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Antiviral Therapy 13:135–139
Short communication Low rate of emergence of nevirapine and lamivudine resistance after post-partum interruption of a triple-drug regimen Héctor Pérez1†, Moira Vignoles 2†, Natalia Laufer 1,2, Alejandro Gómez 2, Patricia Coll1, Jorge Lattner1, María Rolón1, Horacio Salomón2 and Pedro Cahn1,3* 1
Fernandez Hospital, Infectious Diseases Unit, Buenos Aires, Argentina National Reference Center for AIDS, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina 3 Huésped Foundation, Buenos Aires, Argentina 2
†
These authors contributed equally to this work *Corresponding author: E-mail:
[email protected]
Introduction: Emergence of nevirapine (NVP) resistance may be a consequence of its use in monotherapy to prevent HIV mother-to-child transmission (MTCT). The aim of this study was to evaluate the emergence of strains resistant to NVP and lamivudine (3TC) after discontinuation of antiretroviral therapy (ART) with 3TC/zidovudine (ZDV)/NVP. Methods: Twenty pregnant women (ART-naive or preexposed only to ZDV), to whom 3TC/ZDV/NVP was prescribed as MTCT prophylaxis, were studied. They received ART for a median of 4 months with median viral load (VL) at labour
