Oxidative Phosphorylation Fatty Acid TCA Cycle ...

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HADHA. PECR. TER. PECR. TER. PECR. TER. E1.3.3.6. fabG. HSD17B12. PHS1. PHS1. HSD17B12. fabG. 1.1.1.37. (S)-Malate. 4.2.1.2. Fumarate. Succinate.
T4

Fatty Acid

Glycolysis

E1.3.3.6

HADHA

α-D-Glucose

PHS1

PECR fabG

TER HSD17B12 fabG

TER Docosanoyl-CoA PHS1

PECR TER

fabG

HSD17B12

ß-D-Fructose-1,6P2

D-Erythrose -4P

4.1.2.13

ß-D-Fructose-1,6P2

4.1.2.13

D-Glyceraldehyde-3P

SCD

1.2.4.1

HSD17 Hexade- ACSL B12 canoyl-[a AA cp] PHS1

Glycerate-2P Palmitoylcamitine

fabG

TER

fabF

2.3.3.1 Oxaloacetate

Tetradecanoyl-[acp]

TER HSD17B12

fabG

S-Acetyldihydro-lipoamide-E

6.4.1.1

1.8.1.4

1.2.4.1 fabG

FASN

Fumarate

Butanoyl-CoA

Dodecanoyl-CoA

Lipoamide-E 2-Hydroxyethyl-ThPP

Decanoyl-[acp]

TER

1.3.5.1

FADS2 fabF E1.3.3.6

fabG

fabF

FASN

Octanoyl-CoA

Hexanoyl-[acp]

fabG

Complex I

FASN

Butanoyl-[acp]

ND1

fabG

fabF FASN

1.1.1.42

ND2

ND4

ND4L

ND5

Ndufs1

Ndufs2

Complex III

ISP

Cytb

Cyt1

QCR2

2-Oxo-glutarate 1.2.4.2

1.2.4.2

2.3.1.61

Dihydrolipoamide-E Complex II

Ndufs3 Ndufs4

Ndufs6 Ndufs7 Ndufs8

Ndufv1 Ndufv2

FASN

1.8.1.4

3-Carboxy-1-hydropropyl.ThPP Lipoamide-E

Complex IV

COX10 COX3

Complex V

COX1

alpha

beta

COX4 COX5A

delta

OSCP

gamma

FASN fabF

Acetyl[acp] (AcACP)

COX2

a

SDHD Ndufa2

ACP

1.1.1.41

SDHC

FASN

FASN

1.2.4.1

S-Succinyl-dihydrolipoamide-E

6.2.1.5 6.2.1.4 Succinyl-CoA

Oxidative Phosphorylation fabF

Oxalosuccinate

TCA Cycle

Succinate

Hexanoyl-CoA

Decanoyl-CoA

fabG

1.1.1.42

Pyruvate

FASN

Octanoyl-[acp]

HADHA

Malonyl-CoA (MalCoA)

Isocitrate

4.2.1.2

fabF

fabD

4.2.1.3

Dihydrolipoamide-E

2.3.1.12

FASN

Dodecanoyl-[acp]

Malonyl-[acp] (MalACP)

4.2.1.3 cis-Aconitate

1.1.1.37 (S)-Malate

Tetradecanoyl-CoA

PHS1

PECR

Citrate

2.3.3.8

Acetyl-CoA

PHS1

fabG

Acetate 1.2.1.3

Acetyl-CoA

fabF

6.2.1.1

Dihydrolipoamide-E Acetaldehyde

1.1.1.1

Hexadecanoyl-CoA

Acetyl -CoA 2.3.1.12

1.8.1.4

Ethanol

Phosphoenolpyruvate

FASN

HSD17B12

PECR

2-Hydroxy-ethylThPP

D-ribose-1P

2-Deoxy-D-ribose-1P

Lipoamide-E

2.7.1.40 4.1.1.32

4.2.1.11

CPT1A CPT2

Palmitic FASN acid PPT

PECR

fabG

5.4.2.11

3.1.3.80

PRPP

S-Acetyl-dihydrolipoamide-E

1.2.4.1

5.4.2.2

2.7.6.1

2-DeoxyD-ribose

Glycerate-3P

Glycerate-2,3P2

FADS2 Hexadecanoyl-CoA (Palmitoyl-CoA)

2.2.1.2

2-Deoxy-D-ri- 5.4.2.7 bose-5P

4.1.2.4

TER Stearoyl-CoA/ACP

Pyruvate

fabG

5.4.2.7

2.7.1.15

2.7.2.3 fabG

D-ribose

D-Ribose-5P

D-Sedoheptulose -7P

1.2.1.12 Glycerate-1,3P2

-8

2.7.1.15

2.2.1.1

2.7.1.11

Glyceraldehyde-3P

FADS2

D-Ribulose-5P

2.2.1.1 ß-D-Fruc- 5.3.1.6 tose-6P

3.1.3.11

2.7.1.1 2.7.1.147

TER

FAD8

5.3.1.9

2.7.1.11

TER Icosanoyl-CoA PHS1

PECR

5.3.1.9

S+B

D-gluconate-6P 1.1.1.44

D-Glucono -1,5lactone-6P 3.1.1.31 1.1.1.343 D-Xylulose-5P α-D-Glucose -6P 5.1.3.1

ß-D-Fructose-6P

5.3.1.1 fabG

S+M

1.1.1.49

ß-D-Glucose-6P

5.3.1.9

Glycerone-P

PECR

PECR

5.3.1.9

3.1.3.11

PHS1

PHS1

5.4.2.2

ß-D-Glucose ß-D-Glucose-6P

S

2.7.1.12

D-Gluconate H6PD

α-D-Glucose-6P

PECR PHS1

3.1.1.17

3.1.3.9

5.1.3.3 5.1.3.15

HSD17B12 FADS2 Tertracosanoyl-CoA

fabG

Pentose Phosphate D-Glucono-1,5-lactone

α-D-Glucose-1P

E. timida E. cornigera T7 T30 T4 T7

Ndufa4 Ndufa5

Ndufa6

b

COX5B COX6A COX6B

Ndufa7 Ndufa8 Ndufa9 QCR6

Ndufa10 Ndufab1 Ndufa12 Ndufa13 Ndufb2 Ndufb3

Ndufb4

SDHA

c

COX6C COX7C COX11

SDHB

d

FASN ACACA Acetyl-CoA

Ndufb5

Ndufb6

Ndufb7

Ndufb8 Ndufb9 Ndufb10 Ndufb11

QCR7

QCR8

COX15 COX17

f

g

f6/h

0

12