.
Drummond, C. a., and L. Duncan, J. biol. Chem., 245, 976 (1970).
Copyright: Vaprooy Maditslaukey Khimii, 1978
