Peripheral Sensory Neuropathy in Type 2 Diabetes

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Jun 25, 2016 - case control study in Accra, Ghana., Journal of Clinical & Translational ... This is a PDF file of an unedited manuscript that has been accepted for publication. .... From our own literature search, we found few current studies that.
Accepted Manuscript Title: Peripheral Sensory Neuropathy in Type 2 Diabetes Patients: A case control study in Accra, Ghana. Author: Kwame Yeboah, Peter Puplampu, Vincent Boima, Daniel A. Antwi, Ben Gyan, Albert G.B. Amoah PII: DOI: Reference:

S2214-6237(16)30018-7 http://dx.doi.org/doi: 10.1016/j.jcte.2016.07.001 JCTE 88

To appear in:

Journal of Clinical & Translational Endocrinology

Received date: Revised date: Accepted date:

17-5-2016 25-6-2016 18-7-2016

Please cite this article as: Kwame Yeboah, Peter Puplampu, Vincent Boima, Daniel A. Antwi, Ben Gyan, Albert G.B. Amoah, Peripheral Sensory Neuropathy in Type 2 Diabetes Patients: A case control study in Accra, Ghana., Journal of Clinical & Translational Endocrinology (2016), http://dx.doi.org/doi: 10.1016/j.jcte.2016.07.001. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Peripheral Sensory Neuropathy in Type 2 Diabetes Patients: A case control study in Accra, Ghana. Kwame Yeboah,1 Peter Puplampu,2 Vincent Boima,2 Daniel A. Antwi,1 Ben Gyan,3 Albert G.B. Amoah2,4. 1

Department of Physiology, School of Biomedical & Allied Health Sciences, University of Ghana. 2

Department of Medicine & Therapeutics, School of Medicine & Dentistry, University of Ghana. 3

Department of Immunology, Noguchi Memorial Institute of Medical Research, University of Ghana. 4

National Diabetes Management & Research Centre, Korle-Bu Teaching Hospital, Accra, Ghana Abstract

Running title: Peripheral sensory neuropathy in Ghanaian T2DM patients

Corresponding author: Kwame Yeboah, Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, P. O. Box KB 143, Accra, Ghana. E-mail: [email protected]

Key words Diabetes, peripheral sensory neuropathy, vibration perception threshold, Ghana

Abbreviations DM, diabetes mellitus; PSN, peripheral sensory neuropathy; VPT, vibration perception threshold; MNSI, Michigan neuropathy screening instrument.

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Highlights  PNS was assessed by symptoms, examination and quantitative assessment.  High burden of PSN in diabetes patients in Ghana.  The major determinants of PSN by different assessment methods reported. Abstract Objective: Peripheral sensory neuropathy (PSN) is a common cause of ulceration and amputation in diabetes (DM) patients. The prevalence of PSN in DM patients is largely undetermined in sub-Saharan African population. We studied the burden of PSN in DM patients using a validated questionnaire and quantitative sensory test. Methods: In a case-control design, PSN was measured 491 DM patients and 330 non-DM controls using Michigan Neuropathy Screening Instrument (MNSI) and vibration perception threshold (VPT). PSN was defined as MNSI symptom score ≥7, MNSI examination score ≥2 or VPT ≥25V. Results: The prevalence of PSN in DM patients by MNSI symptom score, MNSI examination score and VPT were 7.1%, 51.5% and 24.5%; and 1.5%, 24.5% and 8.5% in non-DM participants respectively. The major determinants of PSN by MNSI examination score were diabetes status [OR (95% CI): 4.31 (2.94 – 6.31), p