(Charles. River. CD) rats weighing. 200-250 g upon arrival were obtained from. Canadian. Breeding. Farms, ..... V., Harwood,. J. P., Dufau,. M. L and. Catt,. K. j.
BIOLOGY
OF
REPRODUCTION
Stimulatory
23,
Effect
924-928
(1980)
of Luteinizing on Testicular
PAUL
A.
KELLY,’
CARL
and Human
Prolactin
Receptor
SEGUIN,
Department Le
Hormone
LIONEL
Hospitalier Quebec
and
FERNAND
LABRIE
Endocrinology,
de GI
Gonadotropin
Levels
CUSAN
Molecular
of
Centre
Chorionic
l’Universit
V 4G2,
Laval,
Canada
ABSTRACT A possible effect of LII or hCG on testicular prolactin receptor levels was investigated in hypophysectomized adult rats. Hypophyseetomy leads to a progressive decrease of testicular prolactin receptor content to ‘\25% of that of controls 12 days after surgery. In animals injected 3 times a day for 10 days with highly purified preparations of ovine LII or hCG, prolactin receptor levels increased from 21 4 to 41 ± 4 and 71 7 fmol/testis, respectively (P