Original Research published: 06 February 2017 doi: 10.3389/fped.2017.00013
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Giuseppe Muscogiuri1,2*, Paolo Ciliberti3, Domenico Mastrodicasa4, Marcello Chinali3, Gabriele Rinelli3, Teresa Pia Santangelo1, Carmela Napolitano1, Benedetta Leonardi3 and Aurelio Secinaro1 for the MD Paedigree Study Investigators 1 Department of Imaging, Bambino Gesù – Children’s Hospital IRCCS, Rome, Italy, 2 Department of Clinical and Molecular Medicine, University of Rome “Sapienza”, Rome, Italy, 3 Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù – Children’s Hospital IRCCS, Rome, Italy, 4 Department of Neurosciences, Imaging and Clinical Sciences, Diagnostic Imaging and Therapy, University “G. D’Annunzio”, Chieti, Italy
Background: Little is known about the clinical value of late gadolinium enhancement (LGE), in children affected by dilated cardiomyopathy (DCM).
Edited by: Giovanni Biglino, University of Bristol, UK Reviewed by: Damiano Caruso, Sapienza University, Italy Mark Hamilton, University Hospitals Bristol, UK *Correspondence: Giuseppe Muscogiuri
[email protected] Specialty section: This article was submitted to Pediatric Cardiology, a section of the journal Frontiers in Pediatrics Received: 30 November 2016 Accepted: 19 January 2017 Published: 06 February 2017 Citation: Muscogiuri G, Ciliberti P, Mastrodicasa D, Chinali M, Rinelli G, Santangelo TP, Napolitano C, Leonardi B and Secinaro A (2017) Results of Late Gadolinium Enhancement in Children Affected by Dilated Cardiomyopathy. Front. Pediatr. 5:13. doi: 10.3389/fped.2017.00013
Frontiers in Pediatrics | www.frontiersin.org
Materials and methods: We retrospectively evaluated 15 patients (8 ± 6 years, 6 males) with diagnosis of DCM who underwent cardiac magnetic resonance since 2014. All scans were performed with a 1.5 T system (Aera, Siemens). Study protocol included cine steady-state free precession sequences, followed by administration of 0.2 mmol/kg of gadolinium-based contrast agent. Inversion recovery Turbo Flash sequences, in the same position of cine images, were acquired 10–15 min after the injection of contrast agent, in order to assess the presence of LGE. The latter was considered positive with a signal intensity >6 SD from normal myocardial tissue. Indexed end-diastolic volume (EDVi) and end-systolic volume (ESVi), and left ventricle (LV) ejection fraction (EF) were calculated by using dedicated software on off-line workstation. Global longitudinal strain and diastolic function were evaluated by echocardiography. Clinical follow-up, including death, transplant, and listing for heart transplant [major adverse cardiac events (MACE)], were evaluated. Patients were divided into two different subgroups: negative (Group A) and positive (Group B) for presence of LGE. Statistical analysis was performed by using Mann–Whitney U test (p 2 and LV EF
