Serum Androstenedione and Testosterone Concentrations during ...

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Jun 26, 1985 - at Amarillo,. Amaril- lo, TX 79106. BIOLOGY. OF REPRODUCTION. 33, 1078-1083. (1985). 1078. Serum Androstenedione and Testosterone.
BIOLOGY

OF REPRODUCTION

33, 1078-1083

(1985)

Serum Androstenedione and Testosterone Concentrations during Pregnancy and Nonpregnant Cycles In Dogs1 PATRICK

W. CONCANNON2’4

York

New

and

V. DANIEL

CASTRACANE3’5

Department of Physiology4 State College of Veterinary Cornell Ithaca,

Medicine

University

York

New

14853

and Department Southwest

of Clinical Sciences Foundation for San

and Reproductive Biology5 Research and Eduction

Antonio,

Texas

ABSTRACT

Concentrations

of testosterone and of androstenedione were determined by radioimmunoassay in serum samples collected every 2-5 days throughout the periovulatory and luteal phases of the ovarian cycles of pregnant and nonpregnant beagle bitches. Testosterone levels were consistently lower than those of androstenedione, reached peaks of 29 ± 4 ng/dl near the time of the preovulatory lutemnizing hormone peak, and were reduced to near the limits of detection (5-10 ng/dl) throughout the luteal phase. Androstenedione levels reached preovulatory peaks of 73 ± 13 ng/dl, were 54 ± 7 ng/ml during early estrus, increased (P0.05). At parturition androstenedione levels fell (P