RONALD E. KUMON - kumonweb.com

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Graduate Student Travel Awards (Grantee: R. E. Kumon). 1997, 1999 .... J. Park, Z. Fan, R. E. Kumon, M. E. El-Sayed, and C. X. Deng. 2010. Modulation of ...
RONALD E. KUMON Department of Biomedical Engineering, University of Michigan, 2117 Carl A. Gerstacker Bldg., 2200 Bonisteel Blvd., Ann Arbor, MI 48109–2099 Voice: 734–763–5448 • Fax: 734–936–1905 • U.S. Citizen [email protected] • http://www.kumonweb.com/ron/pro/ EDUCATION The University of Texas at Austin (UT-Austin), Austin, Texas 1992–1999 Ph.D. in Physics with specialization in physical acoustics (Prof. Mark Hamilton, advisor) Michigan State University (M.S.U.), East Lansing, Michigan B.S. with Honors in Physics and Mathematics

1988–1992

RESEARCH INTERESTS Biomedical Ultrasound Therapeutic ultrasound for ultrasound-mediated drug & gene delivery High-intensity focused ultrasound (HIFU) for tissue ablation High-frequency ultrasound microscopy for biomaterials characterization Diagnostic ultrasound imaging and tissue characterization Ultrasound contrast agents and cavitation bioeffects Biophysics Mechanotransduction of cells and its effect on signalling pathways Cellular membrane damage and repair Mathematical modeling of ion transport in cells Tissue biomechanics Physical and Applied Acoustics Nonlinear acoustics of fluids, solids, and bubbles Surface acoustic wave propagation Acoustical materials characterization of thin-film systems RESEARCH EXPERIENCE Research Investigator (research faculty), Department of Biomedical Engineering 2010–present University of Michigan (U-M), Ann Arbor, Michigan Performing experimental investigations in area of biomedical ultrasound, including therapeutic applications of high-intensity focused ultrasound (HIFU). Supervising graduate and undergraduate students. Current studies include: • Infrared imaging for thermal characterization of HIFU lesions in ex vivo cardiac tissue • High-speed optical mapping of ex vivo heart electrophysiology during HIFU therapy • Ultrasound backscatter imaging of pancreatic disease in vivo with linear-array transducers • Quantitative analysis of photoacoustic imaging data from prostate cancer implants in vivo • High-frequency ultrasound imaging for characterization of engineered tissue constructs

Curriculum Vitae

R. E. Kumon

01/2011

Senior Research Associate, Department of Biomedical Engineering 2007–2010 University of Michigan (U-M), Ann Arbor, Michigan Investigated experimental applications of biomedical ultrasound. Supervised undergraduate students and assisted in building up a new laboratory. Studies included: • Ultrasound-mediated cell membrane disruption (sonoporation) with microbubbles • In vivo ultrasound backscatter imaging of cancerous pancreatic & lymph tissue • Ultrasound-mediated Ca2+ oscillations and waves via epi-fluorescence microscopy • Manipulation of bubbles and cells using acoustical, optical, and microfluidic technologies Senior Research Associate, Department of Biomedical Engineering (BME) 2005–2006 Case Western Reserve University (CWRU), Cleveland, Ohio Performed theoretical and experimental studies in biomedical ultrasound. Helped to supervise graduate students in experiments, modeling, and technical communication. Studies included: • Sonoporation-induced ion transport modeling in cells • In vivo ultrasound backscatter imaging of human upper gastrointestinal tract (pilot study) • In vivo high-frequency imaging and strain determination of cardiac tissue in small animals Postdoctorate Fellow & Lecturer, Department of Physics 2003–2005 University of Windsor, Windsor, Ontario, Canada Performed research in biomedical and physical applications of ultrasound. Helped to supervise undergraduate and graduate students and prepared grant proposals. Studies included: • Ex vivo breast tumor characterization with acoustical microscopy • Acoustical harmonic generation via photo-acoustoelectric effect in a piezo-semiconductor • X-ray spectra measurements and modeling during surface acoustic wave (SAW) propagation Physicist, Materials Reliability Division, Material Science & Engineering Laboratory 2001–2002 National Institute of Standards & Technology (NIST), Boulder, Colorado Studied applications of surface acoustic waves for materials characterization including: • Residual-stress effects on linear and nonlinear SAW propagation • Elastic moduli determination in thin-film systems with residual stress via SAW spectroscopy • Laser-generated, finite-amplitude SAW pulse modeling and measurements Postdoctoral Fellow, Industrial Acoustics Group, Signal Physics Laboratory 1999–2000 Applied Research Laboratories, UT-Austin (ARL:UT), Austin, Texas Conducted studies on various projects involving industrial applications of acoustics including: • Acoustical agglomeration of airborne particulate (coal fly ash) • Thermal and acoustic properties of high-temperature gases • Nondestructive evaluation of adhesive bonds using ultrasound Graduate Research Assistant, Dept. of Mechanical Engineering, UT-Austin 1996–1999 Performed theoretical and computational modeling of nonlinear SAWs in various surface cuts of cubic crystals. Provided novel interpretation of complex-valued nonlinearity in terms of harmonic phase effects and corroborated theory with laser-generated, high-strain pulses in Si. Wrote and defended dissertation entitled “Nonlinear surface acoustic waves in cubic crystals.” Research Scientist Assistant, ARL:UT, Austin, Texas 1993–1996 Studied nonlinear thermoacoustic instability of heat-driven gas flow in a Rijke tube.

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RESEARCH SUPPORT National Institutes of Health R01 Grant (PI: C.X. Deng) 2008–present National Institute of Biomedical Imaging and Bioengineering (EB008999) “Advanced Ultrasound Ablation Therapy for Atrial Fibrillation” Goal: To develop efficient and safe high-intensity focused ultrasound (HIFU) ablation technology for treating atrial fibrillation (AF) by the means of intraoperative or thoracoscopic operation. Role: Research Associate (60–100% effort) Research, Outcomes, and Effectiveness Award (PI: F. T. Farooq) 2007 American Society for Gastrointestinal Endoscopy “Tissue Characterization by Endoscopic Ultrasound Spectrum Analysis” Goal: To characterize pancreatic disease and lymph node malignancy by application of spectrum analysis to radio-frequency data from an endoscopic ultrasound system. Role: Co-investigator (30% effort) National Institutes of Health R01 Grant (PI: C. X. Deng) 2005–2010 National Cancer Institute (CA116592) “Mechanisms of Ultrasound Mediated Intracellular Drug and Gene Delivery” Goal: To develop robust and reliable ultrasound strategy for intracellular delivery of desirable agents (e.g. drugs, genes, imaging markers) for biomedical applications such as targeted cancer treatment, molecular imaging, and gene therapy. Role: Research Associate (20–100% effort) NSERC Industrial Research Chair (PI: R. Gr. Maev)

2003–2005

Natural Sciences and Engineering Research Council (Canada), DaimlerChrysler, Univ. of Windsor “Industrial Research Chair in Applied Solid State Physics and Material Characterization” Goal: To perform research and development of high-frequency acoustic and acousto-optic imaging systems and research in advanced principles and methods for the imaging and qualitative characterization of surface, sub-surface and bulk materials structure. Role: Research Associate (100% effort) NRC/NIST Research Associateship (PI: R. E. Kumon) 2001–2002 National Research Council and National Institute of Standards & Technology “Nonlinear surface Acoustic Waves in Thin-Film Systems with Residual Stress” Goal: To study the effects of residual stress on linear and nonlinear surface acoustic wave (SAW) propagation in thin-film systems for purposes of stress characterization Role: Principle Investigator (100% effort) Graduate Student Travel Awards (Grantee: R. E. Kumon) Acoustical Society of America Goal: To present dissertation work at professional conferences

1997, 1999

TEACHING EXPERIENCE Adjunct Professor, Dept. of Natural Sciences, Lawrence Technological University 2010 Introductory physics laboratory with primarily engineering students (University Physics 2). Topics covered included sound, light, electricity, electric circuits, and magnetism. Prepared short lectures, assisted student experiments, graded lab reports, maintained Blackboard pages. 3

Curriculum Vitae

R. E. Kumon

01/2011

Guest Lecturer, Dept. of Biomedical Engineering, University of Michigan 2009–2011 Gave guest lectures in undergraduate classes on biotransport and graduate courses on (1) ultrasound in drug and gene delivery and (2) cell and microenvironment engineering with microtechnology and ultrasound. Guest Lecturer, Dept. of Radiology, Case Western Reserve University 2006–present Ultrasound physics, imaging, and technology lectures for radiology residents. Reviewed and prepared sample test questions and answered questions from students. Condensed Matter Physics Lecturer, Dept. of Physics, University of Windsor 2003–2005 Solid state physics course (3 joint undergraduate/graduate sections over 3 semesters). Designed course curriculum, chose supplementary readings, prepared lectures, assigned traditional and computer-based homework, and graded student papers, peer reviews, presentations, & exams. Designed web site to post syllabus, lectures, assignments, and other course-related information. Teaching Assistant, Dept. of Physics, The University of Texas at Austin 1995 Fluid mechanics course (1 graduate section). Graded homework and prepared solutions. Laboratory Teaching Assistant, Dept. of Physics, The University of Texas at Austin 1992–1993 Mechanics laboratories (6 sections over 2 semesters). Prepared lectures, demonstrated experiments, wrote quizzes and tests, and graded lab reports. Teaching Assistant, Dept. of Mathematics, Michigan State University 1990–1991 Multivariate calculus recitation (3 undergraduate sections over 3 quarters). Worked problems & answered questions, prepared short lectures, and proctored exams. MENTORING EXPERIENCE Student Advisor, Graduate Research, Dept of BME, University of Michigan 2010–present Co-advising doctoral students during research on applications of high-intensity focused ultrasound. Co-supervisor, Undergraduate Research, Dept of BME, University of Michigan 2009 Co-supervised senior undergraduate during research project on ultrasound phantom creation and characterization. Supervisor, Undergraduate Research, Dept of BME, University of Michigan 2008–2009 Supervised senior undergraduate during research project on microfluidic confinement of microbubbles. Co-supervisor, Senior Design Class Team, Dept of BME, University of Michigan

2008

Co-supervised team of six undergraduate students in senior design class in the design and prototype construction of a fiber-optic imager using a gradient-index lens. Co-supervisor, Undergraduate Research, Dept of BME, University of Michigan 2008 Co-supervised senior undergraduate during directed research project studying the imaging of microbubbles and microbeads in microfluidic channels. Student Advisor, Dept of BME, Case Western Reserve University 2005–2006 Co-supervised master's student research on calcium imaging experiments and simulations on calcium transport. Helped to advise another master's student on thesis project.

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Student Advisor, Dept. of Physics, University of Windsor

01/2011 2003–2005

Helped to advise three master's students during their thesis research. Also supervised undergraduate and high school students during summer research projects. Supervisor, Summer Research Project, Applied Research Laboratories, UT-Austin

2000

Supervised senior undergraduate studying the acoustical characterization of adhesive bond strength in linearly and nonlinearly bonded solids. EDUCATIONAL OUTREACH Science Advisor, Earth & Sky Radio Program, Austin, Texas Assisted in preparation of program scripts by answering physics questions.

1997–1998

Guest Lecturer, Hartland High School, Hartland, Michigan 1992, 2000 Gave lecture to advanced placement chemistry students on quantum mechanics. Talked to physics class about studies and careers in physical sciences and engineering. Science Theatre, Dept. of Physics & Astronomy, Michigan State University 1991–1992 Assisted in giving demonstrations to students and general public about physics. Answered science question for a newspaper column in the Lansing State Journal. SERVICE Acoustics Seminar Administrator, Dept. of Mechanical. Engineering, UT-Austin 1997 Arranged speakers for 12 acoustics seminars during the Fall 1997 semester. Organized publicity via posters, email, and web site and prepared training manual for future administrators. Representative, Graduate Student Assembly, UT-Austin 1993–1998 Represented the Department of Physics at meetings of the university-wide graduate student organization. Prepared and distributed meeting summaries to department. Established and maintained electronic mailing lists and newsgroup. President, Society of Physics Students, Michigan State University Chapter 1991–1992 Revived local S.P.S. chapter by increasing paid members from zero to twenty. Wrote chapter constitution and executive officer job descriptions. Coordinated monthly meetings with invited speakers. Wrote and published chapter newsletter. Promoted physics to prospective students. PROFESSIONAL ACTIVITIES Technical Reviewer Cancer Research Ultrasound in Medicine and Biology IEEE Transactions on Ultrasonics, Frequency Control, & Ferroelectrics Journal of the Acoustical Society of America Composites Science and Technology Journal of Materials Research Canadian Journal of Physics International Journal of Solids and Structures National Institute of Standards and Technology 5

2010 2008–present 2006 2003–2004 2004 2003 2003 2002 2001–2004

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01/2011

Guest Seminars Dept. of Pathology, University of Western Ontario, London, Ontario Ultrasound Research Laboratory, Mayo Clinic, Rochester, Minnesota Dept. of Mechanical Engineering, UT-Austin, Austin, Texas Department of Physics, University of Windsor, Windsor, Ontario Optical Engineering Group, University of Nottingham, United Kingdom Department of Physics, Texas A&M University, College Station, Texas Idaho National Engineering & Environmental Lab., Idaho Falls, Idaho Institute of Physical Chemistry, University of Heidelberg, Germany Fraunhofer Institute for Nondestructive Testing, Saarbrücken, Germany Materials Reliability Division, NIST, Boulder, Colorado

2004 2004 2003 2002 2002 2002 2002 2001 2001 2000

Session Chair 147th Acoustical Society of America Meeting, New York, New York 142nd Acoustical Society of America Meeting, Fort Lauderdale, Florida

2004 2001

PROFESSIONAL AFFILIATIONS International Contrast Ultrasound Society (ICUS), Member

2008–present

International Society for Therapeutic Ultrasound (ISTU), Member

2006–present

Institute of Electrical and Electronics Engineers (IEEE), Member Ultrasound, Ferroelectrics, & Frequency Control Society Engineering in Medicine and Biology Society

2002–present

American Physical Society (APS), Member Divisions: Biological Physics, Computational Physics, Materials Physics Forums: Education, Industrial & Applied Physics, Physics & Society

1998–present

Acoustical Society of America (ASA), Full Member 1992–present Technical Committee: Biomedical Ultrasound/Bioresponse to Vibration (2007 to 2010) ADMINISTRATIVE EXPERIENCE (NON-TECHNICAL) Secretary, Wildflower Homeowners Association, Louisville, Colorado 2001–2002 Recorded minutes for meetings of the Board of Directors of local homeowners' association. Established $160,000 annual budget, managed investment of $170,000 in reserves, planned for capital improvements, reviewed contracts and audits, and developed policies. Chairman, Board of Directors, College Houses, Austin, Texas 1999–2000 Presided over meetings of the Board of Directors for student housing corporation. Reviewed $2,000,000 annual budget, led organizational audit, developed corporate policy, ruled on grievances, and worked as a liaison between staff and board members. Director, Laurel House Cooperative, College Houses, Austin, Texas 1997–1998 Managed student-run housing complex of 45 residents. Supervised and trained staff of 12 officers and directly monitored an annual budget of $120,000. Developed a 100+ page policy manual.

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PEER-REVIEWED PUBLICATIONS 1. J. Park, Z. Fan, R. E. Kumon, M. E. El-Sayed, and C. X. Deng. 2010. Modulation of intracellular calcium concentration in brain microvascular endothelia cells in vitro by acoustic cavitation. Ultrasound in Medicine and Biology 36:1176–1187. 2. Z. Fan, R. E. Kumon, J. Park, and C. X. Deng. 2010. Intracellular delivery and calcium transients generated in sonoporation facilitated by microbubbles. Journal of Controlled Release 142:31–39. 3. R. E. Kumon, M. J. Pollack, A. L. Faulx, K. Olowe, F. T. Farooq, V. K. Chen, Y. Zhou, R. C. K. Wong, G. A. Isenberg, M. V. Sivak, A. Chak, C. X. Deng. 2010. In vivo characterization of pancreatic and lymph node tissue using endoscopic ultrasound spectrum analysis: Validation study. Gastrointestinal Endoscopy 71:53–63. 4. Y. Zhou, R. E. Kumon, J. Cui, and C. X. Deng. 2009. The size of sonoporation pores on the cell membrane. Ultrasound in Medicine and Biology 35:1756–1760. 5. R. E. Kumon, M. Aehle, D. Sabens, P. Parikh, Y. W. Han, D. Kourennyi, and C. X. Deng. 2009. Spatiotemporal effects of sonoporation measured by real-time calcium imaging. Ultrasound in Medicine and Biology 35:494–506. 6. R. E. Kumon, K. Olowe, A. L. Faulx, F. T. Farooq, V. K. Chen, Y. Zhou, R. C. K. Wong, G. A. Isenberg, M. V. Sivak, A. Chak, and C. X. Deng. 2007. EUS spectrum analysis for in vivo characterization of pancreatic and lymph node tissue: A pilot study. Gastrointestinal Endoscopy 66:1096–1106. 7. R. E. Kumon, M. Aehle, D. Sabens, P. Parikh, D. Kourennyi, and C. X. Deng. 2007. Ultrasoundinduced calcium oscillations and waves in Chinese hamster ovary cells in the presence of microbubbles. Biophysical Journal. 93:L29–L31. 8. J. Xu, C. Zhang, Y. Zhou, R. E. Kumon, and T. Goetz. 2007. Evaluation of left ventricular structure and function types in rate heart myocardial infarction model using wideband high frequency echocardiography. Chinese Journal of Medical Ultrasound (Electronic Version). 4:200–204. 9. R. E. Kumon and D. C. Hurley. 2005. Effects of residual stress on the thin-film elastic moduli calculated from surface acoustic wave spectroscopy experiments. Thin Solid Films. 484:251–256. 10. R. Tucoulou, V. Mocella, O. Mathon, C. Ferrero, D. V. Roshchupkin, and R. E. Kumon. 2005. Investigation of surface acoustic wave fields in silicon crystals by x-ray diffraction: A dynamical theory approach. Journal of Applied Physics. 97:113505. 11. A. M. Lomonosov, P. Hess, R. E. Kumon, and M. F. Hamilton. 2004. Laser-generated nonlinear surface wave pulses in silicon crystals. Physical Review B. 69:035314. 12. R. E. Kumon and M. F. Hamilton. 2003. Nonlinear coupling of surface and quasitransverse bulk modes in cubic crystals. Journal of the Acoustical Society of America. 113:3060–3064. 13. R. E. Kumon and M. F. Hamilton. 2003. Effects of harmonic phase on nonlinear surface acoustic waves in the (111) plane of cubic crystals. Journal of the Acoustical Society of America. 113:1293– 1303. 14. R. E. Kumon and M. F. Hamilton. 2002. Directional dependence of nonlinear surface acoustic waves in the (001) plane of cubic crystals. Journal of the Acoustical Society of America. 111:2060– 2069. 7

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01/2011

PROCEEDINGS 1. R. E. Kumon, C. X. Deng, X. Wang. 2011. Spectrum analysis of photoacoustic imaging data from prostate adenocarcinoma tumors in a murine model. In Photons Plus Ultrasound: Imaging and Sensing 2011, Proceedings of SPIE Vol. 7899. A. A. Oraevsky, L. V. Wang, editors. SPIE, Bellingham, WA (in press). 2. R. E. Kumon, Y. Zhou, K. Yang, C. X. Deng. 2009. Spectral analysis of ultrasound backscatter for characterization of HIFU lesions in cardiac tissue with high-frequency imaging. In 2009 IEEE International Ultrasonics Symposium. M. P. Yuhas, editor. IEEE, Piscataway, NJ. 244–247. 3. (Invited) R. E. Kumon, M. J. Pollack, A. L. Faulx, K. Olowe, F. T. Farooq, V. K. Chen, Y. Zhou, R. C. K. Wong, G. A. Isenberg, M. V. Sivak, A. Chak, C. X. Deng. 2009. Characterization of pancreatic cancer and intra-abdominal lymph node malignancy using spectrum analysis of endoscopic ultrasound imaging. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, Piscataway, NJ. 1949–1952. 4. Y. Zhou, R. E. Kumon, C. X. Deng, J. Cui. 2008. The size of sonoporation pores on the cell membrane. In 2008 IEEE International Ultrasonics Symposium. K. R. Waters, editor. IEEE, Piscataway, NJ. 558–561. 5. R. E. Kumon, P. Parikh, D. Sabens, M. Aehle, D. Kourennyi, and C. X. Deng. 2007. Measuring and modeling sonoporation dynamics in mammalian cells via calcium imaging. In Proceedings of the 6th International Symposium Therapeutic Ultrasound. C.-C. Coussios and G. ter Haar, editors. AIP Conference Proceedings 911. AIP, Melville, NY. 484–491. 6. I. Bruno, R. E. Kumon, B. Heartwell, E. Maeva, and R. Gr. Maev. 2007. Ex vivo breast tissue imaging and characterization using acoustic microscopy. In Acoustical Imaging. M. André. Springer, New York. 28:279–287. 7. W. Arthur, R. E. Kumon, F. Severin, and R. Gr. Maev. 2006. Acoustoelectric harmonic generation in a photoconductive piezoelectric semiconductor. In Innovations in Nonlinear Acoustics: 17th International Symposium on Nonlinear Acoustics. A. A. Atchley, V. W. Sparrow, and R. F. Keolian, editors. AIP Conference Proceedings 838. AIP, Melville, NY. 135–138. 8. R. E. Kumon. 2002. Nonlinear SAW propagation in thin-film systems with residual stress. In 2002 IEEE International Ultrasonics Symposium. D. E. Yuhas and S. C. Schneider, editors. IEEE, Piscataway, NJ. 1:419–422. 9. R. E. Kumon, M. F. Hamilton, P. Hess, A. Lomonosov, and V. G. Mikhalevich. 2000. Dependence of surface acoustic wave nonlinearity on propagation direction in crystalline silicon. In Nonlinear Acoustics at the Turn of the Millenium: 15th International Symposium on Nonlinear Acoustics. W. Lauterborn and T. Kurz, editors. AIP Conference Proceedings 524. AIP, Melville, NY. 265–268. 10.R. E. Kumon, M. F. Hamilton, Yu. A. Il'inskii, E. A. Zabolotskaya, P. Hess, A. Lomonosov, and V. G. Mikhalevich. 1998. Pulsed nonlinear surface acoustic waves in crystals. In Proceedings of the 16th International Congress on Acoustics and 135th Meeting of the Acoustical Society of America. P. K. Kuhl and L. A. Crum, editors. Acoustical Society of America, Woodbury, New York. 1557– 1558.

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PROPRIETARY REPORTS 1. E. Yu. Bakulin, R. E. Kumon, et al. 2004. Tessonics acoustical microscope user's guide. Centre for Imaging Research and Advanced Materials Characterization, University of Windsor, Windsor, Ontario, Canada (90 p.). 2. R. E. Kumon and C. A. Mouton. 2000. Modelling the acoustical characterization of adhesive bond strength in linearly and nonlinearly bonded solids. Applied Research Laboratories, Austin, Texas. 3. G. D. Meegan, T. Hawkins, C. Peterson, R. Kumon, and J. Gantt. 2000. Acoustic agglomeration in coal-fired power plants: Phase II—Laboratory proof of concept. Applied Research Laboratories, Austin, Texas. ABSTRACTS 1. T. M. Krupka, H. Wu, R. Wilson, Y. Zhou, R. E. Kumon, C. X. Deng, and A. A. Exner. 2010. Development of echogenic nanobubbles for ultrasound molecular imaging. In 2010 World Molecular Imaging Congress program (http://www.wmicmeeting.org/2010/Abstracts/Start.htm). 2. R. E. Kumon, M. Atkinson, A. L. Faulx, B. Wolf, R. C. Wong, G. A. Isenberg, Y.-S. Hsiao, Y. Zhou, C. X. Deng, A. Chak. 2010. Characterization of pancreas and lymph nodes by endoscopic ultrasound spectrum analysis using single-element and electronic-array echoendoscopes. Gastrointestinal Endoscopy. 71:AB120–121. 3. Z. Fan, J. Park, R. E. Kumon, C. X. Deng. 2009. Sonoporation outcome correlated with timeresolved measurements of microbubble dynamics. In 9th International Symposium on Therapeutic Ultrasound: Final Program. 74. 4. R. E. Kumon, M. J. Pollack, A. L. Faulx, K. Olowe, F. T. Farooq, V. K. Chen, Y. Zhou, R. C. K. Wong, G. A. Isenberg, M. V. Sivak, A. Chak, C. X. Deng. 2009. Characterization of pancreatic cancer and intra-abdominal lymph node malignancy using spectrum analysis of in vivo endoscopic ultrasound imaging. Ultrasonic Imaging. 31:39–40. 5. A. L. Faulx, R. E. Kumon, M. J. Pollack, R. C. K. Wong, G. A. Isenberg, B. Wolf, F. T. Farooq, Y. Zhou, C. X. Deng, A. Chak. Validation of tissue characterization by endoscopic ultrasound spectrum analysis in differentiating pancreatic adenocarcinoma from normal pancreas. Gastrointestinal Endoscopy. 69:S241. 6. (Invited) R. E. Kumon and C. X. Deng. 2007. Spatiotemporal response of mammalian cells to sonoporation measured using calcium imaging. Journal of the Acoustical Society of America. 122:2956(A). 7. K. Olowe, R. Kumon, F. T. Farooq, Y. Zhou, V. K. Chen, A. L. Faulx, G. A. Isenberg, M. V. Sivak, C. Deng, A. Chak. 2007. Pancreatic tissue characterization by endoscopic ultrasound (EUS) spectrum analysis. Gastrointestinal Endoscopy 65:AB195. 8. K. Olowe, R. Kumon, F. T. Farooq, Y. Zhou, V. K. Chen, A. L. Faulx, G. A. Isenberg, M. V. Sivak, A. Chak, C. Deng. 2007. Differentiation of benign and malignant lymph nodes by endoscopic ultrasound (EUS) spectrum analysis. Gastrointestinal Endoscopy 65:AB194. 9. R. E. Kumon, I. Bruno, B. Heartwell, and E. Maeva. 2004. Breast tissue characterization with high-frequency acoustic microscopy. Journal of the Acoustical Society of America. 115:2376(A).

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10. R. E. Kumon, D. C. Hurley, and V. K. Tewary. 2003. Effects of residual stress on surface acoustic wave spectroscopy measurements of thin-film elastic moduli. Bulletin of the American Physical Society. 48:572–573. 11. A. Lomonosov, P. Hess, R. E. Kumon, and M. F. Hamilton. 2001. Periodicity of linear and nonlinear surface acoustic wave parameters in the (111) plane of cubic crystals. Journal of the Acoustical Society of America. 110:2702(A). 12. (Invited) G. D. Meegan, C. E. Peterson, and R. E. Kumon. 2001. Acoustic agglomeration experiments and modeling. Journal of the Acoustical Society of America. 110:2676. 13. R. E. Kumon and M. F. Hamilton. 2000. A simple method for comparing waveform distortion of nonlinear surface waves in different cubic crystals. Journal of the Acoustical Society of America. 107:2912(A). 14. R. E. Kumon, M. F. Hamilton, Yu. A. Il'inskii, and E. A. Zabolotskaya. 1998. Dependence of surface wave nonlinearity on propagation direction in crystalline silicon. Journal of the Acoustical Society of America. 104:1815(A). 15. R. E. Kumon, M. F. Hamilton, Yu. A. Il'inskii, E. A. Zabolotskaya, P. Hess, A. Lomonosov, and V. G. Mikhalevich. 1998. Pulsed nonlinear surface waves in crystals. Journal of the Acoustical Society of America 103:2926(A). 16. R. E. Kumon, M. F. Hamilton, Yu. A. Il'inskii, E. A. Zabolotskaya. 1997. Modeling of harmonic generation and shock formation in nonlinear surface acoustic waves in several real crystals. Journal of the Acoustical Society of America 102:3064(A). 17. R. E. Kumon. 1994. A nonlinear analysis of a simple thermoacoustic system. Journal of the Acoustical Society of America 96:3220(A). PRESENTATIONS AND POSTERS 1. Poster. 2011. Photoacoustic spectral analysis: a pilot study on human prostate cancer xenografts. Photons Plus Ultrasound: Imaging and Sensing 2011, BiOS Symposium, 2011 SPIE Photonics West conference, San Francisco, CA. 2. Presentation. 2009. Spectral analysis of ultrasound backscatter for characterization of HIFU lesions in cardiac tissue with high-frequency imaging. 2009 IEEE Ultrasonics Symposium, Rome, Italy. 3. Invited Presentation. 2009. Characterization of pancreatic cancer and intra-abdominal lymph node malignancy using spectrum analysis of endoscopic ultrasound imaging. 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, Minnesota. 4. Presentation. 2009. Characterization of pancreatic cancer and intra-abdominal lymph node malignancy using spectrum analysis of in vivo endoscopic ultrasound imaging. 34th International Symposium on Ultrasonic Imaging and Tissue Characterization, Arlington, Virginia. 5. Invited Presentation. 2007. Spatiotemporal response of mammalian cells to sonoporation measured using calcium imaging, 154th Meeting of the Acoustical Society of America, New Orleans, Louisiana. 6. Poster. 2006. Measuring and modeling sonoporation dynamics in mammalian cells via calcium imaging. 6th International Symposium on Therapeutic Ultrasound, Oxford, England.

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7. Poster. 2005. Ex vivo breast tissue imaging and characterization using acoustic microscopy. 28th International Symposium on Acoustical Imaging, San Diego, California. 8. Presentation. 2004. Breast tissue characterization with high-frequency acoustic microscopy. 147th Meeting of the Acoustical Society of America, New York, New York. 9. Presentation. 2003. Effects of residual stress on surface acoustic wave spectroscopy measurements of thin-film elastic moduli. American Physical Society March Meeting, Austin, Texas. 10. Poster. 2002. Nonlinear SAW propagation in thin-film systems with residual stress. 2002 IEEE Ultrasonics Symposium, Munich, Germany. 11. Poster. 2002. Effects of residual stress on linear and nonlinear surface acoustic waves in thin film systems. Gordon Conference on Thin Film Mechanical Behavior, Waterville, Maine. 12. Poster. 2001. Nonlinear surface acoustic waves in cubic crystals. Ultrasonics International 2001, Delft, The Netherlands. 13. Presentation. 2001. Nonlinear surface acoustic waves in cubic crystals. 6th International Workshop on Nonlinear Elasticity in Materials, Leuven, Belgium. 14. Presentation. 2001. Periodicity of linear and nonlinear surface acoustic wave parameters in the (111) plane of cubic crystals. 142nd Meeting of the Acoustical Society of America, Fort Lauderdale, Florida. 15. Presentation. 2000. A simple method for comparing waveform distortion of nonlinear surface waves in different cubic crystals. 139th Meeting of the Acoustical Society of America, Atlanta, Georgia. 16. Presentation. 1998. Dependence of surface wave nonlinearity on propagation direction in crystalline silicon. Journal of the Acoustical Society of America. 136th Meeting of the Acoustical Society of America, Norfolk, Virginia. 17. Presentation. 1998. Pulsed nonlinear surface waves in crystals. 16th International Congress on Acoustics and 135th Meeting of the Acoustical Society of America, Seattle, Washington. 18. Presentation. 1997. Modeling of harmonic generation and shock formation in nonlinear surface acoustic waves in several real crystals. 134th Meeting of the Acoustical Society of America, San Diego, California. 19. Presentation. 1994. A nonlinear analysis of a simple thermoacoustic system. 128th Meeting of the Acoustical Society of America, Austin, Texas. CONTINUING EDUCATION Electrophysiology Fellows Conference, Univ. of Michigan, Ann Arbor, MI Introduction to Engineering Education Research, Univ. of Michigan, Ann Arbor, MI Biological Micro Electro Mechanical Systems Workshop, EMBC, Minneapolis, MN Midwest Biomedical Engineering Conference, Ann Arbor, MI Preparing Future Faculty Conference, Univ. of Michigan, Ann Arbor, Michigan Applied Biostatistics in Clinical Research Lectures, CWRU, Cleveland, Ohio Funding Seminars, Office of Sponsored Projects, CWRU, Cleveland, Ohio Advances in Convection-Enhanced Drug Delivery, Cleveland Clinic, Cleveland, Ohio Biochemistry, Organic Chemistry, & Cell Biology, Univ. of Windsor, Windsor, Ontario 11

2010–present 2010 2009 2009 2007 2006 2006 2006 2004–2005

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R. E. Kumon

APS Opportunities in Biology for Physicists Topical Conference, San Diego, California NSF Surface Analysis Workshop, Kettering University, Flint, Michigan Gordon Conference on Thin Film Mechanical Behavior, Waterville, Maine 6th International Workshop on Nonlinear Elasticity in Materials, Leuven, Belgium Physical Acoustics Summer School, Pacific Grove, California

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