Novel Trends in Bioactive Heterocyclic Compounds

“GUJCOST” Sponsored National Conference on “Novel Trends in Bioactive Heterocyclic Compounds....Recent Perspective” ORGANIZED BY DEPARTMENT OF CHEMISTRY M.N.COLLEGE Visnagar-384315 Gujarat, India

Date: 28th February- 2017

SOUVENIR M.N. College, Visnagar-384315, Gujarat

About college M.N. College, Visnagar M. N. College, Visnagar was established in June, 1946 by Gaekwads to spread higher education in this area of their rule. In North Gujarat it was the only institution for higher education. Mr. V.K. Gokak (later on awarded Gyanpith award) was its first principal. In the beginning it was affiliated to Bombay University, later on with Gujarat University and it has been affiliated to H.N.G.U, Patan. Since its establishment in 1986, thus it is the oldest and pioneering institution of this university. The institute has tried to change according to the changing environment and requirements of higher education. This institute is located in the centre of Visnagar city. The green and clean campus with old heritage building increased its beauty and attraction. This college is recognized under section 2(f) and 12(B) of the UGC act. The college was accredited by ‘NAAC’ with 2.85 CGPA

About Chemistry Department M.N. College had made a glorious beginning of teaching & learning in science subjects with the onset of chemistry Department established from 1950. Since then, the department has conducted M.Sc. and Ph.D. programs as well until the recent past. Dr. K.M. Joshi is head of the department of chemistry. He is also working as I/C Principal of our college. The department is housed in with gorgeous building which boost with huge laboratories and sprawling theatre like classrooms.

About Conference Heterocyclic compounds are of very much interest in our daily life. Heterocyclic compounds have one or more hetero atoms in their structure. They may be cyclic or non-cyclic in nature. Heterocyclic compounds have a wide range of applications. Heterocyclic compounds have provided a platform for the rapid exchange of research in the areas of organic, pharmaceutical, analytical and medicinal chemistry. The rich activity of heterocyclic compounds in biological systems is important for pharmaceutical, agricultural, and natural products. They also find applications as sanitizers, developers, antioxidants, corrosion inhibitors, copolymers and dye stuff. Some of the natural products e.g. antibiotics such as penicillin, cephalosporin, alkaloids such as vinblastine, morphine, reserpine etc. have heterocyclic moiety. Heterocyclic chemistry is an enduring field of organic synthesis that continues to provide amazing innovations in chemical synthesis and profoundly impact our society from novel materials (e.g. organic light emitting diodes) to pharmaceutical agents for treatment of human disease and addictions to altering our eating habits.

About Visnagar Visnagar is a city and a municipality in Mehsana Distict in the Indian state of Gujarat. “VISNAGAR” named after its founder king VISHALDEO FROM Ajmer Dynasty was founded in 953 on the auspicious day of ‘Akhatrij’. Founded just as an outpost of the kingdom of king Visaldeo surrounding the present ‘DeliyaTalao’ a huge water tank covering area of approx 2 lac sq. Meter. As it was falling on a very strategic geographical location, visnagar faced many war fights between Vishaldeo, babis, idar dynasty and Gaekwads with change of rulers Visnagar so many changes and it grew with a fort wall with 6 gates none of them is present at this time but at some places, remain can be seen. Visnagar Kasba Under Gaekwad rule, Visnagar become first town in North Gujarat to have underground water supply and sewage system, railway was also brought glory with it for the development of Visnagar with electricity. Visnagar produced many freedom fighters during the time of British Rule. Noted teachers, painters, drama artists, writers were also among those who highlighted Visnagar. Earlier Visnagar was known as “Copper City” because there were so many workers who used to make pot from copper. Education facilities were instrumental in getting awareness among people. Nearly 35 schools of which two are for girls only, 10 colleges and one University attract students and people outside Visnagar for years. Visnagar City Industrial establishments like submersible pumps, thrashers, diamonds and copper vessels drew attention nationwide.

From the Desk of Petron and Principal

It is a matter of pride for all of us to organize National Conference on ‘’Novel Trends in Bioactive Heterocyclic Compounds....Recent Perspective’’ in our institute. We have been thinking about organizing a conference for quite some time and the first aspect which we had to discuss was that would we be able to make it meaningful and fulfill the expectations of the participants and the aspirants. This took us around a year to think over the issues to be floated, the format, the key participants and their orientation and so on. I am sure that you will gain from this event. I believe NTBHC – 2017 is a strong platform for discussions on the recent advancements in this field and it plays a crucial role to enhance knowledge of latest research trends in heterocyclic chemistry to the researchers from universities, national laboratories and also industries all over India. I am sure the conference would certainly give the delegates an opportunity for fruitful discussions and stimulating interactions. I express my good wishes to all of you and shine with your best performance.

Dr. K. M. Joshi Principal M. N. College, Visnagar

WELCOME NOTE OF CONVENER

(1St National Conference in M.N. College, Visnagar) The historical, adventurous and educational land of Visnagar is eagerly awaiting to witness an extremely significant event in the form of national conference on “Novel Trends in Bioactive Heterocyclic Compounds… Resent Perspective” on behalf of M.N. College, Visnagar as well as the Chemistry Department, I heartily welcome all the guest and invitees from deepest core of my heart for this ever national event of our college. A humungous gathering of invited speakers, academicians, industry persons, students, etc., on a single platform, seemingly an unimaginable event a few years back, has become reality today in the premise of this college words simply fail to describe such an amazing beautiful national event. I express my gratitude to Principal Dr. K. M. Joshi for his active and efficient cooperation and inspiration for the successful event. My special thanks to GUJCOST-Gandhinagar as well as other financial supporter for their financial assistance and encouragement to organize this mega event. I have all the words of appreciation and compliments for my colleagues in the department and staff members of all the subjects of the college. Those who have worked with total harmony to make this conference a successful and memorable event on our part. Everyone worked with almost contributing care and commitment. At last, I express my thanks to all the persons who have supported directly and indirectly to organize this event. On behalf of all, I once again welcome everyone to this national event and hope that their stay becomes comfortable and fruitful. I conclude with the beautiful quote of legendary scientist having highest ever number of patents in the history of mankind, Sir Thomas Alva Edison, “I was not unsuccessful but I went through thousands of ways which are totally useless”. Dr. Asha D. Patel Convener NTBHC-2017

MESSAGE

It is a matter of pleasure for me to learn that Department of Chemistry, M. N. College, Visnagar is going to organize a National Conference on “Novel Trends in Bioactive Heterocyclic Compounds... Recent Perspective” (sponsored by GUJCOST) on the occasion of Science Day, 28th February, 2017. Heterocycles is the basic skeleton of many active pharmaceuticals and therefore, the theme selected for the present conference is a need of the day. I wish this conference a grand success.

Professor Suresh C. Ameta Past President, Indian Chemical Society Kolkata & Dean, Faculty of Science, University UDAIPUR.

MESSAGE

I am happy to learn that the M.N. College, Visnagar is organizing a national level conference entitled, “Novel trends in Bioactive Heterocyclic Compounds Recent Perspective” on 28th February, this year. There are several positive points regarding this event. The first and foremost thing is that faculty members of a government college have arranged this important academic event. Secondly, the subject of heterocyclic chemistry is a very vast field that is growing exponentially and these compounds are used in a number of fields. Thirdly, the date, 28th February is nationally celebrated as the ‘Science Day’ and the activity organized has deep scientific significance. When an event of such dimension occurs at Visnagar level, all the students of Visnagar and Colleges or departments affiliated to different universities of the country will really be benefitted to a high level. I, as the Ex. Dean of the faculty of science of the Hemchandracharya North Gujarat University, Patan, congratulate Prin. Dr. K.M. Joshi, Dr. Ashaben D. Patel and faculty members for such efforts to elevate the academic environment of North Gujarat region. I hope that the academic deliberations will be very useful to all research students.

Prof. J. J. Vora Head, Department of Chemistry Hemchandracharya North Gujarat University, Patan

MESSAGE

Dear Colleagues, We are indeed privileged and delighted to host the National Conference on ‘’Novel Trends in Bioactive Heterocyclic Compounds....Recent Perspective’’ in M.N. College, Visnagar. We express our sincere thanks to GUJCOST for giving us an opportunity to host this conference. Such a herculean task would not have been possible without delegates who have travelled far distance for their participation & young students and researchers. The conference program has been planned to deliver the most recent advancement in chemistry. The plenary lectures are planned featuring interesting scientific sessions on Novel trends in heterocyclic compounds & many more. We hope that all of you will enjoy the academic feast, warm hospitality of our college. This is the great occasion for all of us to have an opportunity to interact with the leading scientists from across the Nation and to bridge the collaborative efforts for solving many of the mysterious events of chemistry. Let us join our hands together to share our knowledge and experience that will go a very long way in helping to build up the healthy, prosperous and developed nation. We express our gratitude to everyone who involved in making this conference a great successful.

Mr. P.S. Patel

Dr. U.R. Patel

Organizing Secretary


NTBHC-2017

NTBHC-2017

Prof. V. H. Shah

Summary of the Keynote Address Role of Heterocyclic Compound as Potential Antituberculer Agents In order to develop scientific ethos to enhance the knowledge for the utilization and development of science and technology, a motivational introductory lecture related to various Nobel scientists: including their idea, thoughts, and creativity will be given. The rest of the presentation related to heterocyclic compounds, with their role, classification and utility. Moreover, having scientific experience of 9 years in CSMCRI and thorough knowledge in the field of medicinal chemistry, in the journey as Professor and Head in the Department of Chemistry, Saurashtra university, Rajkot. A brief introduction on Tuberculosis, their types, treatments, class of Antituberculosis drugs, mechanism is also included in the presentation. At the end of the presentation a summary of work done by group of Dr. V. H. Shah in tubercular research is also included.

Prof. V. H. Shah, Head, Dept. of Chemistry, Saurashtra University, Rajkot

Invited Talk

Summary of Invited Talk Regioselectivity in organic synthesis Nucleophilic substitution reaction and elimination reactions lies in the heart of numerous organic synthesis. Aromatic nucleophilic substitution as well as aliphatic nucleophilic substitution reactions has attracted attention of many researchers to carried out synthesis of vast number of organic materials. Like substitution-elimination reaction, another and most recent synthetic protocol is transition metal catalysed coupling reaction. Nowadays, certain transition metals including palladium, copper, iron, rhodium, ruthenium etc. are widely used to construct C-C, C-N, C-S and C-O bond. Cross-coupling reaction offers alkenylation, alkylation, arylation, amination, alkynylation etc. in regioselective mean. Along with coupling-, substitution- and elimination reaction is also a promising chemistry and often deals with wide knowledge of organic chemistry. Insertion reactions including carbene, nitrene, isocyanide and benzyne will be discussed citing synthesis of drug intermediates. Prof. K. H. Chikhalia Dept. Of Chemistry, School of Sciences, Gujarat University, Ahmedabad.

Special Talk

Summary of Special Talk Concepts, tools and techniques for in silico drug discovery Drug discovery process is long, time and money intensive process. Chemists are screening large number of novel compounds in the lab but very few can pass through the vigorous journey of drug discovery pipeline from lab the market. Recent development of Bioinformatics and chemoinformatics opened a new way to solve the problem. Unlike the historical method of drug discovery, by trial-and-error testing of chemical substances on cultured cells or animals, and matching the apparent effects to treatments, new drug discovery begins with a knowledge of specific chemical responses in the body or target organism, and tailoring combinations of these to fit a treatment profile. Computer-assisted drug design uses computational chemistry to discover, enhance, or study drugs and related biologically active molecules. In slilico drug discovery includes the QSAR study for druglikness, toxicity, carcinogenicity and mutagenicity prediction. The virtual screening included the computer aided ligand based, structure based screening of the large in silico library of the ligand molecules. The purpose is to reduce the number of targets for a good drug that have to be subjected to expensive and time-consuming synthesis and trialing. Dr. Rajesh K. Patel Associate Professor, Department of Life Sciences, H. N. G. University, Patan.

M.N. COLLEGE, VISNAGAR

Science Faculty B. Sc. Core Subjects offered at UG Level Chemistry Physics Mathematics Botany Zoology

M. Sc. Core Subjects offered at PG Level Organic Chemistry Physics Botany

CONSULTANCY SERVICES-CHEMISTRY SOIL ANALYSIS, GEMI Project, Minor Research Project DELL LAB

Ph. D. Main Subject Chemistry

Arts Faculty B. A. Core Subjects offered at UG Level Sanskrit Gujarati Hindi English Economics Psychology Political Science History

M. A. Core Subjects offered at PG Level Sanskrit Gujarati Hindi History

Ph. D. Main Subject Gujarati History

“GUJCOST” Sponsored National Conference on “Novel Trends in Bioactive Heterocyclic Compounds...Recent Perspective” SCHEDULE Date: 28-02-2017 1. 08.00 to 09.30 am: Registration & Breakfast 2. 09.45 to 10.45 am: Inaugural function Patron & President of the Function: Prin.(Dr).K. M. Joshi Chief Guest: Mrs. Bhavnaben Dave Inaugural Talk by Prof. V. H. Shah Blessings by Prof. S. C. Ameta 3. 11.00 am to 12.10 pm: Plenary Talk by Prof V. H. Shah 4. 12.15 to 01.15 pm: Invited Talk by Prof. K. H. Chikhalia 5. 01.15 to 02.10 pm: Lunch 6. 02.10 to 03.00 pm: Special Talk by Dr. Rajesh. K. Patel 7. 03.00 to 04.30 pm: Poster Presentation 8. 04.30 to 05.00 pm: Tea Break 9. 05.00 to 05.30 pm: Valedictory

Committee Members Patron

Dr. K.M. Joshi (I/C Principal, MNC, Visnagar)

Convener

Dr. A.D. Patel (Assistant Professor, MNC, Visnagar)

Treasurer

Dr. P.A. Parmar


Mr. P.S. Patel

Dr. U.R. Patel

Dr. S.A. Joshi

Mr. J.S. Patel

Dr. Y.M. Patel

Dr. J.M. Chaudhari

Mr. Y.J. Thakar

Mr. R.M. Bhavsar

Mr. J.C. Patel

Mr. M.G. Patel

Organizing Committee

Advisory Committee

Prof. S.C. Ameta (Dean, Pecific Uni., Udaipur) Prof. Y.T. Naliyapara (Saurashtra Uni., Rajkot) Prof. J. J. Vora (H.N.G.Uni., Patan) Prof. M.N. Patel (S.P. Uni., V.V. Nagar) Prof. S.S. Sharma (H. N. G. Uni., Patan) Prof. P.S. Shrivastav (Gujarat Uni. Ahmedabad) Prof. Mahesh Sharma (Rajasthan Uni., Jaipur) Prin. (Dr.) S.S. Shah (M.G. Panchal Sci. College, Pilvai) Dr. P.J. Vyas (Sheth M.N. Sci. College, Patan)

List of Committee for National Conference February-2017 No. Committee

Member of Committee

1 2

Invitation Food & Refreshment

Dr. J. M. Chaudhari Dr. Y. M. Patel Mr. M. G. Patel

3

Stage Decoration

Mr. P. S. Patel Mr. J. C. Patel Ms. Dipti Patel Ms. Sejal Patel

4

Announcement

Mr. R. M. Bhavsar

5

Account

Dr. P. A. Parmar

6

Registration & Certificate Distribution

Dr. D. K. Chandavt Dr. Sejal Joshi Dr. Khushboo Vithlani

Dr. Sanju Joshi Ms. Ranna Chaudhari Dr. Mittal Chaudhari

7

Poster Presentation

Mr. Y. J. Thakar Dr. P. U. Sharma Dr. Rakesh Prajapati

Mr. J. S. Patel Mr. A. K. Patel Ms. Mayuri Gajjar

8

Press & Media

Mr. M. G. Patel

Dr. H. V. Joshi

9

Accommodation & Transport

Mr. J. S. Patel Mr. M. G. Patel

Dr. J. M. Chaudhari

10

Souvenir & Banner

Dr. U. R. Patel

11

Advertising

Mr. J. C. Patel

12

Purchase

Dr. U. R. Patel

13

Welcome

Dr. J. M. Chaudhari

14

Prize Presentation

Dr. H. V. Joshi

Mr. R. N. Parmar Mr. Chetan Patel Dr. G. J. Jani Dr. P. U. Sharma Mrs. Bindu Patel

Mr. R. M. Bhavsar

Mr. P. S. Patel Mr. Mitesh Parmar

GUJCOST SPONSORED NATIONAL CONFERENCE on

“Novel Trends in Bioactive Heterocyclic Compounds... Recent Perspective” Organized by Dept. of Chemistry, M. N. college, Visnagar 28th February, 2017

POSTER PRESENTATION-1

Physicochemical methods as applied to Synthesis and Catalytic studies of selected lanthanide Complexes Dr. Haresh R. Patel, J. J. Vora* Smt. S. S. Patel Nootan Science and Commerce College, Visnagar, India *Department of Chemistry, Hemchandracharya North Gujarat University, Patan, India Email:- [email protected] , *[email protected]

Abstract The compound of lanthanide ions with complexing or chelating biologically important kynurenic acid ligand to form coordination compound is an important area of current research. Less explored biologically important kynurenic acid ligand is allowed to react with solution of lanthanides perchlorates and attempt has been made to synthesize solid kynurenic acid complexes. These complexes are subjected to U.V visible spectroscopy, IR spectroscopy, TGA analysis, Mass Spectroscopy, Elemental analysis and antimicrobial activity of these compounds has been evaluated by standard methods and attempts have been made to correlate structural characteristic with properties of these complexes.

Keyword:- Spectroscopic characterization, lanthanide complexes, elemental analysis

Dr. Asha Patel Convener

antimicrobial activity,

Mr. P. S. Patel Dr. U. R. Patel Organizing Secretaries




Synthesis of 2-amino-4-(2-chloro-5-(4-aryl) pyridin-3-yl)-1-(4-aryl)-7, 7disubstituted-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile derivatives and evaluation of their pharmacological activity. Sarju N. Prajapati, Kokila A. Parmar* Sheth P.T. Arts and Science College, Godhra Department of Chemistry, H.N.G.University, Patan [email protected] Abstract Quinoline derivatives are valuable intermediates in the preparations of a wide range of biologically active compounds. In the present investigation the synthesis of 2-amino-4-(2-chloro5-(4-aryl)pyridin-3-yl)-1-(4-aryl)-7,

7-disubstituted-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-

carbonitrile derivatives is carried out. A number of quinoline derivatives have been synthesized, purified and characterized with the help of their analytical and spectral data (IR, NMR & Mass). Synthesis of 2-amino-4-(2-chloro-5-(4-aryl) pyridin-3-yl)-1-(4-aryl)-7, 7-disubstituted-5-oxo-1, 4, 5, 6, 7, 8-hexahydroquinoline-3-carbonitrile have been synthesized by the reaction of 5-(4aryl)-2-chloro-3-formyl pyridine, {[2-chloro-5-(4-aryl)pyridin-3-yl]methylidene}propanedinitrile and enaminone in ethanol containing piperidine as catalyst. The synthesized compounds were screened for their pharmacological activities in comparison with the standard drugs.

Key words: Quinoline derivatives, pharmacological activit






A Comparative study for force degradation of three local anesthetic drugs Bupivacaine, Ropivacaine, Mepivacaine and Quantitative Analysis of degraded products by newly developed and validation HPLC-UV method. Kamlesh M. Patel1, Asha D. Patel1* 1

Department of chemistry, M.N.College, Visnagar (N.G) – 384315 Corresponding address: [email protected]

Abstract Reversed phase isocratic method has been developed for the quantitative analysis of local anesthetics BUP, ROP & MEP with very good separation for determination in bulk drug and dosage form of pharmaceutical. A Hypersil BDS C18 250×4.6mm,5µm column, Mobile phase mix buffer and Acetonitrile (34:66v/v) in 1000 ml and adjust pH 7.5 with diluted KOH solution,Isocratic flow rate 0.9 mL/min and System detection is performed at 220 nm has been used for HPLC and LC-MS. Forced degradation study is perform in different stress condition such as by keeping it in Sunlight, UV light, Thermal, Humidity, Acidic, Basic, and oxidative for extended time. Degradation products separation on HPLC chromatography. Degradation study experiments are also analyzed on newly developed HPLC method. Key words: Local anesthetic drug, Forced degradation, Isocratic, Acidic,Basic, UV light,Sunlight,oxidative, thermal.






Green synthesis of some bioactive heterocyclic compounds from natural precursors Mr. P.V. Upadhyay1, Mr. D.H. Gandhi 2 1. Arts,Commerce & Science college .Khambhat 2. C.U.Shah University. Wadhvan ABSTRACT: Heterocyclic compound, particularly those possessing N –or S-containing moieties, have attracted significant interest due to their useful biological and pharmaceutical properties. Many natural and synthetic drugs ,dyes pesticides are heterocyclic in nature.Also,biological processes such as provision of energy , transmission of nerve impulse ,sight , metabolism and transfer of hereditary information are all based are reaction involving the participation of heterocyclic compounds, such as vitamins,enzymes , coenzymes, ATP, DNA, RNA and serotonin.The conventional method for the synthesis of dihydropyrimidinones is the one-pot three component reaction using benzaldehyde ,ethyalacetoacetate and urea in the presence of acid catalyst.






Synthesis, characterization and biological aspects of some new cobalt (III) complexes derived from N, S and O donor Schiff bases. Chetna Ameta*, Mitthu Lal Gurjar, Pinki B. Punjabi Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India ABSTRACT The aim of the present study is to synthesize some novel ecofriendly fungicides and bactericides of 3-Acetyl coumarinderivatives, having important pharmacodynamic significance. The N, S and O donor Schiff base ligands used in the present account are 3-Acetyl coumarin hydrazinecarbothioamide and 3-acetyl coumarin hydrazine carboxamide derived by the condensation of 3-acetylcoumarinwith thiosemicarbazide andwith semicarbazide hydrochloride (in presence of sodium acetate) in 1:1 molar ratio using ethanol as a solvent. These imines, on interaction with cobalt (III) yield complexes having Co-O or Co-S and Co-N bonds. The cobalt (III) complexes have been prepared by mixing CoCl3∙6H2O in 1:1 and 1:2 molar ratios with Schiff base ligands. The structure of the ligands and their transition metal complexes were confirmed by the elemental analysis, IR, 1H NMR, electronic, EPR spectral studies. On the basis of these studies an octahedral environment around the cobalt (III) ion has been proposed. The in vitro antimicrobial activities of Schiff base ligands and their respective cobalt (III) complexes were performed on pathogenic bacterial and fungal strains.






Sonochemical synthesis and characterization of imidazolium based ionic liquids: A green Pathway Garima Ameta* and Pinki B. Punjabi Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India ABSTRACT The emerging importance of sonochemistry as "green" process and ionic liquids (ILs) as "green" materials with their wide applications are rapidly increasing. Imidazolium-based ionic liquids derivatives are synthesized using a facile and green ultrasound-assisted procedure. Their structures were characterized by IR, 1H-NMR, 13C-NMR and Mass spectroscopy. The main advantages of the present procedure as compared with conventional method are mainly, its milder conditions, shorter reaction time, higher yields and selectivity without the need for a transition metal or base catalyst.






EFFECT OF ANNEALING ON SPECTRAL AND ANTIMICROBIAL PROPERTIES OF TERPOLYMER Nd (III) METAL CHELATE Kiran Meghwal* and Pinki Bala Punjabi Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India ABSTRACT The terpolymer was prepared by solution condensation polymerization technique in acidic medium. Nd (III) metal chelate was synthesized by using terpolymer resin of 2-amino-5-chloro benzophenone, salicylic acid and formaldehyde. The metal complex was annealed at three different temperature i.e. 373, 473 and 573 K. The spectral study was done by FTIR spectroscopy. Examination of antimicrobial activity against gram positive, gram negative and fungal strains clearly shows that with increase in thermal annealing temperature the activity increases which may be due to the increase in isotropic nature of metal chelate leading to greater conjugation of π-electrons.






Microwave assisted synthesis, spectroscopic characterization and biological aspects of some new cobalt (III) complexes derived from N, S and O donor Schiff bases. Mitthu Lal Gurjar* and Pinki B. Punjabi Mohan Lal Sukhadia University, Udaipur-313001, Rajasthan, India ABSTRACT Microwave synthesis represents one of the important dimensions of modern chemistry attracting a considerable amount of attention due to its ability to dramatically reduce reaction times, improve yield, and simplify procedures. The present study is structured to address the development of green microwave processes in the manufacture of a new series of biologically potent (N, S and O) donor Schiff bases and their cobalt (III) complexes using microwave irradiation technique as well as conventional heating. The hydrazine carbothioamide ligand 2acetyl-5-methyl furan hydrazine carbothioamide (L1H) have been synthesized by the condensation of 2-acetyl-5-methyl furan with thiosemicarbazide in 1:1 molar ratio and hydrazine carboxamide ligand 2-acetyl-5-methyl furan hydrazinecarboxamide (L2H) have been synthesized by the condensation of 2-acetyl-5-methyl furan with semicarbazide hydrochloride (in presence of sodium acetate) in 1:1 molar ratio using ethanol as a solvent. The cobalt (III) complexes have been prepared by mixing CoCl3∙6H2O in 1:1 and 1:2 M ratios with Schiff base ligands. The structure of the ligands and their transition metal complexes were confirmed by the elemental analysis and IR, 1H NMR, electronic, EPR spectral studies. On the basis of these studies an octahedral environment around the cobalt (III) ion has been proposed. The in vitro antimicrobial activities of Schiff base ligands and their respective cobalt (III) complexes were performed on pathogenic bacterial and fungal strains. The results indicated that the complexes showed higher activity than the parent ligands.






Preparation of conducting polyanilines via catalytic oxidative polymerization Gunjan Kashyap*, Nirmala K. Jangid, and Pinki B. Punjabi Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India ABSTRACT Polyanilines have been prepared by catalytic oxidative polymerization of aniline in an acidic solution using H2O2 as an oxidant and ferrous sulfate as a catalyst in presence of light by photoFenton process. The structures of polyanilines were elucidated by UV-vis, Fourier transform infrared, and nuclear magnetic resonance spectroscopy, which confirmed the presence of benzenoid and quinoid rings in the polyanilines. Molecular weight and specific surface area were determined by gel permeation chromatography and BET analysis.






SYNTHESIS OF SUBSTITUTED PYRAZOLE DERIVATIVES USING IONIC LIQUID IN MICROWAVE EXPOSURE Sharoni Gupta*, Arpit Kumar Pathak and Pinki B. Punjabi Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India.. Abstract An efficient and mild synthesis of some pyrazole derivatives have been carried out. Compounds (8a-b) have been synthesized by the treatment of isoniazide with chalcones (6ab) using [bbim][BF4] ionic liquid as a solvent under microwave irradiation. Compounds (8ab) on reaction with various aldoses afforded corresponding compounds containing pyrazole moiety (9a-l) in presence of ionic liquid under microwaves. The products have been isolated, purified and characterized by different spectral methods i.e. IR, 1H NMR, 13C NMR and Mass spectra. The potent antimicrobial effects (MIC) of the synthesized compounds were investigated.






ROLE OF COPPER PYROVANADATE AS HETEROGENEOUS PHOTOFENTON LIKE CATALYST FOR THE DEGRADATION OF NEUTRAL RED AND AZURE-B Nutan Salvi*, Sangeeta Kalal and Pinki B. Punjabi Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India

Abstract The heterogeneous photo-Fenton like process is a green chemical pathway. It has an edge over conventional Fenton and photo-Fenton processes as it does not require the removal of ferrous/ferric ions in the form of sludge. We prepeared copper pyrovanadate or Volborthite (Cu3V2(OH)2O7∙2H2O) composite photocatalyst by wet chemical method. The photocatalyst was characterized by SEM, XRD, IR, TGA/DSC, EDX and BET. Experiments demonstrated that catalyst could effectively catalyze degradation of neutral red and azure-B in presence of H2O2 in visible light. Moreover, the photo-Fenton-like catalytic activity of Cu3V2(OH)2O7∙2H2O was much higher than CuO and V2O5, when used alone as photocatalyst. The effect of variation of different parameters, i.e., pH, amount of photocatalyst, concentration of dye, amount of H2O2and light intensity was also investigated. The degradation was well fitted under pseudo-first-order reaction with a rate constant of 2.081×10−4 sec−1 and 3.876×10−4 sec−1 for neutral red and azureB, respectively. Quality parameters of dye solutions before and after photo-Fenton degradation were also determined. A tentative mechanism involving •OH radical as an oxidant has been proposed. The high catalytic activity may be due to the Cu3V2(OH)2O7∙2H2O shell, which not only increased the surface hydroxyl groups, but also enhanced the interfacial electron transfer. The catalyst has been found to possess good recyclability






DEGRADATION OF ALIZARIN RED S BY NAIVE AND NANO-SIZED TITANIUM DIOXIDE AS A PHOTOCATALYST Srishti Kumawat*, Arpita Pandey and Chetna Ameta Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India

Abstract In the present work, photocatalytic degradation of alizarin red S has been carried out using naive titanium dioxide, nano-sized titanium dioxide and H2O2 under visible light. The catalysts, naive and nano-sized titanium dioxide were prepared by the sol–gel method. Characterization of synthesized catalysts has been done by scanning electron microscopy (SEM), X-ray diffraction (XRD) and UV–Visible spectroscopy. The rate of degradation of dye was monitored spectrophotometrically by measuring absorbance of dye at regular time intervals. The effect of various parameters such as pH, concentration of dye, amount of catalyst, amount of H2O2 and light intensity on the rate of reaction has been studied. Various parameters like chemical oxygen demand (COD), conductance, pH, TDS, salinity and dissolved oxygen (DO) for the reaction mixture have also been determined. A tentative mechanism for degradation of dye has been proposed involving OH radical as an oxidant. The participation of OH radical has been confirmed by using 2-propanol (scavenger) as the rate of reaction was drastically reduced in its presence.






Synthetic approach of novel pyridine clubbed acetamides via N-alkylation/CN coupling, sulfonamide drug and their pharmacological evaluation *Prakash Prajapat, and G. L. Talesara Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001, India Email:- [email protected]

ABSTRACT A library of novel pyridine scaffolds assembled with isatin/thiazolidione/sulphonamide/pyrazolone designed and synthesized via N-alkylation (C–N coupling) approach is described. The target compounds were obtained by a two step synthetic strategy starting from substituted 2-amino pyridine using appropriate synthetic routes. The structures of all novel constructed derivatives were corroborated by elemental and spectral data (FT-IR, 1H-NMR and Mass) and chemical tests. Subsequently, compounds were aimed to their in-vitro antimicrobial and in-vivo anti-inflammatory activity. Some of the compounds were found to be more active than the reference drugs.






Studies on transition metal chelates of heterocyclic ligands containing furan ring Harshadkumar P. Patel1 and Dr.Asha D. Patel1* Email: [email protected] / [email protected]* S.S.Polytechnic College,Visnagar1 and M.N.College Visnagar* (N.G) India-384315 Abstract:

4-(5-((dipropylamino)methyl)furan-2-carboxamido)-2-hydroxybenzoic acid (DPMFSA) was prepared by reaction between 5-((dipropylamino)methyl)furan-2-yl propionate and 4-amino salicylic acid. The synthesized ligand was further characterized on the basis of their elemental as well as spectral analyses. Further the transition metal chelates of newly synthesized ligand (DPMFSA) were synthesized according to reported method. The characterization of all metal chelates (i.e. Cu, Ni, Co, Mn and Zn) were carried out by elemental analyses, metal-ligand (M:L) ratio, spectral analyses, reflectance spectroscopies and magnetic properties. The antifungal screening of synthesized ligand and its metal chelates against various fungal strains shows the higher antifungal activity of all metal chelates than its parent ligand. Keywords: 5-((dipropylamino)methyl)furan-2-yl propionate, 4-amino salicylic acid, Reflectance spectroscopy, Spectral studies and Antifungal activity.






Synthesis Characterization, Spectroscopic and Catalytic Studies of Some Novel Complexes of Fe (II) and Mn (II) Dip R. Patel, Jenith K. Pandya, Dr. Haresh R. Patel* Smt. S. S. Patel Nootan Science and Commerce College, Visnagar, India Email:- [email protected] Abstract:The Schiff base and Complexes were prepared. The new complexes have been characterized using elemental analysis, conductance measurements, Infrared Spectroscopy, Thermal Analysis and other physicochemical methods. Catalytic Study has been carried out for selected redox reactions. The antimicrobial behavior have also been determined for both, Ligand and Complexes Keyword:- Spectroscopic characterization, transition metal complexes, elemental analysis






SYNTHESIS, CHARACTERISATION ANDSTUDY ON NOVEL TRANSITION METAL CHELATESCONTAINING PYRIMIDINE AND 8HQ MOIETIES. Ajay Solanki, Dr.S.V.Patel , Dr.J.N.Patel Chemistry Department, Sir P.T.Science College, Modasa. Di. Aravalli (Gujarat). Email: [email protected] ABSTRACT:

N-(4-chlorophenyl)-4-(8-hydroxyquinolin-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5carboxamide(PYCHQ) was prepared by reaction of 6-methyl-4-(8-hydroxyquinolin-5-yl)-6methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (PYHQ) and p-chloroaniline.The novel ligand was characterized usingCHN, IR and NMR analysis. The transition metal chelates of synthesized ligand (PYCHQ) were prepared and further characterized by metal-ligand (M:L) ratio, IR and electronic spectra and magnetic measurement studies. The evaluated antifungal activity of all synthesized compoundssuggests good to moderate activity against various employed fungal strains.

Keywords: 8-hydroxyquinoline, Pyrimidine, Electronic spectra, Magnetic moment and Biological properties.




“Novel Trends in Bioactive Heterocyclic Compounds... Recent Perspective” Organized by Dept. of Chemistry, M. N. college, Visnagar 28th February, 2017 POSTER PRESENTATION-17

Synthesis, Characterization and Antibacterial activity of Pyrazole Derivatives derived from Chalcone Falguni. G. Bhabhora , Ketankumar H. Parmar, Harish R.Dabhia , K.P.Patelb a

Department of chemistry, Navjivan Science College, Dahod (guj) India b

Department of chemistry, Sir P.T.Science college,Modasa (guj) India Email: [email protected]

ABSTRACT A Chalcone was prepared by the reaction of 4-acetyl-5-methyl-2-(4-methylphenyl)-2, 4dihydro-3H-pyrazole-3-one with different substituted aldehydes. Treatment of this Chalcone with hydrazine hydrate afforded the corresponding pyrazole in good yields. All the new compounds have been characterized by IR, 1H-NMR, GC-MS and element analysis. The antibacterial activity of these compounds was determined with the reference of standard drug

Key-words: Chalcone, Pyrazole, Antibacterial activity






Simultaneous quantification of antihypertensive diuretic drugs, amiloride and hydrochlorothiazide in human plasma by liquid chromatography-tandem mass spectrometry Jaivik V. Shah and Pranav S. Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009 E-mail: [email protected] and [email protected] Abstract A selective, sensitive and precise assay based on solid phase extraction and liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the simultaneous determination of amiloride (AMI) and hydrochlorothiazide (HCTZ) in human plasma. Sample clean-up with 250 µL of plasma was done on Phenomenex StrataTM-X extraction cartridges using their labelled internal standards. Chromatography was performed on Hypersil Gold C18 (50 mm × 3.0 mm, 5 µm) column using acetonitrile with 4.0 mM ammonium formate (pH 4.0, adjusted with 0.1 % formic acid) (80:20, v/v) as the mobile phase. Detection was carried out on a triple quadrupole API 5500 mass spectrometer utilizing an electrospray ionization interface and operating in the positive ionization mode for AMI and negative ionization mode for HCTZ. Multiple reaction monitoring was used following the transitions at m/z 230.6/116.0, m/z 233.6/116.0, m/z 296.0/204.9 and m/z 299.0/205.9 for AMI, AMI-15N3, HCTZ and HCTZ13C,d2 respectively. Calibration curves were linear (r2 ≥ 0.9997) over the concentration range of 0.050-50.0 and 0.50-500 ng/mL for AMI and HCTZ with acceptable accuracy and precision. The signal to noise ratio at the limit of quantitation was ≥ 14 for both the analytes. The mean recovery of AMI and HCTZ from plasma was 89.0 % and 98.7 %, respectively. The ISnormalized matrix factors determined for matrix effect ranged from 0.971 to 1.024 for both the analytes. The validated LC-MS/MS method was successfully applied to a bioequivalence study using 5 mg amiloride and 50 mg hydrochlorothiazide fixed dose tablet formulation in 18 healthy Indian volunteers.






Assessment of matrix effect related to chromatography for reliable estimation of four representative drugs by LC-MS/MS from biological matrices Priyanka A. Shah and Pranav S. Shrivastav Email: [email protected]; [email protected] Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad- 380009, India Abstract A systematic study was undertaken to tackle chromatography related issues for matrix effect in the quantitation of gemfibrozil, rivastigmine and telmisartan from human plasma and tacrolimus from human whole blood by LC-MS/MS. All four methods were thoroughly developed by appropriate selection of chromatography column (nature of stationary phase and dimension), elution mode and pH of mobile phase for improved chromatography performance. Matrix effect was assessed by post column analyte infusion, calculation of slope of calibration lines and post extraction spiking for all the methods. The best chromatographic conditions with minimum ion suppression/enhancement were, Acquity BEH (50 × 2.1 mm, 1.7 µm) under gradient program of 5mm ammonium acetate, pH 6.00 : methanol for gemfibrozil; Luna CN (50 × 2.0 mm, 3 µm) column with a mobile phase consisting of acetonitrile-10 mM ammonium acetate, pH 7.00 (90:10, v/v) for rivastigmine under isocratic conditions; inertsustain C18 (100 × 2.0 mm, 5 µm) column and methanol- 2mM ammonium formate, pH 5.50 (80: 20, v/v) as the mobile phase for isocratic elution of telmisartan; and Acquity BEH (50 × 2.1 mm, 1.7 µm) with methanol-10mM ammonium acetate, pH 6.00 (95:5, v/v) as mobile phase for tacrolimus. All the methods were validated and applied successfully for bioequivalence studies in healthy subjects. The method reproducibility was also checked by reanalysis of incurred samples.






GOLD NANOBIPYRAMIDS – THE NEW GENERATION NANO-TOOL FOR DETECTION OF H5N1 VIRUS

Archana George and Pranav S. Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009 Email: [email protected]; [email protected]

Abstract Gold nanoparticles (AuNPs) have proved to be an apt candidate for the construction of diverse colorimetric biosensors. In this work, highly uniform gold nanobipyramids (AuNBPs) with sharp edges have been prepared for ultra-sensitive colorimetric detection of H5N1 virus. The proposed method is based on the mechanism that alkaline phosphatase (ALP) can catalyze the decomposition of 4-aminophenyl phosphate (4-APP) to generate 4-aminophenol (4-AP), which can then reduce silver nitrate to metal silver, which would later deposit on AuNBPs. The metal silver shell coated on the AuNBPs changed the refractive index of gold and thus resulted in a blue shift of longitudinal localized surface plasmon resonance (LSPR) and accompanied a vivid color change. It exhibited a higher sensitivity than that of other AuNPs such as gold nanorods due to the high-index-faceted on the tips of the AuNBPs. This method was used to detect the activity of ALP. It exhibited a linear range of 0.1 ~ 5 mU/mL with a limit of detection (LOD) of 0.086 mU/mL. Finally, the proposed method was used in immunoassay to detect H5N1 virus. The results showed that the corresponding linear range for the detection of H5N1 virus antigen was 0.001 ~ 2.5 ng/mL, and the LOD was determined to be 1 pg/mL, which is more sensitive than the existing colorimetric biosensors.






Environment Friendly Separation Techniques Qureshi Anisa M.A., Jaivik V. Shah and Pranav S. Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009 E-mail: [email protected]; [email protected]; [email protected]

Abstract Green analytical chemistry is a widely recognized concept that has led to the development of new analytical methods with reduced environmental impact and minimized analyst occupational exposure. Chromatographic techniques have the potential to be greener at all steps of the analysis, from sample collection and preparation to separation and final determination. Significant developments have been observed to make chromatography more environmentally friendly. Prominent among these include the development of micro-extraction, ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE) techniques. The approaches used to make chromatographic separations greener differ depending on the type of chromatography. Research towards greener separation processes focuses on the elimination of toxic solvents in liquid chromatography (LC) and in reduction of separation time. The recent developments in the labelling and categorization of analytical procedures are also presented. There has been a shift towards miniaturization and organic solvents have been substituted with water and other less toxic alternatives. What should be highlighted is that there are concerted efforts to qualitatively measure and compare the chromatographic procedures in terms of possible harm to the environment. Although this is a recent development, there are still a lot of issues, such as the amount and toxicity of solvents and reagents, to be improved upon to make the chromatography even "greener".






Application of Super Critical Fluid Extraction Hetal V. Rabari and Pranav S. Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad- 380009, India

E-mail address: [email protected]; [email protected] CCCJHSJDKDDHSKJA Abstract Among the different extraction techniques used at analytical and preparative scale, supercritical fluid extraction (SFE) is one of the most widely used extraction procedure. SFE is the process of separating one component (the extractant) from another (the matrix) using supercritical fluids as the extracting solvent. Extraction is usually from a solid matrix, but can also be from liquids. SFE can be used as a sample preparation step for analytical purposes, or on a larger scale to either strip unwanted material from a product or collect a desired product. Carbon dioxide (CO2) is the most widely used supercritical fluid, sometimes modified by co-solvents such as ethanol or methanol. Extraction conditions for supercritical carbon dioxide are above the critical temperature of 31 °C and critical pressure of 74 bar. This technique finds extensive use in the field of food science, natural products, by product recovery, pharmaceutical and environmental sciences. Additionally, it is also focused on the most recent advances and applications in the areas which require harvesting of high value compounds from food and natural products and also in heavy metal ion recovery, enantiomeric resolution and drug delivery systems.






Application of Supercritical Fluid Chromatography in Analysis Nita J. Ram and Pranav S. Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009, India E-mail: [email protected]; [email protected]

Abstract In analytical chemistry the subject of pharmaceutical and environmental analysis is being routinely done by using HPLC, UHPLC or GC. In an effort to make a technique more versatile, new advances in chromatography are constantly been done with respect to the instrument and the process involved. The last 20 years have seen an intense interest in the use of supercritical fluids as the mobile phase in separation sciences. Supercritical fluid chromatography(SFC) bridges the gap between gas and liquid chromatography and is considered to be a complimentary technique. SFC is a useful separation technology for hydrophobic metabolites, which are difficult to be separated by HPLC. SFC now exhibits improved precision, reproducibility, accuracy and robustness; also providing superior resolution and peak capacity compared to HPLC. SFC is a technique where we use a fluid in its super critical region. The most widely used supercritical fluid material is CO2. In modern medicinal chemistry, combinational drugs are making an international market and for methods to determine these drugs, they should be fast, sensitive, selective and that which involves eco-friendly diluents. One big approach of SFC is that it can also separate isomers i.e. distereomers as well as enantiomers of drugs and thus can help to determine their enantiomeric purity. This instrumental analysis can reduce the cost and time of analysis, provides higher efficiency, recyclable mobile phase and more green or eco-friendly compared to other separation techniques.






There’s too much carbon dioxide in the air. Why not turn it back into fuel? Paras A. Rana and Pranav S. Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad- 380009, India E-mail address: [email protected]; [email protected] 09743618current Abstract Every year, we talk about climate change and global warming and quite likely our own eventual extinction by injecting more than 30 billion tons of carbon dioxide into the atmosphere. There is a way to convert all these emissions using the energy of sunlight back into fuel. Scientist named Stuart Licht has designed the ultimate recycling machine, where the solar reactor takes carbon dioxide (CO2) from the atmosphere—a by product of fossil fuel combustion and uses the energy from the sunlight to turn it back into fuel. There are a few steps in between and water is also involved in the reaction, which produces hydrogen (H2) and carbon monoxide (CO); they in turn can be stitched into liquid hydrocarbon fuels. It is only one of the solar fuel technologies taking shape in labs around the world. Another way to convert all these emissions into energyrich fuel in a carbon-neutral cycle is in the use of a very abundant natural resource-silicon. Silicon, readily available in sand, is the seventh most-abundant element in the universe and the second most-abundant element in the earth's crust. A chemistry solution to climate change requires a material that is a highly active and a selective catalyst to enable the conversion of carbon dioxide to fuel. It also needs to be made of elements that are of low cost, non-toxic and readily available. The hydride-terminated silicon nanocrystals-nanostructured hydrides have an average diameter of 3.5 nm and feature a surface area and optical absorption strength sufficient to efficiently harvest the near-infrared, visible and ultraviolet wavelengths of light from the sun together with a powerful chemical-reducing agent on the surface that efficiently and selectively converts gaseous carbon dioxide to gaseous carbon monoxide. The potential result: energy without harmful emissions.






Low Density Polyethylene: An Alternate Source of Energy Jay S. Dave and Pranav S. Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad- 380009, India Email: [email protected]; [email protected] Abstract The global plastic production increased over years due to vast application of plastics in many sectors. The continuous demand of plastics has caused accumulation of plastic wastes in the landfill, which has consumed a lot of space and thus contributed to the environmental problem. Some alternatives that have been developed to manage plastic wastes like recycling and energy recovery methods. However, there are some drawbacks of the recycling method as it requires high labor cost for the separation process and causes water contamination that reduces the process sustainability. Due to these drawbacks, the researchers have diverted their attention to the energy recovery method to compensate the high energy demand. Through extensive research and technology development, the plastic waste conversion to energy was developed. As petroleum was the main source of plastic manufacturing, the recovery of plastic to liquid oil through pyrolysis process has a great potential since the oil produced has high calorific value comparable with the commercial fuel. The modern plastic along with a catalyst is taken in a reactor, which is maintained at temperature between 350-6000C and at atmospheric pressure. The vapor which comes out of the reactor can be distilled to obtain different fractions of petroleum products. The various fractions obtained depend upon type of feed, catalyst/feed ratio, temperature and time of heating. Various properties of the products obtained can then be tested and compared with the actual values for petroleum range products.






Empagliflozin/Linagliptin Combination with Metformin for Triple Therapy more efficient than Empagliflozin/Metformin as Antiglycemic Drugs Panchal Siddhi S. Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009, India E-mail address: [email protected]

Abstract: The U.S. Food and Drug Administration (FDA) have approved empagliflozin and metformin hydrochloride extended-release tablets for adults with type 2 diabetes. A empagliflozin/ metformin single-tablet combination (STC) ‒ two medicines with complementary mechanisms of action ‒ helps to improve blood glucose in type 2 diabetic adults. For the majority of patients with type 2 diabetes, the recommended first-line pharmacotherapy consists of metformin, but most will ultimately require additional therapies to help sustain glycemic control. Upholding intensive glucose control early on in the disease process is imperative and may eventually lead to benefits that continue beyond the period of treatment. Consequently, when metformin fails to attain glycemic control, combination therapy with additional anti-diabetes agents may be valuable. Given their corresponding mechanisms of action, the once-daily combination of empagliflozin/linagliptin adjunct to metformin may offer certain treatment benefits compared with the addition of either empagliflozin or linagliptin individually as dual therapy. In the drugnaïve patient population being treated with empagliflozin/linagliptin STC, there was a significant improvement in glycemic control compared with all respective mono-treatments. In contrast, patients undergoing dual therapy (with metformin and the empagliflozin/linagliptin STC), the STC helped achieve glycemic control relative to all mono-treatments. Besides overall glycemic control, the empagliflozin/linagliptin STCs attained statistically noteworthy mean differences in body weight and blood pressure reduction, and proved to be well tolerated with overall reduced rates of hypoglycemic events. The results therefore advocate the immediate use of triple therapy in patients who have been unsuccessful on metformin alone, suggesting that this approach may provide advantages over the traditional staggered treatment regimens






Status of Heterocyclic Compounds in Pharmaceutical & Biological Sciences Kinjal S. Singh and Pranav Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-38009, India E-mail: [email protected]; [email protected]

Abstract Nowadays heterocyclic compounds are very useful in our daily lives. They possess hetero atoms in their structure and have a cyclic & non cyclic structure or polycyclic ring system. They are predominantly used as pharmaceuticals, agrochemicals and as veterinary products. Further, they include many of the biochemical materials essential to life. For examples, nucleic acid is the chemical substance that carries the genetic information controlling inheritance. Heterocyclic compounds are active in substantial biological actions as antifungal, antiinflammatory, antibacterial, antidepressant, anthelmintic, anticancer activity, antiviral, antidiabetic, antimicrobial, herbicidal, fungicidal and insecticidal agents. They also find application as sanitizers, developers, antioxidants, corrosion inhibitors; copolymers dye stuff and many others. Heterocyclic compounds have sulfur, oxygen and nitrogen as hetero atoms and are widely used in the biological sciences and pharmaceutical industries as drugs. They are also found in nature particularly in nucleic acids, plants alkaloids, anthocyanins and flavones as well as in heam and chlorophyll. More than 90% of new drugs contain heterocyclic system and are at the interface of chemistry and biology.






THINK GREEN GO GREEN Radhisha Pillai and Pranav Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009, India Email: [email protected] and [email protected] Abstract The main aim of this study is to create novel, efficient and environment-friendly techniques for the synthesis of bioactive heterocyclic compounds which has applications in a wide variety of fields, from pharmaceuticals, agrochemicals, dyes, petrochemicals, medicinal chemistry and various drug developments. With the recent breakthrough of usage of heterocycles in anti-cancer drugs, it has become important for synthesis of similar organic molecules. The heterocyclic compounds currently used have many short-comings which include high toxicity and poor bioavailability. The demand of bioactive heterocyclic compounds keeps increasing day by day due to which there is need of increase in production of heterocycles. The present techniques require longer reaction time, organic solvents, high temperature and pressure and costly catalysts which cannot be recovered after the synthesis. The greener approach to this synthesis involves using green solvents having low toxicity, low vapour pressure and good biodegradability. The issue of catalysts being used up and many of them being toxic and nonbiodegradable can be solved by the microwave irradiation technique for synthesis of heterocycles. This technique involves microwave exposure on reactants which gives faster yield, with minimal usage of solvents or hypervalent iodine complexes or eco-friendly solvents. This alternative technique with more benefits and fewer shortcomings should be polished and improvised to its full potential for a greener and safer environment. Green revolution is the best solution to arrest pollution.






Acid blue 15 is not just a colour, it’s an attitude!

Patel Gaurang, Pandit Bhoomika and Pranav Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009 Email: [email protected]; [email protected] Abstract Globalisation is myriad and a commonly used term in 21st century. The advance in dye science has allowed business to cross over territory boundaries. Consequently, companies tend to become more productive and comparative and living standard has become exquisite which comprises high quality and standard goods. Acid blue 15 is very important dye which comes in this category. Consequently, the use of acid blue 15 dyes on textiles such as wool, silk, and cotton has decreased as dyes from other classes with superior light-fastness and wash-fastness properties have become available. It gives very bright blue colour and the selling market of this dye is very good. Even though the Acid blue 15 dye has a good market, still industries are facing problems with the practical yield and skin allergies when the fabric comes in contact with the skin. We have explored a new technique to prepare the dye which gives more yields compared to already established technique. By using less toxic reagent during the preparation of Acid blue 15 we have also been able to solve the problem of skin irritation. Moreover, the price of this dye has reduced by 65 - 70 Rs/kg.






A NEW FAST HPLC Method for Some Tablet in frnished dosage form Tejal K Joshi1, G R Jani2, K.B.Vyas3 1

Government Polytechnic College, Himmatnagar. 2

M.G.Panchal Science College, Pilvai, 3

Sheth L H Science College, Mansa.

Abstract High performance liquid Chromatography method was developed and validated for the detection of XXXXXXXX in tablet dosage form. The method was carried out on a Sunshell C18 Column (125 × 4.6 mm id, 2.6µ) maintained at 30ºC. The mobile phase consisted of water-acetonitrile (50 + 50, vol./vol.) pumped at a flow rate 0.8 mL/min. PDA detection was at 255 nm. The chromatography separation was obtained with a retention time of 2.8 min, and the method was linear in the range of 1-25 mg/mL (r2 = 0.9997). The specificity and stability indicating capability of the method was proven through forced degradation studies, which also showed that there was no interference of the excipients. The method was validated for linearity, precision, accuracy, robustness, and specificity, limit of detection and limit of quantitation. The developed method, after being validated was successively applied to the anal. of tablet formulations. Hence the method can be used for stability analysis. Keywords: Darunavir Ethanolate, ICH guidelines, Validation, RP-HPLC, Core shell Technology.






STUDIES OF NOVEL PYRROLE AND THEIR BIOLOGICAL STUDIES R.A.Shah1, R.A.C1 Sheth L.H.Science College, Mansa ABSTRACT 2-(1H-benzo[d]imidazol-2-ylthio)-N-arylidene aceto hydrazide (4a-f) was synthesized in good yields by facile condensation of 2-(1H-benzo[d]imidazol-2-ylthio) acetohydrazide(3) with aromatic aldehydes to afford the corresponding. Cyclocondensation of compounds (4a-f) with maleic anhydride yields 1-(2-(1Hbenzo[d]imidazol-2-ylthio)acetamido)-5-oxo-2-subsituted phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (5a-f). The structures of these compounds were established on the basis of analytical and spectral data. The synthesized compounds were tested for their antibacterial and antifungal activities. Keywords: 2-(1H-benzo[d]imidazol-2-ylthio) acetohydrazide, pyrrole, Antibacterial activity and antifungal activity.






Synthesis characterization and Antifungal Activities of 1-((dimethylmino) methyl)-3-(naphtha [2,1-b]furan-2-yl)-4-(phenylamino)-1H1,2,4-triazole-5(4H)-thione(4a-e). Name of author- DarshansinhAjitsinhRaol, Dr.G.D.Acharya R.R.Mehta College of Science , Palanpur (north Gujarat) Email- [email protected] ABSTRACT Ethyl naphtho[2,1-b]furan-2-carboxylate (1) react with hydrazine hydrate gives naphtho[2,1-b]furan2-carbohydrazide (2),Which on reaction with CS2/KOH gives 5-(naphtho[2,1-b] furan-2-yl)-1,3,4oxadiazole-2(3H)-thione (3). The compound (3) on mannich reaction followed by reaction with phenyl hydrazine gives different 1-((dimethylamino) methyl)-3-(naphtha [2,1-b]furan-2-yl)-4-(phenylamino)-1H1,2,4-triazole-5(4H)-thione(4a-e). The structures of these compounds were established on basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities. KEYWORDS: naphtho[2,1-b]furan, Oxadiazine, Mannich reaction, Spectral studies, antibacterial and antifungal activity.






Title : “A rapid and sensitive UHPLC-MS/MS assay for the determination of Clobazam in human plasma using Electro Spray Ionization technology” Smith Christian, Dr. Rashmikant Patel Address: Department of Chemistry, Municipal Arts & Urban Bank Science College, Mehsana, Gujarat State, India Abstract: A simple, highly sensitive, precise and accurate high-performance liquid chromatographic (LC-MS/MS) method with mass detection was developed and validated for the rapid quantification of Clobazam in human plasma samples. The chromatographic separation was achieved with a reverse phase column Reprosil Gold XBD C18 (100 × 3 mm,3µm) and the mobile phase consisted of 10 mM Ammonium Acetate Buffer and 0.1 % Acetic acid in Methanol (15:85v/v) as eluent by running a linear gradient method. The effluence was ionized by positive electro spray ionization and measured by mass spectrometry. The calibration curve was linear with range of 0.501-499.995 ng/mL and the lower limit of quantification was 0.501ng/mL with good accuracy and precision. The mean extraction recovery of the method was higher than 96.4% and 103.3% for clobazam and IS, respectively The method was successfully demonstrated for evaluation of pharmacokinetic profile of clobazam in human plasma and validated for excellent selectivity, accuracy, precision, recovery and stability.






Synthesis and characterisation of some novel Acid azo dyes. Dr. D.G.Patel, Dr. N. K.Prajapati* Department of Chemistry, Municipal arts and Urban bank science college, Mehsana-384001, Gujarat, India. *Department of Chemistry, M.N. College, Visnagar-384315, Gujarat, India. Email : [email protected]

Abstract Novel acid azo dyes have been prepared by the coupling of diazo solution of 4 –methyl Aniline with 1-(4-N-acetyl amino) 2-methyl phenyl , 2-chloro ethanone. The resultant product were hydrolysis by refluxing with ethanol containing for 4-5 hours .The coupling compound of various aromatic acid 1a-1g with above diazonium salt soln. The resultant DG-1 to DG-7 dyes were characterized by spectral techniques, i.e., elemental analysis, IR, UV––visible spectroscopy. Keywords: acid azo dye, UV––visible spectroscopy. .






Title: Transition metal complexes with N2O2-donor azo ligand containing antipyrine moiety: Synthesis, characterization biological and chelating properties. Khushbu K. Mehta1, Dr. Asha D. Patel Address: Department of Chemistry, M. N. College, Visnagar, North Gujarat.

Abstract: The novel heterocyclic azo ligand namely, 4-((8-hydroxyquinolin-5-yl)diazenyl)1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (DpAAPHQ) prepared by coupling reaction between diazotized aminoantipyrine and 8-hydroxyquinoline (HQ). The prepared ligand was characterized by elemental analysis and spectral studies. The transition metal complexes viz. Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ of N2O2 donor DpAAPHQ ligand were characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The biological activity of DpAAPHQ and its metal complexes was examined against various bacterial and fungal strains using agar cup method. Also Ferric-reducing anti-oxidant power of all complexes were measured using FRAP method. Keywords: Aminoantipyrine, 8-hydroxy quinolinol, FRAP method, Antioxidant activity, Chelating properties






Synthesis and Recent developments in biological activities of 1, 3-diaryl-2propen-1-ones core M. M. Khanusiya*, Z. M. Gadhawala The HNSB Ltd Science College, Himatnagar affiliated with Hemchandracharya North Gujarat University, Patan, Gujarat, India. E-mail: [email protected]

Abstract A novel 1, 3-diaryl-2-propen-1-one (Chalcone) derivatives has been designed by condensing aromatic aldehyde with amino acetophenone. Hydroxyl and methoxy substitution on aryl ring of chalcone, depending upon position in aryl ring influence anticancer and other activities. These chalcone with modification yielded synergistic efficacy and have shown promising in vitro anticancer activity and to be non-toxic to normal cells. The synthesized compounds were characterized by means of their FT-IR and 1HNMR spectral study. Keywords: Chalcone, Aromatic aldehyde, Anticancer, Normal cell.






Title: Synthesis, Characterization and antifungal activity transition metal chelates c ontaining heterocyclic ligand and sulfa drug moieties Sefali S. Patel1 , Dr. Asha D. Patel* Address: Department of Chemistry, M.N. College, Visnagar (N.G) India-384315 Abstract:

The reaction between 4-(((5-(ethoxycarbonyl) furan-2-yl)methyl)(propyl)amino)-2- hydroxy benzoic acid and Sulfa pyridine in ethanol gave 2-hydroxy-4-(propyl((5-(4-(N-pyridin-2ylsulfamoyl)phenylcarbamoyl)furan-2-yl)methyl)amino) benzoic acid (HPPSPCFMAB). The synthesized ligand was further characterized by using their elemental analysis as well as spectral studies such as IR, NMR and Mass spectroscopy. Furthermore, the transition metal chelates (M(II)) viz. Cu, Ni, Co, Mn, Zn of ligand (HPPSPCFMAB) were prepared and characterized using metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. Also the antifungal activity of synthesized ligand and its metal chelates was screened against various fungi. The results revealed that all the compounds were shown good antifungal activity.

Keywords: N-propyl-p-Amino salicylic acid, sulfa pyridine, Metal chelates, Spectral analysis and Antifungal activity.






Synthesis and Characterization of 3-{4-[6-(substituted phenyl)-2-thioxo1,2,5,6-tetrahydro pyrimidin-4-yl] phenyl}-6-iodo-2-thioxo-2,3dihydroquinazolin-4-one derivatives. *Dr. Naresh K. Prajapati,, *Milan R. Dave *Department of Chemistry, M.N.College, Visnagar-384315, Dist: Mehsana, Gujarat.

ABSTRACT : Some new derivatives of 3-{4-[6-(substituted phenyl)-2-thioxo-1,2,5,6-tetrahydro pyrimidin-4-yl] phenyl}-6-iodo-2-thioxo-2,3-dihydroquinazolin-4-one have been synthesized by reacting of 3-{4-[3-(substituted phenyl) prop-2-enoyl]phenyl}-6-iodo-2-thioxo-2,3dihydroquinazolin-4-one with thiourea and potassium hydroxide (KOH) in 30 ml of ethanol was refluxed for 3 hours. The synthesized compounds were characterized by means of their IR, 1HNMR spectral data and elemental analysis. Key words: quinazolin-4-one, thiourea, ethanol, IR, NMR.






Evaluation of biological activities of some Schiff Bases and Metal Complexes Jatin G. Jayswal and Vijay M. Barot P.G. Center of Chemistry, Smt. S.M. Panchal Science College Talod. 383215 (India)

Abstract: Schiff bases were synthesised from substituted acetophenone and aromatic amines. The characterization was done by CHN analysis, IR and NMR spectral data. These Schiff bases were evaluated for their antimicrobial activity against both Gram-Positive and Gram-Negative bacteria as well as fungi. In addition, copper, nickel, cobalt, and manganese complexes of synthesised Schiff bases were also synthesised. Their structural assignments was performed using CHN analysis and IR,NMR, and TGA data.






Synthesis of Some bio active Benzimidazoles Rupal G.Gajjar

Abstract: A series of ten benzimidazole derivatives were prepared by the reaction of different aromatic aldehydes and 1,2 phenelene diamines in presence of NH4Cl. The structures of the synthesized compounds were confirmed by IR, 1H-NMR,13CMR and LCMass spectra. All the synthesized compounds were screened for their antibacterial activity against S.aureus, S.pyogenes (Gram positive) E.coli and P.aeruginosa, (Gram negative) and compared with standard drug Streptomycin. Their antifungal activity is evaluated against C. albicans and A. niger and compared with standard drug K.Nystanin.






ANTIMICROBIAL ACTIVITY OF SOME BINARY AND TERNARY TRANSITION METAL COMPLEXES L. S. Bhutadiya Sheth M. N. Science College, Patan

ABSTRACT The antimicrobial activities of the binary and ternary complexes were carried out. In binary complexes Co(II),Ni(II),Cu(II),Zn(II) were used as metals and pentaprazole used as ligand. The test organisms were used Escherichia coli., Bacillus sub tills, s. aureus and fungi A. niger. The novel ternary chelates of d10 [Zn(II),Cd(II),Hg(II)]metal ions with oxine as primary and vitamin U as secondary ligands have been synthesized. Keywords: Metal Complexes, Vitamin-U






Pharmacological importance of 2-Amino-4,5,6,7-tetrahydro-1benzothiophene-3-carbonitrile clubbed moiety Maharshi B. Shukla*1, Prakash J. Johi1, Bharat B. Patel2 Dr. Indu-Dayal Meshri College of Sci. & Technology,Patan Sheth M. N. Science College,Patan H. N. G. University, Patan- 384 265 Gujarat, INDIA [email protected]

Abstract: Compound N-(3-cyano-4’5’6’7-tetrahydro-1-benzothiophen-2-yl)-2-amino were synthesized and further reacted with different reactant to have clubbed compound with this species with different structural diversity to obtained efficient biological activity. Synthesized compounds were elucidated by H1 NMR, Mass spectra and elemental analysis and then the various clubbed literature survey revealed that the compound having such moieties are showing good activity against cancer cell lines of breast cancer, multiple mayeloma and MCF-7 and comparison study is discussed.






DYES Chaudhary Bhavna, Chaudhary Avni , Dr. H.D. Chaudhary*, Dr.J.J. Vora** 1) Department of chemistry Adarsh science college ,Radhanpur 2) **Department of chemistry H.N.G.U, Patan Email :**jabali- [email protected], *[email protected]

ABSTRACT The majority of the molecules of dyes in which investigated by them, among which were also the molecules of fluorescine, so an ability to phosphoresce when energetically isolated, for example, when absorbed by convient adsorbent. Dyes have two main groups Auxophore and chromophore group, there are various other dyes such as Acidic dyes, Basic and mode rent dyes.






WATER POLLUTION Suthar Vipul1, Gauswami Ravi2, Dr H.D.Chaudhary*, Dr J.J Vora** 1,2,*-Department of chemistry Adarsh science college ,Radhanpur **Department of chemistry H.N.G.U, Patan Email : 1 [email protected] **

[email protected]

*

[email protected].

ABSTRACT Water pollution is a serious problem for the entire world .It threaten the health and well being of humans, plants, and animals. As the world become more industrial and smaller due to communications and trade, accidental and purposive hazardous dumping have contributed to the problem of sea pollution. AII water pollution is dangerous to the health of living organisms, but sea and river pollution can be especially detrimental to the health of humans and animals. Rivers and seas are used as primary sources of potable water by populations all over the world. Another serious consequence of this pollution is the effect of this pollution on trade in the polluted areas .This paper examines cases which reflect different causes of sea and river pollution, the seriousness of this pollution, the effect of this pollution on trade, and possible global solution to this problem.






WHY FOOD SAFETY IS IMPORTANT? Rathod Bhargavi, Chaudhary Jalpa, Dr. H. D.Chaudhary*,Dr. J.J. Vora** 1)Department of chemistry Adarsh science college ,Radhanpur 2) **Department of chemistry H.N.G.U, Patan Email :**jabali- [email protected] *

[email protected].

ABSTRACT Food is an widely used substrate for living sources. All food are susceptible to spoilage, thus to preserve it we can use chemicals and preservatives .This foods can be exported and imported in case of needs and requirement .Milk is an complete food that have been wide nutritive values






DRINKING WATER ANALYSIS Chaudhary Jayshree, Dr.H.D.Chaudhary*, Dr.J.J Vora** 1)Shree Adarsh science college ,Radhanpur 2) **Department of chemistry H.N.G.U, Patan Email :**jabali- [email protected], *[email protected]. Abstract The Drinking water is found to be most precious thing in the world. Water consist of seventy five percent of earth surface ,water is said to be pure if found no containment in the water is called as potable water, The water that is not suitable for drinking is called as non potable drinking water. Various sources from where water can collected are natural source, anthropogenic source etc., Drinking water can be tested various biological and chemical test analysis like BOD, COD,TDS, TS etc., water can be tested for consumption point of view it must be free from all pathogenic sources’ Various chemical , physical and biological treatment can be used to make potable water from various source .u.v can be treated with waste water to make it as potable water.






NOISE POLLUTION Chaudhary Sumitra, Chaudhary Manisha, Dr.H.D.Chaudhary*, Dr.J.J Vora** 1)Shree Adarsh science college ,Radhanpur 2) **Department of chemistry H.N.G.U, Patan Email :**jabali- [email protected], *[email protected] ABSTRACT Noise is responsible for cochlear and general damages. Hearing loss and tinnitus greatly depends on sound intensity and duration .Popular and largely amplified music is today one of the most dangerous causes of noise induce hearings loss .Individuals noise sensibility depends on several factors .Strategies to prevent damage from sound exposure should include the use of individual hearings protection device, education programs beginning with school age children, consumer guidance, increased product noise labelling and hearing conversation programes for occupational setting.






VITAMINS Nayi Apexa, Jigyna, Dr.H.D.Chaudhary*,Dr.J.J Vora** 1)Shree Adarsh science college ,Radhanpur 2) **Department of chemistry H.N.G.U, Patan Email :**jabali- [email protected], *

[email protected].

ABSTRACT The vitamins are one of the most important substances found in food source, vitamins can be organic compound and essential nutrient the body cannot produced enough of and which it needs get from food. These can be grouped into water soluble and fat soluble. Vitamins are essential for human body .The fat soluble vitamins are A,D,E and k and water soluble include all vitamin B complexes.






FOOD CHEMISTRY Shekh Gazala, Panchal Twinkle, Dr.H.D.Chaudhary*,Dr.J.J Vora** 1)Shree Adarsh science college ,Radhanpur 2) **Department of chemistry H.N.G.U, Patan Email :**jabali- [email protected], *

[email protected].

ABSTRACT Food is an widely used substrate for living sources. All food are susceptible to spoilage, thus to preserve it we can use chemicals and preservatives .This foods can be exported and imported in case of needs and requirement .Milk is an complete food that have been wide nutritive values.






ADVANCEMENT OF NANOTECHNOLOGY AND NANOPARTICLES IN DIAGNOSIS AND DRUG DELIVERY. Kajal Prajapati , Ritu Panchal , Pooja Barot DEPARTMENT OF CHEMISTRY M.N COLLAGE VISNAGAR – 384315 , MEHSANA ABSTRACT Nanotechnology is a developing branch of science and technology in the 21 century. This paper present the history and development of nanoparticles. It also represent development of biodegradable materials and nanoparticle surface functionalization has allowed new treatment strategies. The reasons why only very few nanoparticles based medicines are on the market or in let clinical trials are discussed and some new approaches were identified.






CHEMICAL PROPERTYS OF SOIL Patel Neeta, Panchal Kinjal, Dr.H.D.Chaudhary*,Dr.J.J Vora** 1)Department of chemistry Adarsh science college ,Radhanpur 2) **Department of chemistry H.N.G.U, Patan Email- **[email protected], *

[email protected]

ABSTRACT We investigated the effects of land use and cover and surface geology on soil properties in Baltimore, MD, with the objectives to: (i) measure the physical and chemical properties of surface soils (0–10 cm) by land use and cover; and (ii) ascertain whether land use and cover explain differences in these properties relative to surface geology. Mean and median values of each variable measured across all plots showed that soil properties varied considerably. Chemical properties generally varied more than physical properties. Potassium, P, and bulk density were the most discerning variables differentiating forest cover from land uses dominated by turfgrass cover. Soil pH differentiated residential land use and cover from the other turfgrass types. This separation may reflect differences in management. Differences in surface soil properties among land use and cover types could be useful when conducting urban soil surveys, at least to spatially differentiate remnant soils from highly disturbed and managed soils. Other soil properties (Al, Mg, V, Ti, Mn, Fe, Ni, and soil texture) were related to surface geology and thus unique to the Baltimore region. The importance of surface geology was contrary to our expectation that urban factors would be more important in determining the distribution of surface soil characteristics. Heavy metal concentrations did not differentiate land use and cover, suggesting that these elements are more related to other factors.






Biodiesel Yogi Suraj, Gaoswani Ashish, Dr. H. D. Chaudhary*, Dr.J.J. Vora** 1) Shree Adarsh science college, Radhanpur 2) **Department of chemistry H.N.G.U, Patan Email- **jabali [email protected], *[email protected]. ABSTRACT Biodiesel is an alternative to conventional diesel fuel made from renewable resources, such as non-edible vegetable oils. The oil from seeds can be converted to a fuel commonly referred to as "Biodiesel." No engine modifications are required to use biodiesel in place of petroleum-based diesel. Biodiesel can be mixed with petroleum-based diesel in any proportion. This interest is based on a number of properties of biodiesel including the fact that it is produced from a renewable domestic source, its biodegradability, and its potential to reduce exhaust emissions. The climate change is presently an important element of energy use and development. Biodiesel is considered "climate neutral" because all of the carbon dioxide released during consumption had been sequestered out of the atmosphere during crop growth. Biodiesel also increased catalytic converter efficiency in reducing particulate emissions. Chemical characterization also revealed lower levels of some toxic and reactive hydrocarbon species when biodiesel fuels were used. The fuel consumption in the world particularly in developing countries has been growing at alarming rate. Petroleum prices approaching record highs and they will deplete within few decades, it is clear that more can be done to utilize domestic non-edible oils while enhancing our energy security. The economic benefits include support to the agriculture sector, tremendous employment opportunities in plantation and processing.






SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW (E)-4CHLORO-2-((3-(SUBSTITUTED ARYL)-1-PHENYL-1H-PYRAZOLE-4YL) METHYLENE AMINO)-6-METHOXY PYRIMIDINE-5CARBALDEHYDE DERIVATIVES

Dr. Akash. R. Patel, Dr. Jabali J. Vora, Dr. Dinesh R. Patel, Prof. Yamini. S. Patel Shankersinh vaghela bapu institute of science,vasan,gandhinagar-382650. Department of Chemistry, Hemchandracharya North Gujarat University,Patan,Gujarat, India. . The UrbaScience College, Mehsana, Gujarat, India. Goverment polytechnic,sector26,Gandhinagar ABSTRACT Schiff Base derivatives are important class of compounds. They possess different types of Biological activities like antibacterial, antiviral, anti HIV, antifungal etc. Schiff base derivatives are prepared by the condensation of aldehyde and amine and these compounds are characterized by chemical and instrumental methods. Their important biological properties have been investigated. Key words: Schiff Base derivatives, Biological study, pyrimidine derivatives, Hydrazone derivatives






STUDY OF GROUND WATER QULITY OF KAPADWANJ TEHSIL OF KHEDA DISTRICT IN DIFFERENT SEASON Pravin Mevada1, Dr.G.R.Jani,2 Department of Chemistry, Parekh Brothers Science College, Dakor Road, Kapadwanj Arts, Science and Commerce College, Pilvai Ta: Vijapur,Dist: Mahesana Email:[email protected]

ABSTRACT: At the present work various some Physico-chemical characters like, Turbidity, Temperature, pH, Total hardness, Chlorides, Dissolved Solids, Calcium, Sulphate, Nitrate, Fluoride, total alkalinity are analyzed for Ten villages (Samples) of Kapadwanj Tehsil of Kheda, located at middle Gujarat. Variation significant of Physico-chemical characters of ground water were observed; various Physico-Chemical characters for the ground water samples (from bore well & tube well) were villages different seasons within highest desirable limit (HDL) prescribed by WHO for drinking & agriculture purposes. We all know that water is our most important life survival factor, but due to urbanization our ground water bodies are being polluted day by day. In order to maintain the water quality of ground water body it requires accessing the Physico-chemical aspects of water periodically. This investigation is one of the most overlooked aspects of drinking water and agricultural management system. Present study highlights the preliminary investigation of Physico-Chemical characteristics of ten villages of Kapadwanj Tehsil.

Key words: Physico-chemical characters, pH, dissolved solids, total alkalinity, highest desirable limit (HDL), WHO, urbanization,






Heavy Metals Removal from Industrial Wastewater by Nano Adsorbent Prepared from Cucumis Melopeel Activated Carbon Devdatt Patel1, Chirag Prajapati1 & M.G.Patel2 1Department

of Chemistry, M. N. College, Visnagar, Gujarat, India

2Department

of Zoology, M.N.College, Visnagar, Gujarat,India E-mail:- [email protected]

Abstract Activated carbon produced from Cucumis Melopeel (CM) was used as adsorbent to remove Cr6+, Cd2+, Ni2+ and Pb2+ ions from Battery industry and electroplating industrial wastewater. Batch adsorption experiment was conducted to examine the effects of adsorbent dosage, contact time, pH and metal ion concentration on adsorption of Cr6+, Cd2+, Ni2+ and Pb2+ ions from the wastewater. The obtained results showed that, the adsorption of the metal ions was adsorbent dosage, contact time, pH and metal ion concentration dependent. The optimum adsorbent dosage, metal ion concentration and pH, were found to be at 250 mg, 100 mg/L and pH 3 to 6 respectively. The study also showed that activated carbon prepared from Cucumis Melopeel can be efficiently used as low cost alternative for removal of metal ions.

Keywords: Cucumis melopeel; Activated carbon; Heavy metals; Adsorption; Kinetic; Wastewater






Industry Effect on Human Beings and Atmosphere Vidhi P.Patel, Henal G. Patel, Kinjal P. Chaudhari, Darshti M. Patel, Dr. Haresh R. Patel* Smt. S. S. Patel Nootan Science and Commerce College, Visnagar, India Email:- [email protected] Abstract:The effect of industrial on human beings, atmosphere and animal. How much effect on atmosphere presented by the graph. There the effect on the human body is described by the human effect of pollution for the industrial wastes. Then we are described to the toxicology on the human body. Keyword:- industrial effects, atmosphere , pollution






STUDIES ON NOVEL 1,2,4-OXADIAZOLE DERIVATIVES Dr.G.D.Acharya, Dr. M.R.Solanki and Dr. M.C.Limachiya Department of Chemistry R.R.Mehta College of Science & C.L.Parikh College of Commerce, Palanpur

ABSTRACT The Mannich reaction between 5-(naphtho [2,1- b]furan-2- yl)-1,2,4- oxadiazole-2(3H)thione (NFOD) and p-amino salicylic acid (SA) was give 2-hydroxy- 4-((5- (naphtho [2,1b]furan-2- yl)-2- thioxo-1,2,4-oxadiazol-3(2H)- yl) methyl amino) benzoic acid (NFODMSA). The novel ligand was characterized by elemental analysis and spectral studies. The transition metal chelates viz. Cu 2+ , Ni 2+ , Co 2+ , Mn 2+ and Zn 2+ of NFODMSA were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The antifungal activity of NFODMSA and its metal chelates was examined against various fungi. 1,2,4-Oxadiazole is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five membered ring. It is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogens (-N=) [31-32].There are three known isomers: 1,2,4-oxadiazole, 1,3,5-oxadiazole and 1,2,5- oxadiazole. However, 1,3,4-oxadiazole and 1,2,4-oxadiazole are better known, and more widely studied by researchers because of their many important chemical and biological properties. Keywords: Naphtho[2,1-b]furan,1,2,4-oxadiazole, p-aminosalicylic acid, Magnetic moment, Spectroscopies study and Antifungal properties.






STUDIES ON SOME ORGANIC MOLECULES CONTAINING LIGAND AND SULFA DRUG MOETIES 1

Vipul Prajapati, 2Piyush Vyas & 3Madhu Patel 1&2

3

Sheth M. N. Science College, Patan-384265 and

Main Sorghum Research Centre, Navsari Agriculture University, Surat -395007 E-mail: [email protected]

Abstract: The condensation reaction between 4-(((5-(ethoxycarbonyl)furan-2yl)methyl)(methyl)amino)-2-hydroxybenzoic acid and Sulphanilamide was give 2hydroxy-4-(methyl((5-(4-sulfamoylphenylcarbamoyl)furan-2-yl)methyl)amino)benzoic acid (SAFSD). The novel ligand was characterized by elemental analysis and spectral studies. The transition metal chelates viz. Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ of SAFSD were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopic study and magnetic properties. The antifungal activity of SAFSD and its metal chelates was examined against various fungi. Keywords: 4-(((5-(ethoxycarbonyl)furan-2-yl)methyl)(methyl)amino)-2-hydroxybenzoic acid, Sulphanilamide, Magnetic moment, Spectroscopic study and Antifungal properties.






HERBALOPATHY: A New Pathway towards Health care 1

Dr. V.P.Prajapati & 2 Madhu I. Patel

1

Sheth M.N.Science College, Patan-384265 and 2

Navsari Agriculture University, Surat Email: [email protected]

Abstract As human being destroying the environment in the race for advancement, newer strains of bacteria developed. New toxins that polluted the environment gave rise to new diseases. This lead to further research for the development of new antibiotics. The process continues even new and creates conditions for new disease to occur and only later realize that we need to make research for their cures. As life became fast, so the need to get back to work as soon as possible to prevent further damage caused by the same. The antibiotic alternative gradually ceased to be the last resort for treatment. Actually it became the first resort for treating even the common cold, which created resistant to antibiotics and their side effects. As new information started powering in, it was already too late- neither doctors nor patients had time to waste on slow acting Herbal Antibiotics.To increase the acting of Herbal antibiotics we add some other active component or chemical constituent or active ingredient by which the effectiveness of herbal becomes higher and faster.






SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF FLAVONES

M.L.Leuva and V. M. Barot P.G. Centre of Chemistry, Smt. S. M. Panchal Science College, Talod - 383 215, Hemchandracharya North Gujarat University, Patan (Gujarat) India. ABSTRACT 2’-hydroxy-3’-iodo-4’-ethoxy-5’-nitro substituted phenyl chalcones were condensed with DMSO in presence of catalytic amount of iodine to give flavones (1a-g), further react with 15% bromine in acetic acid in presence of catalytic amount of mercuric acetate to give 3- bromo flavones (2a-g). Chalcones were condensed with DMSO in presence of copper (II) chloride to give corresponding 3-chloro flavones (3a-g). The structural assignment of the compounds was based on elements analysis and IR, 1H NMR and Mass spectral data. All the synthesized compounds have been screened for their antimicrobial activity to gram-positive and gram-negative bacterial strains and antifungal activity. The antimicrobial activities of the synthesized compounds have been compared with standard drugs like Amoxycillin, Ciprofloxecine and Griseofulvin. Purity of synthesized compounds have been checked by TLC.






Synthesis, characterization and antimicrobial studies of transition metal complexes of 4-(8-quinolinol-5yl-methylamino)azobenzene. Jigna D. Modia and Rajendra M. Jadavb a b

Government polytechnic college, Palanpur, Gujarat, India

Department of chemistry, Bhavan’ssheth R. A. college of science, Ahmedabad,Gujarat, India

Abstract 4-(8-quinolinol-5yl-methylamino)azobenzene was synthesized by condensation of 5chloromethyl-8-quinolinol hydrochloride and 4-aminoazobenzene. The transition metal complexes (i.e. Cu2+, Co2+, Ni2+, Zn2+, Mn2+) of 4-(8-quinolinol-5ylmethylamino)azobenzenehave been prepared and their elemental and metal contents have been determined. The newly synthesized compounds were characterized by elemental analysis, IR and NMR spectroscopy. The number of hydroxyl and azo groupsand dyeing assessment of 4-(8quinolinol-5yl-methylamino)azobenzene on fiber also studied. The antimicrobial activity studies of azo ligand and their metal complexes were examined.






SOURCES OF GLUCOSE MISTRY POOJA ; VAGHELA SARVASHI, Dr.H.D.CHAUDHARY*,Dr.J.J VORA** 1)Department of chemistry Adarsh science college ,Radhanpur 2) **Department of chemistry H.N.G.U, Patan Email :**jabali- [email protected], *[email protected].

ABSTRACT Glucose testing in the hospital with point-of-care devices presents multiple opportunities for error. Any device can fail under the right conditions. For glucose monitoring in the hospital, with thousands of operators, hundreds of devices, and dozens of locations involved, there is ample opportunity for errors that can impact the quality of test results. Common sources of meter error include patient or methodology interferences, operator mistakes, environmental exposure, and device malfunction. Early models of glucose meters had few internal checks or capability to warn the operator of meter problems. The latest generation of glucose monitors has a number of internal checks and controls engineered into the testing process to prevent serious errors or warn the operator by suppressing test results. The reliability of a glucose result will depend on the balance of internal control features available from manufacturers in conjunction with the liquid control analysis and other control processes (operator training, device validation, and maintenance) utilized by the hospitals.





A NEW SPECTROPHOTOMETRIC METHOD FIR THE DETERMINATION OF CHLORINATED NEONICOTINOID INSECTICIDE ACETAMIPRID. CHAUDHARY ASHOK, ARZU, DR.H.D.CHAUDHARY*,DR.J.J VORA** 1)Department of chemistry Adarsh science college ,Radhanpur 2) **Department of chemistry H.N.G.U, Patan **

Email : jabali- [email protected], *[email protected]. ABSTRACT A new spectrophotomeric method the determination of insecticide acetamiprid. The method is based on the bromination of acetamiprid which reacts with potassium iodide in the presence of acetamiprid which reacts with potassium iodide in the presence of leucomalachite green to from a water soluble blue coloured complex. The complex shows maximum absorbance at 620 nm. The reproducibility assessed by carrying out seven days replicate analysis of 10 ml. The proposed method is free from the interference of other toxicants.






RARE EARTH METAL COMPLEXES OF SCHIFF BASE : SYNTHESIS, CHARACTERIZATION . Jabali J.Vora1, Manish P.Brahmbhatt2, Toral Yadav2 1

Department of chemistry, Hemchandracharya North Gujarat University, Patan 2

Sheth M.N.Science College, Patan

ABSTRACT The more biologically important Schiff base ligand was synthesized and used for synthesis of rare earth metal complexes. The metals used for this are samarium and neodymium. Synthesized complexes were characterized by UV-visible, IR, Mass spectra. Key words: Lanthanide rare earth metal complexes, Schiff base






SYNTHESIS CHARACTERIZATION, SPECTROSCOPIC AND CATALYTIC STUDIES OF SOME NOVEL COMPLEX OF Cr(II), Fe(III) AND Mn(II) H. D. Chaudhari1, Pararsar modh and J. J. Vora* 1 2

Adarsh Science College, Radhanpur

Department of Chemistry, scince collage dabhoi 3

Department of Chemistry, H.N.G.U., Patan

E-Mail: [email protected], [email protected] Abstract The Schiff base and complexes were prepared, the new complexes have been characterized using measurements, Infrared spectroscopy, Nuclear magnetic resonance spectroscopy, Thermal analysis and other physicochemical methods. Catalytic study have been carried out for been determined for bath, ligand and complexes.






Highly Efficient Photocatelytic PEG assisted synthesis of s-dopeed ZnO Nanoparticals Reshma bharti, Roshni Joy , Depa asani 1) Department of chemistry science college, Mumbai Email: Neha powar @gmail.com Abstract The S-doped Znonanoparticles were synthesized via surfactant template assistedcopreceptation method. In this method , zinc nitrate hex hydrate was used as a precursor and thiourea was used as a spurce for sulfur do pant . The reaction between zinc salt and thiourea occurred in ammonia using PEG -4000 as a surface directing agent . As synthesized materials were calcined at 450⁰c and characterized by using sophisticated technique such as TGA , XRD ,SEM ,EDX , UV – DRS and FT - IR . This can be used as an study purpose for assement





Analysis of Cadmium Traces jn water sample s using a new microcyclic PVC Based sensor Vimu princesses, Miki Donald 1)Department of chemistry science college ,Raipur Email: *[email protected]. Abstract: A PVC based membrane of 3,10-c-meso-3,5,7,7,10,12,14,14,-octamethyl-1,4,8,11tetraazacyclotetradecane diperchlorate shows a Nernstain response to Cd(Ⅱ) ions over a wide concentration range (1.25 x 10⁻5 _1.00 × 10-1 mol L⁻⁻1 ) with a nernstain slope of 29 mV⁄ decade of concentration . This electrode has been found to be chemically inert and of adequate stability with a response time of 15s.The electrode gives reproducible results with a lifetime of 130days. The potentiometric selective coffecient.






Synthesis, Characterization and AntimicrobialEducation of Novel Nitrogen Based Benzimidazole Derivatives Piyush Dholaria*1, Kalpesh Parikh2 and Deepkumar Joshi1 1

Chemistry Division, Sheth M. N. Science College - Patan, Gujarat 2

Principal, C. U. Shah Science College – Ahmedabad, Gujarat Email: [email protected]

Abstract: Benzimidazole is an aromatic heterocycles that forms the major constituent for a variety of important biological functions. The chemistry of benzimidazole has generated intensive scientific thrust in its research, throughout the world, especially its biological and industrial application.A series of nitrogen based benzimidazole derivatives were synthesized by the authors to pay some novel bioactive antimicrobial agents to fight against multi-drug resistant bacteria and fungi. The titled compounds 2-((6-nitro-1H-benzo[d]imidazol-2-yl)thio)-N-arylacetamide derivativeswere synthesized by multi-step synthesis process. The formation of their corresponding derivatives were confirmed by spectral characterization such as 1H NMR, 13C NMR, mass spectra, IR and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel of gram-positive and gram-negative bacteria as well as fungi. From the SAR studies data, it was detected that the derivatives with electronwithdrawing functional groups were more bio-active than that with electron-donating functional groups. Keywords: Benzimidazole, Antimicrobial, SAR, MIC





Breath Analysis Mir Yasmin , Patel Asha B. Department of Chemistry M.N.College, Visnagar(Mehsana) 384315

Abstract:Breath test are among the least invasive methods available forclinical diagnosis, disease state monitoring and environmental exposure assessment. The developments in medical monitoring technologies and diagnostic methods have focused on blood and urine analysis for clinical diagnostics. The bulk matrix of breath is a mixture of nitrogen, oxygen, CO2, H2O and inert gases. Depending on the origin of the substances found in human breath. i.e.- endogenous or oxygenous, the typical application of breath test fall into two main categories.






PHOTODYNAMIC THERAPY Patel Amee V., Mansuri Nisha A., Chaudhary Ashvini H. Department of Chemistry M.N.College, Visnagar(Mehsana) 384315 Abstract:Periodontal disease caused by dental plaque which is a biofilm of mixed aetiology is one of the most prevalent disease in oral cavity caused by periodontopathic bacteria. Periodontits is conventionally treated with mechanical debridement procedure and adjuctive antimicrobials therapy. Photodynamic therapy is novel noninvasive therapeutic approch with increased pathogen and site specificity. Photodynamic therapy involves use of photosensitzer that is activated by exposure to light of specific wavelength to torm toxic oxygen species therby causing localized photo damage and cell death.






Synthesis and characterization of novel 1,3,4-oxadiazol derivatives and it’s biological evaluation Ravindra M. Gol and Vijaykumar M. Barot* Department of Chemistry, Smt. S.M. Panchal Science College, Talod-383340, Gujarat, India. *E-mail: [email protected]

Abstract Recently, increasing interests have been focused on the oxadiazole derivatives due to their broad spectrum of biological activities. Synthesis of 1,3,4-oxadiazol derivatives designed and evaluated antibacterial and antitubercular activity. Different (4a-k) 1, 3, 4-oxadiazole derivatives synthesized using substituted hydrazide and carbon disulphide in a basic media. The reactions were performed under conventional heating with higher yields. All the synthesized compounds were characterized by their spectral study (IR, MS, 1H and 13C NMR) and were tested for their antibacterial and antitubercular activities.






Environmental lead exposure: a public health problem of global dimensions Dinesh S Chaudhari, Kaushik P Makwana Department of M.N.College,Visnagar,Gujarat,India E-Mail:- [email protected] Abstract Lead is the most abundant of the heavy metals in the Earth’s crust. It has been used since prehistoric times, and has become widely distributed and mobilized in the environment. Exposure to and uptake of this non-essential element have consequently increased. Both occupational and environmental exposures to lead remain a serious problem in many developing and industrializing countries, as well as in some developed countries. In most developed countries, however, introduction of lead into the human environment has decreased in recent years, largely due to public health campaigns and a decline in its commercial usage, particularly in petrol. Acute lead poisoning has become rare in such countries, but chronic exposure to low levels of the metal is still a public health issue, especially among some minorities and socioeconomically disadvantaged groups. In developing countries, awareness of the public health impact of exposure to lead is growing but relatively few of these countries have introduced policies and regulations for significantly combating the problem. This article reviews the nature and importance of environmental exposure to lead in developing and developed countries, outlining past actions, and indicating requirements for future policy responses and interventions. Keywords: lead, adverse effects; lead toxicity; lead poisoning; environmental exposure; occupational diseases; epidemiologic studies.






Subject:Easy printable nano coating for glass Prajapati Sunilkumar Baldevbhai, Thakor Anilkumar Rameshji *Department of Chemistry M.N College Visnagar(Mehsana)384315 Abstract:

A novel process to apply transparent coating on glass will be presented.Functionalizing glass will no longer only rely on CVD-or PVD coated substrates .For example anti-reflective ,partial reflective and partial absortivecoating with self-clean or anti-biotic properties could be applied by common screen-or roller printing process on glass .More Flexibility will be realized in the customizing of glass: New designs, layouts and a combination with traditional glass coating will be possible.






Effect of initiator concentration on grafting parameters of vinyl monomers grafted natural polymers Mahendrasinh Raj1, Ravikumar Savaliya1, Sagar Joshi1, Lata Raj2 1. Institute of Science & Technology for Advanced Studies & Research (ISTAR), Vallabh Vidyanagar – 388120, Gujarat, India. 2. C. N. P. F. Arts & D. N. Science College, Dabhoi, Vadodara, Gujarat, India. Abstract The modification of polymers has received much attention recently. Among the methods available for the modification of polymers, grafting is one of the promising methods. Polymerization is an attractive method to impart a variety of functional groups to a polymer. In the present investigation various vinyl monomers were grafted on different natural polymers. Graft co-polymerization was chemically initiated by using redox initiator. The effects of Ceric Ammonium Nitrate (CAN) concentration on resulting graft co-polymer were studied keeping other parameters like temperature and time constant. The representative graft copolymers were characterized by their FTIR spectroscopic analysis to confirm the modification imparted on the natural polymer. Grafting percentage and grafting efficiency were examined corresponding to the initiator concentration. The optimum results for the grafting parameters were evaluated. Key Words: Natural Polymer, vinyl monomer, Graft co-polymer, CAN





BREATH ANALYSIS Patel Dhara S., Patel Khyati C. M.N.College Visnagar (north Gujarat). Email:- pateldhara929@gmailcom

Abstract Breath analysis has attracted a considerable amount of scientific and clinical interest during the last decade. In contrast to no which is predominantly generated in the bronchial system. Volatile organic compounds (VOCs) are mainly blood borne and therefore enable monitoring of different processes in the body. Breath analysis is play important role in the disease related breath like as Aasthma, Lung cancer, Tuberculosis, Pneumonia. Diagnostic potential of breath analysis focus on volatile organic compounds. Breath testing for volatile organic compounds provides intrinsically safe method for investigating human metabolism.






A structure and Antioxidant activity Study of Paracetamol and Salicylic acid Khushboo D Patel , Kavita M. Gohil, Jaimini A. Patel Department of Chemistry, M.N.College ,Visnager , Gujarat ,India E-Mail- [email protected]

Abstract The paracetamol has more antioxidant properties than the salicylic acid on the several oxidative stressforced models and one possible mechanism is due to electron or hydrogen transfer by the evaluated hydroxyl radicals the antioxidant mechanism for the compounds studied here was performed by molecular modeling using quantum chemical calculations at the B3LYP level of theory our results show that the paracetamol has more antioxidant properties than the salicylic acid in experimental and theoretical studies the hydrogen transfer is more favorable than the electron transfer from the study it was concluded that the electron abstraction for paracetamol is more favored than salicylic acid.






Graft Copolymerisation of poly(hydroxyl ethyl methacrylate Onto Wool Using Ceric Ammonium Nitrate Khatri Jyoti B., Dr.K. M. Joshi Department of chemistry,M.N.College,Visnagar Corresponding Address:[email protected]

Absract: Poly (hydroxyl ethyl methacrylate) has been grafted onto wool by using ceric ion as redox initiator in aqueous medium. Initiation by ceric ammonium nitrate (CAN) was carried out in the presence of nitric acid of variying concentration at 35,45 and 500 C for a period of 1.5 or 3 hr. Percentage of grafting was determined as a function of concentration of acid and monomer, reaction time, and temperature. An optimized condition was observed. Nitric acid catalyzed the reaction and concentration of 0.17-0.19 M HNO3 was found suitable.





A Microwave Assisted Grafting Onto Wool Urvi N. Prajapati, Dr.K.M.Joshi Department of chemistry, M.N.College,Visnagar Corresponding Address:[email protected]

Abstract In order to study the role of heating Electromagnetic radiation (Microwave irradiation) for grafting onto Patanwadi Wool. An attempt has been made to study grafting of acrylic acid onto wool in aqueous medium using Ceric Ammonium Nitrate as redox initiator at 300-400 C and under Microwave irradiation. Grafted wool was isolated and %age grafting was evaluated.The grafting efficiency and optimum grafting conditions are compared.






POTENTIAL HEALTH EFFECTS OF PESTICIDES ON HUMAN Patel Kajal1& Prajapati Rakesh2 1 2

U.G. Student, Dept. of Biology, M. N. College, Visnagar, Gujarat.

Asst. Lecturer, Dept. of Biology, M. N. College, Visnagar, Gujarat.

Abstract Toxicity is the ability of a chemical to cause harm to health. The amount needed to cause harm depends on the chemical. With most pesticides, the longer you are exposed the greater the chance of harm. Pesticides have different distribution and persistence patterns in the environment, even if all of them are distributed in some way through air, soil and water. This scheme illustrates the routes followed by an agricultural chemical (spray, granulate or seed treatment) that is applied to a given site, representing a risk to applicators, bystanders and wildlife. Pesticides are inherently toxic materials – they are developed and used with the explicit intention to destroy or prevent the growth of life. We have not focused in basic chemical background of pesticide but having secondary view we focuses on awareness for using and effects of pesticides among people. The data has been collected from different authentic published journals. Diseases those are most linked to pesticide exposure are asthma, autism and learning disabilities, birth defects and reproductive dysfunction, metabolic disorders, Parkinson’s and Alzheimer’s diseases, and several types of cancer. People are exposed to pesticides through many routes, including spray drift, skin contact even for non‐users, and in food and drinking water. Keywords:pesticides, health, effects, human






SYNTHESIS

AND

SPECTROPTOMETRIC

STUDY

OF

BIS

[1-

4ˈHYDROXY-8ˈ-METHYL COUMARIN-3ˈ-YL)-3-o –NITROPHENYL2-PROPENE-ONE] Cd(II) COMPLEX *Dr. S. M. DAVE, Dr. D. R. FUDANI, Dr. M. P. GONGIWALA Sir P. T. Science College, Modasa-Arvalli (Gujarat) Abstract Chalcones are the compounds which possess. Unique therapeutic activities. Found to be applicable for photosensitive materials, Polymerization catalyst and cheating agents. We have synthesized chalcones, which chelates with metals and forms a complex. These metal complexes are used as an analytical reagent. The parent compound 4-Hydroxy-8-methyl coumarin was acetylated and subjected to fries migration to give 3-acedyl-4-hydroxy-8-methyl coumarin, which on condensation with o-nitro benzaldehyde yielded the chalcone. This chalcone was reacted with CdCl 2 to give metal complex. We have studied the spectrophotometric characterization of ligand and metal complexes at different temperature by various spectro photometric techniques. We have studied elemental analysis and stability constant. The ligand tested used for the estimation of commercial samples like alloys and drugs.






Suzuki Reaction for Cross C-C Coupling in the Synthesis of Heterocycles Patel Nidhi G. and Patel Avani R. M G Science Institute, Navrangpura, Ahmedabad, Email: [email protected] Absract: The use of catalytic cross-coupling methodologies for preparing aryl or heteroaryl functionalized heterocycles with pharmaceutical, agrochemical properties and supramolecular applications is a burgeoning field of study. The Suzuki reaction is the organic reaction that is classified as a coupling reaction where the coupling partners are boronic acid and halide catalyzed by a palladium(0) complex. In general Suzuki reaction is used to form a carbon-carbon single bond by coupling an organoboron species (R1-BY2) with a halide (R2-X) using a palladium catalyst and a base forming R1-R2 i.e. diaryls,,heteroaryls or diheteroaryls. The Suzuki cross coupling reaction is an extremely advantageous and versatile methodology for generation of carbon carbon bond.

R1 BY2

+

R2 X

Pd catalyst

R1 R2

Base






Subject: Biodiesel Thakor Pintubhai Keshaji, Suthar Viralkumar Maheshbhai Department of Chemistry, M.N.College,Visnagar.(Mehsana) pin no:384315 Email: [email protected]

Absract: Biodiesel refers to a vegetable oil or animal fast based diesel fuel consisting of long chain alkyl(methyl,ethyl or propyl) ester.Biodiesel is typically made by chemically reacting lipids(e.g,avgetable oil, soybeanoil, animal fat (tallow)) With an alcohol produsing fatty acid ester.Biodiesel is meant to be used in standard diesel engines and thus distinct from the vegetable and waste oil used to fuel converted diesel engine.Biodiesel can be used alone, or blended with petrodiesel is in any proportions. Biodiesel blend can also be used as heating oil.The National Biodiesel Board (USA) also has technical definition of “biodiesel” as a mono alkyl ester.






Options to accelerate ozone recovery: ozone and climate benefits Rimpal.H.Parmar, Hiral.D.Prajapati, Chirag.R.Chaudhary Department of Chemistry,M.N.College,Visnagar,Gujarat,India E-mail: [email protected] E-mail:[email protected]

Abstract: Hypothetical reductions in future emissions of ozone-depleting substances(ODSs) and N2O are evaluated in terms of effects on equivalent effective strato-Spheric chlorine (EESC), globally-averaged total column ozone,andradiativeforc-ing through 2100.Due to the establishad success of the Montreal protocol,theseaction can have only a fraction of the impact on ozone depletion that regulationalready in force have had.If all anthropogenic ODS and N2O emissions were haltedbeginning in 2011.ozone is calculated to be higher by about 1-2% during the period 2030-2100 compared to a case of no additional restrictions.Directradiativeforcing by 2100 would be about 0.23 W/m2 lower from the elimination of anthropogenice N2O emissions and about 0.005 W/m2 lower from the destruction if thechiorofluorocarbon(CFC) bank.Due to the potential impact of N2O on future ozonelevels,we provide an approach to incorporate it into the EESC formulation,which is used extensively in ozone changes arising from additional ODS and N 2O controlsis also quantified.





Nanoparticles in Forensic Science Akash M. Prajapati & Tejas V. Patel Department of chemistry, M. N. College, Visnagar Gujarat-384315 Email: [email protected]

Abstract Nanoparticles appear in several areas of forensic science including security documents, paints, inks, and reagents that develop latent prints. One reagent (known as the silver physical developer) that visualizes the water insoluble components of latent print residue is based on the formation of highly charged silver nano particles. These attach to and grow on the residue and generate a silver image. Another such reagent involves highly charged gold nano particles. These attach to the residue forming a weak gold image which can be amplified with a silver physical developer. Nanoparticles are also used in items such as paints, printing inks, and writing inks. Paints and most printing inks consist of nano-sized pigments in a vehicle. However, certain modern ink jet printing inks now contain nano-sized pigments to improve their light fastness and most gel inks are also based on nano scale pigments. These nano particlecontaining materials often appear as evidence and are thus subject to forensic characterization. Both luminescent (quantum dots), up-converting nano scale phosphors, and non luminescent nano particles are used as security tags to label product, add security to documents, and as anti counterfeiting measures. These assist in determining if an item is fraudulently made. Forensic science is the application of science to criminal and civil laws, mainlyon the criminal sideduring criminal investigation, as governed by the legal standards of admissible evidence and criminal procedure.






Applications of Nanomedicine in Antibacterial Medical Therapeutics and Diagnostics Harsh M. Patel & Saurabh D. Patel Department of chemistry, M. N .College, Visnagar, Gujarat-384315 Email: [email protected]

Abstract: Nanomedicine has been defined as a science which emphasizes the use of nanoscale tools in conjunction with background knowledge of the human body for medical diagnosis and treatment. The need for new and effective/efficient antibacterial therapeutics and diagnostics is necessary if we want to be able to maintain and improve the protection against pathogenic bacteria. Bacteria are becoming increasingly resistant to traditionally used antibiotics and as a result are a major health concern. The number of deaths and hospitalizations due to bacteria is increasing. Current methods of bacterial diagnostics are inefficient as they lack speed and ultra sensitivity and cannot be performed on site. This is where nanomedicine is playing a vital role. The discovery of new and innovative materials through the improvement in fabrication techniques has seen the establishment of an influx of novel antibacterial therapeutics and diagnostics. The goal of this review is to highlight the research that has been done through the implementation of nanomaterials and nanotechnologies for antibacterial medical therapeutic and diagnostic.






Fingerprint Detection Smitaben Nayi, Jyoti Vaishnav, Binduben Patel Department of Chemistry, M.N.College, Visnagar 384315 Mehsana,

Abstract:-

Crime scene fingerprint sometimes require chemical techniques to make them visible. Here take a look at for key techniques used. Types of fingerprint are like patent print, latent print and plastic print. In the latent fingerprint powders the pigments and binders. Chemical developers are make fingerprints glow in certain colours of light like Ninhydrin and DFO. Surfaces where latent fingerprints may be found can be exposed to cyanoacrylates fumes to make them visible. The VMD process involves layers of metal atom being left on a surface under vacuum conditions to visualize latent prints. Key words: - Ninhydrin,Ruhemann’s purple, Methyl cyanoacrylate.






Synthesis, characterization and biological evaluation of Sulfamethizole and Maleic anhydride based transition metal complexes Hitesh R Patel,aAsha D Patel*a a

Department of Chemistry, M N College, Visnagar - 384315

E-mail: [email protected] / [email protected]*

Abstract:

In the present study a novel 4-{[4-(N-(5-Methyl-1,3,4-thiadiazol-2yl)sulfamoyl)phenyl]amino}-4-oxobut-2-enoic acid (MTSPAB)was prepared by reaction of maleic anhydride with Sulfamethizole. The prepared ligand was characterized by elemental analysis and spectral studies. The transition metal complexes viz. Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ of MTSPAB were prepared and characterized by metal-ligand (M:L) ratio, IR, reflectance spectroscopies and magnetic properties. All the prepared metal complexes and ligand were studies as antimicrobial agent. Among all the metal complexes, Zn2+ and Cu2+ metal complexes have shown significant activity. Keywords: Maleic anhydride, Sulfamethizole, Magnetic moment, Spectroscopic study and Antifungal properties.






Fluorescence switch on-off-on receptor constructed on quinoline allied calix[4]arene for selective recognition of Cu2+ from blood serum and F- from industrial waste water Pinkesh G Sutariya* *

Department of Chemistry, Bhavan’s Shree I. L. Pandya Arts-Science and Smt. J. M. Shah Commerce College, Dakor:388225, Sardar Patel University E-Mail: [email protected]

Abstract A novel PET with ICT based 3-quinoline carboxylic acid substituted calix[4]arenefluroionophore was synthesized and used for recognition of Cu2+ and F- by emission spectra. For the first time, we have synthesized lower rim calix[4]arenedihydroxyquinolate as fluoroionophore through modified method by using DCC reagent which was exclusively used to substitute calix[4]arene at lower rim to provide stiffness as well as litheness for the recognition of guest ions. The synthesised fluoroionophore was purified and characterised by elemental analysis and various spectroscopic methods such as fourier transform infrared spectroscopy (FT-IR), electron spin ionization mass spectroscopy (ESI-MS) and proton nuclear magnetic resonance spectroscopy (1H NMR). The detection limit of synthesized receptor was found to be 4.16 nM for Cu2+ and 2.15 nM for F-. Recognition event was supported by emission titration, UV-visible and colorimetric detection under fluorescent light. Moreover, this probe has been applied for recognition Cu2+ in blood serum and F- from waste water with 102-115% recovery. This highly sensitive, selective, easy, rapid detection and cost-effective fluorometric method will provide great interest for routine analysis of Cu2+ and F-.






Novel heterocyclic based based “Turn on/off” calix[4]arenefluoroionophore: its sensing efficacy of fluoride from waste water and Zn2+ from blood serum Rinkuben P. Patel* Department of Chemistry, Bhavan’s Shree I. L. Pandya Arts-Science and Smt. J. M. Shah Commerce College, Dakor: 388225, Sardar Patel University E-Mail: [email protected] Abstract

A novel structurally simple calix[4]arene appended 8-amidoquinoline linked conjugate was synthesized which has been used as turn-on fluorescence probe for Zn2+ and turn off for F-. For the first time, we have synthesized lower rim calix[4]arenetetraamidoquinoline as fluoroionophore through modified method by using DCC reagent which was exclusively used to substitute calix[4]arene at lower rim to provide rigidity as well as flexibility for the recognition of guest ions. The synthesised fluoroionophore was purified and characterised by elemental analysis and various spectroscopic methods such as fourier transform infrared spectroscopy (FTIR), electron spin ionization mass spectroscopy (ESI-MS) and proton nuclear magnetic resonance spectroscopy (1H NMR). This fluorescence probe have been applied for recognition and determination of Zn2+ and F- from blood serum and industrial waste water sample respectively with 98% recovery. This highly sensitive, selective, easy and cost-effective fluorometric method will provide great interest for routine analysis of Zn2+ and F-.

Key Words: ICT, calix[4]arene, fluoroionophore






Ultra-Performance Convergence Chromatography Priyal P. Jha and Pranav S. Shrivastav Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad - 380009 E-mail: [email protected], [email protected]

Abstract Ultra-performance convergence chromatography is a new category of separation science which utilizes the unrealized potential of the supercritical chromatography phenomenon. Ultraperformance convergence chromatography integrates the advantages of supercritical fluid chromatography & UPLC technologies. In convergence chromatography separation is achieved by manipulating the density & composition of a supercritical fluid based mobile phase because of the very high diffusivity and high separation efficiency. This is an environmentally friendly analytical technique that dramatically reduces consumption of toxic organic solvents. The technique was developed to improve resolution and attain shorter analysis time in comparison to the conventional high performance liquid chromatography. The main advantage of this technique is indicated in terms of linearity, precision & accuracy. It can be used to efficiently separate, characterize & quantify drugs, macromolecules, other medicinal materials or preparations with advantages of a shorter analysis time, greater sensitivity & better environmental compatibility. Convergence chromatography is a new category of separation science that provides an exceptional increase in selectivity. One of the most interesting features of ultra-pressure gas chromatography would be the convergence with classical liquid chromatography.






Synthesis, characterization and antibacterial study of Mixed Ligand Complexes of 5-(Cyclohexylmethyl-8-Quinolinol) and 8-AQ Dr. D. S. Gandhi1* and Dr. Ketan B. Patel2 1 2

Government Science college, Gandhinagar, GUJARAT (INDIA),

Chemistry Department, Government Science college, Jhalod, GUJARAT (INDIA) *[email protected]

Abstract: 5-(Cyclohexylmethyl-8-Quinolinol) (CHMQ)have been prepared and was screened for its structure determination using Elemental analysis, IR, NMR, Mass spectral studies, Hydroxyl group determination and Oxidation. Mixed ligand complexes of transition metal with 8quinolinols and CHMQ have been prepared. Structural, spectroscopic and thermal properties have been studied on the basis of infrared spectra, Mass spectra, NMR spectra, electronic spectra, and elemental analyses. The ligands, metal complexes, control and standard drug were tested for their antimicrobial activity. The metal complexes exhibit good activity against Bacterial strains two Gram +ve and two Gram –ve and two fungal strains compared with parental compounds and moderate in compared to the standard drugs. Keywords: Transition metal chelates, Spectral studies, Magnetic moment and Antimicrobial activity.





Synthesis and antimicrobial activities of 2-(3,4,5-trimethoxyphenyl)-5-{(1arylamino)-2-oxoethyl}-mercapto-1,3,4-oxadiazole. 1

Jayesh P. Jadhav, 2Maharshi B. Shukla and 1Kokila A. Parmar 1

2

Department of Chemistry, H. N. G. University, Patan, Gujarat, INDIA

Dr. Indudayal Meshri College of Science & Technology, Patan, Gujarat, India E- mail: [email protected]

Abstract: A new series of 2-(3,4,5-trimethoxyphenyl)-5-{(1-arylamino)-2-oxoethyl}-mercapto-1,3,4oxadiazole have been synthesized by the condensation of 5-(3,4,5-trimethoxyphenyl)-1,3,4 oxadiazole-2-thiol and 2- chloro – N – ( Aryl ) – acetamides. The novel compounds structure has been established on the basis of their substituted N-chloro aryl acetamide derivatives. All the compounds were characterized by FT-IR, Mass, 13CMRand 1H-NMR spectroscopy. These new compounds were evaluated for their in vitro antibacterial activity and anti fungal activity.






Synthesis of sulfonamide derivatives using 1-butylimidazolium acetate ionic liquid as a catalyst Arpit Kumar Pathak & Chetna Ameta Microwave Chemistry laboratory, Department of Chemistry, M .L. Sukhadia University, Udaipur (Raj.), 313001, India

Abstract An efficient and environmentally benign procedure for the synthesis of aminopyrimidine by multi component reaction between structurally diverse aldehydes, ethylcyanoacetate and guanidine hydrochloride using 1-butylimidazolium acetate ionic liquid under microwave irradiation is described. This aminopyrimidine diverse reacted with sulfonyl chloride and formed sulfonamide derivatives of amino pyrimidine. The methodology provides synergy of ionic liquid and microwave irradiation which offers several advantages such as high yields in shorter reaction time, convenient operation and easy work-up. The products have been isolated, purified and characterized by different spectral methods i.e. IR, 1H NMR, 13C NMR and Mass spectra. The potent antimicrobial effects (MIC) of the synthesized compounds were investigated. Keyword: Ionic liquid, microwave, MIC.






Synthesis & Characterization of Bioactive Schiff Base of Flupirtine & Ratigabine Drugs Megha M. Patel , Megha N. Patel, Khushbu Dodiya, Dr.Z.M.Gadhwala* Department of chemistry The H.N.S.B Ltd. Science College Himatnagar-383001 E-mail: [email protected] Abstract: A new series of Schiff base have been synthesized from Flupirtine and Ratigabine drugs. The chemical structure of the new Schiff base were confirmed by spectroscopic technique. This Schiff base have been tested for their antibacterial as well as antifungal activity against certain strains of bacteria and fungi and showed significant activity Keywords: Schiff base, Flupirtine, Ratigabine, Antibacterial activity, Antifungal activity.






Phosphorus and zinc management with bio-fertilizers in wheat crop under loamy sand soils Dr. A. K. Patel Assoc. Res. Scientist(Ag. Chem. Soil Sci.), Wheat Research Station, S.D Agricultural University,Vijapur-382 870 ABSTRACT

The experiment was conducted at Wheat Research Station, S. D. Agricultural University, Vijapur( North Gujarat). Split plot design arranged with each of three levels of Bio-fertilizers, phosphorus and Zinc levels. Growing wheat crop (var., GW 322) P2O5 fertilizer applied @ 30 kg /ha with PSB @ 30 gm/1 kg as a seed treatment + 20 kg/ha inoculated VAM (Native mixture) culture and 20 kg ZnSO4/ha (soil application). Treatment B3:(PSB+VAM) recorded higher grain yield in the year 2010-11(57.06 q/ha), 2011-12(39.63 q/ha), 2012-13(52.44 q/ha), 2013-14(45.89 q/ha) and (48.75 q/ha ha). Among different phosphorus levels, treatment P3:(100 % RDP) recorded significantly higher grain yield during 2013-14 (46.65 q/ha and in pooled (47.87 q/ha) analysis. Effect of zinc levels on grain yield was significant except, in 2010-11. Yield was in 2011-12 (40.49 q/ha), 2012-13 (50.66 q/ha), 2013-14 (45.98 q/ha) as well as in pooled (47.79 q/ha) resulted by Z3:(20 kg ZnSO4/ha) over Z1:(No Zinc) i.e. 35.86, 48.69, 43.81 and 45.68 q/ha respectively. However, interaction between all the treatments on grain yiled were found to be non significant, except, Y x P interaction. Straw yield was significant by bio-fertilizer in 2012-13 (87.05 q/ha) as well as in pooled analysis (77.44 q/ha). However, it remained at par with B1:(PSB) in pooled analysis(73.02 q/ha). Zinc levels on straw yield of wheat was found to be non-significant, except, in 2011-12. Treatment Z1:(No zinc) produced 53.42 q/ha straw yield which was significantly highest over the other tretments. Interaction effect due to bio-fertilizers, Phosphorus and Zinc levels were found to be non significant, except, B X P interaction was significant on straw yield in pooled analysis. Bio fertilizers was found significant on pH, Ec, organic carbon and available phosphorus. Treatment B3:(PSB + VAM) recorded significantly higher pH and available phosphorus in soil (39.42 kg/ha), but it remaimed at par with B2:(VAM) treatment. Significantly higher pH (7.55) and organic carbon (0.35 %) in pooled analysis, however, it was at par with P3:(60 kg ZnSO4/ha) in both the cases. Significantly higher organic carbon was recorded under treatment P2:(50% RDP). Significantly higher available nitrogen (188.50 kg/ha) and available phosphorus (38.85 kg/ha) in soil was recorded under treatment P3:(100% RDP). Zinc levels was significant effect on Ec, organic carbon and available phosphorus. Treatment Z3:(20 kg ZnSO4/ha) recorded signifintly

higher Ec (0.22 dS/m), organic carbon (0.35 %) and available phosphorus in soil (38.51 kg/ha), however, in case of organic carbon content it was at par with Z2:(10 kg ZnSO4/ha). Soil pH, EC, Organic carbon and available nitrogen were significantly affected by B x P and B X P X Z interactions. Whereas, B x Z interaction was significant on soil pH, EC,OC and available phosphorus content in soil. Significantly higher nitrogen uptake(59.66 kg/ha) by grain and phosphorus(22.88 and 15.58 kg/ha) and potash(24.20 and 33.09 kg/ha) by grain and straw were recorded by B3: (PSB +VAM) treatment respectively. Higher Potash uptake(22.40 kg/ha) by grain was recorded by P3:(100 % RDP) treatment, However, it was at par with P2:(50 % RDP). Higher Phosphorus uptake(21.82 kg/ha) by grain was recorded by Z3 :(20 kg ZnSO4/ha) and Potash uptake (22.24 kg/ha) by Z2 :(10 kg ZnSO4/ha) but it was at par with Z3 :(20 kg ZnSO4/ha) treatment. Effect of B X P, B X Z, P x Z and B x P x Z Interaction was found significant on nitrogen, and phosphorus uptake by grain. Effect of B X Z and P x Z Interactions was found significant on uptake of nitrogen and phosphorus by wheat straw. ---------------------------------------------------------------------------------------------------------------------Key Words: Biofertiliser, phosphorus, zinc, phosphorus solubilizing bacteria, Vesicular Abescular Mycorhyza, zinc sulfate and Recommended Dose of Phosphoru






Nutrient management through resource conservation in Cotton(Gossypium_herbaceum) – Wheat(Triticum Aestivum L.) sequence in loamy sand soils Dr. A. K .Patel Assoc. Res. Scientist (Ag. Chem. Soil Sci.), Wheat Research Station, S.D Agricultural University, Vijapur-382 870

ABSTRACT

Due to the introduction of Bacillus thuringiensis (Bt) cotton, it has become one of the most important crops of North Gujarat. Cotton-wheat is one of the most remunerative cropping systems of North Gujarat. The sowing time plays an important role to realize maximum cotton as well as wheat yield as the potential optimizing yield is directly influenced by the accumulation of heat units as well as thermal time, particularly in wheat crop. Sowing of wheat is generally delayed due to cultivation of long and medium duration Bt cotton varieties as well as the time required in field preparation for wheat sowing. In-situ recycling of crop residues also improves the soil fertility and facilitates good soil tilth for better seed germination by the use of rotary till drill. Nitrogen is the most important element for both the crops. Efforts were made to study the effect of residue recycling and nitrogen on productivity of wheat under cotton-wheat crop sequence in irrigated condition, optimum nutrient requirement and effect of cotton residues recycling practices on soil properties. While applying the chemical and crop residue recycling using decomposer viz., Tricoderma viridi special attention needs to be paid to environmental aspect especially the toxicity, imbalance of the availability of other nutrients and soil health due to their possible indiscriminate use. Decomposition of cotton stalk may result in buildup of chemicals, upsetting beneficial microbial ecosystems and even contributing to the release of greenhouse gases. The recommended use of fertilizers is often exceeds several folds by the farmers in an attempt to harvest more. The soils under study was sandy loam having low organic carbon and medium in fertility with neutral soil reaction. A significant impact of cotton stalk with two run of rotavator with application of 25 kg urea ha-1+ 3 kg/ha Trichoderma viride 106cfu and then late sown wheat

applying 100% of recommended dose of fertilizers (i.e. 80:40 kg N:P ha-1) was given good quality of higher grain yield 39.77and 38.79 q ha-1 respectively. However, both the organic sources were found compatible towards all the parameters under study. Therefore, this approach could be the most sustainable and also cost effective strategy to conquer the micronutrient deficiency in food crops and human. Key Words: Bacillus thorensium, in-situ recycling, rotavator, Tricoderma viridi , cotton stalk, Trichoderma viride soil properties, sustainable, micronutrient and colony forming units etc.





Impact of agronomic biofortification of Iron and Zinc on soil properties and productivity as well as quality of wheat (Triticum Aestivum L.) Dr. A. K .Patel Assoc. Res. Scientist(Ag. Chem. Soil Sci.), Wheat Research Station, S.D Agricultural University, Vijapur-382 870

Abstract Agricultural tools like agronomic biofortification of available nutrient resources as a complementary approach should be considered for ensuring success of breeding efforts for development of high yielding nutrient efficient genotypes as well as to overcome the effects of soil degradation outcomes. A similar agronomic biofortification strategy has been initiated by applying iron and zinc as such as well as enriched with organics (FYM & Vermicompost) with two levels of recommended dose of nitrogen and phosphorus. The soils under study was sandy loam having low organic carbon and medium in fertility with neutral soil reaction. A significant impact of organic enriched iron & zinc were found on soil properties as well as wheat quality and production. However, both the organic sources were found compatible towards all the parameters under study. The application effect of organic enriched Fe and Zn with RDNP were increased both grain as well as biomass yield of the wheat by 2.3 to 6.6% as compared to direct and by 5.6 to 10.3% as compared to no application of the micronutrients. Similarly, an appreciable improvement in SOC (28%), available nitrogen (5%) and available phosphorus (22%) was observed which are equivalent or better than T1 (i.e., RDNP + 5 t FYM ha-1). Although, the application effect of Fe and Zn enriched organics with RDNP didn’t show any effect on nitrogen and phosphorus uptake by wheat. Therefore, these differences seem to be due to application of organics and RDNP. In contrary, the availability of Fe (5.9 to 18.4 %) & Zn (24.3 to 48.5 %) as well as their uptake (12.9 to 24.1 % for Fe and 13.4 to 28.8 % for Zn) by wheat were appreciably increased by application of organic enriched Fe-Zn as compared to direct and no application of these micronutrients. Further, it is interesting that availability (10 to 37%) as well as uptake (17 to 32%) of these micronutrients was considerably higher under 50% RDNP as compared to 100% RDNP. Therefore, this approach could be the most sustainable and cost effective strategy to conquer the micronutrient deficiency in wheat crop and human. Key Words: Agronomic biofortification, Organic enriched Fe and Zn, Soil properties, Wheat quality & production






A Study on available phosphorus and fertility index of Indian Farmland Soil of Idar Taluka territory District: Sabarkantha (Gujarat) Dr. Jitendra K. Parmar1, Dr. D. P. Patel2 1,2

Department of Chemistry, Government Science College, Idar – 383 430 E-mail: [email protected]

Abstract Essential needs of human beings i.e. food, clothes and shelter fulfill by agricultural products through the medium of soil. Soil is the basic element of our agriculture. Eminence of farmland soil is depended on investigative conclusion of various parameters like pH, electrical conductivity (EC), total organic carbon, available nitrogen (N), available phosphorus (P2O5) and available potassium (K2O). This investigation was carried out during year 2014-15 under soil health card project of Gujarat government. This study leads us to the conclusion of the nutrient content in farmland soils of Idar Taluka, District- Sabarkantha, Gujarat (India). Available phosphorus content falls in all three category i.e. Low, medium and high phosphorus content, found for 17 villages of Idar Taluka covered under the study. The average fertility index for available phosphorus for this taluka is 6.87. This information will help farmers to decide the problems related to soil nutrients, thereby quality as well as quantity of fertilizers would be added to soil in order to achieve high agriculture yield with minimal use of fertilizers. Key Words: Quality of soil, Fertility index, Available phosphorus.






Greenway Synthesis and Characterisation of Anilide Derivatives Asodariya jaldeep, Dhhobi Shrddha, Bhavsar Nirali. Z M Ghadhwala* Department of Chemistry The H. N. S. B. Ltd. Science College, Himmatnagar- 383 001. Correspondace address: [email protected] Abstract : Green chemistry is interested discipline and alternative innovation on many Synthesis aspects for researches and academicians. By changing the methodologies of organic Synthesis health, safety, time and environmental issues can be saved. In this work few anilide derivativeas (compound 1 to 4) were synthesized by conventional and ecofriendly methods. The atom economy was calculated for conventionally and ecofriendly Synthesized Derivatives. The synthesized products werw Characterised by Rf, M.P. and FTIR data. Keywords : green chemistry, ecofriendly, conventional method, atomeconomy.






Subject:-The Chemistry of paper conservation Mittu C. Patel, Diptikumari V. Patel., Sejalkumari H. Patel. *Department of Chemistry, M.N. College, Visnagar, Gujarat, India. E-mail:[email protected]

Abstract:Collectables on paper contain a large number of components of varying degrees of stability. The factors that cause these to deteriorate include oxidation, acid hydrolysis, air pollutants and water. Deacidification is often used by conservators and there are beneficial effects from the introduction of Mg2+ and Ca2+; however, excessive alkalinity must be avoided. There are many mechanisms for the development of discolouration in paper. Several examples of ageing effects of inks and pigments are considered. Keyword:- cellulose, Mg(OH)2 , Ca(OH)2, Mesh, chelating agents.






SYNTHESIS, CARECTERIZATION AND BIOLOGICAL APPLICATION OF SOME HETEROCYCLIC COMPOUNDS S. D. Sutariya*1, K. A. Parmar2 1

Sheth M. N. Science College, Patan, Chemistry Department 2

Department of chemistry

Hemchandracharya North Gujarat University, Patan-384265, Gujarat, India Email: [email protected] Abstract Heterocyclic compounds exhibit exciting medicinal properties. Heterocyclic moieties have been synthesized and check the structural properties by different spectroscopy and give them some biological activity of their moiety. This article describes the importance of heterocyclic nuclei in the development of drugs. The current challenges and future prospective of heterocyclic compounds have also been discussed. Keywords: Heterocyclic Synthesis, Biological Activity, Scaffolds.






Synthesis, Structural Elucidation and Anti-Microbial Screening of N-(4-aryl amine)-2-{[4-phenyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide Derivatives” Anant Patel1, Manish Patel1, Jyotindra Mahyavanshi*1 1

Dept. of Chemistry Sankalchand Patel University, Visnagar-384315 E-Mail – [email protected]

Abstracts A new series of 2-[4-phenyl-5-(pyridine-4-phenyl)-4H-[1,2,4]triazole-3ylSulfanyl]-N-arylacetamide have been synthesized by the condensation of 4-phenyl-5-(pyridine-4-yl)-4H-1,2,4triazole-3-thiol and 2-Chloro-N-(aryl)-acetamide in presence of anhydrous potassium Carbonate. The Structure of Synthesized compound was assigned by H1NMR,MASS Spectra,IR Spectra and Elemental Analysis .All the compound were Screened for their in-vitro Antibacterial, Antifungal and anti-tuberculosis activity. Key Words-1,2,4 triazole, Acetamide, Anti-bacterial activity.





Heavy Metal Contamination in Aquatic Food (Fish) – A Review Falguni V. Patel, Dr. A.S.Prajapati+ and Dr. A. D. Patel,* *Department of Chemistry M. N. College, Visnagar.

+Department of Chemistry Goverament science college, Limkheda Abstract In the recent years, human activities produce different environmental pollution. Around the globe, marine environment is heavily polluted with various organic (Pesticides) and inorganic contaminants (Heavy Metals) in aquatic food or aquatic organisms. Contamination due to heavy metal for aquatic ecosystem is acknowledged as a serious environmental concern because of their potential toxicity, abundance, persistence and tendency to subsequent bioaccumulation. The aim of the present study is to assess the distribution of trace elements (Ag, Al, As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Mo, Ni, Pb, Se, Sn, Ti, V, Zn) in the fish and its tissues (Muscle, Liver, Gills, Kidney, Intestine). The samples of fish were collected in the different seasons from unlike locations of the world and sample prepared by different sample preparation methods (Acid digestion, Microwave Digestion, Dry ashing and Wet ashing method). For the analysis of heavy metals was carried out by analytical instruments such as AAS, GFAAS, ICP-MS, ICO-MS, HR ICP-MS and the recovery was 77-114 %. Cadmium (91 %), Copper (83%), Lead (91 %) and Zink (70 %) metals were frequently found in different fish species in various locations.





POSTER PRESENTATION-104 ANTIMICROBIAL ACTIVITY OF EXTRACTION OF CASSIA FISTULA AND ITS COMBINATION ALONG WITH ANTIBIOTICS JIGAR S. PATEL1, RIGNESH S. PATEL2 Dr. PIYUSH J. VYAS 1 1 2

SHETH M. N SCIENCE COLLEGE, PATAN

Dr. Indu Dyal Meshri College Of Science An D Technohy, Patan

ABSTRACT: Plant extracts have showed effective antimicrobial activity against bacteria. Cassia fistula Linn is an important medicinal plant commonly known as golden shower has been used as medicines for various ailments since ancient times. Combination of Herbal extracts and antibiotics are used to decrease side effect of Allopathy drugs and also used to increase sensitivity of plant extracts. Day by day bacteria regaining antibody against traditional antibiotics and becoming more powerful. To stop their regenerating power, combination of plant extracts and antibiotics provide one of the best results in such direction. If nontoxic plant extracts have been taken in suitable doses, it may prove best supplementary remedies patient. This is in vitro study and such combination must be followed by toxicity test and in vivo tests to determine its therapeutic application. KEYWORDS: Extraction, Cassia Fistula, Antibiotics, Antimicrobial Activities.






Study of physical parameters of ternary liquid mixtures M. R. Chavda Department of Chemistry The H. N. S. B. Ltd. Science College, Himmatnagar- 383 001. Abstract: In this paper physical parameters likes density, viscosity, surface tension and refractive index of ternary liquid mixtures, viz. ethanol-water - acetone have been determined for varying mole fractions of solvent components. Molar refraction of these solutions was calculated from measured refractive indices. The results have been discussed in terms of intermolecular interactions and structural properties of ternary liquid mixtures. Keywords: Density, Viscosity, ternary liquid mixtures and refractive index






EXTRACTION OF NICOTINE SULPHATE FROM SAMPLES OF CIGARETTES PATEL HARSH J., PATEL DINSHA M., MODI HIREN M. ([email protected]) College:- MUIS,Ganpat University Kherva.

Abstract:A simple and accurate method, gas chromatography (GC) with flame-ionization detection (FID) has been used for determination of the four main nicotine-related alkaloids in tobacco. Tobacco samples were treated with a small quantity of aqueous ammonia solution, to loosen the tobacco tissue and to convert all alkaloids to free bases, then extracted with 1:3 CH3OHCH2C12. A method for further simultaneous and comprehensive determination of six nicotine-related alkaloids in cigarette smoke was also developed. Because of the complexity of the cigarette smoke matrix and the small amounts of alkaloids, except nicotine, in cigarette smoke, the smoke extract was concentrated after removal of the acidic and neutral fractions. To reduce the adsorption and thermal degradation of alkaloids in the liner, especially for nornicotine, a suitable injector temperature was selected and pulsed injection mode was studied. Different cigarette smokes and tobaccos were analyzed for levels of nicotine-related alkaloids.






RESIDUAL PESTISIDE IN VEGETABLE PATEL KAMAL A. ,PATEL KAPIL M. , PATEL BHAVIKA K. ([email protected]) College:- MUIS,Ganpat University Kherva.

ABSTRACT: The pressure on land in our country is constantly mounting due to rapidly increasing need for providing food to the ever increasing population. Owing to the limited scope for agriculture, the solution lies in intensive and extensive cultivation to increase production and productivity. Pesticide may continue to play an essential role to ensure an adequate supply of food to meet the food needs of human beings. Many farmers in India have an impression and belief that if the pesticides are used in excess, the pests can be controlled quickly to get more yields. Because farmers and farm workers directly handle 70-80% of the pesticides, they are at the greatest of exposure and are often less well trained in the safe handling of toxic materials. This can sometimes cause serious accidents and one can state without exaggeration that here the most serious risks in pesticide use are found. It is well known to the specialists working in pesticide toxicology and occupational health, that dermal exposure is much greater than respirator exposure, but this fact is usually not known to spraymen working in the field or to other pest control workers.






EFFECTS OF HEAT ON VITAMIN C IN JUICES PATEL GAURAV M., PATEL MAYUR B.,

PATEL RAJ D.

([email protected]) College:- MUIS,Ganpat University Kherva.

Abstract:Vitamin C in different juice samples, including fresh and packed juices, was investigated. The melting temperature of vitamin C is above 100 °C suggesting that boiling of vegetables does not destroy vitamin C, but the vitamin becomes dissolved in the boiling water. When juices are preserved and packed much vitamin C is lost. Redox titration was utilized for determination of vitamin C in the different samples. Highest amount of vitamin C content was observed in fresh lemon, whereas fresh apple, orange, pineapple, mango, water melon, melon and tomato showed low levels. The effect of temperature was highest in fresh lemon. In packed juices the same tendency was observed, though the content of vitamin C was found to be less than in fresh juices.






Zinc oxide assisted photocatalytic degradation of d10 metal- picratein aqueous solution using UV-light irradiation 1*

J J Vora, 2 L S Bhutadiya, 2 V R Shukla

1

Department of chemistry, Hemchandracharya North Gujarat University, Patan -384265 (India) 2

Sheth M N Science College, Patan-384265 (India) Email address: [email protected]

Abstract In a laboratory study, the photocatalytic degradation d10 metal picrate in aqueous solution using ZnOphotocatalyst has been carried out. The absorbance of photocatalytic reaction at different time intervals was examined by spectrophotometrically. The effect of various parameters like concentration of substrate, amount of photocatalyst, pH, light intensity and band gap on the efficiency of photocatalytic degradation was studied. Key words:Photocatalysis, metal picrate, ZnO semiconductor.






Catalytic and Biochemical study of novel Complexes of some Lanthanides\ H.D.Chaudhari, Bhumika, Bharat, J. J. Vora* 1

Adarsh Science College, Radhanpur,India

*Department of Chemistry, Hemchandracharya North Gujarat University, Patan, India Email:- [email protected], *[email protected]

Abstract: Lanthanide ions are possessing typical characteristics for example, lanthanide contraction, unique magnetic properties etc. The product of lanthanide ions with 2-(1,3-benzoxazole -2-yl sulfanyl )-N-phenyl acetamide ligand to form coordination compounds is an important area of current research. Less explored ,biologically important, 2-(1,3-benzoxazole -2-yl - sulfanyl )-Nphenyl acetamide (expressed as BSPA) ligand is allowed to react with solution of lanthanide perchlorates and attempt has been made to synthesize solid BSPA complexes. These complexes are subjected to U.V visible spectroscopy, IR spectroscopy, TGA analysis, mass spectroscopy, elemental analysis etc. For structure elucidation and then antimicrobial activity studies by standard methods. Catalytic effects of these complexes are studied for different types of chemical reactions. Attempts have been made to correlate structural characteristics with properties of these complexes. Keywords: lanthanide complexes, catalytic studies, antimicrobial activity.





Green Chemistry Microwave Synthesis Akash D Joshi, Arif A Ghanchi Department of M.N.College,Visnagar(N.G)-384315 E-Mail :- [email protected] Abstract:Microwave radiation, an electromagnetic radiation, is widely use as a source of heating in organic synthesis. The basic mechanism observed in microwave assisted synthesis are dipolar polarization and conduction. Microwave assisted organic synthesis (MAOS) has emerged is a new “lead” in organic synthesis. The technique offers simple, clean, fast, efficient and economic of the synthesis of a large number of organic molecules, have provided the momentum for many chemist to switch from tradition heating method to microwave assisted chemistry. In the recent year microwave assisted organic reaction has emerged as new tool in organic synthesis. In the present article an attempt was made to focus on what is microwave, how is it generated and what important may it have.






Nickel Metal Removal From Bioadsorbent (Castor seed-beancapsules ) Dr.P.S.Patel, Sangita M. Suthar, Kinjal K. Patel Department of Chemistry R.R.Mehta College of Science &C.L.Parikh College of commerce, Palanpur-385001 E-mail: [email protected]

Abstract The removal of toxic heavy metal ion from wastewater is of great importance from an environment viewpoint. Castor seed-bean capsules can be used as a low costbioadsorbent for the removal of metal ion in wastewater. In this study, Nickel ion (Ni +2) in aqueous solution were removed by adsorption process on low cost activated carbon prepared from castor bean–seed capsules. The analyses are performed using 1 gm of absorbent in the solution with five different concentrations of Nickel solution. Metal ion optical density and transmittance were determined by spectrophotometer. Results indicate that castor seed-beam capsules areless expensive adsorbents and their utilization possibilities for theelimination of Nickel metal ions from waste water.

Key Words :adsorption, castor seed-bean capsules, Nickel, wastewater,bioadsorbent.






Cadmium Metal Removal FromCastor seed-bean capsules(Bioadsorbent) Sunita K. Thumbadiya, Komal S. Patel, Bhoomika S. Prajapati [email protected] Department of Chemistry R.R.Mehta College of Science &C.L.Parikh College of commerce, Palanpur-385001

Abstract The removal of toxic heavy metal ion from wastewater is of great importance from an environment viewpoint. Castor seed-bean capsules can be used as a low cost bioadsorbent for the removal of metal ion in wastewater. In this paper, Cadmium ion (Cd +2) in aqueous solution were removed by adsorption process on low cost activated carbon prepared from castor bean– seed capsules. The analyses are performed using the absorbent in the solution with different concentrations of Cadmium solution. Metal ion concentrations were determined by spectrophotometer. Results indicate that castor seed-beam capsules are less expensive adsorbentfor the elimination of Cadmium metal ions from waste water.

Key Words : adsorption, castor seed-bean capsules, Cadmium, wastewater, bioadsorbent .






Optimization tactic of solvent extracts for Argemone Mexicana Linn. G. R. Patel, D. S. Patel and H. A. Trivedi [email protected] Chemistry department, Sheth M.N. Science College, Patan-384265 Abstract

Enhancing the release of secondary metabolites from Argemone Mexicana Linn. using different extraction is reported in this article. Variations in the parameters like type of solvent, time of extraction and number of extraction helps to attain the optimum amount of secondary metabolites. Nature of plant material and physiochemical nature of secondary metabolites are also responsible for the quantity in which they are extracted. Petroleum ether, n-hexane, chloroform, ethyl acetate, ethanol, methanol are used as solvents for extraction by using cold maceration method. Keywords Argemone mexicana Linn., optimization of extraction condition.






Synthesis and Antimicrobial Activities of SalophH2 and its chelates with Inner Transition metal

Akshay Patel*, D.S.Pabreja (*Student of M.Sc. Sem-IV) (Inorganic Chemistry) Smt.S.M.Panchal Science College,Talod

Abstract Schiff base, tetra dentate ligand (SalophH2), is derived by the simple condensation of o/m/pphenylenediamine and salicylaldehyde. It forms stable complexes quantitatively with common inner transition metal ions. In this regard, tetra dentate ligand has been used to synthesize the Sm and Pr chelates. Chelates are different in color and characterized by elemental, IR, Conductivity etc. Antimicrobial Activity of this chelates were also studied. Key Word: Chelates of Schiff base






CORRELATION OF VARIOUS PHYSICO-CHEMICAL PARAMETERS OF SHARMISTHA LAKE, VADNAGAR, GUJARAT, INDIA MITTAL A.CHAUDHARY* AND DR.N.K. PATEL BOTANY DEPARTMENT, SHETH M. N. SCIENCE COLLEGE, PATAN – 384 265, GUJARAT, INDIA. Email: mittalbotany @gmail.com ABSTRACT A systematic study has been carried out to assess the Water Quality Index of Sharmistha Lake, Vadnagar, Gujarat, India. Water samples from ten sampling sites were collected and analysed for physico-chemical parameters (Temperature, pH, Electrical conductivity, TDS (Total dissolved solids), Turbidity, Total Hardness, Calcium, Magnesium, Sodium, Potassium, Alkalinity, Phosphate, Chloride, Free CO2, DO (Dissolved Oxygen) and BOD (Biological oxygen demand). The study area experiences a seasonal climate and broadly divided into three seasons as monsoon (June to September), winter (October to January) and summer (March to May). The samples were collected and analysed for one year from September 2013 to August 2014. Each parameter was compared with the standard desirable limit of that parameter in lake water as prescribed by different agencies. The analytical data of various physico-chemical parameters indicates that some parameters like total dissolved solids, pH, alkalinity, total hardness and calcium was beyond the permissible limit according to WHO and BIS standards for drinking purpose in the year. The WQI value indicates that water samples of summer and monsoon season were unsuitable for drinking.






Mechanism of action, applications and safety concern of Paracetamol Komal k Patel , Akta s Patel, Srushti k Nayak Department of Chemistry, M.N.College, Visnagar Abstract Paracetamol is one of the most popular and most commonly used analgesic and antipyretic drugs around the world,available without a prescription both in mono and multicomponent preparations. It is the drug of choice in patients that can not be treated with nonsteroidal anti inflammatory drugs (NSAID), such as people with bronchial asthma peptic ulcer disease, hemophilia, salicylate sensitized people, children under 12 years of age, pregnant or breastfeeding women. Paracetamol is well tolerated drug and produces few side effects from the gastrointestinal tract, however, despite that,every year.,has been a steadily increasing number of registered case of paracetamol induces liver intoxication all over the world.






Microwave-Assisted Synthesis of Heterocylic Polyethers Upendra R. Patel1*, Pradhuman A. Parmar1, Pravin S. Patel1 1

Department of chemistry, M.N.College, Visnagar (N.G) – 384315 Corresponding address: [email protected]

ABSTRACT: A rapid polycondensation reaction of aromatic diols with 4,7- dichloro 6-nitroquinazoline was preformed with a domestic microwave oven by using Tetrabutyl ammonium bromide as phase transpher catalyst. The polymerization reactions, in comparison with conventional heating polycondensation, proceeded rapidly. The polymerizations gave the corresponding polyethers with inherent viscosities of 0.58– 0.78 dL/g. Prepared polyethers also characterized by Thermogravimetric analysis, GPC, FT-IR. Microbial activity of resulting polyethers are also good.






Synthesis and studies on antimicrobial evaluation of new Formazans containing 2-Amino Thiazole moiety Suresh B. Ahir, Parashar H. Modh Chemistry Department, Shri C. N. P. F. Arts & D. N. Science College, Dabhoi Email ID: [email protected]

Abstract Compounds bearing Formazans are endowed with a variety of biological activities like, bactericidal, antiviral, antifungal etc. Again the 2-amino Thiazole moiety also exhibit a wide range of biological activities. Looking over to these properties it was decided to prepare some new Formazans having Thiazole moiety, which may enhance the biological activity. The structure of the compounds have been confirmed by elemental analysis and spectral data. Novel formazan compounds were tested for their anti bacterial activity.

Keywords: Thiazole Schiff base, Formazans, antimicrobial activity






Synthesis Characterization and Microbial Screeningof S-triazine derivatives

H.D. Chaudhry, A.H. Prajapati and J.J. Vora* Department of Chemistry Hemchandracharya North Gujarat University, Patan [email protected] Abstract: A new series of 2-(4-Chlorophenyl-1,3,4-Oxadiazolyl)-5-thio-4-(Cyclohexylamino)-6(arylamino)-S-triazine have been synthesized. The novelcompounds structure has established based on their substituted aryl amine derivatives.All the compounds were characterized by FTIR, and 1H-NMR spectroscopy as wellas elemental analysis. These new compounds were evaluated for their in vitroantibacterial activity. Key words: s-triazine, Spectral data, Elemental analysis and bacterial activity.





Formation and characterization of 1H-Pyrrole-3-Carboxylic acid derivatives and its biological screening Sejal A. Joshi, Kalpeshgiri V. Goswami2 and Kokila A. Parmar M N Science, Visnagar 2

HNSB Ltd. Science College, Himatnagar

Hemchandracharya North Gujarat University, Patan Gujarat, INDIA [email protected], [email protected] Abstract: The present study deals with the heterocyclization of Schiff bases of 4-(benzylideneamino)N-(4-(2,4-dichlorophenyl)-6-(6-methylnaphthalen-2-yl)pyrimidin-2-yl)benzenesulfonamide] into (2H)-Pyrrole-2-ones derivatives. Synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, MASS spectral and elemental analysis. The reaction was performed by using ordinary condensation type, which enabled to easy work-up and good yield. All the newly synthesized compounds were evaluated for their antibacterial activities.





High-efficiency solution processable polymer photovoltaic cells by selforganization of polymer blends...... Chaudhary Brijesh A., Nadoda Bhavesh D., Raval Nirav P. *Department of chemistry M.N College, Visnagar(Mahesana) 384315, Gujarat. E- mail id : [email protected]

Abstract:Converting solar energy into electricity provides a much needed solution to the energy crisis the world is facing today. Polymer solar cells have shown potential to harness solar energy in a cost -effective way. Significants efforts are underway to improve their efficiency to the level of practical applications. Here, we report highly efficient polymer solar cells based on a bulk heterojunction of polymer poly( 3-hexylthiophene) and methanofullerence. Controlling the active layer growth rate results in an increased hole mobility and balanced charge transport. Together with increased absorption in the active layer, this results in much-improved device performance, particulary in external quantum efficienc. The power-conversion effiviency of 4.4% achieved here is the highest published so far for polymer-based solar cells. The solution process involved ensures that the fabrication cost remains low and the processing is simple. The high efficiency achieved in this work brings these devices one step closer to commercialization.






1,3,4-oxadizoles : A potential bio-active skeleton in medicinal chemistry Kalpesh Parikh1, Piyush Vyas2, Vipul Prajapati3 & Deepkumar Joshi*4 Chemistry Research Laboratory, Chemistry Department, Sheth M. N. Science College, Patan-384265 (INDIA) *

e-mail: [email protected]

Abstract The widespread diseases prevailing in the society and the high resistivity of the microbes against the drugs available in the market demonstrates a challenge for the scientific persons working in the field of medicinal chemistry to design and develop novel and effective bioactive molecules. In context to the above issue, the author(s) in the current chapter delivers various methods of synthesis for 1,3,4-oxadizole ring bearing molecules demonstrating extensive biological properties along with an extensive review on current dugs available with the same oxadiazole skeleton and its mode of action. The reason behind selecting 1,3,4-oxadiazole derivatives, is its high versatility in exhibiting excellent potency against several infective strains as reported by many researchers. This chapter deals in detail with the review encompassing several illustrations promoting the synthesis of derivatives bearing 1,3,4-oxadiazoles as well as the extent of its various biological properties. Second important factor covered in this chapter is the details of the drugs bearing 1,3,4-oxadiazole nuclei and its medicinal efficacy. A detailed reviews and results on the computational studies including QSAR and docking studies results have been displayed in the chapter. Overall the details provided in the chapter will help the readers to deal with the basic feature of 1,3,4-oxadiazole as well as its chemical reactivity and biological activity.






SYNTHESIS AND BIOLOGICAL STUDY OF SOME NEW THIAZOLIDINONE DERIVATIVES VANDANA B. PATEL , M.K. THAKOR MUNICIPAL ARTS AND URBAN SCIENCE COLLEGE,MEHASANA E-mail: [email protected]

ABSTRACT

Fused heterocyclic compounds (3a-h) namely N-(3,5diphenyl-3,3a-dihydrothiazolo[4,5c]isoxazol-6(5H)-yl-2-(5-2-hydroxyphenyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl propanamide were prepared and characterized. 2-(5-(2hydroxyphenyl)-2-thioxo-1,3,4 oxadiazol-3(2H)-yl)N(4-oxo-2-phenylthiazolidin-3-yl)spropanamide (1a-h) on condensation with benzaldehyde give the arylidine derivatives (2a-h). Such compounds 2a-h on reaction with hydroxyl amine give the title compounds i.e. 3a-h. All the compounds were screened for their antimicrobial activity.






NOVEL 4-THIAZOLIDINONE DERIVATIVES AS ANTI-MICROBIAL AND ANTIFUNGAL ACTIVITY SANSKRUTI V. MAHESHWARI , M.K. THAKOR MUNICIPAL ARTS AND URBAN SCIENCE COLLEGE, MEHSANA E-mail: [email protected] ABSTRACT Fused heterocyclic compounds (3a-h) namely N-(3,5diphenyl-3,3adihydrothiazolo[4,5-c]isoxazol-6(5H)-yl-2-(5-phenyl-2-thioxo-1,3,4-oxadiazol-3(2H)-yl propanamide were prepared and characterized. N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(5-phenyl2-thioxo-1,3,4-oxadiazol-3(2H)-yl)propanamide (1a-h) on condensation with benzaldehyde give the arylidine derivatives (2a-h). Such compounds 2a-h on reaction with hydroxyl amine give the title compounds i.e. 3a-h. All the compounds were screened for their antimicrobial activity.






Virtual screening for tyrosine kinase based anticancer activity Bhrugesh Patel ¹, Bina Patel ¹, Jignesh Pandya ², Himani Gandhi ² Department of Life sciences, Hemchandracharya north Gujarat University, Patan Adarsh Science College, Patan Corresponding Author: [email protected]

ABSTRACT A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase. The phosphate group is attached to the amino acid tyrosine on the protein. Protein kinases can become mutated, stuck in the "on" position, and cause unregulated growth of the cell, which is a necessary step for the development of cancer. In present work virtual screening using ligand library of 60 novel heterocyclic compounds was carried out against the Protein tyrosine kinase ( PDB Id : 5J7S). The protein is belonging to TAK1 (transforming growth factor-β-activated kinase 1) group which is an essential intracellular mediator of cytokine and growth factor signaling and a potential therapeutic target for the treatment of immune diseases and cancer. Crizotinib is commercially available drug for cancer treatments. The docking was carried out with iGemdock software in linux environment and result indicated the Ligand 53, 20, 23, 33 and 38 among the top scoring ligand. The comparative protein ligand interaction indicate the possibility of positive binding pattern and need of further in vitro and in vivo study.





Molecular docking of novel heterocyclic compound against Aromatase for anticancer activity Ashish Asari¹, Priyanka Patel¹, Sejal Jadav¹, Dr. Vishal Mevada ² 1

Department of Life sciences, Hemchandracharya north Gujarat University, Patan 2

Shri Sarvjanik Science College, Mehsana E-mail: [email protected]

Abstract The aromatase is member of the cytochrome P450 superfamily represents both an enormous opportunity and a unique challenge for drug discovery. Aromatase play a central role in extragondal estrogen synthesis. It is well known that large number of cancer involves aberrant Aromatase activity it represents a major class of drug targets for the pharmaceutical industry and the identification of aromatase inhibitors with novel and diverse chemotypes is therefore high priority. We have conducted a virtual screening using a 60 novel hetero cyclic compound along with the commercial drug Anstrazole. The docking was performed with iGemdock software in linux environment against the Human cytochrome P450 aromatase (PDB ID : 3S7S). Top five scoring ligand were 18, 45, 26 55 and 34. The fitness a score of binding similarity is nearby to commercially utilized drug

Anstrazole. Thus present result indicated the possibility anti

aromatase activity by ligands.





P-glycoprotein molecular docking study for anticancer activity Kavita Vihol ¹, Priyank Rathod ¹, Ripal Fadiya ¹, Dr. Vishal Mevada ² 1

Department of Life sciences, Hemchandracharya north Gujarat University, Patan 2

Shri Sarvjanik Science College, Mehasana E-mail : [email protected]

Abstract P-glycoprotein (P-gp) detoxifies cells by exporting hundreds of chemically unrelated toxins but has been implicated in multidrug resistance (MDR) in the treatment of cancers. Substrate promiscuity is a hallmark of P-gp activity, thus a structural description of poly-specific drugbinding is important for the rational design of anticancer drugs and MDR inhibitors.Some common pharmacological inhibitors of P-glycoprotein includes amiodarone , clarithromycin , ciclosporin , colchicine , diltiazem,erythromycin , felodipine , lansoprazole , omeprazole and other proton pump inhibitors, nifedipine , paroxetine , sertraline, quinidine, tamoxifen and verapamil. We have conducted a virtual screening using a ligand library of novel 60 heterocyclic compound. Molecualr Docking studies were carried out against P-glycoprotein ( PDB Id : 3G60) with iGemdocking in linux environment. The top scoring ligand molecules were 8, 11, 37, 54 and 50. The ligand * had the fitness score more than the commercially used drug Elacridar.






QSAR study of novel heterocyclic ligand for drug likeness, carcinogenicity and mutagenicity Chetan Mehta ¹, Ankita Murnal ¹, Ravina Parmar ¹, Falguni Thakkar ² Department of Life sciences, Hemchandracharya north Gujarat University, Patan

Adarsh Science College, Patan Corresponding Author: [email protected] Abstract Quantitative structure–activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering. Like other regression models, QSAR regression models relate a set of "predictor" variables (X) to the potency of the response variable (Y), while classification QSAR models relate the predictor variables to a categorical value of the response variable. In in silico drug discovery QSAR is mainly used for for prediction of Lipinski's rule of five, mutagenicity and Carcinogenicity. Lipinski's rule of five also known as the Pfizer's rule of five or simply the Rule of five (RO5) is a rule of thumb to evaluate drug likeness or determine if a chemical compound with a certain pharmacological or biological activity has properties that would make it a likely orally active drug in humans. The rule was formulated by Christopher A. Lipinski in 1997, based on the observation that most orally administered drugs are relatively small and moderately lipophilic molecules. In present work in silico screening of 60 novel heterocyclic compounds was carried out using VEGA and ToxRead for drug likeness, carcinogenicity, mutagenicity






In silco prediction of biological activity of novel heterocyclic compound Hadmat Gadhavi ¹, Apoorva Maheta ¹, Kiran Chaudhary ¹, Jignesh Pandya ² Department of Life sciences, Hemchandracharya north Gujarat University, Patan Adarsh Science College, Patan E-mail: [email protected] Abstract PASS software predicts over 4000 kinds of biological activity, including pharmacological effects, mechanisms of action, toxic and adverse effects, interaction with metabolic enzymes and transporters, influence on gene expression, etc. PASS predicts simultaneously 3678 kinds of activity with mean accuracy of prediction about 95% (leave-one-out cross validation) on the basis of the compound's structural formula. So that we can use PASS for the prediction of the biological activity spectrum for existing compounds and compounds, which are only planned to synthesize. In present work PAAS based prediction of various biological activities was carried out for the novel heterocyclic compound.





Significance of ascorbic acid(Vitamin-C) in Human Health Patel Chrami V., Rana Pooja J., Berva Priya S. *Department of Chemistry, M.N.College,Visnagar-384315 . Abstract:-

The recognisation of vitamin C is associated with history of an unrelenting search for the cause of the ancient hemorrhagic disease scurvy. Isolated in 1982, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in a number of metabolic functions including the activation of the b vitamin, Folic acid, The converstion of cholesterol to bile acids and the converstion of the amino acid, tryptophan, to the neurotransmitter Serotonin. It is an antioxidant that protects body from free radicals damages. It is used as therapeutic agent in many disease and disorders. Vitamin C protects the immune system reduce the Severity of allergic reaction and helps fight of infections.






Green Chemistry as a prevent pollution Swanti A. Jain [email protected] Chemistry department, Shree M.P.Pandya Science college lunawada Abstract:

Green chemistry is how and rapid branch of chemistry. The beginning of green chemistry considered as a response to the need to reduce the damage of the environment by human made materials and the process use to produce them, which are useful to get the information about green chemistry article present the importance of catalyst in green chemistry. There are 12 major principle of green chemistry which chemistry addresses the environmental impact of both chemical product and the processes by which they are produced. Key words: GREEN CHEMISTRY

