Published Ahead of Print on May 5, 2011, as doi:10.3324/haematol.2011.042333. Copyright 2011 Ferrata Storti Foundation.
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Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis by Sarah E. Gibson, Steven H. Swerdlow, Judith A. Ferry, Urvashi Surti, Paola Dal Cin, Nancy Lee Harris, and Robert P. Hasserjian Haematologica 2011 [Epub ahead of print] Citation: Gibson SE, Swerdlow SH, Ferry JA, Surti U, Dal Cin P, Harris NL, and Hasserjian RP. Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis. Haematologica. 2011; 96:xxx doi:10.3324/haematol.2011.042333 Publisher's Disclaimer. E-publishing ahead of print is increasingly important for the rapid dissemination of science. Haematologica is, therefore, E-publishing PDF files of an early version of manuscripts that have completed a regular peer review and have been accepted for publication. E-publishing of this PDF file has been approved by the authors. After having E-published Ahead of Print, manuscripts will then undergo technical and English editing, typesetting, proof correction and be presented for the authors' final approval; the final version of the manuscript will then appear in print on a regular issue of the journal. All legal disclaimers that apply to the journal also pertain to this production process. Haematologica (pISSN: 0390-6078, eISSN: 1592-8721, NLM ID: 0417435, www.haematologica.org) publishes peer-reviewed papers across all areas of experimental and clinical hematology. The journal is owned by the Ferrata Storti Foundation, a non-profit organization, and serves the scientific community with strict adherence to the principles of open access publishing (www.doaj.org). In addition, the journal makes every paper published immediately available in PubMed Central (PMC), the US National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature.
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DOI: 10.3324/haematol.2011.042333
Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis
Sarah E. Gibson1, Steven H. Swerdlow1, Judith A. Ferry2, Urvashi Surti1,3, Paola Dal Cin4, Nancy Lee Harris2, and Robert P. Hasserjian2 1| 2
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;
Department of Pathology, Massachusetts General Hospital, Boston, MA, USA; 3Pittsburgh
Cytogenetics Laboratory, Magee-Women's Hospital of UPMC, Pittsburgh, PA, USA, and 4
Center for Advanced Molecular Diagnostics, Brigham and Women's Hospital,
Boston, MA, USA
Short title: SLL in the era of MBL Key words: chronic lymphocytic leukemia, small lymphocytic lymphoma, monoclonal B-cell lymphocytosis, MBL.
Correspondence Robert P. Hasserjian, Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 USA. Phone: international: +1.617.7241445. Fax: international +1.6177267474. E-mail:
[email protected]
1
DOI: 10.3324/haematol.2011.042333
ABSTRACT Background. In the 2008 World Health Organization Classification, small lymphocytic lymphoma is defined as a neoplasm with tissue morphology and immunophenotype of chronic lymphocytic leukemia, but with absence of leukemia. Minimal criteria of tissue involvement to separate small lymphocytic lymphoma from monoclonal B-cell lymphocytosis have not been defined. Design and Methods. We reviewed the clinicopathologic features of 36 patients with extramedullary tissue biopsies containing chronic lymphocytic leukemia-type cells and
