relating pet and csf measure of tau pathology - Alzheimer's & Dementia

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Tyler Blazey1, Yi Su1,2, Jon Christensen1, Jonathan McConathy4,. Patricia Aldea3, David M. Holtzman1,2,5, Nigel J. Cairns2,3,. John C. Morris2,3, Anne M.
Poster Presentations: Sunday, July 24, 2016

P513

Medicine, St. Louis, MO, USA; 2Knight Alzheimer’s Disease Research Center, St. Louis, MO, USA; 3Washington University School of Medicine, St. Louis, MO, USA; 4University of Alabama at Birmingham, Birmingham, AL, USA; 5Hope Center for Neurological Disorders, St. Louis, MO, USA; 6Hope Center for Neurological Disorders, St. Louis, MO, USA. Contact e-mail: [email protected] Background: The two primary pathologies in Alzheimer disease

Figure. Voxel-based comparisons of Flutametamol vs. PiB. Greater grey matter signal with both Flutametamol and PiB in AD vs eCN is seen (A). Greater white matter signal with Flutametamol vs PiB is seen in all groups (B; AD and yCN shown). Greater signal for both Flutametamol and PiB in eCN vs yCN is seen(C). (FDR corrected, p