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May 29, 2013 - Lacunar Stroke: Distinguishing between what we see and what we think we see ..... Sixty patients (mean age 78 years, 38 females, mean NIHSS 19) were ...... profile and prognosis of TIA and ischaemic stroke of undetermined.
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7th Stroke Meeting for Nurses, Physiotherapists, Speech and Occupational Therapists, Study/Research Assistants

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22. European Stroke Conference

Committees Programme Committee Michael G. Hennerici, Germany, Chairman Martin M. Brown, United Kingdom José M. Ferro, Portugal Jean-Louis Mas, France Bo Norrving, Sweden Senior Members Committee F. Aichner, Austria M.G. Bousser, France A. Chamorro, Spain C. Gerloff, Germany W.D. Heiss, Germany P. Koudstaal, The Netherlands G.L. Lenzi,Italy J. Matias-Guiu, Spain J.M. Orgogozo, France N.G. Wahlgren, Sweden C. Warlow, United Kingdom

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Scientific Committee R. Ackerman, USA A. Algra, The Netherlands H. Ay, USA H. Bäzner, Germany J.-C. Baron, United Kingdom P. Bath, United Kingdom O. Benavente, Canada E. Berge, Norway J. Bernhardt, Australia J. Betlehem, Hungary J. Bogousslavsky, Switzerland N. Bornstein, Israel M. Brainin, Austria M. Breteler, The Netherlands J. Broderick, USA M. M. Brown, United Kingdom A. Carolei, Italy V. Caso, Italy J. Castillo, Spain H. Chabriat, France C.Cordonnier, France A. Czlonkowska, Poland A. Davalos,Spain S. Davis, Australia A. M. Demchuk, Canada M. Dichgans, Germany H.C. Diener, Germany E. Diez-Tejedor, Spain V. Di Piero, Italy D.W.J. Dippel, The Netherlands M. Endres, Germany F. Fazekas, Austria V. Feigin,New Zealand J. M. Ferro, Portugal M. Fisher, USA G. A. Ford, United Kingdom G. de Freitas, Brazil A. Gass, Germany M. Giroud, France A. Grau, Germany W. Hacke, Germany G. Hankey, Australia J. Harbison, Ireland M.G. Hennerici, Germany I. Henriques, Portugal R. Herzig, Czech Republic

V. Hömberg, Germany M. Hommel, France T. Karapanyiotides, Greece M. Kaste, Finland J. S. Kim, South Korea Y. Kokubo, Japan P. Langhorne, United Kingdom K. R. Lees, United Kingdom D. Leys, France A. Lindgren, Sweden P. Lindsberg, Finland D. McCabe, Ireland J.-L. Mas, France A. Massaro, Brazil H. Mattle, Switzerland J.P. Mohr, USA J. Montaner, Spain K. Muir, United Kingdom N. Nighoghossian, France B. Norrving, Sweden B. Ovbiagele, USA J.D. Pandian, India L. Pantoni, Italy A. Planas, Spain J.E. Rinkel, The Netherlands J. Röther, Germany P.M. Rothwell, United Kingdom P. Sandercock, United Kingdom A.P. Sigurdsson, Iceland H. Sillesen, Denmark K. Spengos, Greece J. Stam, The Netherlands C. Stapf, France T. Steiner, Germany D. Tanne, Israel T. Tatlisumak, Finland V. Thijs, Belgium D. Toni, Italy E.Touzé, France K. Toyoda, Japan A. Tsiskaridze, Georgia S. Uchiyama, Japan N. Venketasubramanian, Singapore A. Verdelho, Portugal D. Vivien, France J. Wardlaw, United Kingdom

D. Werring, United Kingdom K.S. Wong, China

Scientific Programme

London, United Kingdom 2013

Acknowledgements

The Conference Committee thanks the following companies for supporting ESC 2013: Boehringer Ingelheim International Bayer Healthcare H. Lundbeck BMS/Pfizer Covidien Moleac Stryker Neurovascular EVER Neuro Pharma St. Jude Medical Boston Scientific Siemens Ferrer Takeda Pharmaceuticals Penumbra Meytec Medizinsysteme Digital Spark Grupo Uriach Corpak Medsystems UK Cardiox Corporation Ekso Bionics Zenicor Medical Systems Phagenesis Medtronic Hocoma Wisepress Karger Publishers

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22. European Stroke Conference

Tuesday 28 May 2013 Scientific Programme

Tuesday 28 May 2013 - Programme Overview Auditorium

Capital Suite Room 7,8,11,12

Capital Suite Room 14,15,16

Capital Suite Room 2,3,4

Capital Suite Room 9,10

Capital Suite Room 13

Capital Suite Room 1

13:00 - 15:00 Teaching Course 1-5 p. 5

13:00 - 15:00 Teaching Course 1-5 p. 5

13:00 - 15:00 Teaching Course 1-5 p. 5

13:00 - 15:00 Teaching Course 1-5 p. 5

13:00 - 15:00 Teaching Course 1-5 p. 5

13:00 - 14:30 7. Nurses/AHP‘s Meeting p.7

Meeting Room 3

14:30 -15:30 Coffee Break /Poster Session

15:00 -15:30 Coffee break 15:30 - 17:30 Teaching Course 6-10 p.6

15:30 - 17:300 Teaching Course 6-10 p.6

15:30 - 17:300 Teaching Course 6-10 p.6

15:30 - 17:300 Teaching Course 6-10 p.6

15:30 - 17:300 Teaching Course 6-10 p.6

15:30 - 17:30 7. Nurses/AHP‘s Meeting Workshop A p.7

15:30 - 17:30 7. Nurses/AHP‘s Meeting Workshop B p.7

17:45 Opening Ceremony

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Scientific Programme

London, United Kingdom 2013

Teaching Courses Teaching Course 1- 5, 13:00 – 15:00

1. Teaching Course Subarachnoid haemorrhage Chairs: G. Rinkel, The Netherlands and O. Nilsson, Sweden Diagnostic aspects of subarachnoid haemorrhage M. Vergouwen, The Netherlands Less common variants of SAH: perimesencephalic and convexal bleeds R. Geraldes, Portugal Update on SAH management and therapeutics O. Nilsson, Sweden Long term prognostic aspects after SAH G. Rinkel, The Netherlands 2. Teaching Course Paediatric stroke: recent insights into aetiology and treatment Chairs: K. Braun, The Netherlands and M. Steinlin, Switzerland The role of thrombolysis in paediatric stroke V. Ganesan, UK Overlaps between young adult and pediatric arteriopathies K. Braun, The Netherlands Insigths from population-based studies of pediatric stroke M. Steinlin, Switzerland Current management of sickle cell stroke: insights from recent clinical trials F. Kirkham, UK

Delirium J. McManus, Ireland Cognitive impairment and dementia after stroke L. Pantoni, Italy

4. Teaching Course Update on stroke prevention Chairs: J. Kappelle, The Netherlands and A. Lindgren, Sweden Ischaemic stroke risk factors: current status. A. Lindgren, Sweden Investigation strategies to direct secondary prevention: Ischaemic stroke and TIA V. Thijs, Belgium Secondary prevention of ischaemic stroke and TIA: what is the current evidence base? What are the gaps in knowledge? J. Kappelle, The Netherlands Cost-effectiveness of secondary stroke prevention M. Walters, UK 5. Teaching Course Rehabilitation after stroke Chairs: N. Ward, UK and T. Nyffeler, Switzerland Mechanisms of stroke recovery and restorative stroke therapeutics S. Cramer, USA Neglect: mechanisms, diagnostics and therapeutics. T. Nyffeler, Switzerland Rehabilitation of language after stroke A. Leff, UK Current evidence for motor rehabilitation after stroke G. Kwakkel, The Netherlands

3. Teaching Course Long term neuropsychiatric consequences of stroke Chairs: G. Mead, UK and M. Endres, Germany Post stroke depression; what is known, what is in development? M. Endres, Germany Fatigue G. Mead, UK

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22. European Stroke Conference

Teaching Course 6-10, 15:30 – 17:30 6. Teaching Course Vascular lesions of the spinal cord Chairs: M. Arnold, Switzerland and D. Hänggi, Germany Ischaemic lesions of the spinal cord: clinical features, diagnostic procedures and treatment M. Arnold, Switzerland

9. Teaching Course New oral anticoagulants for secondary stroke prevention in atrial fibrillation: current difficult decisions in clinical practice Chairs: J.L. Mas, France and T. Steiner, Germany New oral anticoagulants vs. vitamin K antagonists in secondary stroke prevention J.L. Mas, France Acute stroke in patients on new oral anticoagulants: how to manage, how to treat? T. Steiner, Germany

Vascular malformations of the spinal cord A. Valavanis, Switzerland

Intracranial hemorrhage in patients on oral anticoagulants: when and how to restart? C. Cordonnier, France

Spinal haemorrhage U. Fiscsher, Switzerland

Combination of oral anticoagulants and antiplatelet therapy : when is it justified ? J. Oldgren, Sweden

7. Teaching Course Organization of acute stroke services Chairs: A. Rudd, UK and D. Toni, Italy

10. Teaching Course Scientific publishing and presentation in the stroke field Chairs: B. Norrving, Sweden and A. Alexandrov, USA

Sources and impact of time delays in acute stroke management. D. Toni, Italy

How to write a good manuscript D. Leys, France

Types of solutions for acute care services A. Rudd, UK

How to handle a rejection S. Davis, Australia

Implementing systems for monitoring quality of acute stroke services P. Heuschmann, Germany

How to write an abstract and effectively present at a congress A. Alexandrov, USA

Certification of stroke services O. Busse, Germany

How to review B. Norrving, Sweden

8. Teaching Course Posterior circulation stroke Chairs: H. Mattle, Switzerland and P. Lindsberg, Finland The clinical spectrum of basilar artery occlusion H. Mattle, Switzerland Imaging posterior circulation strokes. C. Brekenfeld, Germany Antithrombotic therapy and iv-thrombolysis for posterior circulation stroke. P. Lindsberg, Finland Endovascular therapy of basilar artery occlusion. G. Schroth, Switzerland

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Scientific Programme

London, United Kingdom 2013

7. Stroke Meeting for Nurses – Physiotherapists – Speech and Occupational Therapists Study/Research Assistant Tuesday 28 May 2013 13:00 - 17:30 Room 1 and Room 13 13.00-14.30 Room 1 Plenary Session Chair: S. Middleton, Australia

Therapist : P. Maurer, Germany 2. Special aspects in nursing Nursing in delirium C. Moderow, Germany Care giver training in stroke A. Forster, UK 15.30-17.30 WORKSHOP B - Room 13 How playful should neurorehabilitation be? Chair: V. Hömberg, Germany

How do you determine what is best evidence? Levels of evidence and general princiHomo ludens: work or play ? What is the difference? pals of evidence-based care, use of guidelines V. Hömberg, Germany S. Middleton, Australia Leading change in early supported discharge R. Fisher, UK GRASP: A Graded Repetitive Arm Supplementary Program: A home-work based program to improve arm and hand function in people living with stroke L. Connell, UK

Group vs individual treatments G. Kwakkel, The Netherlands Creating new virtual reality and game devices for stoke rehabilitation J. Eyre, UK

14.30-15.30 Lunch Break/POSTER SESSION p.195 15.30-17.30 WORKSHOP A - Room 1 Nursing aspects in early rehabilitation of diminished states of consciousness (DSC) Chair: V. Binder, Austria 1. Physicians and nurses view Maintaining vegetative balance Physician: H. Binder, Austria Nurse: T. Zaussinger, Austria

18:30 Opening Ceremony

Measures to increase level of consciousness Physician: F. Müller, Germany Nurse: R. Dohrendorf, Germany Cognitive and behavioral assessment in DSC Physician: D. Boering,Germany

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22. European Stroke Conference

Wednesday 29 May 2013 Wednesday 29 May 2013 - Programme Overview Auditorium 8:30

8:30 - 10:00

9:00 9:30

Capital Suite Room 7,8,11,12

Capital Suite Room 14,15,16

8:30 - 10:00 Mini Symposium 1 Update on cerebral small vessel disease – challenges and opportunities p.9

8:30 - 10:00 Oral Session Acute stroke: current treatment & new treatment concepts p.9

10:00 10:30 11:00 11:30 12:00

Capital Suite Room 2,3,4

Capital Suite Room 9,10

8:30 - 10:00 Oral Session 8:30 - 10:00 Stroke progOral Session nosis Heart and brain p.21 p.15

Capital Suite Room 17

Capital Suite Room 1

8:30 - 10:00 Oral Session Vascular biology & Translational stroke research p.27

10:00- 10:30  Coffee Break 10:30 - 11:25 Opening/ Wepfer Award/Lecture 11:25 - 12:30 Oral Session Large clinical trials 1 p.32

12:30 12:45 13:00

12:45 - 14:15 E-Poster Session Red Poster Session Red

13:30

12:45 - 14:15 Lunch Satellite  Symposium Boehringer Ingelheim p.35

12:45 - 14:15 Lunch Satellite  Symposium Moleac p.35

12:45 - 14:15 Lunch Satellite  Symposium Bayer p.36

12:45 - 14:15 E-Poster Session Red p.220 Poster Session Red p.276

14:15 14:30 15:00 15:30 16:00 16:15 16:30 16:45 17:00 17:30 18:00 18:15 18:30 19:45

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14:30 - 16:30 Educational Symposium 1 Management of hypertension in acute ICH p.36 

14:30 - 16:00 ESC/ESNCH Joint Symposium 1 p.37

14:30 - 16:00 14:30 - 16:00 Oral Session Oral Session Small vessel stroke and white Brain imaging matter disease p.37 A p.43

14:30 - 16:00 Oral Session Etiology of stroke and risk factors A p.49

14:30 - 16:00 Oral Session Experimental studies A p.56

16:30 - 18:00 Oral Session Etiology of stroke and risk factors B p.72

16:30 - 18:00 Oral Session Experimental studies B p.78

16:00- 16:30  Coffee Break 16:30 - 17:30 Special Session SVD on neuroimaging p.61

16:30 - 18:00 Oral Session 16:30 - 18:00 Vascular surgery and neuroOral Session surgery Brain imaging  & B p. 67 Management and economics p.62 18:15 - 19:45 Satellite Symposium Bristol-Myers Squibb/Pfizer p.84

18:15 - 19:45 Satellite Sym18:15 - 19:45 posium Satellite Symposium Ever Neuro Covidien p.85 Pharma p.84

18:15 - 19:45 18:15 - 19:45 Satellite SymYoung Stroke Physicians posium p.85 St.Jude Med. p. 85 Scientific Programme

London, United Kingdom 2013

8:30-10:00 Rooms 7,8,11,12 Mini Symposium 1 Update on cerebral small vessel disease – challenges and opportunities Update on cerebral small vessel disease – challenges and opportunities Chairs: M. Dichgans, Germany and M.G. Hennerici, Germany Lacunar Stroke: Distinguishing between what we see and what we think we see B. Norrving, Sweden Imaging microvessels and microinfarcts using high field MRI G.J. Biessels, The Netherlands Brain atrophy in subcortical ischemic vascular disease: mechanisms and clinical correlates M. Düring, Germany Subcortical ischemic lesions in neurodegenerative dementia: innocent bystanders? F. Fazekas, Austria

8:30-10:00 Oral Session Room 14,15,16 Acute stroke: current treatment & new treatment concepts Chairs: A. Alexandrov, USA and C. Roffe,UK 1 Acute stroke: current treatment & new treatment concepts 8:30 - 8:40 ENDOVENOUS ALTEPLASE FACILITATES MECHANICAL THROMBECTOMY WITH STENT RETRIEVERS IN ACUTE ISCHEMIC STROKE M. Gomis1, C. Castaño2, L. Dorado3, P. García-Bermejo4, N. Pérez de la Ossa5, M. Hernández6, E. Palomeras7, E. López-Cancio8, M. Millán9, A. Dávalos10 Hospital Universitari Germans Trias i Pujol, Badalona, SPAIN1,Hospital Universitari Germans Trias i Pujol, Badalona, SPAIN2, Hospital Universitari Germans Trias i Pujol, Badalona, SPAIN3, Hospital Universitari Germans Trias i Pujol, Badalona, SPAIN4, Hospital Universitari Germans Trias i Pujol, Badalona, SPAIN5, Hospital Universitari Germans Trias i Pujol, Badalona, SPAIN6, Hospital de Mataró, Mataró, SPAIN7, Hospital Universitari Germans Trias i Pujol, Badalona, SPAIN8, Hospital Universitari Germans Trias i Pujol, Badalona, SPAIN9, Hospital Universitari Germans Trias i Pujol, Badalona, SPAIN10 Background: The success of mechanical thrombectomy (MT) for acute ischemic stroke may be influenced by factors such as the size and composition of the occlusive thrombus. We aimed to study the effect of intravenous tPA on the number of passes (NP) of stent retrievers needed to open the occluded vessel as surrogate of fast and successful recanalization. Methods: We retrospectively analyzed data from our register of all acute stroke cases of the anterior circulation treated with iv-tPA plus MT or MT alone with the stent retrievers in a single comprehensive stroke centre during a period of 3 years. We prospectively recorded NP and time from groin puncture to complete recanalization (mTICI 2b/3) or to the end of the procedure in patients who failed MT. The effect of i.v tPA on NP and functional outcome was analyzed by multivariate logistic regression models adjusted for relevant baseline clinical and neuroimaging variables. Results: A total of 79 patients were treated with iv-tPA plus MT (mean age 65; median NIHSS 18), and 75 with MT alone (mean age 67; median NIHSS 18). There were no differences in TOAST and in arterial occlusion site. A total of 15 (19%) patients versus 29 (38.7%) needed more than 2 passes (p= 0.006) and 70 (88.6%) versus 57 (76%) achieved mTICI 2b/3 (p=0.032). In the overall group, NP did not correlate with age and NIHSS but correlated with groin puncture to recanalization time or to the end of the procedure (p50% (140)

38 69.5 (20) 63.89% 53.57%

67 67(16) 44.83% 49.02%

0.408 0.036* 0.349

Proportion Diabetes Proportion Hyperlipidemia Proportion Current Smoking Proportion Atrial Fibrillation Proportion with Coronary artery disease Proportion Antiplatelet Proportion Anticoagulation Median baseline NIHSS(IQR)

21.43% 48.15% 24.14% 25.0% 32.14%

15.69% 36.73% 18.75% 28.0% 24.49%

0.261 0.166 0.286 0.6325 0.2342

45.83% 21.74% 17.5(7)

37.5% 13.04% 17 (8)

0.249 0.176 0.513

Proportion treated with IV-tPA

45.45%

70.21%

0.026*

Median imaging to reperfusion (min)

116.5 (82.5)

94 (70)

0.029**

Median puncture to reperfusion(min)

54 (53)

33 (29)

0.021**

Median onset to reperfusion(min)

265 (140)

257(251.5)

0.794

* Two-sample test of proportions p>0.05 ** Kruskal-Wallis equality of proportions rank test p>0.05

9:00 - 9:10 Optimisation of sample size calculation in thrombectomy trials using the natural history of proximal occlusions after i.v. thrombolysis failure A.I. CALLEJA1, E. CORTIJO2, P. GARCÍA-BERMEJO3, C. DE LA CRUZ4, J REYES5, N. TELLEZ6, N FERNÁNDEZ-BUEY7, J.F ARENILLAS8 HOSPITAL CLÍNICO UNIVERSITARIO, VALLADOLID, SPAIN1,HOSPITAL CLÍNICO UNIVERSITARIO, VALLADOLID, SPAIN2, HOSPITAL CLÍNICO UNIVERSITARIO, VALLADOLID, SPAIN3, HOSPITAL CLÍNICO UNIVERSITARIO, VALLADOLID, SPAIN4, HOSPITAL CLÍNICO UNIVERSITARIO, VALLADOLID, SPAIN5, HOSPITAL CLÍNICO UNIVERSITARIO, VALLADOLID, SPAIN6, HOSPITAL CLÍNICO UNIVERSITARIO, VALLADOLID, SPAIN7, HOSPITAL CLÍNICO UNIVERSITARIO, VALLADOLID, SPAIN8 BACKGROUND:Stroke patients who do not respond to intravenous thrombolysis are being considered for endovascular rescue therapy worldwide. For many stroke physicians, randomized controlled clinical trials(RCTs)to evaluate safety and efficacy of endovascular treatment represent an ethical problem. Ideally, such trials should be powered to provide rapidly definite response with minimum sample size needed. We applied our data on the natural history of this group of patients to estimate the minimum sample size needed to prove superiority of rescue endovascular-treatmentMETHODS:We included consecutive ischemic stroke patients with an acute intracranial occlusion in anterior circulation, with a baseline NIHSSscore >10, who were treated with intravenous-thrombolysis, and showed persistence of arterial occlusion after i.v.-therapy. A superiority clinical trial was designed with Ene 3.0 assuming an overall difference of >10% in good outcome favouring endovascular therapy, drop-out rate 10%, alpha-error 2.5%, beta-error 10%. Outcome of i.v group was inferred from our sample of i.v failure, whereas a wide range of expected outcomes in the endovascular arm was extracted from main thrombectomy registries with stent-retriever-devices. Primary outcome variable was modified Rankin scale 16 and lack of early response to tPA, only 15% achieved good outcome. Assuming an intermediate response rate in the stenttriever arm of 45%, the sample size dramatically fell from 2,137 to 112 patients per arm when baseline NIHSS entry threshold was moved from initial 10 to 16. CONCLUSION: An increase of baseline NIHSS from 10 to 16 as inclusion criteria would dramatically reduce the sample size needed to prove superiority of endovascular therapy in a RCT.

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22. European Stroke Conference 5 Acute stroke: current treatment & new treatment concepts

6 Acute stroke: current treatment & new treatment concepts

9:10 - 9:20

9:20 - 9:30

Predictive factors of dramatic recovery after IV thrombolysis in anterior circulation ischemic stroke J.M. Rocha1, J.D. Pinho2, S.D. Varanda3, M. Ribeiro4, J. Rocha5, J.R. Fontes6, R. Maré7, C. Ferreira8

Safety of thrombolysis in stroke mimics: results from a multicenter cohort study P.J. Nederkoorn1, S.M. Zinkstok2, S.T. Engelter3, H. Gensicke4, P.A. Ringleb5, V. Artto6, D. Leys7, H. Sarikaya8, C Odier9, J. Berrouschot10, M.R. Heldner11, A. Zini12, V. Padjen13, A. Pezzini14

Hospital de Braga, Braga, PORTUGAL1,Hospital de Braga, Braga, PORTUGAL2, Hospital de Braga, Braga, PORTUGAL3, Hospital de Braga, Braga, PORTUGAL4, Hospital de Braga, Braga, PORTUGAL5, Hospital de Braga, Braga, PORTUGAL6, Hospital de Braga, Braga, PORTUGAL7, Hospital de Braga, Braga, PORTUGAL8

Academic Medical Center University of Amsterdam, Amsterdam, THE NETHERLANDS1,Academic Medical Center University of Amsterdam, Amsterdam, THE NETHERLANDS2, University Hospital Basel, Basel, SWITZERLAND3, University Hospital Basel, Basel, SWITZERLAND4, University Hospital Heidelberg, Heidelberg, GERMANY5, Helsinki University Central Hospital, Helsinki, FINLAND6, Lille University Hospital, Lille, FRANCE7, University Hospital Zurich, Zurich, SWITZERLAND8, Centre Hospitalier Universitaire Vaudois, Lausanne, SWITZERLAND9, Municipal Hospital Altenburg, Altenburg, GERMANY10, University Hospital Bern, Bern, SWITZERLAND11, Nuovo Ospedale Civile, AUSL Modena, Modena, ITALY12, Clincal Center, School of Medicine, University of Belgrade, Belgrade, SERBIA13, University Hospital of Brescia, Brescia, ITALY14

BACKGROUND: Dramatic recovery (DR) after thrombolysis in ischemic stroke is predictive of favorable clinical outcome and is associated with complete arterial recanalization and time to recanalization. However, successful recanalization is not equivalent to DR. Our objective was to evaluate clinical and analytical predictors of DR after IV thrombolysis. METHODS: Prospectively registered data on IV thrombolysis from January 2007 to September 2012 was analyzed and 230 patients with anterior circulation stroke with NIHSS ≥10 were included. Improvement of ≥10 on NIHSS or NIHSS ≤3 24h after thrombolysis was defined as DR. We compared patients with and without DR concerning demographics, vascular risk factors, clinical presentation, ASPECTS, presence of hyperdense MCA sign (HMCA) on admission CT and 24h after thrombolysis, any intracranial hemorrhage on 24h-control CT and stroke etiology. RESULTS: DR occurred in 53 patients (23%). DR group had lower admission NIHSS (14 vs 17, p=0.038), less total anterior circulation infarcts (p=0.009), more partial anterior circulation infarcts (p=0.003) and lower blood glucose on admission (122.9 vs 142.5mg/dL, p=0.004). All patients with DR had ASPECTS ≥7, vs 89,3% without DR (p=0.013). Arterial recanalization, defined as HMCA disappearance on control CT, was more frequent in the DR group (68.4% vs 14.1%, p