Risk factors for cervical intraepithelial neoplasia

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Mar 12, 2017 - Zhilian Wang1*; Jintao Wang2*; Jinrong Fan3*; Weihong Zhao1; Xin Yang1; ... Junjie Xu1; Michelle Stram4; Chengquan Zhao4; Min Hao1✉. 1.
Journal of Cancer 2017, Vol. 8

924

Ivyspring

Journal of Cancer

International Publisher

2017; 8(6): 924-932. doi: 10.7150/jca.17416

Research Paper

Risk factors for cervical intraepithelial neoplasia and cervical cancer in Chinese women: large study in Jiexiu, Shanxi Province, China Zhilian Wang1*; Jintao Wang2*; Jinrong Fan3*; Weihong Zhao1; Xin Yang1; Lingmei Wu3; Dongyan Li1; ling Ding2; Wei Wang1; Junjie Xu1; Michelle Stram4; Chengquan Zhao4; Min Hao1 1. 2. 3. 4.

Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China. Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, China. Jiexiu Family Planning/Women and Children Health Service Center, Jinzhong, China. Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center. 300 Halket St, Pittsburgh, PA, 15213, USA.

* These authors contributed equally to this work.  Corresponding author: Min Hao, MD. Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, China. Email address: [email protected]; Fax: +86 3513362866 © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

Received: 2016.08.31; Accepted: 2016.12.22; Published: 2017.03.12

Abstract We aimed to investigate the risk factors for cervical intraepithelial neoplasia (CIN) in Jiexiu, Shanxi Province, China. Twenty thousand eligible married women (age: 18–65 years) were administered with a questionnaire on potential risk factors for CIN and underwent liquid based Pap test. All women with abnormal cytological results underwent colposcopy with biopsy. Based on the biopsy pathology results, women were then assigned to either study group (with CIN) or control group (negative for histological results and volunteered to participate in the follow up study). The women in both study group and control group underwent vaginal microflora detection and dietary survey. The potential risk factors were analyzed by using ordinal logistic regression. Among the 20,000 women ne 1,438 women (7.19%) had cytologic abnormalities and 410 (2.05%) women were diagnosed histologically with CIN lesions, including 317 (1.58%) with CIN1, 93 (0.50%) with CIN2/3and 11 (55/100,000) with squamous cell carcinoma (SCC). The average daily dietary folate intake was significantly lower in the study group (344.61±153.07μg) than in the control group (371.50±166.58μg; P

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