Sensitization of Moderate to Severe Persistent Pediatric Asthmatics to ...

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68 Sensitisation Patterns To House Dust And Storage Mites In Two. Different Climatic ... matic patients. Different from mites, domestic animals and cockroaches,.
AB18 Abstracts

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Sensitisation Patterns To House Dust And Storage Mites In Two Different Climatic Areas Of Spain V. Iraola1, H. Pinto1, F. Rodrı´guez2, A. Huertas3, J. Bartra4, M. Boquete5, M. Paniagua6, S. Dı´az Angulo2, F. Carballada5, J. Carne´s1; 1Laboratorios LETI S.A., Tres Cantos, SPAIN, 2Hospital Valdecilla, Santander, SPAIN, 3 Hospital Santa Marı´a del Rosell, Cartagena, SPAIN, 4Hospital Clı´nico de Barcelona, Barcelona, SPAIN, 5Hospital Xeral de Calde, Lugo, SPAIN, 6 Fundacio´n Hospital San Pere Claver, Barcelona, SPAIN. RATIONALE: Previous studies have demonstrated different exposition to storage mites (SM) depending on the climatic areas (Atlantic and Mediterranean) in Spain. The aim of this study was to determine the different sensitisation to House dust mites (HDM) and SM in these regions. METHODS: Skin prick tests to HDM (Dermatophagoides pteronyssinus, D. farinae, Euroglyphus maynei) and SM (Lepidoglyphus destructor, Glycyphagus domesticus, Tyrophagus putrescentiae and Acarus siro) were performed in four different cities located in two climatic areas with high exposition to mites (Atlantic: Lugo, Santander; Mediterranean: Barcelona, Cartagena). 420 individuals were included in the study. 197 serum samples from patients sensitized to SM were collected and the specific IgE determined. RESULTS: Percentages of patients sensitised to mites were: Lugo 100%, Santander 68%; Cartagena 100%; Barcelona 56%. Most mite-sensitised patients residing in Atlantic localities were sensitised to HDM and SM (Lugo 100%; Santander 98%), whereas a significant lower number of patients from Mediterranean were sensitised to both type of mites (Cartagena 70%, Barcelona 78%). The solely sensitisation to SM was very low in all cities (0-3%). The SM species with highest percentage of sensitisation and largest wheal sizes was L. destructor, although they always were lower than those obtained with HDM. Specific IgE levels were statistically significant higher in Lugo (Atlantic) than in the other cities. Specific IgE to HDM were significant higher than those observed to SM, except for L. destructor in Lugo. CONCLUSIONS: The HDM are the main sensitising species in Spain, being sensitisation to SM partially related with exposition to these species.

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Evaluation of the Prevalence of Rat and Mouse Allergens Sensitization in Asthmatic Patients Followed at Hospital das Cli´nicas at Sa˜o Paulo, Brazil C. M. Kokron1, B. C. Nicoletti1, C. E. Galva˜o1, P. Giavina-Bianchi1, B. F. C. Santos2, F. F. M. Castro1, J. Kalil1; 1University of Sa˜o Paulo Medical School, Sa˜o Paulo, SP, BRAZIL, 2Instituto Israelita de Ensino e Pesquisa Albert Einstein, Sa˜o Paulo, SP, BRAZIL. RATIONALE: Aeroallergen sensitization is observed in 70 to 85% of asthmatic patients. Different from mites, domestic animals and cockroaches, sensitization to rat and mouse proteins in the general population is still not well defined. Recent studies have shown the role of sensitization to these allergens in the development and morbidity of asthma in suburban populations. The aim of this study was to evaluate the prevalence of sensitization to rat and mouse allergens in asthmatic patients followed at the Immunology and Allergy Clinic of Hospital das Clı´nicas of the University of Sa˜o Paulo Medical School to determine its association with the asthma severity. METHODS: We evaluated 150 adult asthmatic patients and 50 controls. The participants were submitted to questionnaires to classify their asthma and their domestic environment. Skin prick tests to common aeroallergens and also for rat and mouse epithelium were performed. RESULTS: Among 150 asthmatic patients, 79% were female, average age of 49 years. Mild asthma was diagnosed in 28% of patients, 39% moderate asthma and 33% severe asthma, being 84% controlled or partially controlled. Sensitization to rat and mouse was seen in 29% of asthmatic patients and 2% of controls. No correlation was found between sensitization to these allergens and severe uncontrolled asthma. CONCLUSION: The study shows that among asthmatic persons, the sensitization rate to rat and mouse allergens is highly significant. However, no correlation was found between sensitization to these allergens and a more severe disease showing the need of a better evaluation of the role of this sensitization in the population.

J ALLERGY CLIN IMMUNOL FEBRUARY 2010

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Sensitization to Tyrophagus putrescentiae in Korean Children with Allergic Diseases B. Choi1, Y. Lee1, T. Song2, K. Kim1, M. Sohn1, K. Kim1, J. Baek1; 1Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 2Inje University College of Medicine, Koyang, REPUBLIC OF KOREA. RATIONALE: Tyrophagus putrescentiae(Tyr p) is known as the third most common mite following Dermatophagoides pteronyssinus(Der p), and Dermatophagoides farina(Der f) in Korea. However, there have been few reports on its sensitization rate. The aim of this study was to evaluate its sensitization rate and clinical features of Tyr p sensitized patients in Korea. METHODS: Skin prick tests with 32 common allergens were done in 662 allergic patients who had visited allergy clinic of Severance Children’s Hospital from 2005 to 2008, and their clinical characteristics were analyzed. Subjects were consisted of 472 asthmatic children, 286 patients with allergic rhinitis and 114 patients with atopic dermatitis and 29 with other diseases. The number of patients with asthma and allergic rhinitis was 155, with asthma and atopic dermatitis was 55, and with allergic rhinitis and atopic dermatitis was 65. Allergic skin prick tests, measurements of peripheral blood eosinophil count, serum total IgE level and eosinophil cationic protein(ECP) were performed in subjects. RESULTS: 592(89.4%) out of 662 patients showed positive responses to more than one allergen. Patients sensitized to Tyr p were 129(19.5%). The wheal sizes of Tyr p were positively correlated to their age(r50.102 P50.009) and the wheal sizes of house dust(r50.298 P