Jun 13, 2015 - support from: Pfizer, Consultant for: Pfizer. DOI: 10.1136/annrheumdis-2015-eular.5196. SAT0557 PREDICTORS OF RESPONSE IN ...
Scientific Abstracts cyclooxygenase inhibitors and aspirin can be safely used during the first and second trimester but should be withdrawn after gestational week 20 for the risk of ductus constriction. When corticosteroids are needed they are safe when used at low dosages.The effects of colchicine during pregnancy are only studied in patients with familial Mediterranean fever condition in which it appeared to be safe. Nowadays the general outcomes of pregnancies in patients with pericarditis can be similar to the general population, especially when carefully followed by multidisciplinary teams. A rheumatological approach to these pregnancies was safe and effective. References: [1] Imazio M, Brucato A, Belli R, Forno D, Ferro S, Trinchero R, Adler Y. Colchicine for the prevention of pericarditis: what we know and what we do not know in 2014 - systematic review and meta-analysis. J Cardiovasc Med (Hagerstown). 2014 Dec;15(12):840-6.1) [2] Imazio M, Belli R, Brucato A, Cemin R, Ferrua S, Beqaraj F, Demarie D, Ferro S, Forno D, Maestroni S, Cumetti D, Varbella F, Trinchero R, Spodick DH, Adler Y. Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2): a multicentre, double-blind, placebo-controlled, randomised trial. Lancet. 2014 Jun 28;383(9936):2232-7. [3] Imazio M, Brucato A, Adler Y. A randomized trial of colchicine for acute pericarditis. N Engl J Med. 2014 Feb 20;370(8):781. [4] Imazio M, Spodick D.H., Brucato A., Trinchero R., Adler Y. Controversial issue in the management of pericardial disease. Circulation. 2010; 121: 916-928. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.6342
SAT0555
ERYTHEMA NODOSUM IN RHEUMATOLOGY CLINIC: A STUDY OF 130 CASES
Y. Karpova, B. Belov, O. Egorova. V. A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation Background: Erythema nodosum (EN) is a type of septal panniculitis that occurs predominantly without vasculitis. EN can be caused by a wide range of etiological factors (infection, sarcoidosis, rheumatic diseases, medications, and other). Objectives: To examine the incidence and clinical features of EN in modern rheumatology practice. Methods: The study included 130 patients (19 men and 111 women, median age 39±13 years) who applied with EN as referral diagnosis to rheumatology clinic during 3-year period. Examination of patients was performed according to the developed algorithm, necessitating collection of thorough medical history, physical examination, clinical, biochemical and immunological blood tests (including CRP, ASLO, RF, anti-DNA), as well as HBs, HCV and RW/VDRL. All patients also underwent chest CT. Results: 7 (5%) patients were diagnosed with primary (idiopathic) EN (PEN), 123 - secondary EN (SEN). Association of EN with infectious process (streptococcal infection-16, mycoplasmal pneumonia-3, upper respiratory tract infection-14, yersiniosis -5 hepatitis C- 5, HIV with HCV-1, infectious mononucleosis-1) was established in 45 (35%) patients, Löfgren’s syndrome was diagnosed in 45 (35%) patients, rheumatic diseases - in 20 (15%) patients (7-systemic lupus erythematosus, 5-Behcet’s disease, 3-reactive arthritis, 3-primary Sjögren’s syndrome, 2-rheumatoid arthritis). In 13 (10%) SEN cases other causes were found: cancer-3, allergic reactions, 3-contraception-2, endometriosis-2, vaccination-1, autoimmune thyroiditis -1, ulcerative colitis-1. In general, EN onset more often occurred during the spring-summer period (60%). PEN patients presented with small number of nodes (to 5.66±4,89), localized exclusively in the sural area. In patients with Löfgren’s syndrome skin lesions typically occurred on the ankles (84%) and persisted for the shortest period of time (1,69±2,29 weeks.). In patients with rheumatic diseases EN occurred more frequently in summer time (50%), was prone to chronicity (60%), longer duration (5,51±7,58 weeks.) and wider distribution on the skin involving legs, hips, shoulders and trunk, showing tenderness to palpation while assessing pain intensity by the visual analogue scale (60±23 mm). Wrist joints and small joints of the hands and feet were significantly more often affected in this group (24% and 38%, respectively, p
