CONTROL ID: 2919264 CURRENT CATEGORY: Obesity, Metabolism & Nutrition CURRENT SUBCATEGORY/DESCRIPTORS: Microbial Regulation of Host Metabolic and Energy Homeostasis PRESENTATION TYPE: AGA Institute Oral or Poster PRESENTER: Walter Morales PRESENTER (EMAIL ONLY):
[email protected] Abstract TITLE: THE NON-ABSORBABLE ANTIBIOTIC RIFAXIMIN EXHIBITS WEIGHT NEUTRALITY IN THE HOST 1 1 1 1 AUTHORS (LAST NAME, FIRST NAME): Morales, Walter ; Leite, Gabriela ; Weitsman, Stacy ; Celly, Shreya ; 4 4 1 1 1 1, 3 Schultz, Hailey ; Do, Huongly ; Parodi, Gonzalo ; Singer-Englar, Tahli ; Barlow, Gillian ; Pimentel, Mark ; 1, 2 Mathur, Ruchi INSTITUTIONS (ALL): 1. Medically Associated Science and Technology (MAST) Program, Cedars-Sinai Medical Center, Los Angeles, CA, United States. 2. Division of Endocrine, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States. 3. Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States. 4. Cedars-Sinai Medical Center, Los Angeles, CA, United States. ABSTRACT BODY: Abstract Body: Antibiotic use has been associated with increased risks for weight gain, both in animal models and in human subjects. Sub-therapeutic antibiotic treatment (STAT) has been widely used in agriculture to promote weight gain in young animals across a variety of species, and several major studies have demonstrated an association between antibiotic exposure and obesity in humans, particularly during infancy and early childhood. This association strengthens with the number of antibiotic exposures. The broad-spectrum antibiotic rifaximin is poorly absorbed from the gut and has a bioavailability of
