nZ,(n+4)Z-Dienoic Fatty Acids: A New Method for the Synthesis and. Inhibitory Action on Topoisomerase I and. Inhibitory Action on Topoisomerase I and Iiα.
Institute of Petrochemistry and Catalysis,Russian Academy of Sciences
nZ,(n+4)Z nZ ,(n+4)Z--Dienoic Fatty Acids: A New Method for the Synthesis and Inhibitory Action on Topoisomerase I and Iiα V.A. D’yakonov, D’yakonov, L.U. Dzhemileva Dzhemileva,, A.A. Makarov Makarov,, A.R. Mulyukova Mulyukova,, D.S. Baev Baev,, E.K. Khusnutdinova Khusnutdinova,, T.G. Tolstikova Tolstikova,, U.M. Dzhemilev
1) New effective methods for the synthesis of higher dienoic acids with different positions of the 1Z,5Z-diene group has been developed; 2) For the first time the relationship between the acid structure and activity in the topoisomerase I and IIα inhibition was investigated.
