Stimulatory Effect of Luteinizing Hormone and Human Chorionic ...

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(Charles. River. CD) rats weighing. 200-250 g upon arrival were obtained from. Canadian. Breeding. Farms, ..... V., Harwood,. J. P., Dufau,. M. L and. Catt,. K. j.
BIOLOGY

OF

REPRODUCTION

Stimulatory

23,

Effect

924-928

(1980)

of Luteinizing on Testicular

PAUL

A.

KELLY,’

CARL

and Human

Prolactin

Receptor

SEGUIN,

Department Le

Hormone

LIONEL

Hospitalier Quebec

and

FERNAND

LABRIE

Endocrinology,

de GI

Gonadotropin

Levels

CUSAN

Molecular

of

Centre

Chorionic

l’Universit

V 4G2,

Laval,

Canada

ABSTRACT A possible effect of LII or hCG on testicular prolactin receptor levels was investigated in hypophysectomized adult rats. Hypophyseetomy leads to a progressive decrease of testicular prolactin receptor content to ‘\25% of that of controls 12 days after surgery. In animals injected 3 times a day for 10 days with highly purified preparations of ovine LII or hCG, prolactin receptor levels increased from 21 4 to 41 ± 4 and 71 7 fmol/testis, respectively (P