MacMicking, J., Xie, Q.-W., Nathan, C. (1997) Nitric oxide and macro- phage function. .... Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton,.
Potentiation of interferon-␥-stimulated nitric oxide production by retinoic acid in RAW 264.7 cells Liv M. I. Austenaa*,† and A. Catharine Ross* *Department of Nutrition, The Pennsylvania State University, University Park, Pennsylvania, and †Institute for Nutrition Research, University of Oslo, 0316 Oslo, Norway
Abstract: Nitric oxide (NO) production is essential for normal immunity. We have examined the capacity of retinoic acid (RA), a pleiotropic hormone necessary for normal immunity, to modulate NO production in RAW 264.7 cells. NO production induced by suboptimal concentrations of interferon-␥ (IFN-␥) was significantly greater in cells cultured in low-retinoid medium and treated with all-trans-RA (10ⴚ10– 10ⴚ6 M, P
