Relationship between Serum TNF Activity and Insulin ... - J-Stage

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focused on disorders of lipid metabolism. Recently, in animal models of obesity and insulin-resis- tant diabetes mellitus, it has been reported that tumor necro-.
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Internal Medicine

Relationship between Serum TNF Activity and Insulin Resistance in Dairy Cows Affected with Naturally Occurring Fatty Liver Hiromichi OHTSUKA1), Masateru KOIWA2), Atsushi HATSUGAYA5), Katsunori KUDO6), Fumio HOSHI1), Noboru ITOH2), Hiroshi YOKOTA3), Hiroyuki OKADA4) and Sei-ichi KAWAMURA1) 1)

Department of Veterinary Internal Medicine, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034–8628, 2)Large Animal Clinical Center, Veterinary Teaching Hospital, 3)Department of Veterinary Biochemistry and 4)Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, 5)Department of Iburi Agricultural Mutual Relief Association, Hayakita, Hokkaido 059–1433 and 6)Ishikari Agricultural Mutual Relief Association, Chitose, Hokkaido 034–8628, Japan (Received 19 July 2000/Accepted 11 May 2001)

ABSTRACT.

To clarify the relationship between tumor necrosis factor (TNF) and insulin resistance in dairy cows affected with fatty liver, naturally occurring cases were investigated. The affected cows were classified into following three groups according to histopathologic findings of the liver: mild fat droplet deposition (group 1; n=11), severe fat droplet deposition (group 2; n=10), and cloudy swelling (group 3; n=8). Serum TNF activities in Group 2 (8.67 ± 2.16 U/ml) and Group 3 (11.65 ± 1.92 U/ml) were significantly higher than that in Group 1 (3.57 ± 0.81 U/ml) (p