ASSTRACI: In order to synthesize some new analogs of dehidroepiandrosterone acetate, conditions of catalytic hydrogenation of both (Z)- and (E)-isomers of ...
36opuilr Marrlqe cpncKe3a nplpoAHe HayKe / Proceedingsfor Natural Scibnces,Matica Srpska Novi Sad,No 84,69-:72,-1993. .. t,i r, . ,, UDK 547.48
Ljubica D. Medi6-MijaCevi6t, Duian A. Miljkovii2, Mari.ja N. Sakaiz,Katarina M- Gaii2 i' ICN-Galenika,Institul, 29 November 111, 11000Beograd Institute of Chemistry,Faculty of Sciences;Trg Dositeja Obradovi6a3, 21000Novi Sad
STUDY ON CATALYTIC HYDROGENATION OF ISOMERIC (z) - AND (E)-3p-ACETOXY-71-PTCOLTNYLTDENE-5-ANDROSTEN-16-ONES ASSTRACI: In order to synthesizesome new analogsof dehidroepiandrosteroneacetate, conditionsof catalytic hydrogenationof both (Z)- and (E)-isomersof 3B-acetory-1.7-picolinylidene-5-androsten-16-one (1 and2) were carefullyworked out, whereupon3p-acetory-l7-picolyl-5-androsten-16-ol(3) was formed in both casesin the yields ot 57% and,62Vorespecrively.Catalytic hydrogenationof a mixture of isomericketonesI and2 afforded compound3 in a yield of 60Vo, KEY WORDS: derivativesof S-androstene,catalytichydrogenation
INTRODUCTION - ' In our earlier paper (Miljkovid, et al., 1985),concerningthe partial synrheses of bisnorsolanidane dcrivarives,the key intermediates,(z)- and (E)-3B-aceroxy-17picolinylidene-5-anrrosten-L6-one s (/ and 2) werc dcscribed.in the mentioned work, the isomericketoncs I an
