One of the 216 individuals who have made a significant contribution to the study of cardiovascular .... More than Incomplete Right Bundle Branch Block. MRI.
OMICS and Nobel Prize Ada Yonath invitee Guy Hugues Fontaine MD PhD HDR FACC FAHA FESC FHRS One of the 216 individuals who have made a significant contribution to the study of cardiovascular disease since 14th Century Willis Hurst, Richard Conti, Bruce Fye
Foundation for the Advance of Medicine and Science Mahwah NJ USA 2003
One of the “Life Time of Achievement ONE HUNDRED” International Biographical Center (IBC) Melrose Press Ltd, Cambridge England UK 2006 One of the “500 Greatest Geniuses of the 21th Century” American Biographic Institute (ABI) Selection made by 7,000 Researchers mostly from Universities around the World after study of achievements for the past three decades Raleigh NC USA 2009
Berlin OMICS 19 Jul 2016
Ada Yonath got a well deserved Nobel Prize because or understanding the role of Ribosome for analysing RNA and production of proteins
In the field of Science jealousness is very frequent I am not jealous because I received the ultimate award better than a Nobel Prize !!!
This Award was to be invited to give11 master lectures of 90 min each in the best universities of China during three weeks in May-June 2014
The famous wicker chair of Mao Zedong
It took three months of discussions to provide documents stressing my 16 original contributions at the beginning of cardiac pacing, antiarrhythmic surgery, Identification of ARVD Extension to ARVCs and other forms of inherited cardiomyopathies
Recognition by famous American cardiologists such as Willis Hurst, Richard Conti, Bruce Frye Who have included my name in the 216 individuals who have made a significant contribution to the study of cardiovascular diseases since the 14th century
Lecturer‘s Profile 216 Profiles in Cardiology Book
Nasal Cooling Overview
This explains why OMICS put me on the program to speak just before the Nobel Prize to talk about a new disease called ARVD (and not ARVC) recently reproduced in the dish from fibroblasts of patients specific mutation Kim Nature 2016
I found the first Pathologic presentation of typical ARVD in a famous Leonardo da Vinci sanguine of the Windsor Collection
Any Echocardiographist in this room will immediately recognize the so-called four cavities basic view of the human heart
Arrhythmogenic Right Ventricular Dysplasia First Document on ARVD XV Century
Leonardo da Vinci - Enlarged RV - Thin wall - Segmental abnormalities - No Fat for didactic reasons !
ARVD as observed after exposition of the heart at sugery
First Map of a Normal Heart Graph by Computer (1977)
First ARVD Patient
Epicardial Maps of the First Arrhythmogenic Right Ventricular Dysplasia Patient Origin of Activation emerging from the Right Branch
RV
Map in Sinus Rhythm
Origin of Activation emerging from the Left Branch
LV
Latest Activated Zone during Ventricular Tachycardia
RV
Emerging Area of Activation during Ventricular Tachycardia
LV
Map during Ventricular Tachycardia
Principle of Simple Ventriculotomy to prevent Ventricular Tachycardia
Right Coronary Artery
Ventriculotomy was a simple section of the wall without removal of tissue Performed at the site of Origin of Ventricular tachycardia
Anterior Coronary Artery
RV
RV Apex
Ventriculotomy
Arrhythmogenic Right Ventricular Dysplasia
ARVD typical Patient from the Veneto Region
Imaging techniques used to evaluate right ventricular function
Arrhythmogenic Right Ventricular Dysplasia
Tissue Doppler Measurement an example
Arrhythmogenic Right Ventricular Dysplasia
I am the reviewer of 22 Scientific Journals in both Basic and Clinical Science and served as a member of the Editorial Board of Circulation during five years after reviewing papers during decades for this journal
Arrhythmogenic Right Ventricular Dysplasia
Arrhythmogenic Right Ventricular Dysplasia
Increased picture of trabeculations + VT With LBBB pattern + Granulomatosis (Sarcoïdosis) Suggested a new variant of ARVD
First ARVD Patient
Observation of the post excitation phenomenon named the Epsilon wave
Arrhythmogenic Right Ventricular Dysplasia
ARVD Surgery
Arrhythmogenic Right Ventricular Dysplasia
Mega Epsilon Wave (MTCRBBB)
Arrhythmogenic Right Ventricular Dysplasia 84 Years Old Lady without Symptom More than Incomplete Right Bundle Branch Block
MRI
Incomplete RBBB >> MTIRBBB
Arrhythmogenic Right Ventricular Dysplasia More than Incomplete Right Bundle Branch Block
How to explain this localised trouble in conduction ?
That will be the subject of my second talk tomorrow just before the Nobel Prize if she Is not too late from Tel Aviv
Histology of RV in ARVD as compared to normal was able to explain the post-excitation phenomenon
First Evidence of a Structural Heart Disease explaining the Electrogenesis of Late Potentials in ARVD Normal Human Heart with a Strong Epicardial Layer of Fat Essential Adipomatosis Cordis
Surviving Fibers inside Epicardial Fat suggesting partial Replacement of Myocardium by Fat and Fibrosis
Epicardium
Epicardium Fat
Graisse
Normal Myocardium
Dysplastic Myocardium
Myocardium Endocardium Note : - Clear Limit between Myocardium and Fat - Absence of Strands of Cardiac Cells inside Fat
Endocardium Myocardial Fibers in Red Interstitial Fibrosis in Pink
Value of OMICS -
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Objective choice of speakers based not only on the most recent publications in good journals but beeing able to consider the global career Independent of corporative organisations such as ESC, AHA, ACC, HR etc. The names of managers are unknown Personal contact person for organisation of talks Fast exchange of info No medical politics All of this explains the
OMICS Exponential growth
Exponential Growth of OMICS
Open Access Journals
Readers
Editorial Members Conferences around the world For me Las
Vegas Vienna Baltimore
Such as this one including a Nobel Prize Ada Yonath Weizmann Institute of Science Israel
ARVD LOGO after WHF LOGO
THANK YOU !
Arrhythmias Department LOGO La Salpêtrière
“The Spring” (La Source) after Brancusi & Ingres Louvre Museum, Paris Calligraphic Painting Oil & Acrylic on Wood 120× 30 by Guy Fontaine 1964 #124 out of 4,500 pieces
