Science, Engineering and Technology

International Eurasian Conference on

Science, Engineering and Technology (EurasianSciEnTech 2018) 22-23 November 2018 Ankara / Turkey

EurasianSciEnTech 2018 w w w. e u r a s a n s c e n t e c h . o r g

International Eurasian Conference on

Science, Engineering and Technology (EurasianSciEnTech 2018) November 22-23, 2018 / Ankara, Turkey www.EurasianSciEnTech.org

PROCEEDING BOOK

International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org

Chairman of Conference Assoc. Prof. Dr. Muhittin DOĞAN

Gaziantep University, Turkey

General Coordinator Assist. Prof. Dr. Mustafa PEHLİVAN


Organizing Committee Prof. Dr. Ahmet AKSOY

Akdeniz University, Turkey

Prof. Dr. Mehmet Rüştü KARAMAN

Ankara University, Turkey

Prof. Dr. Osman GÜLNAZ

Cukurova University, Turkey

Prof. Dr. Zeliha SELAMOĞLU

Niğde Ömer Halisdemir University, Turkey

International Scientific Committee* Prof. Dr. Adnan QADIR

NED University of Engineering & Technology, Pakistan

Prof. Dr. Ahmet ŞEKEROĞLU

Niğde Ömer Halisdemir University, Turkey

Prof. Dr. Alpaslan DAYANGAÇ

Osmaniye Korkut Ata University, Turkey

Prof. Dr. Ayşe AYDOĞDU

Gazi University, Turkey

Prof. Dr. Azhar RASUL

Government College University, Pakistan

Prof. Dr. Azize AYOL

Dokuz Eylül University, Turkey

Prof. Dr. Bengi USLU


Prof. Dr. Berna DENGİZ

Baskent University, Turkey

Prof. Dr. Bushra MIRZA

Quaid-i-Azam University, Pakistan

Prof. Dr. Bülent AKAY


Prof. Dr. Bülent YEŞİLATA

Harran University, Turkey

Prof. Dr. Cihangir DURAN

Ankara Yıldırım Beyazıt University, Turkey

Prof. Dr. Deniz UZUNSOY

Bursa Technical University, Turkey

Prof. Dr. Dilek ERDİRENÇELEBİ

Konya Technical University, Turkey

Prof. Dr. Ebru ŞENADIM TÜZEMEN

Cumhuriyet University, Turkey

Prof. Dr. Ebru ŞENEL


Prof. Dr. Fakhru'l Razi bin AHMADUN

National Defence University Malaysia, Malaysia

Prof. Dr. Faruk KARADAĞ

Çukurova University, Turkey

Prof. Dr. Fatma Suna BALCI


Prof. Dr. Ferruh ERDOĞDU


Prof. Dr. Gıyasettin KAŞIK

Selçuk University, Turkey

Prof. Dr. Gul Majid KHAN


Prof. Dr. Hüseyin CANBOLAT


Prof. Dr. Kerim KÜÇÜK

Dokuz Eylül University, Turkey

Prof. Dr. Mehmet SARI

Aksaray University, Turkey

Prof. Dr. Meltem SARIOĞLU CEBECİ

Cumhuriyet University, Turkey

Prof. Dr. Muhammad ANSAR


Prof. Dr. Mustafa ÇİĞDEM

Yıldız Technical University, Turkey

Prof. Dr. Neriman BAĞDATLIOĞLU

Celal Bayar University, Turkey

Prof. Dr. Nil TOPLAN

Sakarya University, Turkey

Prof. Dr. Nuri ÖZALP


Prof. Dr. Osman GÜLNAZ


Prof. Dr. Oya BOZDAĞ DÜNDAR


Prof. Dr. Ozan TEKİNALP

Middle East Technical University, Turkey

ii


Prof. Dr. Sarwat JAHAN


Prof. Dr. Sibel YILDIZ

Karadeniz Technical University, Turkey

Prof. Dr. Siti Khairunniza bt. BEJO

Universiti Putra Malaysia, Malaysia

Prof. Dr. Şule UĞUR


Assoc. Prof. Dr. Abd. Rahim Abu TALIB


Assoc. Prof. Dr. Ahmet EKİCİBİL


Assoc. Prof. Dr. Aslıhan DEMİRDÖVEN

Tokat Gaziosmanpasa University, Turkey

Assoc. Prof. Dr. Aycan TOSUNOĞLU

Uludağ University, Turkey

Assoc. Prof. Dr. Ayla UYSAL

Süleyman Demirel University, Turkey

Assoc. Prof. Dr. Ayşe AVCI


Assoc. Prof. Dr. Ayşe BEDELOĞLU

Bursa Technical University, Turkey

Assoc. Prof. Dr. Bülent KABAK

Hitit University, Turkey

Assoc. Prof. Dr. Dian Darina Indah Binti DARUIS


Assoc. Prof. Dr. Didem ÖZÇİMEN

Yıldız Technical University, Turkey

Assoc. Prof. Dr. Fatma MEYDANERİ TEZEL

Karabuk University, Turkey

Assoc. Prof. Dr. Mahmoud HAFEZİEH

Iranian Fisheries Sciences Research Institute, Iran

Assoc. Prof. Dr. Mohammad SUDAGAR

Gorgan University, Iran

Assoc. Prof. Dr. Muhammad Mohsin AMMAN

NED University of Engineering & Technology, Pakistan

Assoc. Prof. Dr. Nemanja KAŠIKOVIĆ

University of Novi Sad, Serbia

Assoc. Prof. Dr. Niyazi ŞAHİN


Assoc. Prof. Dr. Rani Faryal Faheem TAHIR


Assoc. Prof. Dr. Roselina ARELHI

University of Nottingham, Malaysia

Assoc. Prof. Dr. Sadaf ZAIDI

Aligarh Muslim University, India

Assoc. Prof. Dr. Selma DÜZYOL


Assoc. Prof. Dr. Sezgin AYDIN


Assoc. Prof. Dr. Tayfun DEDE

Karadeniz Technical University, Turkey

Assoc. Prof. Dr. Tevfik AĞAÇAYAK


Assist. Prof. Dr. Ali Osman AYAŞ

Adıyaman University, Turkey

Assist. Prof. Dr. Bilge İMER

Middle East Technical University, Turkey

Assist. Prof. Dr. Ebru SARALOĞLU GÜLER

Başkent University, Turkey

Assist. Prof. Dr. Halil İbrahim DEMİR


Assist. Prof. Dr. İbrahim ÇINAR

Karamanoğlu Mehmetbey University, Turkey

Assist. Prof. Dr. Mustafa AKYOL

Adana Science and Technology University, Turkey

Assist. Prof. Dr. Özge TUFAN ÇETİN


Assist. Prof. Dr. Poonam AGARWAL

Jawaharlal Nehru University, India

Assist. Prof. Dr. Shahram DADGAR

Iranian Fisheries Sciences Research Institute, Iran

Dr. Aainaa Izyan NAFSUN


Dr. Lim Kar SING

Universiti Malaysia Pahang, Malaysia

Dr. Tugay AYAŞAN

East Mediterranean Agricultural Research Institute, Turkey

*This list is arranged in alphabetical order. Conference Secretariats Assist. Prof. Dr. Demet DOĞAN


Dr. Mustafa SEVİNDİK


Dr. Celal BAL


Serap ŞAHİN YİĞİT


iii


CONTENTS Page 1. INVAITED SPEAKERS

1

2. FULL-TEXT PAPERS

8

2.1. ORAL PRESENTATIONS 2.2. POSTER PRESENTATIONS

8 2689

iv


The Importance of Poisonous Mushrooms in Pharmacological Studies Zeliha Selamoglu Department of Medical Biology, Faculty of Medicine, University of Nigde Ömer Halisdemir, Nigde, Turkey [email protected]

Abstract Mushrooms that affect human health negatively due to the toxic compounds they contain are called ''poisonous mushrooms''. Mushrooms, which can cause serious health problems in consumers, can cause death. Although many negative health problems in humans, poisonous mushroom are medically important natural resources. Studies conducted by many researchers have identified antioxidant, antimicrobial, anticancer, antibacterial, antiviral and antiproliferative activities of poisonous mushroom. In these regards, the aim of this review was to evaluate the medical potential of poisonous mushroom. Keywords: Mushroom, Poisonous Mushrooms, Pharmacologia, Antioxidant, Antimicrobial. INTRODUCTION The worldwide diversity of mushroom species is roughly accounted as 140.000 . Of these, 14.000 are known and 7.000 are considered to have varying levels of edibility. More than 2.000 species are safe and 700 are documented to have considerable pharmacological properties (Akgul et al., 2017; Bal et al., 2017). Mushrooms are a recognized component of the human diet, with versatile medicinal properties. Some mushrooms are popular worldwide for their nutritional and therapeutic properties. Some species are well utilized for food and medicine due to the presence of pharmacologically active substances and essential nutrients. Because of these properties, mushrooms were described as popular remedies in ancient oriental documents and some of them became ingredients in traditional medicine (Sevindik 2018a; Sevindik et al., 2018a; Bal 2018). There are many thousands of mushroom species in the world, some are edible and some are poisonous due to containing significant toxins. The edible mushroom is a common food item with tempting flavour, taste and nutritive value; nowadays quite often grown at home and cultured with commercial marketing. A great variety of species was classified as poisonous and represents risks to health if ingested. Apart from mushrooms that contain psychoactive toxins, ingestion of toxic mushrooms is invariably accidental and caused by misidentification of species (Adejumo and Awosanya 2005; Jo et al., 2010; Sanchez, 2017; Sevindik 2018c). Mushrooms are a recognized component of the human diet, with versatile medicinal properties. Some mushrooms are popular worldwide for their nutritional and therapeutic properties. But, some species are dangerous because they cause toxicity. There are many data explaining the medicinal and/or toxic effects of these fungal species. Various substances belonging to poisonous mushrooms were already identified and are related with different symptoms and signs. Intoxications caused by commonly consumed mushrooms were already described, for this reason edible mushrooms and the ones having pharmacological potential must be carefully studied in order to identify the possibility of intoxications, so more studies have to be carefully conducted, clinical and experimental assays with medicinal species must investigate the side effects that may occur (Toth et al., 1989; Tomasi et al., 2004; Riede, 2011;

ORAL PRESENTATION

2379


Ruthes et al., 2013; Chelela et al., 2014; Poyraz et al., 2015; Tel et al., 2015; Akgul et al., 2016; Sevindik et al., 2017; Sevindik et al., 2018b; Sevindik 2018c; Colak et al., 2018). Mushrooms are of particular interest owing to the limited knowledge of mushroom toxins at the present time giving opportunities for further investigative studies. Mushrooms play a great part in numerous cuisines across the world. All mushrooms that are considered poisonous have been classified as such; the classification is actually done following hospital admissions of individuals who, after consuming mushrooms, have suffered symptoms of poisoning. Moreover, it is possible that many of mushrooms will contain toxins which have not yet been scientifically analysed and identified. Especially, when a mushroom was labelled as poisonous, scientists were rarely interested in identifying the hazardous chemical constituents. The lack of interest in the fungi kingdom caused many gaps in our current knowledge about mushrooms, fungi and their toxins (Toth et al., 1989; Tomasi et al., 2004; Riede, 2011; Fiedziukiewicz 2013; Ruthes et al., 2013; Chelela et al., 2014; Poyraz et al., 2015; Tel et al., 2015; Akgul et al., 2016; Sevindik et al., 2017; Sevindik et al., 2018b; Sevindik 2018c; Colak et al., 2018). Mushrooms are enriched with great quantities of complex polysaccharides possessing broad spectrum of therapeutic capacities. They are also rich in vitamins and minerals with excellent bioprotective properties. The amino acid content is well balanced and contains most of the essential amino acids required for normal functions in the body. Also, they have large amounts of trace elements required for major metabolic reactions. Mushrooms have been considered as an important source of bioactive natural compounds and many of the metabolites have shown to possess biological properties and potent health benefits (Adejumo and Awosanya 2005; Jo et al., 2010; Sanchez, 2017; Sevindik 2018b). Finally, we can suggest that natural compounds such as natural products including mushrooms which are exploited for drug development must be evaluated for the presence of toxicity and other physiological effects (Toth et al., 1989; Tomasi et al., 2004; Riede, 2011; Ruthes et al., 2013; Chelela et al., 2014; Poyraz et al., 2015; Tel et al., 2015; Akgul et al., 2016; Sevindik et al., 2017; Sevindik et al., 2018b; Sevindik 2018c; Colak et al., 2018). CONCLUSION Toxicity investigations of mushroom species have showed that mushroom poisoning can cause adverse effects such as liver failure, bradycardia, chest pain, seizures, gastroenteritis, intestinal fibrosis, renal failure, erythromelalgia, and rhabdomyolysis. Different materials responsible for the fatal signs and symptoms of mushroom toxicity have been identified from various poisonous mushrooms. No adequate database exists to estimate the worldwide exposure and fatality due to mushroom poisoning. Correct categorization and better understanding are essential for the safe and healthy consumption of mushrooms as functional foods as well as for their medicinal use. Most important factor is not to eat wild or uncultivated mushrooms as it is very difficult to correctly identify edible from poisonous mushrooms. Although many negative health problems in humans, poisonous mushrooms are medically important natural resources. REFERENCES Adejumo TO, Awosanya OB 2005. Proximate and mineral composition of four edible mushroom species from South Western Nigeria. African Journal of Biotechnology, 4(10): 1084-1088 Akgül H, Nur AD, Sevindik M, Doğan M 2016. Tricholoma terreum ve Coprinus micaceus’un bazı biyolojik aktivitelerinin belirlenmesi. Artvin Çoruh Üniversitesi Orman Fakültesi Dergisi, 17(2): 158162.

ORAL PRESENTATION

2380


Akgul H, Sevindik M, Coban C, Alli H, Selamoglu Z 2017. New approaches in traditional and complementary alternative medicine practices: Auricularia auricula and Trametes versicolor. J Tradit Med Clin Natur, 6(2): 239. Bal C 2018. A study on antioxidant properties of Gyrodon lividus. Eurasian Journal of Forest Science, 6 (2): 40-43. Bal C, Akgul H, Sevindik M, Akata I, Yumrutas O 2017. Determination of the anti-oxidative activities of six mushrooms. Fresenius Envir Bull, 26(10): 6246-6252. Chelela BL, Chacha M, Matemu A 2014. Antibacterial and antifungal activities of selected wild mushrooms from Southern Highlands of Tanzania. American Journal of Research Communication, 2(9): 58-68. Çolak OF, Rasul A, Sevindik M 2018. A study on Paxillus involutus: total antioxidant and oxidant potential. Turkish Journal of Life Sciences, 3(2): 244-247. Fiedziukiewicz M 2013. Mushroom Toxins-The Meixner Test (Doctoral dissertation, University of York). Jo WS, Hossain MA, Park SC 2014. Toxicological profiles of poisonous, edible, and medicinal mushrooms. Mycobiology, 42(3): 215-220. Poyraz B, Güneş H, Bahar TÜL, Sermenli HB 2015. Antibacterial and Antitumor Activity of Crude Methanolic Extracts from Various Macrofungi Species. Biyoloji Bilimleri Araştırma Dergisi, (1): 510. Riede I 2011. Tumor therapy with Amanita phalloides (Death Cap): stabilization of mammary duct cancer. TANG, 1(1): 32-34. Ruthes AC, Carbonero ER, Córdova MM, Baggio CH, Sassaki GL, Gorin PAJ, Iacomini M 2013. Fucomannogalactan and glucan from mushroom Amanita muscaria: Structure and inflammatory pain inhibition. Carbohydrate polymers, 98(1): 761-769. Sánchez C 2017. Reactive oxygen species and antioxidant properties from mushrooms. Synthetic and systems biotechnology, 2(1): 13-22. Sevindik M 2018a. Investigation of Oxidant and Antioxidant Status of Edible Mushroom Clavariadelphus truncatus. Mantar Dergisi, 9 (2): 165-168. Sevindik M 2018b. Investigation of Antioxidant/Oxidant Status and Antimicrobial Activities of Lentinus tigrinus. Advances in Pharmacological Sciences, 2018. https://doi.org/10.1155/2018/1718025 Sevindik M 2018c. Heavy metals content and the role of Lepiota cristata as antioxidant in oxidative stress. J Bacteriol Mycol Open Access, 6(4):237‒239. Sevindik M, Akgül H, Bal C 2017. Determination of Oxidative Stress Status of Ompholatus olearius Gathered from Adana and Antalya Provinces in Turkey. Sakarya University Journal of Science, 21 (3): 324-327. Sevindik M, Bal C, Akgül H 2018a. Comparison of Antioxidant Potentials of the Wild and Cultivated Forms of Edible Pleurotus ostreatus and Agaricus bisporus Mushrooms. Türk Yaşam Bilimleri Dergisi, 3 (2): 263-266. Sevindik M, Akgul H, Korkmaz AI, Sen I 2018b. Antioxidant Potantials of Helvella leucomelaena and Sarcosphaera coronaria. J Bacteriol Mycol Open Access, 6(2): 00173. Tel G, Ozturk M, Duru ME, Turkoglu A 2015. Antioxidant and anticholinesterase activities of five wild mushroom species with total bioactive contents. Pharmaceutical biology, 53(6): 824-830. Tomasi S, Lohezic-Le Devehat F, Sauleau P, Bezivin C, Boustie J 2004. Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 59(4): 290-293.

ORAL PRESENTATION

2381


Toth B, Patil K, Taylor J, Stessman C, Gannett P 1989. Cancer induction in mice by 4hydroxybenzenediazonium sulfate of the Agaricus xanthodermus mushroom. In vivo (Athens, Greece), 3(5): 301-305.

ORAL PRESENTATION

2382