OBJECTIVE: To evaluate the relationship between plasma leptin and the tumor necrosis factor-a (TNFa), TNF receptor p60 (TNF-R1) and TNF receptor p80 ...
International Journal of Obesity (1999) 23, 355±360 ß 1999 Stockton Press All rights reserved 0307±0565/99 $12.00 http://www.stockton-press.co.uk/ijo
Relationship between plasma leptin levels and the tumor necrosis factor-a system in obese subjects F Corica1*, A Allegra1, A Corsonello1, M Buemi1, G Calapai2, A Ruello1, V Nicita Mauro1 and D Ceruso1 1
Department of Internal Medicine, Division of Internal Medicine and Metabolic Diseases, Outpatient's Service for Prevention and Treatment of Obesity, School of Medicine, Policlinico Universitario, University of Messina, Via Consolare Valeria, I-98124 Messina, Italy; and 2Institute of Pharmacology, School of Medicine, University of Messina, Piazza XX Settembre 4, I-98122 Messina, Italy
OBJECTIVE: To evaluate the relationship between plasma leptin and the tumor necrosis factor-a (TNFa), TNF receptor p60 (TNF-R1) and TNF receptor p80 (TNF-R2) concentrations in obese subjects. DESIGN: Case-control study. SETTING: Outpatient's Service for Prevention and Treatment of Obesity at the University Hospital. MEASUREMENTS: Body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance (HOMA IR), plasma leptin, TNFaa, TNF-R1 and TNF-R2 concentrations were evaluated in obese subjects (n 42) and in age- and gendermatched, lean healthy controls (n 16). RESULTS: In obese subjects, fasting plasma glucose and insulin, HOMA IR, plasma leptin, TNFaa, TNF-R1 and TNF-R2 concentrations were signi®cantly higher than in controls. Furthermore, females showed higher leptin, TNF-R1 and TNF-R2 plasma concentrations compared to males, in both control and obese subjects. In control subjects, plasma 0.74, P< 0.94, P< leptin concentrations showed a direct correlation with BMI (r
