Pathol. Oncol. Res. (2011) 17:593–603 DOI 10.1007/s12253-010-9355-6
RESEARCH
Prognostic Significance of Carbonic Anhydrase IX (CA-IX), Endoglin (CD105) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in Breast Cancer Patients Lidija Beketic-Oreskovic & Petar Ozretic & Zahid N. Rabbani & Isabel L. Jackson & Bozena Sarcevic & Sonja Levanat & Petra Maric & Ivan Babic & Zeljko Vujaskovic
Received: 10 September 2010 / Accepted: 28 December 2010 / Published online: 20 January 2011 # Arányi Lajos Foundation 2011
Abstract The aim of this study was to examine the prognostic significance of carbonic anhydrase IX (CA-IX), an endogenous marker for tumor hypoxia; endoglin (CD105), a proliferation-associated and hypoxia-inducible glycoprotein and 8-hydroxy-2′-deoxyguanosine (8-OHdG), an oxidative DNA lesion, in breast cancer patients. Immunohistochemical expressions of CA-IX, CD105 and 8-OHdG, analyzed on paraffin-embedded tumor tissues from forty female breast cancer patients, were used to assess their prognostic implication on overall survival (OS) and relapse-free survival (RFS). Patients with high CA-IX expression (above cut-off value) had a higher occurrence of relapse (P=0.002). High CA-IX expression was significantly associated with shorter RFS L. Beketic-Oreskovic (*) : P. Maric Department of Radiation Oncology, University of Zagreb, School of Medicine, University Hospital for Tumors, Ilica 197, 10000 Zagreb, Croatia e-mail:
[email protected] P. Ozretic : S. Levanat Laboratory for Hereditary Cancer, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia Z. N. Rabbani : I. L. Jackson : Z. Vujaskovic Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA B. Sarcevic Department of Pathology, University of Zagreb, School of Medicine, University Hospital for Tumors, Zagreb, Croatia I. Babic Department of Obstetrics and Gynecology, University of Zagreb, School of Medicine, Zagreb University Hospital Center, Zagreb, Croatia
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