The CeloNova COBRA PzF⢠Coronary Stent is a new stent design, balloon ... COBRA BMS group, with a complete and rapid reendothelialization at day 7 that ...
Evaluation of reendothelialization and thrombus formation with Polyzene-F nanocoated Cobra stent Ipsum in consectetuer Proin in sapien. Proin in sapien. Fusce urna magna neque egeuat vita consectetuer Proin in sapien. Proin in sapien. Fusce urna magna egeuat.
8 janvier 2014 Hall de l’université 20 h
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In vivo results of stented rabbit iliac arteries L u c M a i l l a r d , M D , P h D 1; D e l p h i n e C o r s e a u x , P h D 2; A l e x a n d r e A l t i é 3; A l e x U n g 2; J o ë l C o u r a g e o t , P h D 3 ; E m m a n u e l Te i g e r, M D , P h D 4 ; E r i c V a n B e l l e , M D , P h D 5 1:GCS Axium-Rambot-Aix en Provence ; 2:EA2693 Université Lille Nord de France 3:Service Commun de Microscopie Electronique, Faculté de Médecine La Timone-Marseille ; 4:CHU Henri Mondor - Créteil ; 5:CHRU-Lille
Background: Why do we need short DAPT? High risk hemorrhagic patients, old patients (above 75 yo), atrial fibrillation, mechanic valve, pending surgery, kidney dysfunction... The CeloNova COBRA PzF™ Coronary Stent is a new stent design, balloon expandable cobalt chromium alloy coronary stent that is pre-mounted on a custom rapid exchange balloon delivery catheter. The alloy stent is surface treated with a nano-layer Polyzene®-F (PzF) [Poly-bis(trifluoroethoxy) phosphazene]. Polyzene-F is an inorganic polymer with a high molecular weight. In vitro and in vivo studies have indicated that the nano-layer surface treatment is nonthrombogenic and has antiinflammatory and pro-endothelialization properties that help to prevent tissue reactions. Method:
Results:
Rabbit iliac model
32 external iliac rabbit arteries were harvested at 7 days for EM analysis
Tsunami effect : defect of reendothelialization of the take off of the side branch in large arteries:
Representative samples of EM analysis at day 7
Cobra BMS Cobra PzF Cobra BMS (detail)
Cobra PzF (detail)
Cobra PzF. Large SB Mag = 160x
Cobra PzF. Small SB Mag = 300x
At day 7, on rabbit iliac arteries: Stent Occlusion 15 %
Thrombus 100 %
Reendothelialization 100 %
p=NS
p=NS
99 %
99 %
p=NS
12 %
80 % 11 %
9 %
60 %
6 %
40 %
3 %
20 %
0 %
0 %
Cobra BMS
Cobra PzF
0 %
0 %
0 %
Cobra BMS
Cobra PzF
0 %
Cobra BMS
Cobra PzF
Conclusion: While non significant, there is a reduction of stent occlusion in the COBRA PzF group as compared with COBRA BMS group, with a complete and rapid reendothelialization at day 7 that compare favorably with previous and historical data on the same model. These data will serve as an impetus to perform clinical study with reduction of DAPT.
