Proton beam therapy for pediatric malignancies - Wiley Online Library

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Feb 18, 2016 - Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan. Masashi Mizumoto1, Shigeyuki ...
Cancer Medicine

Open Access

ORIGINAL RESEARCH

Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan Masashi Mizumoto1, Shigeyuki Murayama2, Tetsuo Akimoto3, Yusuke Demizu4, Takashi Fukushima5, Yuji Ishida6, Yoshiko Oshiro1, Haruko Numajiri1, Hiroshi Fuji7, Toshiyuki Okumura1, Hiroki Shirato8 & Hideyuki Sakurai1 1Department

of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, Japan of Proton Therapy, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan 3Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Kashiwa, Chiba, Japan 4Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo, Japan 5Department of Child Health, University of Tsukuba, Tsukuba, Ibaraki, Japan 6Division of Pediatrics, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan 7Department of Radiology, National Center for Child Health and Development, Tokyo, Japan 8Department of Radiation Oncology, Hokkaido University Hospital, Sapporo, Japan 2Division

Keywords Observational study, PBT, pediatric, proton beam therapy, radiotherapy Correspondence Hideyuki Sakurai, Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. Tel: +81 29 853 7100; Fax: +81 29 853 7102; E-mail: [email protected] Funding Information This research was supported by a grant for Practical Research for Innovative Cancer Control (15ck0106186h0001) from the Japan Agency for Medical Research and Development (AMED). This research was supported in part by Grants-in-Aid for Scientific Research (B) (15H04901) and Young Scientists (B) (25861064) from the Ministry of Education, Science, Sports and Culture of Japan. This research was supported in part by Translational research Network Program from the Ministry of Education, Science, Sports and Culture of Japan.

Abstract Recent progress in the treatment for pediatric malignancies using a combination of surgery, chemotherapy, and radiotherapy has improved survival. However, late toxicities of radiotherapy are a concern in long-­term survivors. A recent study suggested reduced secondary cancer and other late toxicities after proton beam therapy (PBT) due to dosimetric advantages. In this study, we evaluated the safety and efficacy of PBT for pediatric patients treated in Japan. A retrospective observational study in pediatric patients who received PBT was performed. All patients aged