Oct-Dec2015 Issue FINAL

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Jun 23, 2016 - Sarita Devi1 , Tinku Thomas2 , Pratibha Dwarkanath1 , Annamma Thomas3 ,. Sheela, C.N., 3. Arpita Mukhopadhyay1 and Anura V. Kurpad1.
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Effect of Increased Dietary Protein on the Plasma Methyl-cycle Amino Acid Profile and Kinetics during Pregnancy S arit a De v i 1 , Tin k u Th o m as 2 , Prat ibh a Dwark an at h 1 , An n am m a Th o m as 3 , S h e e la, C.N., 3 Arpit a Mu k h o padh y ay 1 an d An u ra V. Ku rpad 1 (1 . Divis ion of Nu trition , 2 . Divis ion of Epid em iology a n d B ios ta tis tics Un it, 3 . Depa rtm en t of Obs tetrics a n d Gy n a ecology , S t. J oh n ’s Med ica l College, S t. J oh n ’s Na tion a l Aca d em y of Hea lth S cien ces , Ba n ga lore-5 6 0 0 3 4 , In d ia ) e-m ail: arpitam @s jri.res .in (Received 2 3 rd J u n e, 2 0 1 6 )

Abstract Low intakes of quality dietary protein could affect the methionine cycle during pregnancy, which is important for fetal growth and epigenetic regulations. Since low quality protein intake is prevalent in India, it is important to define biomarkers of the low protein intake, specifically of methyl cycle homeostasis. A secondary analysis of data was performed, from a randomized intervention trial with 500 ml milk/d on south Indian pregnant women, to examine the association of dietary protein intake with concentrations of specific amino acids (methionine, glycine and serine). The subjects also underwent isotopic infusions (n = 52) for the measurement of amino acid kinetics. Dietary intakes were measured each week by multiple 24 h recall until delivery. The plasma concentrations of amino acids (methionine, serine and glycine) were compared with kinetics of methionine i.e. transmethylation, remethylation and transulfuration (TM, RM, TS) and serine to glycine conversion rate, as measured by stable isotope labeled amino acid infusion. Dietary protein intake in the 3rd trimester correlated positively with intakes of milk and milk based food products (ρ=0.52, p