RESEARCH ARTICLE
Preterm Birth Prevention Post-Conization: A Model of Cervical Length Screening with Targeted Cerclage Lindsay M. Kindinger1,2, Maria Kyrgiou1,3*, David A. MacIntyre1, Stefano Cacciatore1, Angela Yulia1,4, Joanna Cook1, Vasso Terzidou1,4, T. G. Teoh1,2, Phillip R. Bennett1,3
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1 Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College, London, United Kingdom, 2 Department of Obstetrics and Gynaecology, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom, 3 Department of Obstetrics and Gynaecology, Queen Charlotte’s and Chelsea—Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom, 4 Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital NHS Trust, London, United Kingdom *
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Abstract OPEN ACCESS Citation: Kindinger LM, Kyrgiou M, MacIntyre DA, Cacciatore S, Yulia A, Cook J, et al. (2016) Preterm Birth Prevention Post-Conization: A Model of Cervical Length Screening with Targeted Cerclage. PLoS ONE 11(11): e0163793. doi:10.1371/journal. pone.0163793 Editor: Rogelio Cruz-Martinez, Fetal Medicine and Surgery, MEXICO Received: February 14, 2016 Accepted: September 14, 2016 Published: November 3, 2016 Copyright: © 2016 Kindinger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: We have uploaded our data to datadryad.org under the details: DOI: 10.5061/dryad.r7r01 Data files: Kindinger data_Uploaded PlosOne. Funding: This study was supported in part by the Genesis Research Trust (P51389), the British Society of Colposcopy Cervical Pathology Jordan/ Singer Award (P47773), and by the Imperial Healthcare NHS Trust Biomedical Research Centre (Grant Ref P45272). MK received support and a research award from the British Society of
Women with a history of excisional treatment (conization) for cervical intra-epithelial neoplasia (CIN) are at increased risk of preterm birth, perinatal morbidity and mortality in subsequent pregnancy. We aimed to develop a screening model to effectively differentiate pregnancies post-conization into low- and high-risk for preterm birth, and to evaluate the impact of suture material on the efficacy of ultrasound indicated cervical cerclage. We analysed longitudinal cervical length (CL) data from 725 pregnant women post-conization attending preterm surveillance clinics at three London university Hospitals over a ten year period (2004–2014). Rates of preterm birth
