Age and Ageing 2017; 46: iii13–iii59 doi: 10.1093/ageing/afx144.171
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Poster presentations 165
ASSOCIATION OF DRUG BURDEN INDEX WITH PHYSICAL FUNCTION IN IRISH OLDER ADULTS WITH INTELLECTUAL DISABILITY
Juliette O’Connell1,2, Máire O’Dwyer1, Eilish Burke2, Martin Henman1, Clare Donegan1,2, Mary McCarron3, Philip McCallion4, Niamh Mulryan2 1 School of Pharmacy & Pharmaceutical Sciences, Trinity College, Dublin, Ireland 2 Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing, School of Nursing & Midwifery, Trinity College, Dublin, Ireland 3 Dean of Health Sciences, Trinity College, Dublin, Ireland 4 Centre for Aging & Excellence in Community Wellness, University at Albany, New York, USA Background: The Drug Burden Index (DBI) is a tool which quantitatively evaluates the burden from anticholinergic and sedative medications [1]. DBI scores have been associated with poorer physical performance in older adults without intellectual disability (ID). This study aims to evaluate the association between DBI scores and two physical function measures - Barthel Index (BI) activities of daily living (lower scores indicate greater dependence) and Functional Comorbidity Index (FCI) in older adults with ID.
Methods: Data from Wave 2 of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA) were analysed. Analysis of Covariance (ANCOVA) was used to compare adjusted means of two physical function measures – BI and FCI. Means were adjusted for gender, age, level of ID, and history of falls. Means for BI were also adjusted for comorbidities. Results: Of the 677 with medication data, 24.4% (n = 165) had a DBI score 0–1, 54.2% (n = 367) had a DBI score of 1+. After adjusting for confounders, DBI 1+ was associated with higher dependence in BI activities of daily living (p = 0.002). Both DBI 0–1 and DBI 1+ were associated with higher FCI scores (p = 0.018 and p < 0.001, respectively). Conclusions: Higher Drug Burden Index was significantly associated with poorer physical function and less independence in older adults with ID. This tool could be useful to trigger medication review and optimising use of anticholinergic and sedative medications in older adults with ID, potentially improving quality of life. Reference 1. Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, Harris TB, Hanlon JT, Rubin SM, Shorr RI, Bauer DC. A drug burden index to define the functional burden of medications in older people. Archives of Internal Medicine 2007 Apr 23; 167(8):781–7.
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