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AUTHOR QUERIES AUTHOR PLEASE ANSWER ALL QUERIES AQ1— Is this 2 supposed to be a reference citation? If not, what does it signify?
Journal of the American College of Cardiology © 2010 by the American College of Cardiology Foundation Published by Elsevier Inc.
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Vol. xx, No. x, 2010 ISSN 0735-1097/$36.00
Letters to the Editor
Secondhand Smoke Exposure and Protective Effects It was of deep interest for me to read the article by Hamer et al. (1) on cardiovascular risk and secondhand smoke (SHS) exposure. After having analyzed data on salivary cotinine measurements in more than 13,400 middle-aged English and Scottish adults, the investigators concluded that participants exposed to high SHS (21% of the total sample) had 1) elevated levels of low-grade inflammation; and 2) elevated risk of cardiovascular death (over a follow-up of 8 years) that was partly accounted for by the former change. Both conclusions seem to be far from convincing and objective. When the mean cotinine levels in current smokers is considered 100, those in high SHS was 1 and those in the medium SHS category 0.06. The referent group (one-eighth of the sample) represented virtually the unexposed category. A biologic parameter that shows a more than 1,500-fold variation across active and passive smokers cannot be used as a continuous parameter over the whole range. Indeed, Cox regression analyses indicated that the association between cotinine categories and both the overall and cardiovascular mortality is not linear: it was lowest in the medium SHS category (65% of nonsmokers exposed to SHS), which hence deserves the greatest attention. Compared with the referent group, the medium SHS category displayed no differences in any of the 4 studied parameters: high-density lipoprotein cholesterol, fibrinogen, C-reactive protein (CRP), and systolic blood pressure. Because systolic blood pressure was unchanged even in smokers, CRP was the only parameter that was raised in the high SHS category significantly, albeit marginally. The increment in CRP, 1.2-fold, is one-sixth of 1 SD, given that 1 SD represents 3-fold values (2). Because such an increment, adjusted for conventional risk factors, confers a hazard ratio (HR) of 1.37 (2), the elicited difference corresponds to merely 1.05, not likely to have a significant influence on the studied risks. In Cox regression models 2, compared with the referent unexposed group, the medium SHS category revealed a borderline significantly lower mortality (by 15%) and again 15% lower cardiovascular deaths, although the difference is insignificant owing to limited statistical power. High SHS displays HRs for overall and cardiovascular mortality similar to the unexposed group (despite a higher prevalence of diabetes).
To sum up, what one can conclude from this paper on the issue of SHS and cardiovascular risk is that the influence of salivary cotinine (by inference, plasma nicotine) is nonlinear but exerts a threshold effect. High exposure to SHS confers no excess cardiovascular or all-cause mortality compared with unexposed individuals, whereas moderate SHS exposure (representing the majority of passive smokers) tends to reduce the risk of death, by approximately 15%. This inference is not surprising in view of the fact that even active smoking has been reported to have beneficial effects on the risk of type 2 diabetes (3), marginally on the risk of congenital heart disease in the general population (4), and on the risk for patients with diabetes on vascular and nonvascular mortality (5). The data of Hamer at al. (1) thus call for globally reassessing the dogmatic acceptance of an adverse relation between active and passive smoking and cardiovascular risk, requiring taking into account genetics, sex, ethnicities, degree of exposure, and glucose intolerance. *Altan Onat, MD *Cerrahpas¸a Medical Faculty Istanbul University 34335 Turkey E-mail: [email protected]
1. Hamer M, Stamatakis E, Kivimaki M, Lowe GD, Batty GD. Objectively measured secondhand smoke exposure and risk of cardiovascular disease. J Am Coll Cardiol 2010;56:18 –23. 2. Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, Lowe G, et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant metaanalysis. Lancet 2010;375:132– 40. 3. Onat A, Özhan H, Esen AM, et al. Prospective epidemiologic evidence of a protective effect of smoking on metabolic syndrome and diabetes among Turkish women—without associated overall health benefit. Atherosclerosis 2007;193:380 –9. 4. Onat A, Hergenç G. Low-grade inflammation and dysfunction of high-density lipoprotein and its apolipoproteins as a major driver of cardiometabolic risk. Metabolism 2010 May 22 [E-pub ahead of print]. 5. Sarwar N, Gao P, Seshasai SR, et al., Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 2010;375:2215–22.
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