Preparation of Manuscripts

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Journal Scope | Types of Manuscripts | Review Process | Submission of Manuscripts – ..... In addition, the ACS website has links to nomenclature .... The best images for these uses are simple, relatively free of text and technical characters, and ...
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Information for Authors (Revised May 2015)

Contents (click on the topic) Journal Scope | Types of Manuscripts | Review Process | Submission of Manuscripts – Journal Publishing Agreement – Reprint Permissions – Correspondence – ORCID | Preparation of Manuscripts – Currently Acceptable Word-Processing Packages – Titles, Authors, and Abstracts – Table of Contents Graphic – Contents of Manuscripts – Nomenclature – Abbreviations – Experimental Section – Characterization – References and Footnotes Guidelines for Illustrations in ACS Journals – Quality – Layout – Color – Chemical Structures – Tables – Figures and Figure Captions – Schemes and Scheme Titles – Spectra – Acknowledgment and Funding Sources | Supporting Information | Just Accepted Manuscripts | Proofs | ASAP Publication | ACS Policies for E-prints and Reprints | ACS AuthorChoice Open Access | Additions and Corrections | Retractions | Conflict of Interest | Professional Ethics | Author List | Assistance with English Language Editing

Journal Scope The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign, and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, it encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development, and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools or flowchemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to this journal. However, studies on new developments from either industry, research institutes, or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up, also serve the mission of OPR&D as a communication tool between the different contributors to the field. The Journal aims to cover R&D from and for the fine organic chemicals and specialty chemicals industries, including pharmaceuticals, agrochemicals, electronic chemicals, flavors and fragrances, intermediates, food additives, and specialty polymers, with work from commodity chemicals, petrochemicals, and polymers being appropriate as well. In summary, Organic Process Research & Development serves the community interested in the practical application of organic chemistry, both in industry and academia, by publishing original scientific work, reviews on relevant topics, as well as opinion articles.

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Types of Manuscripts Several types of manuscripts are admissible: Full Papers describe original work that has not been previously published and that is not for consideration for publication elsewhere. The experimental of a full paper describing the work performed on a preparative scale is a valuable asset of the journal. Requirements for the Experimental part are described below. A Communication focuses on a specific topic of high relevance, e.g., by presenting a new reaction and its development to a preparative usefulness. Again, the experimental description of this reaction is required. Both Full Papers and Communications have the requirement to cover new science. Consequently, any content that has been made publicly available; either in print or electronic format and that contains a significant amount of the information presented in the manuscript, jeopardizes the originality of the work and may thus preclude publication. The novelty requirement for the submitted manuscript is an absolute requirement. Manuscript topics for which an industrial patent application has been published by the authors are an exception to this rule, as it is understood that relevant industrial research is usually patented. The journal also welcomes Reviews that cover a topic of general importance for the field of process research. These may be limited to the work of the author, or be more comprehensive of the field or provide the scientific framework for developments in the industries covered by the journal. Brief reviews of publications and patents (“Highlights”) are an essential part of mission of the journal. Given the industrial relevance, topics dealing with the legal environment of the industry, such as regulatory requirements and environmental regulations, are especially suitable. Editorials provide a discussion forum for topics of interest to the industrial readership.

Review Process Once submitted, the manuscript is checked for suitability for the Journal (content, manner of presentation, linguistic quality) by the Editor. If deemed acceptable, several reviewers are chosen by the Editor to comment on the scientific content of the submitted manuscript. In line with the rules of the ACS, the reviewers are anonymous and are known to the Editor and the Journal staff only. While the ultimate decision for a manuscript is solely at the discretion of the Editor, the input from well thought-through reviews is a very strong determinant in the decision process. Authors are required to submit the names of four scientists with names and e-mail contacts and affiliation that would be suitable to review the contents of the submitted manuscript and are asked to exercise good judgment in making their suggestions.

Submission of Manuscripts Manuscripts must be submitted via the Web, using the ACS Paragon Plus Environment (http://paragonplus.acs.org/login). Complete instructions and an overview of the electronic online (Web) submission process are available through the secure ACS Paragon Plus Web site. Authors must also submit all revisions of manuscripts via the ACS Paragon Plus Environment. The web

3 submission site employs state-of-the-art security mechanisms to ensure that all electronically submitted papers are secure. These same security mechanisms are also utilized throughout the peerreview process, permitting access only to editors and reviewers who are assigned to a particular paper. Authors are advised to review the journal’s Preparation of Manuscripts prior to submission of a manuscript and closely follow the guidance given. Authors will view the PDF version of their manuscripts prior to formal submission to the Editor. In order to use Web submission, authors must be able to provide electronic versions of text and graphics. Authors may now choose to submit their own manuscript PDF file along with a word processing or zipped archive file of their manuscript documents or allow Paragon Plus to generate a PDF automatically. Manuscripts submitted as e-mail attachments will not be accepted. It is the policy of Organic Process Research & Development to publish pertinent experimental details in the manuscript’s Experimental Section but not in the Supporting Information, i.e., experimental information is expected to be part of the manuscript.

Journal Publishing Agreement A properly completed and signed Journal Publishing Agreement (JPA) must be submitted for each manuscript. ACS Paragon Plus provides an electronic version of the Agreement that will be available on the My Authoring Activity tab of the Corresponding Author's Home page once the manuscript has been assigned to an Editor. A PDF version of the Agreement is also available, but Authors are strongly encouraged to use the electronic Journal Publishing Agreement. If the PDF version is used, all pages of the signed PDF Agreement must be submitted. If the Corresponding Author cannot or should not complete either the electronic or PDF version for any reason, another Author should complete and sign the PDF version of the form. Forms and complete instructions are available at http://pubs.acs.org/page/copyright/journals/index.html.

Reprint Permissions You may copy, reprint, republish, reproduce, and/or transmit articles or portions thereof (tables, figures, charts, schemes, photographs, excerpts, etc.) provided that you have permission to do so from the copyright owner. It is the obligation of the person or organization seeking to use the copyrighted material to secure this permission. Even the author must obtain permission to use his/her own material if he/she transferred copyright or plans to transfer copyright to a publisher. This includes material for all types of use of ACS journal material. Permission requests for ACS Journals material are handled through the Rightslink service. Please see the Rightslink instructions for complete details. The link for the copyright permission request form to use figures and tables (only) from other publishers is found at http://pubs.acs.org/page/copyright/permissions.html.

Correspondence Authors are asked to provide their e-mail addresses along with their postal and e-mail addresses and phone and fax numbers. Correspondence to the Editor should be addressed to Dr. Kai Rossen, Building G838, Industriepark Hoechst, Sanofi, 65926 Frankfurt, Germany. Telephone: +(49) 69 305 30202, E-mail: [email protected]. Correspondence regarding accepted papers, proofs, and reprints should be directed to Journal Publications at [email protected].

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ORCID All authors are encouraged to register for an ORCID iD, a unique researcher identifier. With this standard identifier, you can create a profile of your research activities to distinguish yourself from other researchers with similar names, and make it easier for your colleagues to find your publications. Learn more at http://www.orcid.org. Authors and reviewers can add their ORCID iD to, or register for an ORCID iD from, their account in ACS Paragon Plus. Submitting authors have the option to provide existing ORCID iDs for coauthors during submission, but they cannot create new ORCID iDs for coauthors.

Preparation of Manuscripts General information on the preparation of manuscripts for ACS Journals may be found in The ACS Style Guide, 3rd ed. (2006), available from Oxford University Press, Order Department, 201 Evans Road, Cary, NC 27513, U.S.A. Information about The ACS Style Guide may also be found at http://pubs.acs.org/page/books/index.html. Authors less experienced in preparing manuscripts for ACS journals are encouraged to enlist a skilled colleague to review the manuscript prior to submission to help both to eliminate errors in style and grammar and to assure a good presentation of the material. Note that there are professional resources available to assist the writing of scientific papers. These are listed at http://pubs.acs.org/page/4authors/tools/language_editing.html. The ACS does not endorse any of these companies. Manuscripts that are submitted with linguistic and presentation issues that would unduly inhibit the reviewers to judge the content will be rejected. When preparing a manuscript, use the document mode or its equivalent in the word-processing program; i.e., do not save files in “Text Only” (ASCII) mode. If a non-Western version of the wordprocessing software was used to prepare the manuscript, save the file in rich-text format (RTF). Do not include any page-layout instructions such as placement information for graphics in the file. The text should be left justified, and automatic end-of-line hyphenation should be turned off. Use hard returns only to end headings and paragraphs, not to break lines of text. Do not insert spaces before punctuation. References must conform to the format printed in the Journal. All text and graphics (including the title page; the TOC graphic; abstract; all sections of the body of the paper; figures with captions; schemes, charts, and tables with titles; and footnotes and references) should be in one file, with all non-text content (i.e. tables, figures, schemes, charts) inserted close to where each is mentioned. It is best to use the fonts “Times” and “Symbol”. Other fonts, particularly those that do not come bundled with the system software, may not translate properly. Ensure that all special characters (e.g., Greek characters, diacritical marks, math symbols, etc.) are present in the body of the text as characters and not as graphic representations.

Currently Acceptable Word-Processing Packages Please see the guidelines given at http://paragonplus.acs.org.

Titles, Authors, and Abstracts Titles are of great importance for current awareness and for information retrieval. Words should be chosen carefully to provide information on the contents and to function as “points of entry” for retrieval purposes, so that banal and meaningless terms (e.g. novel) are to be avoided. An asterisk should be used to designate the name of the author to whom correspondence should be sent. The corresponding author’s mailing address and e-mail address should be included.

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All manuscripts must be accompanied by an abstract, which should state concisely the purpose of the research, the principal results, and major conclusions. Reference to structural formulas or tables in the text, by number, may not be made in the abstract. Four to six keywords need to be provided following the abstract.

Contents of Manuscripts Given the scope of the journal, particular attention has to be given to the relevance of the described chemistry to be performed reliably on scale. In this context, attention to safety, including choice of acceptable solvents, work-up, and isolation procedures is critically important to give the reader the trust that the chemistry is reliable and likely to be scalable. The scientific rationale for the choice of the optimal reaction conditions has to be explained. The Discussion and Experimental Section should be clearly distinguished from the rest of the text. Tabulation of experimental results is encouraged whenever it leads to a more effective presentation or economical use of space. Avoid the presentation of irrelevant data or lengthy discussion of unproductive pathways. All parts of the narrative should function to advance the central ‘story.’ The presentation of experimental details in the text of the Discussion section should be kept to a minimum. Avoid the reiteration of information that is made obvious in a table or scheme. It is important to define whether the purity stated is determined by HPLC area % (whether absolute area or relative area) or versus a known standard (weight %). If the purity technique stated throughout the manuscript is consistent with the first mention of a purity, it is not necessary to restate the basis thereafter (until the Experimental), but to list it without further explanation until a different basis is used. Supporting Information is a good compromise for the location of data and information that appears superfluous for the Discussion yet would still be useful to a reader desiring further information or for providing experimental basis for observations or conclusions stated in the Discussion. Examples of this might be copies of spectra, safety related data, pictures or schemes of experimental equipment that is not widely understood, details of DOE experiments, or any other data-intense document.

Nomenclature Nomenclature should conform to American usage. Insofar as is practical, authors should use a systematic name, from either Chemical Abstracts or IUPAC, for each title compound in the Experimental Section. Unless the manuscript contains very few structures or the structures are very well known (e.g., benzene), it is generally good practice to identify all structures with a bold-faced Arabic numeral, unless the structure is not discussed in the text or listed in the Experimental Section. If a compound is given a number, it is expected that it also appears in a scheme or figure. It is also acceptable to use “semi-systematic names” for certain specialized classes of compounds, such as steroids, peptides, carbohydrates, and cyclophanes. In such a case, the name should conform to the generally accepted nomenclature conventions for the compound class. If the structures of the compounds in a manuscript are sufficiently complex that determination of their systematic names is impractical or the names are unduly long, compounds should be referred to in some unambiguous manner, such as “ketone 23” or “amino acid 14a”. The latter usage is also particularly convenient in the narrative. Avoid the use of alternative nomenclature systems such as letters or non-Arabic numerals to identify compounds, or unfamiliar acronyms with which to refer to intermediates or

6 products. If the manuscript contains a large number of structures, be careful not to inadvertently assign multiple numerals to the same structure. Letter suffixes (e.g. 7a, 7b, 7c) may be used to identify series of compounds that differ in only one moiety; however, avoid this if clarity is compromised. Chemical Abstracts (CA) nomenclature rules are described in Appendix IV of the Chemical Abstracts Index Guide. For CA nomenclature advice, consult the Manager of Nomenclature Services, Chemical Abstracts Service, P.O. Box 3012, Columbus, OH 43210-0012. A namegeneration service is available for a fee through CAS Client Services, 2540 Olentangy River Road, P.O. Box 3343, Columbus, OH 43210-0334; telephone: (614) 447-3870; fax: (614) 447-3747; or e-mail: [email protected]. In addition, the ACS website has links to nomenclature recommendations at http://chemistry.org.

Abbreviations Authors are encouraged to make use of abbreviations and acronyms if it will result in a significant saving of space. If non-standard abbreviations or acronyms are employed, they have to be defined the first time they are used. Beware of using multiple acronyms or trivial names for the same item, such as ACN or MeCN for acetonitrile. Refer to the list of standard abbreviations and acronyms in the ACS Style Guide, available via registration at ACS ChemWorx (www.acschemworx.org).

The Experimental Section Authors should use a general Experimental Section to provide sources of commercial and known compounds to provide a comprehensive and traceable access to the key starting materials used in the experimental part. Key chromatographic method parameters need to be given. It should be clear if the purity listed is determined by area % (whether absolute area % or relative area %) or weight %. Clear, unambiguous expression in individual experimental descriptions is vital. Authors are encouraged to use the briefest style possible, describing the experiment with quantitative numbers. Any detailed descriptions of apparatus and routine procedures should be avoided unless precise adherence to a protocol is essential to the success of the experiment being described. The title of an experiment should give the full CAS name and structure number of the product prepared, when appropriate, but this compound should only be identified thereafter by structure number. Abbreviations or chemical formulas for simple chemicals are encouraged if consistent with nomenclature used in the Discussion, as well as the use of a structure number rather than a lengthy chemical name to identify a starting material. Standard abbreviations should be used throughout the Experimental Section, without periods. It is critical that special attention be called to hazardous compounds and operations and that appropriate handling procedures and literature references to their properties and safe handling be offered. Please use warnings in bold-face font for significant hazards.

Characterization For all known compounds, the source of the material or references to the utilized literature preparation method and published characterization data must be provided unless the material is a commodity available from common chemical vendors. Spectral data should be presented only if they augment or update the previously published data. Typically, CNMR and HNMR should be included. NMR spectra should be prepared according to the Guidelines for Reporting and Stewardship of

7 NMR Data recently agreed upon by an ACS taskforce. This document may be found at http://pubs.acs.org/page/4authors/tools/index.html. For all new compounds that appear as title compounds in the Experimental Section, adequate evidence to establish both identity and degree of purity must be provided. Such evidence may be best presented as a combination of data/explanation located between the Discussion and Experimental Section. For instance, the Discussion may include information that a novel compound’s identification arose from well well-understood chemistry from a known compound or via a single-crystal X-ray structure determination. And the Experimental Section may include the spectral data that establishes the identity and evidence of purity such as a narrow melting range, high HPLC or GC purity, etc. Alternatively, these data can be published in the Supporting Information. In general, only enough data should be presented in the actual Experimental Section to allow another worker to identify the same compound by comparison. Full lists of infrared absorptions and mass spectral fragmentations should not be presented in the issue publication of the Journal. List only those infrared absorptions that are diagnostic for important functional groups and only those mass spectral fragments that are diagnostic for a particular skeleton. Authors may supply high-resolution mass spectral (HRMS) data as an additional criterion of compound identity. Additional spectral and characterization data may be presented as Supporting Information. Evidence of optical purity should be derived from HPLC, GC or other appropriate analytical data and not simply optical rotation data. Optical rotation, if reported, should be in the form [α]temp λ = (±)value (c x, solv), where λ is the wavelength of light used for the determination, often the sodium D line, temp is the temperature at which the determination was made, x is the concentration in g/100 mL, and solv is the solvent used for the measurement. Note that [α] is expressed without units; the actual units, deg mL/(g dm), are implied. Evidence of the degree of purity of each compound should be presented. Ideally this will include elemental analysis, but it is recognized that this may not always be appropriate, and other methods (e.g., spectroscopic, chromatographic) may be used, provided that the results are justified by the data. Analytical methods should be given in sufficient detail to allow reproduction. Information such as detailed NMR, 2D analysis, or MS data can be included in Supporting Information. Many processes do not require a high level of purification of an intermediate prior to transformation to the subsequent intermediate. The Experimental Section should indicate the actual purity range achieved.

References and Footnotes Avoid unnecessarily long reference lists by selecting citations judiciously and citing reviews when possible. Literature citations and explanatory notes must be numbered in one consecutive series by order of mention in the text, with numbers as superscripts without parentheses. The following are examples of the appropriate style for use in citations. For journals: Laird, T. Spec. Chem. 1992, 12, 324. For books: Lipton, S.; Lynch, J. Handbook of Health Hazard Control in the Chemical Process Industry; Wiley: New York, 1994. For patents: Patent Owner 1; Patent Owner 2; etc. Title of Patent. Patent number, Date. A patent should also include the Chemical Abstract Service abstract number to assist rapid identification of the content. In literature references, journal abbreviations should be those used by Chemical Abstracts Service Source Index (CASSI). Authors are encouraged to make use of footnotes, for example to provide an explanation or clarification of a key point which has been raised during the peer review of the manuscript. Please use letters to cite these footnotes so that they

8 will not be confused with numbered reference citations. In the composed PDF, such footnotes will appear prior to the list of references.

Guidelines for Illustrations in ACS Journals Quality The quality of the illustrations in the Journal depends on the quality of the originals provided by the author. Figures cannot be modified or enhanced by the journal production staff. The graphics files furnished by authors are used in the production of the Journal. To facilitate the publication process, please submit manuscript graphics using the following guidelines: 1. The preferred submission procedure is to embed graphic files in a Word document. It may help to print the manuscript on a laser printer to ensure all artwork is clear and legible. 2. Additional acceptable file formats are: TIFF, PDF, EPS (vector artwork) or CDX (ChemDraw file). If submitting individual graphic files in addition to them being embedded in a Word document, ensure the files are named based on graphic function (i.e. Scheme 1, Figure 2, Chart 3), not the scientific name. Labeling of all figure parts should be present and the parts should be assembled into a single graphic. 3. EPS files: Ensure that all fonts are converted to outlines or embedded in the graphic file. The document settings should be in RGB mode. NOTE: While EPS files are accepted, the vectorbased graphics will be rasterized for production. Please see below for TIFF file production. 4. TIFF files (either embedded in a Word doc or submitted as individual files) should have the following resolution requirements: -

Black & White line art: 1200 dpi

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Grayscale art (a monochromatic image containing shades of gray): 600 dpi

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Color art (RGB color mode): 300 dpi



The RGB and resolution requirements are essential for producing high-quality graphics within the published manuscript. Graphics submitted in CMYK or at lower resolutions may be used, however, the colors may not be consistent and graphics of poor quality may not be able to be improved.



Most graphic programs provide an option for changing the resolution when you are saving the image. Best practice is to save the graphic file at the final resolution and size using the program used to create the graphic.

5. Graphics should be sized at the final production size when possible. Single column graphics are preferred and can be sized up to 240 points wide (3.33 in.). Double column graphics must be sized between 300 and 504 points (4.167 in. and 7 in.). All graphics have a maximum

9 depth of 660 points (9.167 in.) including the caption (please allow 12 pts for each line of caption text). •

Consistently sizing letters and labels in graphics throughout your manuscript will help ensure consistent graphic presentation for publication.

6. A graphic should be submitted for use as in the Table of Contents. This graphic should give the reader a quick visual representation of the essence of the paper without providing specific details. The best images for these uses are simple, relatively free of text and technical characters, and make use of color for visual impact. 7. For more information, please visit http://pubs.acs.org/page/4authors/submission/index.html.

Layout Blocks of structural formulas should be designated as schemes or charts rather than figures (schemes generally include reactions, transformations, or processes; charts consist of structures only). All figures require a caption, and schemes and charts require a title which should be sufficiently descriptive such that the item can be understood without reference to the text and must be consecutively numbered within the subgrouping of schemes, figures, etc. In preparing structures for direct photo reproduction, layout is critical. Equations, schemes, and blocks of structures are presented in the Journal in either one-column or two-column format. The one-column format should be used whenever possible because this permits much greater flexibility in page layout. All structural material that should immediately follow certain text must be designed to fit the one-column format, and its location in the text must be indicated on the manuscript. Structures, arrows, and compound designators should be arranged so as to make maximum use of the width afforded by the one-column or two-column format.

Color Color reproduction, if approved by the Editor, will be provided at no cost to the author. Color illustrations should only be submitted if essential for clarity of communication. Color is generally unnecessary in graphs. Do not submit color files to be printed in black and white because resolution is degraded upon conversion.

Chemical Structures A definite guide to ACS graphics is provided at http://pubs.acs.org/page/4authors/submission/graphics_prep.html

Tables These should be numbered consecutively with Arabic numerals and should be contextual; i.e., placed in the text close to where they are mentioned. Footnotes in tables should be given designations and be cited in the table by the italic superscript letters. The sequence of letters should proceed by line rather than by column. If a reference is cited both in the text and in a table, insert a lettered footnote in the table to refer to the numbered reference footnote in the text. Each table should be provided with a descriptive heading, which, together with the individual column headings, should make the table, as nearly as possible, self-explanatory. In setting up tabulations, authors are requested to keep in mind the type area of the journal page (17.8 cm × 25.4 cm) and the column width (8.5 cm) and to make tables conform to the limitations of these dimensions. Arrangements that leave many columns

10 partially filled or that contain much blank space should be avoided. Inclusion of unimportant data that is not used to support an observation or decision in the Discussion should be avoided.

Figures and Figure Captions Authors are encouraged to supply production-ready figures. Line drawings, graphs, stereograms, histograms, and black and white (or color) photographs are all classifieds as figures and should be numbered consecutively with Arabic numerals in order of citation. Each figure caption should be kept with the figure graphic to which it refers. Figures should be constructed in keeping with the column width, line width, and font size specified above (see Chemical Structures). All illustrations should be numbered as “Figures”, with Arabic numerals.

Schemes and Scheme Titles Schemes show a sequence or group of reactions taking place together. They should be numbered consecutively with Arabic numerals in order of citation. Each scheme title should be kept with the scheme graphic to which it refers. Please save each graphic in a separate file as *.tif and then copy and paste each file directly into the word processing document where it should appear contextually. Color should be saved as RGB at 300 dpi resolution. Consult the documentation in your graphics application for more information on how to save files in this format. The filename should be descriptive of the content graphic, for example, figure1 for Figure 1, scheme1 for Scheme 1, etc.

Spectra Reproductions of spectra, or the relevant segments thereof, will be published only if concise numerical summaries are inadequate for the purposes of the paper. Papers dealing primarily with interpretation of spectra and those in which band shape or fine structure needs to be illustrated might qualify for this exception. When presentation of spectra is deemed essential, only the pertinent sections (prepared as described for “Figures”) should be presented. If an author wishes to publish reproductions of spectra as adjuncts to the characterization of compounds, these can be included as Supporting Information in the Web edition of the Journal.

Acknowledgment and Funding Sources When submitting a manuscript to the Journal via ACS Paragon Plus, the submitting author is asked to identify the funding sources for the work presented in the manuscript. Identifying funding sources is optional during submission of an original manuscript. Funding source information is required when a revised manuscript is submitted. This section should also acknowledge technical assistance, advice from colleagues, gifts, etc. Permission should be sought from persons whose contribution to the work is acknowledged in the manuscript, but this will not need confirmation from the Editor.

Supporting Information Please note: For this Journal, vital experimental procedures must not be placed into Supporting Information but instead should be kept in the paper itself. General Considerations. The Web edition of this Journal can accommodate almost any type of supplementary data (e.g., reproductions of spectra, tabulated spectral data, expanded discussion of peripheral findings, calculational data, detailed structure proofs). If the manuscript is accompanied by any supporting information for publication, a brief description of the supplementary material is required in the manuscript. The appropriate format is:

11 Supporting Information. Brief statement in nonsentence format listing the contents of the material supplied as Supporting Information. All pages of Supporting Information should be numbered consecutively. Captions or legends for figures, spectra, etc. must appear directly on the figure. Relevant compounds reported in Supporting Information are indexed for Chemical Abstracts and assigned Registry Numbers, even if they are not mentioned in the published paper. Supporting Information must be submitted along with the manuscript. A list of acceptable electronic file types for Supporting Information is given on the ACS Paragon Plus Environment website (http://paragonplus.acs.org). All Supporting Information files of the same type should be submitted as a single file (rather than submitted as a series of files containing individual images or structures). For example, all Supporting Information available as PDF files should be contained in one PDF file, and all CIFs should be submitted as a single file. Where possible, Supporting Information should be consolidated into a single, word processing file with graphics embedded (e.g., using the manuscript template). DO NOT UPLOAD FIGURES, TABLES, TOC GRAPHIC THAT ARE TO BE PUBLISHED IN THE ARTICLE AS SUPPORTING INFORMATION.

Just Accepted Manuscripts Just Accepted manuscripts are peer-reviewed, accepted manuscripts that are posted on the ACS Publications website prior to technical editing, formatting for publication, and author proofing— usually within 30 minutes to 24 hours of acceptance by the editorial office. During the manuscript submission process, Authors can choose to have their manuscripts posted online as Just Accepted manuscripts (JAM). To ensure rapid delivery of the accepted manuscript to the Web, Authors must adhere carefully to all requirements in the journal’s Information for Authors. If an Author chooses to have a manuscript posted online as a Just Accepted manuscript, it is considered published when the JAM version appears on the web. All activities pertaining to patents and intellectual property must be completed before this time. For further information, please refer to the Just Accepted FAQ, at http://services.acs.org/pubshelp/passthru.cgi?action=kb&item=244. Note that publishing a manuscript as Just Accepted is not a means by which to comply with the NIH Public Access Mandate.

Proofs The first corresponding author of an accepted manuscript will receive e-mail notification and complete instructions when page proofs are available for review via a secure Web site. Authors will access the secure site through ACS ChemWorx and will need an ACS ID. To obtain an ACS ID or to reset your password, go to www.acschemworx.org. Routine rephrasing of sentences or additions are not permitted at the page proof stage. Alterations should be restricted to serious changes in interpretation or corrections of data. Extensive or important changes on page proofs, including changes to the title or list of authors, are subject to Editorial review. In some cases, it may be necessary to repeat the review process, which will be decided at the discretion of the Editor.

12 It is the responsibility of the corresponding author to ensure that all authors listed on the manuscript agree with the changes made on the proofs. Galley proofs should be returned by the corresponding author within 48 h of receipt in order to ensure timely publication of the manuscript.

ASAP Publication Accepted manuscripts will be published on the “Articles ASAP” page on the Journal Web site as soon as page proofs are corrected and all author concerns are resolved. Publication on the Web usually occurs within 4 working days of receipt of page proof corrections. Manuscripts assigned to a special feature section may remain published ASAP for several months. Authors should take this schedule into account when planning intellectual and patent activities related to a manuscript. The actual date on which an accepted paper is published on the Web is recorded on the Web version of the manuscript and on the first page of the PDF version.

Reprints and ACS Policies for E-prints and Reprints Under the ACS Articles on Request policy, the Society will provide (free of charge) to all contributing authors a unique URL within the ACS Web site that they may e-mail to colleagues or post on external Web sites. These author-directed links are designed to facilitate distribution of an author’s published work to interested colleagues in lieu of direct distribution of the PDF file by the author. The ACS Articles on Request policy allows 50 downloads within the first year after web publication and unlimited access via the same author-directed links 12 months after web publication. For more information on Electronic Reprints, please see http://pubs.acs.org/page/policy/articlesonrequest/index.html. When authors are sent the proof of their paper, they will receive a link to a website where they may order author reprints. They may also call Cierant Corporation, 866-305-0111, from 9AM to 5PM EST. Reprints will be shipped within two weeks after the issue publication date. Neither the Editors nor the Washington ACS Office keeps a supply of reprints; requests for single copies of papers should be addressed to the corresponding author of the paper concerned.

ACS AuthorChoice Open Access ACS AuthorChoice options establish fee-based mechanisms for authors or their research funding agencies to sponsor the open availability of final published articles on the Web. ACS AuthorChoice offers authors a wide range of open access license options, such as Creative Commons licenses and provisions for immediate or 12-month embargoed open access, and includes ACS Certified Deposit. Authors will find useful information about compliance with open access policies available here and FAQs here. Corresponding authors who published with ACS during 2014 may have access to ACS Author Rewards, a $60M stimulus program ACS provided to help authors transition to new open access publishing models.

Additions and Corrections Additions and Corrections may be used to address important issues or correct errors and omissions of consequence that arise after publication of an article. Additions and Corrections may be requested by the author(s) or initiated by the Editor after discussions with the corresponding author. Readers who detect errors of consequence in the work of others should contact the corresponding author of that work. All Additions and Corrections are subject to approval by the Editor, and minor corrections and additions will not be published. Additions and Corrections from authors should be submitted via the ACS Paragon Plus environment by the corresponding author for publication in the “Addition/Correction” section of the Journal. The corresponding author should obtain approval from

13 all of the article coauthors prior to submitting an Addition and Correction, or provide evidence that such approval has been solicited. The Addition and Correction should include the original article title and author list, citation including DOI, and details of the correction. For proper formatting, see examples in a current issue of the Journal.

Retractions Articles may be retracted for scientific or ethical reasons. Articles that contain seriously flawed or erroneous data such that their findings and conclusions cannot be relied upon may be retracted in order to correct the scientific record. Retractions may be requested by the article author(s) or by the journal Editor(s) but are ultimately published at the discretion of the Editor. When an article is retracted, a notice of Retraction will be published containing information about the original article title, author list, and the reason for the Retraction. Retracted articles will be accompanied by the related Retraction notice and will be marked as “Retracted”. The originally published article will remain on the web except in extraordinary circumstances (e.g. where deemed legally necessary, or if the availability of the published content poses public health risks). The American Chemical Society follows guidance from the Committee on Publication Ethics (COPE) when considering retractions; for more information see: http://publicationethics.org/.

Conflict of Interest The authors should disclose at the time of submission all potential sources of bias, including affiliations, funding sources, and financial or management relationships, that may constitute conflicts of interest. The corresponding author should provide a statement on behalf of all authors of a paper. For further information, please read the American Chemical Society’s Ethical Guidelines to Publication of Chemical Research.

Professional Ethics In publishing only original research, ACS is committed to deterring plagiarism, including selfplagiarism. ACS Publications uses CrossCheck's iThenticate software to screen submitted manuscripts for similarity to published material. Note that your manuscript may be screened during the submission process. Further information about plagiarism can be found in Part B of the Ethical Guidelines to Publication of Chemical Research.

Author List During manuscript submission, the submitting author must provide contact information (full name, email address, institutional affiliation and mailing address) for all of the co-authors. Because all of the author names are automatically imported into the electronic Journal Publishing Agreement, the names must be entered into ACS Paragon Plus in the same sequence as they appear on the first page of the manuscript. (Note that co-authors are not required to register in ACS Paragon Plus.) The author who submits the manuscript for publication accepts the responsibility of notifying all coauthors that the manuscript is being submitted. Deletion of an author after the manuscript has been submitted requires a confirming letter to the Editor-in-Chief from the author whose name is being deleted. For more information on ethical responsibilities of authors, see the Ethical Guidelines to Publication of Chemical Research.

Assistance with English Language Editing Authors may want to have their manuscripts edited professionally before submission to improve clarity. The ACS ChemWorx English Editing Service can assist you in improving and polishing the

14 language in your manuscript. You can learn more about the services offered, at http://es.acschemworx.acs.org.