Medicine. 2015 Vol. 10 No. 07s. ISSN 1746-0751 part of. ⢠Meeting Abstracts. World Conference on Regenerative Medicine 2015. Congress Center Leipzig ...
Regenerative Medicine 2015 Vol. 10 No. 07s
ISSN 1746-0751
• Meeting Abstracts World Conference on Regenerative Medicine 2015 Congress Center Leipzig, Leipzig, Germany October 21–23 2015
part of
Oral Presentation
OP-051
3D printing of bone/cartilage substitutes based on bioceramics/polymers N. Sergeeva1, *V. Komlev2, I. Sviridova1, V. Kirsanova1, A. Fedotov2, A. Teterina2, Y. Zobkov2, S. Barinov2 P.A. Herzen Moscow Cancer Research Institute – National Medical Research Radiological Centre, Moscow, Russian Federation 2 Russian Academy of Sciences, A.A. Baikov Institute of Metallurgy and Materials ScienceA.A. Baikov Institute of Metallurgy and Materials Science, Moscow, Russian Federation 1
Development of individual biomedical products designed to restore function and regeneration of lost tissue in the extended (by volume) bone/cartilage defects, is one of the most important and urgent tasks of the practice of dentistry, maxillofacial surgery, orthopedics, oncology and neurosurgery. The major drawback of these products is the absence of freely modality that makes possible their fabrication as patient specific implants. One of the most promising, in our opinion, solutions of this problem is the combination of advanced additive technologies, providing a layered material synthesis (mainly based on calcium phosphates and biopolymers). In this study we demonstrate that combination of three-dimensional (3D) printing with post-treatment methodology is a suitable approach to overcome current limitations in effective and fast fabrication of individual constructions for guided bone/cartilage regeneration. We proposed and developed a relatively simple route and materials for 3D printing process, targeted to production of complexly shaped and structured calcium phosphate/biopolymers grafts. The 3D printed blocks were further investigated in vitro and implanted in the developed in ortopic model. It was shown that these blocks were non toxic, had adhesive (for cells) properties and as a result were cytocompatible. Histological evaluation revealed that 3D printed implants were biocompatible: material directly contacted with original tissue with very thin vascularisated fibrous capsule and slight connective tissue areas making them apart. Acknowledgments This work was supported by the Russian Ministry of Education and Science (agreement no. 14.604.21.0132).
