Mar 3, 2018 - Results: Abnormal RNFL thickness was registered in 13/42(31%) survivors of methanol poisoning and chronic axonal loss in 10/42(24%) ...
Accepted Manuscript Progressive Chronic Retinal Axonal Loss Following Acute Methanol-Induced Optic Neuropathy: Four-Year Prospective Cohort Study Olga Nurieva, MD, Pavel Diblik, MD, Pavel Kuthan, MD, Petr Sklenka, MD, Martin Meliska, MD, Jan Bydzovsky, MD, Jarmila Heissigerova, MD, PhD, Pavel Urban, MD, PhD, Katerina Kotikova, MD, Tomas Navratil, PhD, Martin Komarc, MSc, PhD, Zdenek Seidl, MD, PhD, Manuela Vaneckova, MD, PhD, Daniela Pelclova, MD, PhD, Sergey Zakharov, MD, PhD PII:
S0002-9394(18)30184-3
DOI:
10.1016/j.ajo.2018.04.015
Reference:
AJOPHT 10496
To appear in:
American Journal of Ophthalmology
Received Date: 24 December 2017 Revised Date:
3 March 2018
Accepted Date: 19 April 2018
Please cite this article as: Nurieva O, Diblik P, Kuthan P, Sklenka P, Meliska M, Bydzovsky J, Heissigerova J, Urban P, Kotikova K, Navratil T, Komarc M, Seidl Z, Vaneckova M, Pelclova D, Zakharov S, Progressive Chronic Retinal Axonal Loss Following Acute Methanol-Induced Optic Neuropathy: Four-Year Prospective Cohort Study, American Journal of Ophthalmology (2018), doi: 10.1016/j.ajo.2018.04.015. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Abstract Purpose: To study the dynamics and clinical determinants of chronic retinal nerve fiber layer thickness (RNFL) loss after methanol-induced optic neuropathy.
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Design: Prospective cohort study.
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Methods: All patients underwent complete ophthalmic evaluation including SD-OCT three times during four years of observation:4.9[±0.6], 25.0[±0.6], and 49.9[±0.5] months after discharge. Participants and controls: Eighty-four eyes of 42 survivors of methanol poisoning; mean age (standard deviation) of 45.7[±4.4] years, and 82 eyes of 41 controls; mean age 44.0[±4.2] years. Main Outcome Measures: global and temporal RNFL loss.
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Results: Abnormal RNFL thickness was registered in 13/42(31%) survivors of methanol poisoning and chronic axonal loss in 10/42(24%) patients. Significant decrease of global/temporal RNFL thickness during the observation period was found in the study population compared to the controls (p117 ms, (3) interocular difference of waves P1 latencies >6 ms, and (4) amplitude of evoked complex
