Prolongation of Pseudopregnancy in Rats by LH'

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Jan 16, 1970 - life. However, the possibility that the formation of new corpora lutes was responsible for extending the length of PSP cannot be ruled out. The.
BIOLOGY

OF REPRODUCTION

3, 3 1-34

(1970)

Prolongation

of

ABUBAKAR The

Worcester

Pseudopregnancy

A. SHAIKH

Foundation

for

AND

Experimental

A

single

injection

of

of

66

14.0

rats

PSP

test

revealed

receiving

order

rats

were

These

was

had

However,

functional cycling

extended (PSP),

by and

hypophyseal tend the 1956). arates

life

rat

is

that of

in the

PSP

corpus

luteum 1956;

be

luteinizing

and

of

2 Present

was

supported

which

for many

address:

duction

and

School,

50

Laboratory

Reproductive Binney

by

Street,

Biology, Boston,

or

13.

PSP,

18

15

hrs

later.

respectively. through

cells

corpora

by the

Day

during

indirectly and

lutes

stimu-

prolongs was

their

responsible

LH

life of the corpus

autotransplanted of the work

has There

in

of LH,

in the

action

or

that

tion

of

donald jection

might,

therefore,

on

ovary

tional

Repro-

corpora

possible PSP rats.

Medical 02115. 31

that

lutea.

luteotrophic

lutea

intravenous

an

5 of

ovarian unpublished a intact

This effect

PSP

rat study of

(Macin-

increases

venous data).

different

has

secre-

that

Day

have of

stimulates

corpora

and the

It

1966).

LH

rat

on

in (Shaikh,

rat

the

presence of other It has been redo maintain the corpora

(Bogdanove,

levels

the

influence

hormones.

by 1966)

LH

of

estrogen of

at.,

may

hypophysectomized a possibility of a dif-

estrogens

estrogen

et

luteum

hypophyses. concerning the

been done is, however,

lutea of the rat also been reported

HD-01785.

Harvard

functional

ported

causes

Human

Mass.

control

5.3,

other

results between

examined

and

gonadotropins

months

(LH)

of

3, and

luteal

new

the

except

9 and

the

ferent

keeps

Autotrans-

USPHS

of

length the

out.

rats.

secretion

regression in hypophysectomized rats sep, 1938: Evans et al., 1941; Desclin, 9), it is logical to assume that the increase study

on

prolactin

bearing Much

also ex(Everett,

ii

1 This

average

PSP,

be due to a lack of a luteolytic effect of LH. Rothchild (1965) has demonstrated the luteolytic effect of LH in hypophysectomized rats

uninterrupted

hormone

an

5

in the

ltation also causes the hypophysis to lose *bihity to secrete both FSH and LH (Ev1956; Nikitovitch-Winer and Everett,

). Since

showed of

and

animals

in

autotranspiantation sepfrom its hypothalamic

1960).

or

16.3,

be

luteum

functional

control

a total

can

will

Rothchild,

14.5,

12

ovulation

1.8,

of

affects ruled

Day induce

7,

of

17.8,

The

or

in

luteum but

(LtH),

5,

17.2,

analysis

or

action

intravenously

(p