Research Article A Comparison between Use of

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CS (polyoxyethylated glycolysed glycerides), and Labrasol. (caprylocaproyl polyoxyl-8 glycerides) were purchased from. Gattefosse, India. Capmul MCM C8 ...
Hindawi Publishing Corporation BioMed Research International Volume 2013, Article ID 909045, 13 pages http://dx.doi.org/10.1155/2013/909045

Research Article A Comparison between Use of Spray and Freeze Drying Techniques for Preparation of Solid Self-Microemulsifying Formulation of Valsartan and In Vitro and In Vivo Evaluation Sanjay Kumar Singh, Parameswara Rao Vuddanda, Sanjay Singh, and Anand Kumar Srivastava Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India Correspondence should be addressed to Anand Kumar Srivastava; [email protected] Received 10 April 2013; Accepted 20 June 2013 Academic Editor: Umesh Gupta Copyright © 2013 Sanjay Kumar Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The objective of the present study was to develop self micro emulsifying formulation (SMEF) of valsartan to improve its oral bioavailability. The formulations were screened on the basis of solubility, stability, emulsification efficiency, particle size and zeta potential. The optimized liquid SMEF contains valsartan (20% w/w), Capmul MCM C8 (16% w/w), Tween 80 (42.66% w/w) and PEG 400 (21.33% w/w) as drug, oil, surfactant and co-surfactant, respectively. Further, Liquid SMEF was adsorbed on Aerosol 200 by spray and freeze drying methods in the ratio of 2 : 1 and transformed into free flowing powder. Both the optimized liquid and solid SMEF had the particle size