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Apr 21, 2017 - Satoshi Ito, Tomohisa Nagoshi*, Kosuke Minai, Yusuke Kashiwagi, Hiroshi Sekiyama, ... Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura.

RESEARCH ARTICLE

Possible increase in insulin resistance and concealed glucose-coupled potassiumlowering mechanisms during acute coronary syndrome documented by covariance structure analysis a1111111111 a1111111111 a1111111111 a1111111111 a1111111111

Satoshi Ito, Tomohisa Nagoshi*, Kosuke Minai, Yusuke Kashiwagi, Hiroshi Sekiyama, Akira Yoshii, Haruka Kimura, Yasunori Inoue, Kazuo Ogawa, Toshikazu D. Tanaka, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JAPAN * [email protected]

Abstract OPEN ACCESS Citation: Ito S, Nagoshi T, Minai K, Kashiwagi Y, Sekiyama H, Yoshii A, et al. (2017) Possible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis. PLoS ONE 12(4): e0176435. https://doi.org/10.1371/journal. pone.0176435 Editor: Junichi Sadoshima, Rutgers New Jersey Medical School, UNITED STATES

Objective Although glucose-insulin-potassium (GIK) therapy ought to be beneficial for ischemic heart disease in general, variable outcomes in many clinical trials of GIK in acute coronary syndrome (ACS) had a controversial impact. This study was designed to examine whether “insulin resistance” is involved in ACS and to clarify other potential intrinsic compensatory mechanisms for GIK tolerance through highly statistical procedure.

Received: December 13, 2016 Accepted: April 10, 2017

Methods and results

Published: April 21, 2017

We compared the degree of insulin resistance during ACS attack and remission phase after treatment in individual patients (n = 104). During ACS, homeostasis model assessment of insulin resistance (HOMA-IR) values were significantly increased (P

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