Oct 27, 2014 - Group B Factors 1,4,5,12. BD Difco .... Coatomer subunit gamma-1 OS=Homo sapiens ..... Eukaryotic translation initiation factor 1A, Y-.
Supplemental data
Proteomes of host cells membranes modified by intracellular activities of Salmonella enterica
Stephanie Vorwerk, Viktoria Krieger, Jörg Deiwick, Michael Hensel* and Nicole Hansmeier*
Division of Microbiology, School of Biology/Chemistry, University of Osnabrück, 49076 Osnabrück, Germany
Content: Fig. S1.
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Fig. S2.
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Fig. S3.
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Fig. S4.
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Fig. S5.
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Fig. S6.
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Table S1.
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Table S2.
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Table S3.
p. 51
Table S4.
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References
p. 54
a
b
c
Fig. S1. a) Gene arrangement and fusion construct (SseF-2TEV-2M45) of bait used for SMM enrichment in this study. Gene fusions of sseF with double tobacco etch mosaic virus protease (tev) and double M45 binding sites were cloned in pWSK29 containing the promotor ProsseA (arrow) and chaperone sscB (grey). Construct was named p3711 (pWSK PsseA sscB sseF::tev::tev::M45::M45). Fusion protein SseF-2TEV-2M45 contains chaperone-binding site (hatched), two hydrophobic domains (light grey), two TEV (blue) and M45 antibody (orange) binding sites. b, c) Time lapse microscopy of SIF network development. SIF network formation of Salmonella (red) infected HeLa LAMP1-GFP (green) cells. HeLa LAMP1-GFP cells were infected (MOI 50) with Salmonella WT (b) or SPI2-T3SS deficient strain P2D6 [p3711 p3589] (c). Note the localization of Salmonella (red) and host cell late endosomes/lysosomes labeled by LAMP1-GPF (green). Tubular LAMP1-GFP-positve compartments are present in b) but absent in c). Live cell imaging was performed at various time points p.i. as indicated. Scale bars: 10 µm.
2
Fig. S2. Intracellular proliferation of Salmonella strains. Growth attenuation of Salmonella mutant strain HH107 was restored to WT-levels by complementation with p3711 encoding SseF2TEV-2M45. The amount of intracellular colony forming units (CFU) in macrophage-like RAW264.7 cells was determined at 2 h and 16 h p.i. The x-fold replication was calculated as CFU ratio (16 h vs. 2 h) with the WT normalized to 100%. Means and standard deviation of three independent assays are shown. Statistical analysis was performed by one-way ANOVA with Bonferroni adjustment and indicated as follows: n.s., not significant; *, P < 0.05; **, P < 0.01.
3
a
b
c
Fig. S3. Representative CLSM images of isolated cytosolic (a) and GEMN (b, c) fraction from HeLa LAMP1-GFP cells infected with Salmonella HH107 [p3911 p3589] at 8 h. p.i. Enrichment of SIFs in GEMN fraction (b, c) is evident by detecting LAMP1-positive tubules (green). Note the presence of tubular LAMP1-GFP-positive structures (SIF, arrow) and SCV containing Salmonella (red, arrowhead). Scale bar: 10 µm.
a
b
Fig. S4. Enrichment of SMM by immunomagnetic separation. a) A representative magnetic bead after immunomagnetic separation of the GEMN fraction. The CLSM image shows the presence of LAMP1-GFP-containing membranes (green) on the beads. Note the presence of tubular LAMP1-GFP-positive structures (SIF, arrows) and SCV containing Salmonella (red, arrowheads). Scale bar: 10 µm. b) Confirmation of enriched bait protein SseF-2TEV-2M45 by Western blots after immunoprecipitation. 2 µL IP eluate was separated by 12% SDS-PAGE, transferred on nitrocellulose membrane and the epitope-tagged effector was detected by antiM45 antibody. Molecular weights are indicated. Lane 1: HH107 [p3711]; lane 2: P2D6 [p3711].
5
Cytosolic and membrane components
Trafficking and cytoskeleton
Fig. S5. Overview of the identified SMM proteome mapped onto known protein-protein interactions provided by the STRING (Search Tool for Retrieval of Interacting Genes/Proteins) database. Colored lines represent potential physical and functional protein-protein interactions with different layers of evidence: purple/ experimental; blue/ co-occurrence; red/ fusion; black/ co-expression; light blue/ database; yellow/ text-mining; green/ neighborhood. 6
7
Fig. S6. Localization of identified Rab GTPases and uthrophin in uninfected HeLa cells. GFP fusion proteins Rab GTPAses and utrophin co-localized with their described organelle markers. HeLa cells were either co-transfected with plasmids encoding for various organelle markers (pmTurquoise2-Golgi, pmTurquoise2-ER, pLAMP1-mCherry, pLifeAct-mTurquoise2) and plasmids with GFP fusions of Rab2a, Rab7a, Rab10a, Rab14a or UtrCh (green). Transfected Rab5c or Rab11a-GFP fusion proteins were further immunostained against EEA1 or transferrin receptor (TfR). Fluorophore mTurquoise2 is displayed with a red color for a better distinction from the green GFP signal. Images are shown as maximum intensity projection. Scale bar: 20 μm.
8
Table S1a. Bacterial strains, plasmids and antibodies used in this study. Designation Relevant characteristics Reference S. enterica strains S. Typhimurium Wild-type NCTC, lab stock NCTC 12023 HH107 sseF::aphT (1) P2D6 ssaV::mTn5 (2) Plasmids pWSK29 pSK p3673 p2810
p3589 pFPV-mCherry/2 p3451 pGL-Rab7 wt
Low copy number, AmpR High copy number, AmpR Tev::tev::M45::M45 in pSK ProsseA sscB sseF1-258::lisA51-361::HA in pSK ProsseA sscB sseF1-258::tev::tev::M45:: M45 in pWSK29 const. mCherry expression, CmR const. mCherry expression, AmpR LAMP1-mCherry Rab7a-GFP
pEGFP-C1-Rab11a pEGFP-C2-Rab5c
Rab11a-GFP Rab5c-GFP
pEGFP-C2-Rab2a pEGFP-C2-Rab10a pEGFP-C2-Rab14 GFP-UtrCH pmTurquoise2-Golgi pmTurquoise2-ER pLifeAct-Turquoise2
Rab2a-GFP Rab10a-GFP Rab14-GFP Utrophin-GFP Golgi-Turquoise ER-Turquoise F-actin-Turquoise
p3711
Antibodies Anti-M45 Salmonella O antiserum
Purified mouse anti-M45 epitope tag Rabbit anti-Salmonella O antiserum Group B Factors 1,4,5,12 Anti-human CopA Rabbit anti-alphaCop Anti-human CopG1 Rabbit anti-CopG1 Anti-human Sar1A Rabbit anti-Sar1A Anti-human Sec23A Rabbit anti-Sec23A Anti-human Mitofilin Rabbit anti-Mitofilin Anti-human TfR Mouse anti-Transferrin receptor Anti-human EEA1 Rabbit anti-EEA1 Anti-mouse IgG HRP Peroxidase-conjugated goat anti-mouse IgG Anti-mouse IgG Cy5 Goat anti-mouse IgG (H+L) Cy5 Anti-rabbit IgG Alexa568 Goat anti-rabbit IgG (H+L) Alexa568 Anti-mouse IgG Alexa488 Goat anti-mouse IgG (H+L) Alexa488 Mouse IgG2a isotype Purified mouse IgG2a κ isotype control
(3) Stratagene this study (4) this study (5) (6) this study Martin Aepfelbacher, Munich Addgene #12674 Christian Ungermann, Osnabrück Francis Barr, Oxford Francis Barr, Oxford Francis Barr, Oxford Addgene #26737, (7) Addgene #36205, (8) Addgene #36204, (8) Addgene #36205, (8) (9) BD Difco ThermoFisher Atlas Atlas ThermoFisher Abcam Roche ABR Jackson ImmunoResearch Jackson ImmunoResearch Invitrogen Dianova BD Bioscience 9
Table S1b. Oligonucleotides used in this study. Designation Sequence 5’-3’ mCherry-For-BamHI TTGGGATCCACCGGT CGCCACCATGGTGAGCAA GGGCGAGGAG mCherry-Rev-XbaI-NotI TGATCTAGAGTCGCGGC CGCTTTACTTGTACAGC TCGTCC hLAMP1-For-EcoRI TCTGAATTCATGGCG GCCCCCGGCAGC hLAMP1-Rev-BamHI AATGGATCCCGGATA GTCTGGTAGCCTGCG
10
Table S2. MS-identified proteins. a) Reproducible observed SMM proteins. One hit wonders as well as proteins observed in the control proteome were excluded from the final SMM proteome. b) Proteins observed in the control.1 1 a.
SMM proteome
Data set 1
Data set 2
ID
Accession Protein description
MW (kDa)
pI
ProteinScape score
#Pep. Cov (%)
RMD
1
2AAA_HU Serine/threonine-protein phosphatase 2A 65 MAN kDa regulatory subunit A alpha isoform OS=Homo sapiens GN=PPP2R1A PE=1 SV=4 4F2_HUM 4F2 cell-surface antigen heavy chain OS=Homo AN sapiens GN=SLC3A2 PE=1 SV=3 ACLY_HU ATP-citrate synthase OS=Homo sapiens MAN GN=ACLY PE=1 SV=3 ACTN1_H Alpha-actinin-1 OS=Homo sapiens GN=ACTN1 UMAN PE=1 SV=2 ACTS_HU Actin, alpha skeletal muscle OS=Homo sapiens MAN GN=ACTA1 PE=1 SV=1 ADT3_HU ADP/ATP translocase 3 OS=Homo sapiens MAN GN=SLC25A6 PE=1 SV=4 AHNK_HU Neuroblast differentiation-associated protein MAN AHNAK OS=Homo sapiens GN=AHNAK PE=1 SV=2 AIMP1_H Aminoacyl tRNA synthase complex-interacting UMAN multifunctional protein 1 OS=Homo sapiens GN=AIMP1 PE=1 SV=2 ALDOA_H Fructose-bisphosphate aldolase A OS=Homo UMAN sapiens GN=ALDOA PE=1 SV=2 ANXA1_H Annexin A1 OS=Homo sapiens GN=ANXA1 UMAN PE=1 SV=2 AP2A1_H AP-2 complex subunit alpha-1 OS=Homo UMAN sapiens GN=AP2A1 PE=1 SV=3 AP2B1_H AP-2 complex subunit beta OS=Homo sapiens UMAN GN=AP2B1 PE=1 SV=1 ARAP2_H Arf-GAP with Rho-GAP domain, ANK repeat UMAN and PH domain-containing protein 2 OS=Homo sapiens GN=ARAP2 PE=1 SV=3 ARF4_HU ADP-ribosylation factor 4 OS=Homo sapiens MAN GN=ARF4 PE=1 SV=3 AROS_HU Active regulator of SIRT1 OS=Homo sapiens MAN GN=RPS19BP1 PE=1 SV=1 ARPC4_H Actin-related protein 2/3 complex subunit 4 UMAN OS=Homo sapiens GN=ARPC4 PE=1 SV=3 ASCC3_H Activating signal cointegrator 1 complex UMAN subunit 3 OS=Homo sapiens GN=ASCC3 PE=1 SV=3
65.3
4.9
216.7 (M:216.7)
7
13.8
38.19 107.1 (M:107.1)
3
8.7
55.78
68
4.7
13
24.6
17
37.6
7.1
3
4.4
6
8.4
32.5
103
5.1
10
18.6
14
22.2
44.91
42
5.1
6
17.2
4
17.2
48.48
32.8
10.3
14
39.9
9
27.5
31.35
628.7
5.7
2
0.1
31.11 521.9 (M:521.9) 30.64 318.8 (M:318.8) 21.61 1378.4 (M:1378.4) 58.16 1023.4 (M:1023.4) 24.71 361.6 (M:361.6) 79.61 97.3 (M:97.3)
8
120.8
686.6 (M:686.6) 153.6 (M:153.6) 1197.7 (M:1197.7) 954.3 (M:954.3) 584.5 (M:584.5) 40.6 (M:40.6)
2
0.5
35.99
34.3
9.4
186.0 (M:186.0)
5
22.4
47.94 143.1 (M:143.1)
3
15.1
56.6
39.4
9.2
5
18.7
9.1
26.82
6.7
2
8.4
2
7.8
21.84
107.5
6.7
7
9.5
5
5.9
60.16
104.5
5.1
2
2.8
2
3.6
24.2
193.3
7.3
2
1.2
214.91 160.4 (M:160.4) 49.21 144.2 (M:144.2) 24.75 168.8 (M:168.8) 32.8 154.0 (M:154.0) 29.98 70.5 (M:70.5)
3
38.7
205.2 (M:205.2) 114.0 (M:114.0) 279.0 (M:279.0) 166.8 (M:166.8) 68.7 (M:68.7)
2
1.2
28.19
20.5
7.5
5
27.8
49.1
7
33.9 26.17
15.4
11.5
2
18.4
2
19.1 129.86
19.7
9.4
296.1 (M:296.1) 104.2 (M:104.2) 122.6 (M:122.6) 130.7 (M:130.7)
3
16.1
4
22.6 42.39
4
1.9
2
1.8
2 3 4 5 6 7 8 9 10 11 12 13
14 15 16 17
251.3 6.7
ProteinScape #Pep. Cov score (%)
347.3 (M:347.3) 107.05 81.0 (M:81.0) 42.07 156.3 (M:156.3) 910.6 69.2 (M:69.2)
RMD
560.26
11
18 19 20 21 22 23 24 25 26
27 28 29 30 31 32
AT5F1_H UMAN ATD3A_H UMAN ATP5H_H UMAN ATPG_HU MAN ATPO_HU MAN BAG2_HU MAN BAP31_H UMAN BOP1_HU MAN C1TM_HU MAN CALD1_H UMAN CALX_HU MAN CAPZB_H UMAN CD021_H UMAN CDC5L_H UMAN CLPX_HU MAN
33
CMC2_H UMAN
34
CN166_H UMAN COPA_HU MAN COPG1_H UMAN
35 36
ATP synthase subunit b, mitochondrial OS=Homo sapiens GN=ATP5F1 PE=1 SV=2 ATPase family AAA domain-containing protein 3A OS=Homo sapiens GN=ATAD3A PE=1 SV=2 ATP synthase subunit d, mitochondrial OS=Homo sapiens GN=ATP5H PE=1 SV=3 ATP synthase subunit gamma, mitochondrial OS=Homo sapiens GN=ATP5C1 PE=1 SV=1 ATP synthase subunit O, mitochondrial OS=Homo sapiens GN=ATP5O PE=1 SV=1 BAG family molecular chaperone regulator 2 OS=Homo sapiens GN=BAG2 PE=1 SV=1 B-cell receptor-associated protein 31 OS=Homo sapiens GN=BCAP31 PE=1 SV=3 Ribosome biogenesis protein BOP1 OS=Homo sapiens GN=BOP1 PE=1 SV=2 Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens GN=MTHFD1L PE=1 SV=1 Caldesmon OS=Homo sapiens GN=CALD1 PE=1 SV=3 Calnexin OS=Homo sapiens GN=CANX PE=1 SV=2 F-actin-capping protein subunit beta OS=Homo sapiens GN=CAPZB PE=1 SV=4 Uncharacterized protein C4orf21 OS=Homo sapiens GN=C4orf21 PE=2 SV=2 Cell division cycle 5-like protein OS=Homo sapiens GN=CDC5L PE=1 SV=2 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens GN=CLPX PE=1 SV=2 Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens GN=SLC25A13 PE=1 SV=2 UPF0568 protein C14orf166 OS=Homo sapiens GN=C14orf166 PE=1 SV=1 Coatomer subunit alpha OS=Homo sapiens GN=COPA PE=1 SV=2 Coatomer subunit gamma-1 OS=Homo sapiens GN=COPG1 PE=1 SV=1
28.9
9.8
71.3
9.7
18.5
5.1
33
9.7
23.3
10.5
23.8
6.3
28
9.1
83.6
5.8
105.7 9.2
93.2
5.5
67.5
4.3
31.3
5.2
119.3 4.8
378.6 (M:378.6) 506.2 (M:506.2) 446.5 (M:446.5) 214.3 (M:214.3) 332.0 (M:332.0) 148.5 (M:148.5) 204.0 (M:204.0) 159.0 (M:159.0) 272.5 (M:272.5)
7
23.8
23.97
9
17.8
26.44
8
59
18.88
4
15.4
33.52
7
43.2
16.09
4
26.1
13.29
5
18.7
18.69
2
4.4
52.9
6
7.6
48.37
356.0 (M:356.0) 932.1 (M:932.1) 138.8 (M:138.8) 59.6 (M:59.6) 551.6 (M:551.6) 112.2 (M:112.2)
9
17.9
23.53
20
39.2
3
10.8
2
2.3
11
20.6
3
5.8
271.4 (M:271.4) 491.5 (M:491.5) 95.2 (M:95.2) 214.4 (M:214.4) 274.6 (M:274.6) 144.8 (M:144.8) 125.7 (M:125.7) 67.5 (M:67.5) 368.5 (M:368.5)
5
18.8 52.27
11
21.5 32.75
2
11.8 44.57
4
14.8 38.49
6
31.5 39.46
4
21.8 52.64
2
6.9
28.84
2
2.8
37.25
7
9.2
44.96
619.1 (M:619.1) 30.56 358.9 (M:358.9) 74.75 154.1 (M:154.1) 464.64 60.3 (M:60.3) 31.08 407.3 (M:407.3) 57.1 118.5 (M:118.5)
15
22.3 36.95
9
19.9 38.29
4
17
32.39
2
2.1
73.98
7
11.7 59.4
3
6
61.62
62.44
92.2
8.9
69.2
8.5
74.1
9.4
405.0 (M:405.0)
6
16
19.89
74.3 (M:74.3)
2
3.3
28.1
6.2
572.1 (M:572.1) 122.2 (M:122.2) 86.3 (M:86.3)
11
51.2
32.7
5
26.6 33.49
2
2.5
23.31
10
9.5
53.23
2
3.2
4.08
292.3 (M:292.3) 496.2 (M:496.2) 208.4 (M:208.4)
3
4.5
31.39
138.3 8.5 97.7
5.2
12
37 38 39 40 41 42 43 44 45 46 47 48 49
COR1C_H UMAN CTNA1_H UMAN CUL4A_H UMAN DDX1_HU MAN DDX17_H UMAN DDX23_H UMAN DDX3X_H UMAN DDX56_H UMAN DESP_HU MAN DHB12_H UMAN DHB4_HU MAN DHX30_H UMAN DSRAD_H UMAN
50
DUT_HU MAN
51
DX39A_H UMAN DYH7_HU MAN DYHC1_H UMAN DYST_HU MAN EF1B_HU MAN
52 53 54 55
Coronin-1C OS=Homo sapiens GN=CORO1C PE=1 SV=1 Catenin alpha-1 OS=Homo sapiens GN=CTNNA1 PE=1 SV=1 Cullin-4A OS=Homo sapiens GN=CUL4A PE=1 SV=3 ATP-dependent RNA helicase DDX1 OS=Homo sapiens GN=DDX1 PE=1 SV=2 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens GN=DDX23 PE=1 SV=3 ATP-dependent RNA helicase DDX3X OS=Homo sapiens GN=DDX3X PE=1 SV=3 Probable ATP-dependent RNA helicase DDX56 OS=Homo sapiens GN=DDX56 PE=1 SV=1 Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 Estradiol 17-beta-dehydrogenase 12 OS=Homo sapiens GN=HSD17B12 PE=1 SV=2 Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens GN=HSD17B4 PE=1 SV=3 Putative ATP-dependent RNA helicase DHX30 OS=Homo sapiens GN=DHX30 PE=1 SV=1 Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens GN=ADAR PE=1 SV=4 Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens GN=DUT PE=1 SV=4 ATP-dependent RNA helicase DDX39A OS=Homo sapiens GN=DDX39A PE=1 SV=2 Dynein heavy chain 7, axonemal OS=Homo sapiens GN=DNAH7 PE=1 SV=2 Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens GN=DYNC1H1 PE=1 SV=5 Dystonin OS=Homo sapiens GN=DST PE=1 SV=4 Elongation factor 1-beta OS=Homo sapiens GN=EEF1B2 PE=1 SV=3
53.2
6.7
100
5.9
87.6
9
82.4
6.9
80.2
9.3
95.5
10.1
73.2
6.8
61.6
10
331.6 6.4 34.3
9.8
79.6
9.6
133.9 9.8
112.3 (M:112.3) 548.0 (M:548.0) 83.7 (M:83.7) 723.1 (M:723.1) 363.8 (M:363.8) 292.0 (M:292.0) 661.1 (M:661.1) 140.6 (M:140.6) 143.5 (M:143.5) 116.5 (M:116.5) 117.1 (M:117.1) 471.6 (M:471.6) 98.3 (M:98.3)
3
9.7
13
24.7
2
3.6
14
24.3
6
13.6
6
8.8
12
23.4
3
5.9
2
1
3
13.8
3
7.7
10
11.1
2
2.7
177.77 120.2 (M:120.2) 29.01 372.0 (M:372.0) 48.9 184.3 (M:184.3) 20.69 105.8 (M:105.8) 27.99 395.4 (M:395.4) 74.83 227.4 (M:227.4) 40.11 643.3 (M:643.3) 701.07 149.5 (M:149.5) 46.32 806.5 (M:806.5) 11.85 76.5 (M:76.5) 45.25 60.8 (M:60.8) 54.07 272.5 (M:272.5) 26.18 312.8 (M:312.8)
2
4.4
8
11.3 25.64
4
6.7
286.26
3
5.4
105.54
8
13.9 42.53
5
6.6
13
21.8 52.25
3
6.2
19.14
15
6
33.06
2
8.3
35.41
2
3.7
73.95
5
4.8
49.17
6
6
52.37
2
8.7
83.88
7
17.6 20.23
2
0.2
626.63
10
2.9
40.08
3
0.3
118.33
2
12.4 56.32
136
9.6
26.5
10.2
127.9 (M:127.9)
2
10.7
44.71
49.1
5.4
130.0 (M:130.0) 153.1 (M:153.1) 120.9 (M:120.9) 254.7 (M:254.7) 269.3 (M:269.3)
2
4.9
26.32
3
0.8
2
0.5
3
0.5
4
15.6
460.9 5.6 532.1 6 860.1 5 24.7
4.3
59.0 (M:59.0)
294.6 (M:294.6) 862.08 63.4 (M:63.4) 793.51 372.7 (M:372.7) 379.67 156.3 (M:156.3) 22.5 140.4 (M:140.4)
38.71
215.9
13
56 57 58 59 60 61 62 63 64 65 66 67
68 69
70 71 72 73
74
EF1G_HU MAN EF2_HUM AN EHD4_HU MAN ELAV1_H UMAN ENPL_HU MAN ESYT1_H UMAN EXOS2_H UMAN EZRI_HU MAN F207A_H UMAN FAS_HUM AN FLNA_HU MAN FXR1_HU MAN G3BP2_H UMAN G3PT_HU MAN GALT2_H UMAN GCN1L_H UMAN GLSK_HU MAN GPDM_H UMAN H2B3B_H UMAN
Elongation factor 1-gamma OS=Homo sapiens GN=EEF1G PE=1 SV=3 Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4 EH domain-containing protein 4 OS=Homo sapiens GN=EHD4 PE=1 SV=1 ELAV-like protein 1 OS=Homo sapiens GN=ELAVL1 PE=1 SV=2 Endoplasmin OS=Homo sapiens GN=HSP90B1 PE=1 SV=1 Extended synaptotagmin-1 OS=Homo sapiens GN=ESYT1 PE=1 SV=1 Exosome complex component RRP4 OS=Homo sapiens GN=EXOSC2 PE=1 SV=2 Ezrin OS=Homo sapiens GN=EZR PE=1 SV=4
50.1
6.3
95.3
6.4
61.1
6.3
36.1
9.8
92.4
4.6
Protein FAM207A OS=Homo sapiens GN=FAM207A PE=1 SV=2 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 Fragile X mental retardation syndrome-related protein 1 OS=Homo sapiens GN=FXR1 PE=1 SV=3 Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens GN=G3BP2 PE=1 SV=2 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific OS=Homo sapiens GN=GAPDHS PE=1 SV=2 Polypeptide N-acetylgalactosaminyltransferase 2 OS=Homo sapiens GN=GALNT2 PE=1 SV=1 Translational activator GCN1 OS=Homo sapiens GN=GCN1L1 PE=1 SV=6 Glutaminase kidney isoform, mitochondrial OS=Homo sapiens GN=GLS PE=1 SV=1 Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Homo sapiens GN=GPD2 PE=1 SV=3 Histone H2B type 3-B OS=Homo sapiens GN=HIST3H2BB PE=1 SV=3
122.8 5.5 32.8
7.8
69.4
5.9
25.4
11.6
273.3 6 280.6 5.7 69.7
5.8
54.1
5.3
44.5
9.2
64.7
9.5
292.6 7.6 73.4
8.8
80.8
8.4
13.9
10.8
88.4 (M:88.4) 741.8 (M:741.8) 244.7 (M:244.7) 220.6 (M:220.6) 134.7 (M:134.7) 297.2 (M:297.2) 221.8 (M:221.8) 201.1 (M:201.1) 64.1 (M:64.1) 121.7 (M:121.7) 2223.0 (M:2223.0) 128.8 (M:128.8)
2
5.3
16
23.9
5
12
5
22.1
3
6.1
8
11.4
3
15.7
4
7.5
2
11.7
2
1.8
45
27.2
3
8.4
289.7 (M:289.7) 162.4 (M:162.4)
5
75.8
137.6 (M:137.6) 32.72 392.0 (M:392.0) 41.44 346.6 (M:346.6) 176.85 179.2 (M:179.2) 16.63 115.4 (M:115.4) 218.74 252.6 (M:252.6) 22.42 118.5 (M:118.5) 40.3 129.7 (M:129.7) 48.46 137.0 (M:137.0) 94.49 1273.6 (M:1273.6) 30.12 2636.6 (M:2636.6) 38.69 62.2 (M:62.2)
2
4.6
9
11.4 26.08
9
19.6 26.04
4
13.8 18.52
2
2.9
17.03
5
6.8
42.15
2
9.2
1.54
3
7.2
213.72
3
16.5 26.98
26
12.6 31.39
51
25.7 30.58
2
5.3
59.74
12
36.78
4
9.8
86.48
4
4.7
18.13
170.1 (M:170.1) 97.9 (M:97.9)
3
4.7
54.25
294.7 (M:294.7) 165.8 (M:165.8) 95.4 (M:95.4) 339.4 (M:339.4)
4
11.9
4
9.5
344.28
3
2.2
14
7.9
47.2
2
4.6
2
5.4
437.91
8
16.4
349.93 250.1 (M:250.1) 23.07 667.7 (M:667.7) 46.24 108.0 (M:108.0) 21.33 239.7 (M:239.7)
6
11.6 37.91
115.8 (M:115.8)
3
27.8
46.04
3
27
121.7 (M:121.7)
40.71
587.08
14
75 76
77 78 79 80
81 82 83 84 85 86
87 88 89 90
91 92 93
HDAC2_H UMAN HNRCL_H UMAN HNRPD_H UMAN HNRPL_H UMAN HYOU1_H UMAN IF1AY_HU MAN IMA4_HU MAN IMDH2_H UMAN IMMT_H UMAN IPO7_HU MAN IPO9_HU MAN IQCB1_H UMAN K0020_H UMAN K1C15_H UMAN K6PP_HU MAN KHDR1_H UMAN LAP2A_H UMAN LDHA_HU MAN LIMA1_H
Histone deacetylase 2 OS=Homo sapiens GN=HDAC2 PE=1 SV=2 Heterogeneous nuclear ribonucleoprotein Clike 1 OS=Homo sapiens GN=HNRNPCL1 PE=1 SV=1 Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens GN=HNRNPD PE=1 SV=1 Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens GN=HNRNPL PE=1 SV=2 Hypoxia up-regulated protein 1 OS=Homo sapiens GN=HYOU1 PE=1 SV=1 Eukaryotic translation initiation factor 1A, Ychromosomal OS=Homo sapiens GN=EIF1AY PE=1 SV=4 Importin subunit alpha-4 OS=Homo sapiens GN=KPNA3 PE=1 SV=2 Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens GN=IMPDH2 PE=1 SV=2 Mitochondrial inner membrane protein OS=Homo sapiens GN=IMMT PE=1 SV=1 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 Importin-9 OS=Homo sapiens GN=IPO9 PE=1 SV=3 IQ calmodulin-binding motif-containing protein 1 OS=Homo sapiens GN=IQCB1 PE=1 SV=1 Pumilio domain-containing protein KIAA0020 OS=Homo sapiens GN=KIAA0020 PE=1 SV=3 Keratin, type I cytoskeletal 15 OS=Homo sapiens GN=KRT15 PE=1 SV=3 6-phosphofructokinase type C OS=Homo sapiens GN=PFKP PE=1 SV=2 KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens GN=KHDRBS1 PE=1 SV=1 Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens GN=TMPO PE=1 SV=2 L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 LIM domain and actin-binding protein 1
55.3
5.5
32.1
4.8
38.4
8.5
64.1
9.2
111.3 5 16.4
4.9
57.8
4.7
55.8
6.5
83.6
6.1
119.4 4.6 115.9 4.6 68.9
9.8
73.5
10.2
49.2
4.6
85.5
8.5
48.2
9.2
75.4
8.5
36.7
9.3
85.2
6.4
109.0 (M:109.0) 518.4 (M:518.4)
3
9
35.74
156.9 (M:156.9) 415.8 (M:415.8)
5
15.2 27.55
2
5.5
16.5
2
5.5
12.39
97.6 (M:97.6) 262.4 (M:262.4) 131.1 (M:131.1) 105.4 (M:105.4)
2
9.3
45.79
98.6 (M:98.6) 315.1 (M:315.1) 210.5 (M:210.5) 91.4 (M:91.4)
2
9
54.33
7
24.1
37.9
6
16.1 40.12
3
5.3
15.27
4
6.5
2
15.3
8.77
2
15.3 44.91
142.1 (M:142.1) 252.0 (M:252.0) 541.5 (M:541.5) 267.2 (M:267.2) 150.0 (M:150.0) 66.6 (M:66.6)
3
11.5
62.79
167.0 (M:167.0) 370.84 105.2 (M:105.2) 26.99 381.8 (M:381.8) 24.19 419.6 (M:419.6) 20.73 236.4 (M:236.4) 50.89 60.5 (M:60.5)
3
8.6
6.71
5
13.4
2
6
100.88
13
22.4
8
13.7 25.54
6
7
8
11.3 36.22
3
5.8
3
4.8
45.11
2
5
2
5.4
301.2
201.6 (M:201.6) 337.8 (M:337.8) 480.9 (M:480.9) 269.4 (M:269.4)
5
10.6
47.04
2
3.9
9
2
5.5
54.28
4
5.5
66.59
10
14.8
39.24
3
5.1
60.2
7
24.8
28.68
6
16.9 36.81
838.2 (M:838.2) 104.8 (M:104.8) 275.2
17
40.9
32.28
15
33.1 31.82
3
15.1
2
5.7
5
9.6
7
11.5 26.77
114.7 (M:114.7) 452.1 (M:452.1) 155.5 (M:155.5) 219.4 (M:219.4)
642.7 (M:642.7) 267.18 94.4 (M:94.4) 23.47 254.5
44.84
83.1
15
94 95 96
97 98 99 100 101 102 103
104 105 106 107 108 109 110
111
UMAN LMNB2_H UMAN LMO7_H UMAN M2OM_H UMAN MACOI_H UMAN MAFK_H UMAN MAGD2_ HUMAN MGST1_H UMAN MISP_HU MAN MPCP_H UMAN MPP10_H UMAN MTCH2_H UMAN MYH10_H UMAN MYH9_H UMAN MYO1B_ HUMAN MYO1C_ HUMAN NB5R3_H UMAN NDUA9_H UMAN NDUS1_H UMAN
OS=Homo sapiens GN=LIMA1 PE=1 SV=1 Lamin-B2 OS=Homo sapiens GN=LMNB2 PE=1 SV=3 LIM domain only protein 7 OS=Homo sapiens GN=LMO7 PE=1 SV=3 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Homo sapiens GN=SLC25A11 PE=1 SV=3 Macoilin OS=Homo sapiens GN=TMEM57 PE=1 SV=1 Transcription factor MafK OS=Homo sapiens GN=MAFK PE=1 SV=1 Melanoma-associated antigen D2 OS=Homo sapiens GN=MAGED2 PE=1 SV=2 Microsomal glutathione S-transferase 1 OS=Homo sapiens GN=MGST1 PE=1 SV=1 Mitotic interactor and substrate of PLK1 OS=Homo sapiens GN=MISP PE=1 SV=1 Phosphate carrier protein, mitochondrial OS=Homo sapiens GN=SLC25A3 PE=1 SV=2 U3 small nucleolar ribonucleoprotein protein MPP10 OS=Homo sapiens GN=MPHOSPH10 PE=1 SV=2 Mitochondrial carrier homolog 2 OS=Homo sapiens GN=MTCH2 PE=1 SV=1 Myosin-10 OS=Homo sapiens GN=MYH10 PE=1 SV=3 Myosin-9 OS=Homo sapiens GN=MYH9 PE=1 SV=4 Unconventional myosin-Ib OS=Homo sapiens GN=MYO1B PE=1 SV=3 Unconventional myosin-Ic OS=Homo sapiens GN=MYO1C PE=1 SV=4 NADH-cytochrome b5 reductase 3 OS=Homo sapiens GN=CYB5R3 PE=1 SV=3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Homo sapiens GN=NDUFA9 PE=1 SV=2 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens GN=NDUFS1 PE=1 SV=3
67.6
5.2
192.6 9.1 34
10.4
76.1
9.8
17.5
10.7
64.9
9.9
17.6
9.8
75.3
6.4
40.1
10.1
78.8
4.6
33.3
9.3
228.9 5.3 226.4 5.4 131.9 10 121.6 10.1 34.2
7.9
42.5
10.3
79.4
5.8
(M:275.2) 772.8 (M:772.8) 104.0 (M:104.0) 135.4 (M:135.4)
12
23.5
39.87
2
1.7
8.41
3
15
51.3
125.0 (M:125.0) 67.8 (M:67.8) 91.4 (M:91.4) 143.9 (M:143.9) 110.9 (M:110.9) 209.0 (M:209.0) 105.0 (M:105.0)
2
3.9
53.57
2
11.5
42.05
2
8.1
28.45
2
18.1
62.69
3
5.9
22.54
4
12.2
33.48
3
7.3
37.41
172.6 (M:172.6) 109.1 (M:109.1) 1237.4 (M:1237.4) 244.8 (M:244.8) 256.7 (M:256.7) 418.6 (M:418.6) 144.6 (M:144.6)
4
17.8
24.66
3
1.4
23
16.9
6
9.5
5
6.4
8
30.6
4
12.5
118.3 (M:118.3)
2
4.3
(M:254.5) 503.1 (M:503.1) 547.7 (M:547.7) 163.2 (M:163.2)
7
15.2 37.52
14
11.8 43.5
4
13.1 560.85
3
3.9
6
39.7 20.54
2
5.8
2
14.2 53.11
5
9.7
54.84
2
7.2
54.26
2
4.8
51.21
104.8 (M:104.8) 979.13 737.4 (M:737.4) 40.92 3145.5 (M:3145.5) 40.16 287.8 (M:287.8) 38.7 309.0 (M:309.0) 43.01 224.8 (M:224.8) 26.44 105.5 (M:105.5)
3
12.5 65.42
7
5.2
50.82
58
36
39.81
6
5.5
37.06
6
8.1
22.83
5
20.9 38.94
3
8.8
53.82
5
10.3 50.38
111.7 (M:111.7) 191.3 (M:191.3) 95.6 (M:95.6) 112.9 (M:112.9) 152.2 (M:152.2) 105.6 (M:105.6) 121.7 (M:121.7)
293.6 (M:293.6)
96.72
66.81
40.55
16
112
113
114 115 116 117 118 119 120 121 122 123 124 125
126 127 128 129 130
NDUS3_H NADH dehydrogenase [ubiquinone] iron-sulfur UMAN protein 3, mitochondrial OS=Homo sapiens GN=NDUFS3 PE=1 SV=1 NDUV2_H NADH dehydrogenase [ubiquinone] UMAN flavoprotein 2, mitochondrial OS=Homo sapiens GN=NDUFV2 PE=1 SV=2 NH2L1_H NHP2-like protein 1 OS=Homo sapiens UMAN GN=NHP2L1 PE=1 SV=3 NHP2_HU H/ACA ribonucleoprotein complex subunit 2 MAN OS=Homo sapiens GN=NHP2 PE=1 SV=1 NOL11_H Nucleolar protein 11 OS=Homo sapiens UMAN GN=NOL11 PE=1 SV=1 NOLC1_H Nucleolar and coiled-body phosphoprotein 1 UMAN OS=Homo sapiens GN=NOLC1 PE=1 SV=2 NU107_H Nuclear pore complex protein Nup107 UMAN OS=Homo sapiens GN=NUP107 PE=1 SV=1 NU155_H Nuclear pore complex protein Nup155 UMAN OS=Homo sapiens GN=NUP155 PE=1 SV=1 NU160_H Nuclear pore complex protein Nup160 UMAN OS=Homo sapiens GN=NUP160 PE=1 SV=3 NU205_H Nuclear pore complex protein Nup205 UMAN OS=Homo sapiens GN=NUP205 PE=1 SV=3 NUP53_H Nucleoporin NUP53 OS=Homo sapiens UMAN GN=NUP35 PE=1 SV=1 NXF1_HU Nuclear RNA export factor 1 OS=Homo sapiens MAN GN=NXF1 PE=1 SV=1 ODO1_H 2-oxoglutarate dehydrogenase, mitochondrial UMAN OS=Homo sapiens GN=OGDH PE=1 SV=3 ODPA_HU Pyruvate dehydrogenase E1 component MAN subunit alpha, somatic form, mitochondrial OS=Homo sapiens GN=PDHA1 PE=1 SV=3 OPA1_HU Dynamin-like 120 kDa protein, mitochondrial MAN OS=Homo sapiens GN=OPA1 PE=1 SV=3 P5CR2_H Pyrroline-5-carboxylate reductase 2 OS=Homo UMAN sapiens GN=PYCR2 PE=1 SV=1 P5CS_HU Delta-1-pyrroline-5-carboxylate synthase MAN OS=Homo sapiens GN=ALDH18A1 PE=1 SV=2 PCLO_HU Protein piccolo OS=Homo sapiens GN=PCLO MAN PE=1 SV=4 PCNA_HU Proliferating cell nuclear antigen OS=Homo MAN sapiens GN=PCNA PE=1 SV=1
30.2
7.8
442.5 (M:442.5)
8
40.5
33.07
263.0 (M:263.0)
5
21.6 223.39
27.4
9.2
63.5 (M:63.5)
2
9.2
25.4
107.5 (M:107.5)
3
9.2
33.69
14.2
9.7
2
18
53.16
18
73.75
9.4
3
25.5
2
13.1 19.22
81.1
5.7
5
9.9
4
8.2
18.97
73.6
10
2
4.1
6
9.7
39.42
6
11.4
3
3.6
7.6
9
11.1
9
10.4 28.31
5
5.4
5
4.8
53.27
2
2.1
9
6
47.29
3
10.1
3
13.8 60.74
2
4.8
2
4
42.36
3
4.2
4
4.7
44.84
6
13.6
93.0 (M:93.0) 30.72 75.5 (M:75.5) 31.05 225.0 (M:225.0) 10.24 229.6 (M:229.6) 20.52 139.5 (M:139.5) 57.85 490.1 (M:490.1) 28.46 213.9 (M:213.9) 62.17 405.3 (M:405.3) 61.62 149.1 (M:149.1) 11.39 108.0 (M:108.0) 303.05 160.7 (M:160.7) 52.55 124.0 (M:124.0)
2
17.2
119.6 (M:119.6) 172.8 (M:172.8) 254.2 (M:254.2) 82.3 (M:82.3) 319.3 (M:319.3) 477.9 (M:477.9) 229.2 (M:229.2) 96.4 (M:96.4) 104.4 (M:104.4) 110.1 (M:110.1) 144.8 (M:144.8) 203.4 (M:203.4)
4
10.8 53.58
178.1 (M:178.1) 151.1 (M:151.1) 522.3 (M:522.3) 99.6 (M:99.6) 173.3 (M:173.3)
4
6.6
17.69
5
8
3
13.4
2
10.9 56.69
11
16.7
8
14.1 34.18
3
0.4
3
0.4
2
12.3
4
15.7 75.02
106.3 5.2 155.1 5.7 162
5.2
227.8 5.8 34.8
9.7
70.1
9.5
115.9 6.4 43.3
9.3
111.6 8.6 33.6
9
87.2
6.7
552.9 6.1 28.8
4.4
219.2 (M:219.2) 48.1 99.5 (M:99.5) 30.4 438.9 (M:438.9) 1026.2 114.5 1 (M:114.5) 36.11 203.2 (M:203.2)
38.66
833.44
17
131 132 133 134 135
PDIA1_H UMAN PDIA3_H UMAN PDIA6_H UMAN PESC_HU MAN PGAM5_ HUMAN
136
PGRC2_H UMAN
137
PLST_HU MAN PP1A_HU MAN
138
139
PRDX3_H UMAN
140
PRP6_HU MAN PRP8_HU MAN PRS4_HU MAN PSMD1_H UMAN
141 142 143
144
PSMD2_H UMAN
145
PTBP1_H UMAN PUF60_H UMAN PUR2_HU MAN
146 147
Protein disulfide-isomerase OS=Homo sapiens GN=P4HB PE=1 SV=3 Protein disulfide-isomerase A3 OS=Homo sapiens GN=PDIA3 PE=1 SV=4 Protein disulfide-isomerase A6 OS=Homo sapiens GN=PDIA6 PE=1 SV=1 Pescadillo homolog OS=Homo sapiens GN=PES1 PE=1 SV=1 Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens GN=PGAM5 PE=1 SV=2 Membrane-associated progesterone receptor component 2 OS=Homo sapiens GN=PGRMC2 PE=1 SV=1 Plastin-3 OS=Homo sapiens GN=PLS3 PE=1 SV=4 Serine/threonine-protein phosphatase PP1alpha catalytic subunit OS=Homo sapiens GN=PPP1CA PE=1 SV=1 Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens GN=PRDX3 PE=1 SV=3 Pre-mRNA-processing factor 6 OS=Homo sapiens GN=PRPF6 PE=1 SV=1 Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens GN=PRPF8 PE=1 SV=2 26S protease regulatory subunit 4 OS=Homo sapiens GN=PSMC1 PE=1 SV=1 26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens GN=PSMD1 PE=1 SV=2 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens GN=PSMD2 PE=1 SV=3 Polypyrimidine tract-binding protein 1 OS=Homo sapiens GN=PTBP1 PE=1 SV=1 Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens GN=PUF60 PE=1 SV=1 Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens GN=GART PE=1 SV=1
57.1
4.6
103.2 (M:103.2) 734.8 (M:734.8) 341.3 (M:341.3) 298.1 (M:298.1) 116.2 (M:116.2)
2
5.1
46.79
187.2 (M:187.2) 400.3 (M:400.3) 460.2 (M:460.2) 240.5 (M:240.5) 119.6 (M:119.6)
5
11.4 76.75
56.7
5.9
15
34.5
34.28
8
19.8 39.54
48.1
4.8
6
21.8
37.57
9
27.5 48.99
68
7.1
6
11.1
66.72
5
8
32
9.7
4
14.9
23.66
3
11.8 49.17
23.8
4.6
150.2 (M:150.2)
3
18.4
31.43
122.2 (M:122.2)
3
15.7 56.29
70.8
5.3
8
37.5
5.9
356.6 (M:356.6) 295.5 (M:295.5)
16
44.86
4
7.3
6
19.4
27.13
290.8 (M:290.8) 218.0 (M:218.0)
4
15.5 25.24
27.7
8.9
477.2 (M:477.2)
9
35.5
29.97
318.2 (M:318.2)
6
24.2 20.37
106.9 9.3
371.2 (M:371.2) 156.1 (M:156.1) 174.9 (M:174.9) 258.0 (M:258.0)
8
10.4
23.39
10
13.2 33.42
4
3.4
26.23
24
12.9 41.47
3
10.7
12.57
3
11.8 19.86
6
12
27.95
402.4 (M:402.4) 1093.8 (M:1093.8) 285.3 (M:285.3) 170.6 (M:170.6)
4
5.6
66.45
100.1 4.9
210.8 (M:210.8)
5
12.3
34.32
118.3 (M:118.3)
3
5.8
51.09
57.2
9.8
5
18.5
23.17
5.8
38.4
5.1
3
13.4
20.9
2
5.7
44.6
3
6.1
30.92
87.3 (M:87.3) 115.8 (M:115.8) 85.2 (M:85.2)
2
59.8
265.0 (M:265.0) 176.0 (M:176.0) 129.0 (M:129.0)
2
2.7
521.62
273.4 9.5 49.2
5.8
105.8 5.1
107.7 6.3
67.27
50.83
18
148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168
PUR9_HU MAN RAB10_H UMAN RAB14_H UMAN RAB2A_H UMAN RAB5C_H UMAN RAB7A_H UMAN RALA_HU MAN RAP1B_H UMAN RB11A_H UMAN RBM14_H UMAN RBM3_H UMAN RCC1_HU MAN RECQ1_H UMAN RFC4_HU MAN RFC5_HU MAN RL32_HU MAN RL7L_HU MAN RM04_H UMAN RM12_H UMAN RM13_H UMAN RM19_H
Bifunctional purine biosynthesis protein PURH OS=Homo sapiens GN=ATIC PE=1 SV=3 Ras-related protein Rab-10 OS=Homo sapiens GN=RAB10 PE=1 SV=1 Ras-related protein Rab-14 OS=Homo sapiens GN=RAB14 PE=1 SV=4 Ras-related protein Rab-2A OS=Homo sapiens GN=RAB2A PE=1 SV=1 Ras-related protein Rab-5C OS=Homo sapiens GN=RAB5C PE=1 SV=2 Ras-related protein Rab-7a OS=Homo sapiens GN=RAB7A PE=1 SV=1 Ras-related protein Ral-A OS=Homo sapiens GN=RALA PE=1 SV=1 Ras-related protein Rap-1b OS=Homo sapiens GN=RAP1B PE=1 SV=1 Ras-related protein Rab-11A OS=Homo sapiens GN=RAB11A PE=1 SV=3 RNA-binding protein 14 OS=Homo sapiens GN=RBM14 PE=1 SV=2 Putative RNA-binding protein 3 OS=Homo sapiens GN=RBM3 PE=1 SV=1 Regulator of chromosome condensation OS=Homo sapiens GN=RCC1 PE=1 SV=1 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 Replication factor C subunit 4 OS=Homo sapiens GN=RFC4 PE=1 SV=2 Replication factor C subunit 5 OS=Homo sapiens GN=RFC5 PE=1 SV=1 60S ribosomal protein L32 OS=Homo sapiens GN=RPL32 PE=1 SV=2 60S ribosomal protein L7-like 1 OS=Homo sapiens GN=RPL7L1 PE=1 SV=1 39S ribosomal protein L4, mitochondrial OS=Homo sapiens GN=MRPL4 PE=1 SV=1 39S ribosomal protein L12, mitochondrial OS=Homo sapiens GN=MRPL12 PE=1 SV=2 39S ribosomal protein L13, mitochondrial OS=Homo sapiens GN=MRPL13 PE=1 SV=1 39S ribosomal protein L19, mitochondrial
64.6
6.3
22.5
9.4
23.9
5.8
23.5
6.1
23.5
9.5
23.5
7.2
23.6
7.5
20.8
5.5
24.4
6.1
69.4
10
17.2
9.2
44.9
7.9
73.4
9
39.7
9.3
38.5
6.9
15.8
12.1
28.6
11.1
34.9
10.1
21.3
9.9
20.7
9.6
33.5
10.2
101.3 (M:101.3) 313.2 (M:313.2) 186.8 (M:186.8) 253.6 (M:253.6) 357.2 (M:357.2) 254.0 (M:254.0) 70.5 (M:70.5) 200.7 (M:200.7) 172.2 (M:172.2) 121.6 (M:121.6) 152.0 (M:152.0) 244.1 (M:244.1) 117.8 (M:117.8) 174.1 (M:174.1) 182.9 (M:182.9) 173.3 (M:173.3) 83.6 (M:83.6) 114.8 (M:114.8) 170.4 (M:170.4) 142.1 (M:142.1) 99.8
2
8.3
6
30.5
3
24.7
4
26.4
6
38
4
27.5
2
11.2
4
26.1
3
16.2
3
7.6
4
35
5
19.2
3
6.3
3
12.1
3
11.8
5
23.7
2
9.8
3
15.1
3
28.8
4
22.5
2
11
222.65 77.5 (M:77.5) 60.43 206.1 (M:206.1) 30.73 125.3 (M:125.3) 21.71 58.6 (M:58.6) 23.15 172.5 (M:172.5) 18.87 204.9 (M:204.9) 54.72 68.0 (M:68.0) 20.07 85.9 (M:85.9) 25.32 153.3 (M:153.3) 46.23 355.6 (M:355.6) 464.56 90.3 (M:90.3) 270.34 119.3 (M:119.3) 17.21 82.0 (M:82.0) 19.24 132.5 (M:132.5) 34.53 150.1 (M:150.1) 26.29 132.5 (M:132.5) 440.97 80.2 (M:80.2) 55.67 74.4 (M:74.4) 10.96 112.1 (M:112.1) 30.47 65.2 (M:65.2) 46.53 91.6
2
5.1
47.7
4
22.5 23.48
4
20.5 736.28
2
12.7 32.63
4
23.6 22.29
4
23.2 399.6
2
14.1 102.72
2
11.4 10.59
3
16.2 31.94
9
17
3
15.9 469.7
2
8.1
40.98
2
3.9
73.4
4
11.8 27.09
3
10.6 14.75
4
23
28.55
2
8.5
48.41
2
11.3 34.15
2
11.6 18.82
2
10.1 61.63
2
6.2
37.1
70.02
19
169 170 171 172 173 174
UMAN RM20_H UMAN RM22_H UMAN RM43_H UMAN RM48_H UMAN RN123_H UMAN RPAB3_H UMAN
175
RPN2_HU MAN
176
RRP1_HU MAN RRP1B_H UMAN RS15HUMAN RS24HUMAN RSMN_H UMAN
177 178 179 180
181 182 183 184 185 186
RTCB_HU MAN RU2B_HU MAN SAFB1_H UMAN SAP18_H UMAN SAR1A_H UMAN SC23A_H UMAN
OS=Homo sapiens GN=MRPL19 PE=1 SV=2 39S ribosomal protein L20, mitochondrial OS=Homo sapiens GN=MRPL20 PE=1 SV=1 39S ribosomal protein L22, mitochondrial OS=Homo sapiens GN=MRPL22 PE=1 SV=1 39S ribosomal protein L43, mitochondrial OS=Homo sapiens GN=MRPL43 PE=1 SV=1 39S ribosomal protein L48, mitochondrial OS=Homo sapiens GN=MRPL48 PE=1 SV=2 E3 ubiquitin-protein ligase RNF123 OS=Homo sapiens GN=RNF123 PE=1 SV=1 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Homo sapiens GN=RPN2 PE=1 SV=3 Ribosomal RNA processing protein 1 homolog A OS=Homo sapiens GN=RRP1 PE=1 SV=1 Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens GN=RRP1B PE=1 SV=3 40S ribosomal protein S15a OS=Homo sapiens GN=RPS15A PE=1 SV=2 40S ribosomal protein S24 OS=Homo sapiens GN=RPS24 PE=1 SV=1 Small nuclear ribonucleoprotein-associated protein N OS=Homo sapiens GN=SNRPN PE=1 SV=1 tRNA-splicing ligase RtcB homolog OS=Homo sapiens GN=RTCB PE=1 SV=1 U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens GN=SNRPB2 PE=1 SV=1 Scaffold attachment factor B1 OS=Homo sapiens GN=SAFB PE=1 SV=4 Histone deacetylase complex subunit SAP18 OS=Homo sapiens GN=SAP18 PE=1 SV=1 GTP-binding protein SAR1a OS=Homo sapiens GN=SAR1A PE=1 SV=1 Protein transport protein Sec23A OS=Homo sapiens GN=SEC23A PE=1 SV=2
17.4
11.7
23.6
10.5
23.4
10.2
23.9
9.6
148.4 6.3
(M:99.8) 63.3 (M:63.3) 208.4 (M:208.4) 80.6 (M:80.6) 130.3 (M:130.3) 66.4 (M:66.4) 116.4 (M:116.4)
2
14.1
32.4
4
25.7
42.64
2
10.2
76.04
3
15.6
43.47
2
1.4
20.85
2
16
35.26
(M:91.6) 94.7 (M:94.7) 144.9 (M:144.9) 112.6 (M:112.6) 110.9 (M:110.9) 85.8 (M:85.8) 85.1 (M:85.1)
2
12.8 50.18
3
18
3
15.3 18.85
2
11.8 26.01
2
2.3
2
19.3 44.41
52.13
117.27
17.1
4.3
69.2
5.4
439.9 (M:439.9)
9
19.3
39.75
137.4 (M:137.4)
3
7.8
28.45
52.8
10
5
14.5
9.3
70.84
10.4
10
19.3
3
5
58.22
14.8
10.9
5
24.8
6
29.2 31.74
15.4
11.3
5
29.3
2
15.8 78.92
24.6
12.1
2
9.6
170.14 180.0 (M:180.0) 39.8 110.9 (M:110.9) 209.01 199.4 (M:199.4) 30.06 101.2 (M:101.2) 47.67 112.9 (M:112.9)
4
84.4
232.2 (M:232.2) 383.1 (M:383.1) 310.3 (M:310.3) 221.7 (M:221.7) 157.9 (M:157.9)
3
12.5 38.79
55.2
6.9
8
18.2
50.67
2
5.3
121.47
25.5
10.1
419.9 (M:419.9) 146.6 (M:146.6) 145.0 (M:145.0) 140.6 (M:140.6) 199.3 (M:199.3) 194.6 (M:194.6)
3
12
36.27
3
12
76.45
4
10.3
61.9
4
8
53.48
4
17.6
79.34
2
15
14.67
3
23.2
29.24
2
11.6 24.07
5
9
32.32
3
5.6
102.6 5.2 17.5
9.9
22.4
6.2
86.1
6.7
94.9 (M:94.9) 131.5 (M:131.5) 188.5 (M:188.5) 76.3 (M:76.3) 114.7 (M:114.7) 129.6 (M:129.6)
53.14
20
187 188 189
SC61BHUMAN SF3A3_H UMAN SLIRP_HU MAN
190
SMC1A_H UMAN
191
SMC3_HU MAN
192
SNAA_HU MAN SNR40_H UMAN
193
194 195 196 197 198 199 200 201 202 203 204
SNRPA_H UMAN SNUT2_H UMAN SPIR2_HU MAN SPTB2_H UMAN SPTN1_H UMAN SRP72_H UMAN SRP14HUMAN SRPR_HU MAN STAT3_H UMAN SYLC_HU MAN SYMC_HU MAN
Protein transport protein Sec61 subunit beta OS=Homo sapiens GN=SEC61B PE=1 SV=2 Splicing factor 3A subunit 3 OS=Homo sapiens GN=SF3A3 PE=1 SV=1 SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens GN=SLIRP PE=1 SV=1 Structural maintenance of chromosomes protein 1A OS=Homo sapiens GN=SMC1A PE=1 SV=2 Structural maintenance of chromosomes protein 3 OS=Homo sapiens GN=SMC3 PE=1 SV=2 Alpha-soluble NSF attachment protein OS=Homo sapiens GN=NAPA PE=1 SV=3 U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens GN=SNRNP40 PE=1 SV=1 U1 small nuclear ribonucleoprotein A OS=Homo sapiens GN=SNRPA PE=1 SV=3 U4/U6.U5 tri-snRNP-associated protein 2 OS=Homo sapiens GN=USP39 PE=1 SV=2 Protein spire homolog 2 OS=Homo sapiens GN=SPIRE2 PE=1 SV=3 Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens GN=SPTBN1 PE=1 SV=2 Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens GN=SPTAN1 PE=1 SV=3 Signal recognition particle subunit SRP72 OS=Homo sapiens GN=SRP72 PE=1 SV=3 Signal recognition particle 14 kDa protein OS=Homo sapiens GN=SRP14 PE=1 SV=2 Signal recognition particle receptor subunit alpha OS=Homo sapiens GN=SRPR PE=1 SV=2 Signal transducer and activator of transcription 3 OS=Homo sapiens GN=STAT3 PE=1 SV=2 Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens GN=LARS PE=1 SV=2 Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens GN=MARS PE=1 SV=2
10
12.3
160.6 (M:160.6) 167.9 (M:167.9) 81.2 (M:81.2)
3
37.5
68.28
58.8
5.1
12.3
11
5
15.8
49.78
2
22
64.8
143.1 8.2
288.5 (M:288.5)
6
5.8
141.5 6.8
702.0 (M:702.0)
16
33.2
5.1
39.3
9.3
339.4 (M:339.4) 160.3 (M:160.3)
31.3
10.3
65.3
9.6
79.6
9
177.7 (M:177.7) 240.4 (M:240.4) 75.1 (M:75.1) 1247.5 (M:1247.5) 1473.2 (M:1473.2) 178.2 (M:178.2) 313.1 (M:313.1) 104.9 (M:104.9) 148.4 (M:148.4) 85.8 (M:85.8) 171.6 (M:171.6)
274.4 5.3 284.4 5.1 74.6
9.9
14.6
10.6
69.8
9.8
88
5.9
134.4 7.1 101.1 5.8
113.3 (M:113.3) 171.8 (M:171.8) 81.0 (M:81.0)
3
37.5 26.43
3
7.8
74.27
2
22
24.27
65.79
614.3 (M:614.3)
13
12.5 58.4
17.6
34.09
491.8 (M:491.8)
10
11.7 43.84
8
38.6
18.37
3
12.2 25.18
4
22.4
48.87
134.1 (M:134.1) 114.0 (M:114.0)
3
9.2
5
26.6
4
12.1 25.81
5
14
4
10.3 76.6
2
1
2
1
26
15.4
58
30.5 29.81
31
18.6
88
40.1 32.11
4
8.9
4
9.8
5
55.1
5
44.9 41.99
2
4.4
4
6.9
310.6
2
5.7
2
5.1
79.28
2
2.6
2
2.2
89.87
4
5.6
202.75 154.8 (M:154.8) 14.15 120.4 (M:120.4) 5.5 68.6 (M:68.6) 34.11 2952.2 (M:2952.2) 25.72 4213.7 (M:4213.7) 45.14 220.0 (M:220.0) 23.0 263.1 7 (M:263.1) 64.53 188.2 (M:188.2) 21.47 135.6 (M:135.6) 772.12 110.7 (M:110.7) 24.39 100.4 (M:100.4)
2
2.6
49.66
33.17
36.05
42.29
21
205 206 207 208 209 210 211 212 213 214 215 216
217 218 219 220 221 222 223
SYMPK_H UMAN SYNE1_H UMAN SYNE2_H UMAN SYQ_HU MAN SYRC_HU MAN SYVC_HU MAN TBL3_HU MAN TBRG4_H UMAN TCPE_HU MAN TCPG_HU MAN TCPZ_HU MAN TDIF2_HU MAN TERA_HU MAN TFR1_HU MAN TGM2_H UMAN THOC1_H UMAN TIF1B_HU MAN TLK1_HU MAN TMED9_H UMAN
Symplekin OS=Homo sapiens GN=SYMPK PE=1 SV=2 Nesprin-1 OS=Homo sapiens GN=SYNE1 PE=1 SV=4 Nesprin-2 OS=Homo sapiens GN=SYNE2 PE=1 SV=3 Glutamine--tRNA ligase OS=Homo sapiens GN=QARS PE=1 SV=1 Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens GN=RARS PE=1 SV=2 Valine--tRNA ligase OS=Homo sapiens GN=VARS PE=1 SV=4 Transducin beta-like protein 3 OS=Homo sapiens GN=TBL3 PE=1 SV=2 Protein TBRG4 OS=Homo sapiens GN=TBRG4 PE=1 SV=1 T-complex protein 1 subunit epsilon OS=Homo sapiens GN=CCT5 PE=1 SV=1 T-complex protein 1 subunit gamma OS=Homo sapiens GN=CCT3 PE=1 SV=4 T-complex protein 1 subunit zeta OS=Homo sapiens GN=CCT6A PE=1 SV=3 Deoxynucleotidyltransferase terminalinteracting protein 2 OS=Homo sapiens GN=DNTTIP2 PE=1 SV=2 Transitional endoplasmic reticulum ATPase OS=Homo sapiens GN=VCP PE=1 SV=4 Transferrin receptor protein 1 OS=Homo sapiens GN=TFRC PE=1 SV=2 Protein-glutamine gamma-glutamyltransferase 2 OS=Homo sapiens GN=TGM2 PE=1 SV=2 THO complex subunit 1 OS=Homo sapiens GN=THOC1 PE=1 SV=1 Transcription intermediary factor 1-beta OS=Homo sapiens GN=TRIM28 PE=1 SV=5 Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens GN=TLK1 PE=1 SV=2 Transmembrane emp24 domain-containing protein 9 OS=Homo sapiens GN=TMED9 PE=1 SV=2
141.1 5.8 1010. 5.3 5 795.9 5.1 87.7
6.8
75.3
6.3
140.4 8.4 89
6.5
70.7
7.1
59.6
5.3
60.5
6.1
58
6.2
84.4
5.8
89.3
5
84.8
6.2
77.3
5
75.6
4.8
88.5
5.4
86.6
9.5
27.3
8.9
59.9 (M:59.9) 228.0 (M:228.0) 152.7 (M:152.7) 180.1 (M:180.1) 198.9 (M:198.9) 138.4 (M:138.4) 217.8 (M:217.8) 153.5 (M:153.5) 498.0 (M:498.0) 294.7 (M:294.7) 626.7 (M:626.7) 140.7 (M:140.7)
2
2
3
0.4
3
0.5
4
7.5
4
8.9
2
2.8
5
9.9
4
8.4
11
29.4
6
17.2
12
29.6
3
5.6
548.3 (M:548.3) 467.4 (M:467.4) 207.6 (M:207.6) 115.5 (M:115.5) 207.5 (M:207.5) 82.7 (M:82.7) 94.6 (M:94.6)
11
19.5
9
15
5
11.6
3
6.8
5
10.5
2
1.6
2
8.5
1169.7 87.0 6 (M:87.0) 64.65 226.2 (M:226.2) 51.93 169.9 (M:169.9) 24.82 75.4 (M:75.4) 59.75 302.0 (M:302.0) 425.02 167.1 (M:167.1) 53.45 119.9 (M:119.9) 16.07 83.8 (M:83.8) 239.02 493.3 (M:493.3) 16.32 559.1 (M:559.1) 23.67 528.5 (M:528.5) 106.46 176.5 (M:176.5)
2
2.5
45.23
6
0.6
38.6
4
0.6
39.56
2
4
39.9
7
13.6 32.71
4
4.7
61.3
2
4.1
52.18
2
5.2
37.54
12
23.7 40.78
11
26.4 33.25
11
29.2 38.13
3
6.9
15.62
8
13.9 26.06
6
9.7
38.66
3
7.9
63.23
2
5
33.19
6
8.5
35.5
2
1.6
16.56
2
8.9
95.11
485.9 (M:485.9) 20.52 265.8 (M:265.8) 121.66 127.3 (M:127.3) 6.7 87.0 (M:87.0) 51.18 243.0 (M:243.0) 54.63 74.3 (M:74.3) 39.99 74.7 (M:74.7)
32.99
22
224
225 226 227 228 229 230 231 232 233 234 235 236
237
238 239
240 241
TMEDA_H Transmembrane emp24 domain-containing UMAN protein 10 OS=Homo sapiens GN=TMED10 PE=1 SV=2 TMM43_ Transmembrane protein 43 OS=Homo sapiens HUMAN GN=TMEM43 PE=1 SV=1 TMOD3_ Tropomodulin-3 OS=Homo sapiens HUMAN GN=TMOD3 PE=1 SV=1 TNPO1_H Transportin-1 OS=Homo sapiens GN=TNPO1 UMAN PE=1 SV=2 TOIP1_H Torsin-1A-interacting protein 1 OS=Homo UMAN sapiens GN=TOR1AIP1 PE=1 SV=2 TOM70_H Mitochondrial import receptor subunit TOM70 UMAN OS=Homo sapiens GN=TOMM70A PE=1 SV=1 TOP2B_H DNA topoisomerase 2-beta OS=Homo sapiens UMAN GN=TOP2B PE=1 SV=3 TPM2_HU Tropomyosin beta chain OS=Homo sapiens MAN GN=TPM2 PE=1 SV=1 TPM3_HU Tropomyosin alpha-3 chain OS=Homo sapiens MAN GN=TPM3 PE=1 SV=2 TPM3L_H Putative tropomyosin alpha-3 chain-like UMAN protein OS=Homo sapiens PE=5 SV=2 TR150_H Thyroid hormone receptor-associated protein UMAN 3 OS=Homo sapiens GN=THRAP3 PE=1 SV=2 TRAP1_H Heat shock protein 75 kDa, mitochondrial UMAN OS=Homo sapiens GN=TRAP1 PE=1 SV=3 TXTP_HU Tricarboxylate transport protein, MAN mitochondrial OS=Homo sapiens GN=SLC25A1 PE=1 SV=2 U520_HU U5 small nuclear ribonucleoprotein 200 kDa MAN helicase OS=Homo sapiens GN=SNRNP200 PE=1 SV=2 UBA1_HU Ubiquitin-like modifier-activating enzyme 1 MAN OS=Homo sapiens GN=UBA1 PE=1 SV=3 UT14A_H U3 small nucleolar RNA-associated protein 14 UMAN homolog A OS=Homo sapiens GN=UTP14A PE=1 SV=1 UTRO_HU Utrophin OS=Homo sapiens GN=UTRN PE=1 MAN SV=2 VAPA_HU Vesicle-associated membrane proteinMAN associated protein A OS=Homo sapiens GN=VAPA PE=1 SV=3
25
7.8
317.4 (M:317.4)
6
25.1
9.77
229.8 (M:229.8)
5
21.9 35.56
44.8
8.7
2
13.5
8.04
7.5
4.9
4
16.5
23.72
4
13.1 57.64
9
11.8
30.01
7
9.1
40.41
4
8.9
13.98
2
4.3
51.84
2
5.4
32.31
2
4.1
67.58
2
0.8
41.09
8
6
22.34
5
19
25.74
4
15.5 80.09
2
8.4
44.78
4
14
3
8.1
22.66
4
11.2 54.21
2
3.4
47.02
11
12.1 46.25
2
5.8
28.53
4
7.4
2
7.7
17.51
84.1 (M:84.1) 166.3 (M:166.3) 307.0 (M:307.0) 64.8 (M:64.8) 125.5 (M:125.5) 401.0 (M:401.0) 132.8 (M:132.8) 458.1 (M:458.1) 212.9 (M:212.9) 478.2 (M:478.2) 198.0 (M:198.0) 106.1 (M:106.1)
3
39.6
86.6 (M:86.6) 184.4 (M:184.4) 444.4 (M:444.4) 185.5 (M:185.5) 137.1 (M:137.1) 96.2 (M:96.2) 197.9 (M:197.9) 329.1 (M:329.1) 214.1 (M:214.1) 67.9 (M:67.9) 108.6 (M:108.6) 103.7 (M:103.7)
3
11.3 47.8
244.4 5.7
300.9 (M:300.9)
6
4.4
22.32
1217.9 (M:1217.9)
24
14
32.61
117.8 5.4
129.8 (M:129.8) 125.6 (M:125.6)
2
3.9
37.59
3
5.1
33.27
3
4
58.42
163.0 (M:163.0) 346.9 (M:346.9)
6
10.4 37.78
145.1 (M:145.1) 194.9 (M:194.9)
4
1.7
50.87
2
0.7
6
25.7
29.51
122.4 (M:122.4) 151.2 (M:151.2)
4
22.5 48.21
102.3 4.7 66.2
8.9
67.4
6.9
183.2 8.8 32.8
4.5
32.9
4.5
26.3
4.3
108.6 10.6 80.1
9
34
10.6
87.9
8.5
394.2 5.1 27.9
9.6
549.67
242
65.63
25.22
23
242
243 244 245
246 247
VAPB_HU Vesicle-associated membrane proteinMAN associated protein B/C OS=Homo sapiens GN=VAPB PE=1 SV=3 VIGLN_H Vigilin OS=Homo sapiens GN=HDLBP PE=1 UMAN SV=2 VP26B_H Vacuolar protein sorting-associated protein UMAN 26B OS=Homo sapiens GN=VPS26B PE=1 SV=2 VWA3B_ von Willebrand factor A domain-containing HUMAN protein 3B OS=Homo sapiens GN=VWA3B PE=2 SV=3 WDR43_ WD repeat-containing protein 43 OS=Homo HUMAN sapiens GN=WDR43 PE=1 SV=3 ZN207_H Zinc finger protein 207 OS=Homo sapiens UMAN GN=ZNF207 PE=1 SV=1
27.2
7.7
135.4 (M:135.4)
3
17.7
63.96
116.4 (M:116.4)
3
15.2 44.13
141.4 6.4
349.9 (M:349.9) 72.3 (M:72.3) 89.9 (M:89.9)
9
9.1
38.87
2
1.8
33.61
2
3.6
102.9
2
3.6
69.82
2
1.2
31.59
69.5 (M:69.5) 69.4 (M:69.4) 134.5 (M:134.5)
2
1.2
106.21
177.3 (M:177.3) 77.0 (M:77.0)
3
5.8
26.63
4
6.1
22.84
2
6.9
16.44
132.5 (M:132.5) 62.9 (M:62.9)
2
4
41.04
39.1
7
145.7 7.2
74.8
5.3
50.7
9.8
1
,IP proteomes of biological replicates
24
b. MS-identified control proteome
Data set 1
1
Data set 2
ID
Accession
Protein description
MW (kDa)
pI
ProteinScape score
#Pep.
Cov (%)
RMD
1
1433E_HUMAN
29.2
4.5
12.5
54.8
1433G_HUMAN
28.3
4.7
2
9.7
31.3
3
1433T_HUMAN
27.7
4.5
2
13.1
60.5
4
1433Z_HUMAN
27.7
4.6
5
29
45.6
5
ABCF1_HUMAN
95.9
6.4
190.3 (M:190.3) 183.3 (M:183.3) 186.3 (M:186.3) 396.3 (M:396.3) 680.6 (M:680.6)
2
2
8
10.5
6
ACTB_HUMAN
41.7
5.2
ACTG_HUMAN
41.8
5.2
8
ACTH_HUMAN
41.8
5.2
9
ACTN4_HUMAN
104.8
5.2
10
ADT2_HUMAN
32.8
10.2
1190.4 (M:1190.4) 2420.1 (M:2420.1) 430.4 (M:430.4) 581.2 (M:581.2) 193.8 (M:193.8)
21
7
11
ALBU_HUMAN
69.3
5.9
12
AN32A_HUMAN
28.6
3.8
13
AN32B_HUMAN
28.8
14
AN32E_HUMAN
15
ANK3_HUMAN
14-3-3 protein epsilon OS=Homo sapiens GN=YWHAE PE=1 SV=1 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 14-3-3 protein theta OS=Homo sapiens GN=YWHAQ PE=1 SV=1 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 ATP-binding cassette sub-family F member 1 OS=Homo sapiens GN=ABCF1 PE=1 SV=2 Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 Actin, cytoplasmic 2 OS=Homo sapiens GN=ACTG1 PE=1 SV=1 Actin, gamma-enteric smooth muscle OS=Homo sapiens GN=ACTG2 PE=1 SV=1 Alpha-actinin-4 OS=Homo sapiens GN=ACTN4 PE=1 SV=2 ADP/ATP translocase 2 OS=Homo sapiens GN=SLC25A5 PE=1 SV=7 Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens GN=ANP32A PE=1 SV=1 Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens GN=ANP32B PE=1 SV=1 Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens GN=ANP32E PE=1 SV=1 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3
1
ProteinScape score
#Pep.
Cov (%)
RMD
46.7
183.8 (M:183.8)
3
4.4
46.7
50.9
46.2
801.2 (M:801.2)
14
37.9
27.5
38
63.7
50.2
2
4.3
32.4
8
11.1
45.6
6
9.9
32.9
4
12.8
79.2
331.0 (M:331.0) 128.6 (M:128.6) 175.9 (M:175.9) 169.4 (M:169.4)
2
8.1
8.9
4
5.4
26.3
2
7.6
14.1
3.8
229.5 (M:229.5)
5
13.9
27.1
30.7
3.6
98.6 (M:98.6)
2
5.2
88.7
480.1
6.1
75.9 (M:75.9)
2
0.8
49.8
25
16
ANXA2_HUMAN
17
ASF1A_HUMAN
18
ASPH_HUMAN
19
ATPA_HUMAN
20
ATPB_HUMAN
21
ATX10_HUMAN
22
BASP1_HUMAN
23
BUB3_HUMAN
24
C1QBP_HUMAN
25
C1TC_HUMAN
26
CAC1D_HUMAN
27
CAF1A_HUMAN
28
CAF1B_HUMAN
29
CALM_HUMAN
30
CALU_HUMAN
31
CAPR1_HUMAN
32
CAZA1_HUMAN
Annexin A2 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 Histone chaperone ASF1A OS=Homo sapiens GN=ASF1A PE=1 SV=1 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens GN=ASPH PE=1 SV=3 ATP synthase subunit alpha, mitochondrial OS=Homo sapiens GN=ATP5A1 PE=1 SV=1 ATP synthase subunit beta, mitochondrial OS=Homo sapiens GN=ATP5B PE=1 SV=3 Ataxin-10 OS=Homo sapiens GN=ATXN10 PE=1 SV=1 Brain acid soluble protein 1 OS=Homo sapiens GN=BASP1 PE=1 SV=2 Mitotic checkpoint protein BUB3 OS=Homo sapiens GN=BUB3 PE=1 SV=1 Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens GN=C1QBP PE=1 SV=1 C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens GN=MTHFD1 PE=1 SV=3 Voltage-dependent L-type calcium channel subunit alpha-1D OS=Homo sapiens GN=CACNA1D PE=1 SV=2 Chromatin assembly factor 1 subunit A OS=Homo sapiens GN=CHAF1A PE=1 SV=2 Chromatin assembly factor 1 subunit B OS=Homo sapiens GN=CHAF1B PE=1 SV=1 Calmodulin OS=Homo sapiens GN=CALM1 PE=1 SV=2 Calumenin OS=Homo sapiens GN=CALU PE=1 SV=2 Caprin-1 OS=Homo sapiens GN=CAPRIN1 PE=1 SV=2 F-actin-capping protein subunit alpha-1 OS=Homo sapiens GN=CAPZA1 PE=1 SV=3
38.6
8.5
1264.1 (M:1264.1)
540.2 (M:540.2) 158.2 (M:158.2) 132.8 (M:132.8)
10
33
39.1
23
4.1
3
15.7
32.2
85.8
4.8
3
5.7
46.7
59.7
9.6
783.6 (M:783.6)
10
18.3
62.8
56.5
5.1
7
14.4
57.2
53.5
5
3
9.5
50.2
22.7
4.5
4
29.5
75.8
37.1
6.4
5
17.7
76.4
31.3
4.6
503.8 (M:503.8) 243.2 (M:243.2) 242.4 (M:242.4) 290.6 (M:290.6) 408.9 (M:408.9)
200.7 (M:200.7) 639.3 (M:639.3)
4
16.8
79.8
6
22
290.5
10
29.1
32.6
101.5
7
352.0 (M:352.0)
4
5.7
57.0
245
6.3
125.1 (M:125.1)
3
2
243.8
106.9
5.6
414.3 (M:414.3) 206.5 (M:206.5)
7
12.6
21.2
61.5
7.8
5
11.6
391.6
16.8
3.9
37.1
4.3
60.5 (M:60.5)
2
7.9
69.1
78.3
5
190.1 (M:190.1)
5
10.6
534.2
32.9
5.4
89.8 (M:89.8)
217.5 (M:217.5)
24
2
3
49.6
20.1
14.3
57.6
53.5
62.9
26
33
CBX3_HUMAN
34
CBX5_HUMAN
35
CDK1_HUMAN
36
CG050_HUMAN
37
CH60_HUMAN
38
CHCH3_HUMAN
39
CHTOP_HUMAN
40
CKAP4_HUMAN
41
COPE_HUMAN
42
COX41_HUMAN
43
COX5A_HUMAN
44
COX5B_HUMAN
45
CPSF5_HUMAN
46
CPSF6_HUMAN
47
CY1_HUMAN
48
CYBP_HUMAN
Chromobox protein homolog 3 OS=Homo sapiens GN=CBX3 PE=1 SV=4 Chromobox protein homolog 5 OS=Homo sapiens GN=CBX5 PE=1 SV=1 Cyclin-dependent kinase 1 OS=Homo sapiens GN=CDK1 PE=1 SV=3 Uncharacterized protein C7orf50 OS=Homo sapiens GN=C7orf50 PE=1 SV=1 60 kDa heat shock protein, mitochondrial OS=Homo sapiens GN=HSPD1 PE=1 SV=2 Coiled-coil-helix-coiled-coil-helix domaincontaining protein 3, mitochondrial OS=Homo sapiens GN=CHCHD3 PE=1 SV=1 Chromatin target of PRMT1 protein OS=Homo sapiens GN=CHTOP PE=1 SV=2 Cytoskeleton-associated protein 4 OS=Homo sapiens GN=CKAP4 PE=1 SV=2 Coatomer subunit epsilon OS=Homo sapiens GN=COPE PE=1 SV=3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens GN=COX4I1 PE=1 SV=1 Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens GN=COX5A PE=1 SV=2 Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens GN=COX5B PE=1 SV=2 Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens GN=NUDT21 PE=1 SV=1 Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens GN=CPSF6 PE=1 SV=2 Cytochrome c1, heme protein, mitochondrial OS=Homo sapiens GN=CYC1 PE=1 SV=3 Calcyclin-binding protein OS=Homo sapiens GN=CACYBP PE=1 SV=2
20.8
5.1
22.2
5.6
34.1
9
22.1
10.2
61
5.6
26.1
9.3
26.4
12.7
66
5.6
34.5
4.8
19.6
253.5 (M:253.5) 92.9 (M:92.9)
3
14.8
30.0
2
15.7
371.4
146.2 (M:146.2)
3
11.8
117.1
168.4 (M:168.4)
3
22.4
22.9
78.8 (M:78.8)
2
18
15.0
72.4 (M:72.4)
2
5.9
25.6
2382.7 (M:2382.7) 148.8 (M:148.8)
34
42.6
61.7
2
11.9
43.3
579.6 (M:579.6) 507.0 (M:507.0) 65.8 (M:65.8)
7
19.4
51.5
8
16.6
56.9
2
7.1
69.2
10
155.8 (M:155.8)
4
19.5
51.2
16.8
6.4
218.0 (M:218.0)
4
20
31.8
13.7
10.2
136.6 (M:136.6)
3
33.3
25.7
26.2
9.4
130.4 (M:130.4)
2
11.9
113.1
59.2
6.7
144.2 (M:144.2)
2
5.1
38.7
35.4
9.8
191.2 (M:191.2)
2
7.4
50.6
26.2
9
148.6 (M:148.6)
4
18.9
32.9
27
49
DDB1_HUMAN
50
DDX18_HUMAN
51
DDX21_HUMAN
52
DDX24_HUMAN
53
DDX27_HUMAN
54
DDX3Y_HUMAN
55
DDX47_HUMAN
56
DDX5_HUMAN
57
DEK_HUMAN
58
DHX15_HUMAN
59
DHX36_HUMAN
60
DHX9_HUMAN
61
DJB11_HUMAN
62
DNJA1_HUMAN
63
DNJA3_HUMAN
64
DNJC9_HUMAN
DNA damage-binding protein 1 OS=Homo sapiens GN=DDB1 PE=1 SV=1 ATP-dependent RNA helicase DDX18 OS=Homo sapiens GN=DDX18 PE=1 SV=2 Nucleolar RNA helicase 2 OS=Homo sapiens GN=DDX21 PE=1 SV=5 ATP-dependent RNA helicase DDX24 OS=Homo sapiens GN=DDX24 PE=1 SV=1 Probable ATP-dependent RNA helicase DDX27 OS=Homo sapiens GN=DDX27 PE=1 SV=2 ATP-dependent RNA helicase DDX3Y OS=Homo sapiens GN=DDX3Y PE=1 SV=2 Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens GN=DDX47 PE=1 SV=1 Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens GN=DDX5 PE=1 SV=1 Protein DEK OS=Homo sapiens GN=DEK PE=1 SV=1 Putative pre-mRNA-splicing factor ATPdependent RNA helicase DHX15 OS=Homo sapiens GN=DHX15 PE=1 SV=2 Probable ATP-dependent RNA helicase DHX36 OS=Homo sapiens GN=DHX36 PE=1 SV=2 ATP-dependent RNA helicase A OS=Homo sapiens GN=DHX9 PE=1 SV=4 DnaJ homolog subfamily B member 11 OS=Homo sapiens GN=DNAJB11 PE=1 SV=1 DnaJ homolog subfamily A member 1 OS=Homo sapiens GN=DNAJA1 PE=1 SV=2 DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens GN=DNAJA3 PE=1 SV=2 DnaJ homolog subfamily C member 9 OS=Homo sapiens GN=DNAJC9 PE=1 SV=1
126.9
5
75.4
10.1
87.3
9.9
96.3
9.8
89.8
10
73.1
7.8
50.6
9.8
300.7 (M:300.7)
4
7.7
77.9
69.1
9.7
214.5 (M:214.5)
3
5
76.7
42.6
9.4
4
12.5
62.3
90.9
7.4
199.5 (M:199.5) 121.8 (M:121.8)
2
3.3
61.0
114.7
8.3
140.9
6.4
40.5
5.8
44.8
6.7
52.5
10.1
29.9
5.5
146.1 (M:146.1) 705.5 (M:705.5)
98.5 (M:98.5)
3
7.5
81.6
10
16.7
64.3
2
3.3
308.7 (M:308.7) 108.4 (M:108.4) 934.9 (M:934.9) 85.5 (M:85.5)
6
7.1
25.2
2
3.1
40.3
20
29.9
51.3
2
2.8
60.0
293.5 (M:293.5)
6
11.1
31.5
537.0 (M:537.0)
14
20.7
49.2
152.0 (M:152.0)
4
5.3
18.8
538.2 (M:538.2)
13
13
38.9
135.3 (M:135.3)
2
6.3
33.3
609.1 (M:609.1)
12
40
32.7
59.4
585.8 (M:585.8) 262.5 (M:262.5)
10
8.8
65.1
4
14
308.8
249.7 (M:249.7) 159.1 (M:159.1)
3
8.8
37.5
3
5.8
75.2
28
65
DPOLQ_HUMAN
66
DREB_HUMAN
67
DRG1_HUMAN
68
DYH10_HUMAN
69
EBP2_HUMAN
70
ECHA_HUMAN
71
EF1A1_HUMAN
72
EF1D_HUMAN
73
EFTU_HUMAN
74
EIF3A_HUMAN
75
EIF3B_HUMAN
76
EIF3C_HUMAN
77
EIF3D_HUMAN
78
EIF3E_HUMAN
79
EIF3F_HUMAN
DNA polymerase theta OS=Homo sapiens GN=POLQ PE=1 SV=2 Drebrin OS=Homo sapiens GN=DBN1 PE=1 SV=4 Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens GN=DRG1 PE=1 SV=1 Dynein heavy chain 10, axonemal OS=Homo sapiens GN=DNAH10 PE=1 SV=4 Probable rRNA-processing protein EBP2 OS=Homo sapiens GN=EBNA1BP2 PE=1 SV=2 Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2 Elongation factor 1-alpha 1 OS=Homo sapiens GN=EEF1A1 PE=1 SV=1 Elongation factor 1-delta OS=Homo sapiens GN=EEF1D PE=1 SV=5
289.4
7.2
60.4 (M:60.4)
2
0.8
46.2
71.4
4.2
40.5
9.6
152.2 (M:152.2)
2
7.6
7.5
514.5
5.6
93.3 (M:93.3)
4
0.7
417.2
34.8
10.6
117.9 (M:117.9)
4
13.1
48.5
82.9
9.8
737.7 (M:737.7)
14
21.6
36.7
50.1
9.7
284.1 (M:284.1)
6
13
13.1
31.1
4.8
Elongation factor Tu, mitochondrial OS=Homo sapiens GN=TUFM PE=1 SV=2 Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens GN=EIF3A PE=1 SV=1 Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens GN=EIF3B PE=1 SV=3 Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens GN=EIF3C PE=1 SV=1 Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens GN=EIF3D PE=1 SV=1 Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens GN=EIF3E PE=1 SV=1 Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens GN=EIF3F PE=1 SV=1
49.5
7.9
179.7 (M:179.7) 328.9 (M:328.9)
4
10.2
57.4
166.5
6.4
8
7.2
30.8
92.4
4.7
307.7 (M:307.7)
6
8.4
23.7
105.3
5.4
157.6 (M:157.6)
4
4.3
66.7
63.9
5.7
279.0 (M:279.0)
6
15
38.2
52.2
5.7
220.6 (M:220.6)
6
17.1
12.8
37.5
5.1
206.5 (M:206.5)
5
16
34.3
190.1 (M:190.1) 117.5 (M:117.5)
367.7 (M:367.7)
3
5.7
66.1
2
7.6
28.2
8
22.9
76.8
212.3 (M:212.3) 109.0 (M:109.0)
4
8.2
64.6
2
12.8
39.5
453.5 (M:453.5) 216.1 (M:216.1)
4
10.6
72.5
2
1.3
1.3
29
80
EIF3H_HUMAN
81
EIF3I_HUMAN
82
EIF3L_HUMAN
83
EMC2_HUMAN
84
EMD_HUMAN
85
EP300_HUMAN
86
EPIPL_HUMAN
87
ERLN1_HUMAN
88
ERLN2_HUMAN
89
ETFA_HUMAN
90
ETFB_HUMAN
91
EXOS6_HUMAN
92
EXOSX_HUMAN
93
FAT3_HUMAN
94
FBRL_HUMAN
95
FEN1_HUMAN
96
FUS_HUMAN
Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens GN=EIF3H PE=1 SV=1 Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens GN=EIF3I PE=1 SV=1 Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens GN=EIF3L PE=1 SV=1 ER membrane protein complex subunit 2 OS=Homo sapiens GN=EMC2 PE=1 SV=1 Emerin OS=Homo sapiens GN=EMD PE=1 SV=1 Histone acetyltransferase p300 OS=Homo sapiens GN=EP300 PE=1 SV=2 Epiplakin OS=Homo sapiens GN=EPPK1 PE=1 SV=2 Erlin-1 OS=Homo sapiens GN=ERLIN1 PE=1 SV=1 Erlin-2 OS=Homo sapiens GN=ERLIN2 PE=1 SV=1 Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens GN=ETFA PE=1 SV=1 Electron transfer flavoprotein subunit beta OS=Homo sapiens GN=ETFB PE=1 SV=3 Exosome complex component MTR3 OS=Homo sapiens GN=EXOSC6 PE=1 SV=1 Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 Protocadherin Fat 3 OS=Homo sapiens GN=FAT3 PE=2 SV=2 rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens GN=FBL PE=1 SV=2 Flap endonuclease 1 OS=Homo sapiens GN=FEN1 PE=1 SV=1 RNA-binding protein FUS OS=Homo sapiens GN=FUS PE=1 SV=1
39.9
6.1
118.4 (M:118.4)
2
8.8
45.0
244.4 (M:244.4)
6
16.8
29.3
36.5
5.3
94.8 (M:94.8)
2
6.8
27.0
146.6 (M:146.6)
3
11.1
21.5
66.7
5.9
351.7 (M:351.7)
6
13.7
31.2
34.8
6.1
29
5.2
264
9.7
89.7 (M:89.7)
3
2.7
96.0
555.3
5.3
89.2 (M:89.2)
2
0.4
18.7
38.9
8.6
37.8
5.4
35.1
9.5
27.8
9.2
28.2
6
68.4 (M:68.4)
2
11.4
33.1
100.8
9.4
3
4.7
505.2
4.6
62.8 (M:62.8)
2
0.4
72.0
219.2 (M:219.2) 83.2 (M:83.2)
2
0.6
33.8
10.7
8
25.9
44.2
75.8 (M:75.8)
2
7.5
42.6
9.5
443.4 (M:443.4) 299.7 (M:299.7)
4
15.3
88.8
53.4
9.7
125.3 (M:125.3)
2
4.4
284.1 (M:284.1) 275.0 (M:275.0)
4
18.2
47.0
4
18.5
89.5
226.7 (M:226.7) 129.9 (M:129.9) 348.6 (M:348.6)
4
13
95.1
2
7.1
72.6
5
18.9
74.9
88.9 (M:88.9)
2
8.6
39.4
30
97
G3BP1_HUMAN
98
G3P_HUMAN
99
GBLP_HUMAN
100 GELS_HUMAN 101 GNL3_HUMAN 102 GPR98_HUMAN 103 GRP75_HUMAN 104 GRP78_HUMAN 105 GRWD1_HUMAN
106 GSTK1_HUMAN 107 H12_HUMAN 108 H14_HUMAN 109 H15_HUMAN 110 H1X_HUMAN 111 H2A1H_HUMAN 112 H2AV_HUMAN 113 H2AY_HUMAN 114 H2B1B_HUMAN
Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens GN=G3BP1 PE=1 SV=1 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 Guanine nucleotide-binding protein subunit beta-2-like 1 OS=Homo sapiens GN=GNB2L1 PE=1 SV=3 Gelsolin OS=Homo sapiens GN=GSN PE=1 SV=1 Guanine nucleotide-binding protein-like 3 OS=Homo sapiens GN=GNL3 PE=1 SV=2 G-protein coupled receptor 98 OS=Homo sapiens GN=GPR98 PE=1 SV=2 Stress-70 protein, mitochondrial OS=Homo sapiens GN=HSPA9 PE=1 SV=2 78 kDa glucose-regulated protein OS=Homo sapiens GN=HSPA5 PE=1 SV=2 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens GN=GRWD1 PE=1 SV=1 Glutathione S-transferase kappa 1 OS=Homo sapiens GN=GSTK1 PE=1 SV=3 Histone H1.2 OS=Homo sapiens GN=HIST1H1C PE=1 SV=2 Histone H1.4 OS=Homo sapiens GN=HIST1H1E PE=1 SV=2 Histone H1.5 OS=Homo sapiens GN=HIST1H1B PE=1 SV=3 Histone H1x OS=Homo sapiens GN=H1FX PE=1 SV=1 Histone H2A type 1-H OS=Homo sapiens GN=HIST1H2AH PE=1 SV=3 Histone H2A.V OS=Homo sapiens GN=H2AFV PE=1 SV=3 Core histone macro-H2A.1 OS=Homo sapiens GN=H2AFY PE=1 SV=4 Histone H2B type 1-B OS=Homo sapiens GN=HIST1H2BB PE=1 SV=2
52.1
5.3
36
9.3
297.0 (M:297.0)
6
12.5
55.4
35.1
8.9
613.6 (M:613.6)
8
25.6
60.5
85.6
5.9
62
9.9
692.6
4.4
73.6
5.8
72.3
4.9
49.4
4.7
25.5
9.3
21.4
11.4
21.9
11.5
22.6
11.4
22.5
11.2
13.9
11.3
13.5
11
39.6
10.3
13.9
10.8
169.0 (M:169.0) 465.4 (M:465.4)
185.7 (M:185.7) 670.7 (M:670.7) 758.2 (M:758.2) 621.5 (M:621.5) 205.0 (M:205.0) 576.1 (M:576.1) 316.5 (M:316.5) 678.6 (M:678.6)
2
4.9
19.0
6
14.2
18.5
2
13.3
66.2
10
28.2
74.1
11
27.4
63.7
8
23.9
361.3
3
21.1
41.9
12
35.9
59.7
3
18.8
29.7
10
30.4
36.6
235.6 (M:235.6)
4
14.6
20.1
219.9 (M:219.9)
4
16.1
38.1
101.7 (M:101.7) 155.0 (M:155.0) 79.3 (M:79.3)
3
3.1
107.3
2
6
13.1
3
0.8
37.0
864.4 (M:864.4) 674.1 (M:674.1) 129.8 (M:129.8)
15
27.5
43.6
13
27.8
20.7
3
7.8
344.5
111.3 (M:111.3) 144.7 (M:144.7) 77.7 (M:77.7)
2
10.8
44.3
3
11
23.6
2
8.8
879.9
187.9 (M:187.9) 72.9 (M:72.9)
5
31.2
37.2
2
5.1
34.0
75.8 (M:75.8)
1
11.9
21.6
31
115 H2B1J_HUMAN
Histone H2B type 1-J OS=Homo sapiens GN=HIST1H2BJ PE=1 SV=3 116 H2B1K_HUMAN Histone H2B type 1-K OS=Homo sapiens GN=HIST1H2BK PE=1 SV=3 117 H2B1L_HUMAN Histone H2B type 1-L OS=Homo sapiens GN=HIST1H2BL PE=1 SV=3 118 H2BFS_HUMAN Histone H2B type F-S OS=Homo sapiens GN=H2BFS PE=1 SV=2 119 H32_HUMAN Histone H3.2 OS=Homo sapiens GN=HIST2H3A PE=1 SV=3 120 H33_HUMAN Histone H3.3 OS=Homo sapiens GN=H3F3A PE=1 SV=2 121 H3C_HUMAN Histone H3.3C OS=Homo sapiens GN=H3F3C PE=1 SV=3 122 H4_HUMAN Histone H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 123 HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens GN=HSD17B10 PE=1 SV=3 124 HMGA1_HUMAN High mobility group protein HMG-I/HMGY OS=Homo sapiens GN=HMGA1 PE=1 SV=3 125 HNRDL_HUMAN Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens GN=HNRNPDL PE=1 SV=3 126 HNRH1_HUMAN Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens GN=HNRNPH1 PE=1 SV=4 127 HNRH3_HUMAN Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens GN=HNRNPH3 PE=1 SV=2 128 HNRL2_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens GN=HNRNPUL2 PE=1 SV=1 129 HNRPC_HUMAN Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens GN=HNRNPC PE=1 SV=4 130 HNRPF_HUMAN Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens GN=HNRNPF PE=1 SV=3
13.9
10.8
13.9
10.8
13.9
10.8
13.9
10.8
15.4
11.9
15.3
11.9
15.2
11.9
11.4
11.8
26.9
9.1
11.7
171.6 (M:171.6)
3
27
23.6
279.4 (M:279.4) 74.7 (M:74.7)
7
27
52.2
2
19
20.7
257.4 (M:257.4) 261.3 (M:261.3)
3
19
694.8
2
12.7
11.6
84.3 (M:84.3)
3
16.9
47.9
363.3 (M:363.3)
7
52.4
34.7
555.6 (M:555.6) 143.5 (M:143.5) 222.6 (M:222.6) 66.8 (M:66.8)
11
46
34.2
5
25.7
84.3
6
29.4
82.6
2
11.9
84.3
906.5 (M:906.5) 191.9 (M:191.9)
14
57.3
51.0
3
9.6
57.2
10.8
81.5 (M:81.5)
2
23.4
74.8
46.4
10
93.4 (M:93.4)
2
5.7
72.3
49.2
5.9
154.9 (M:154.9)
2
8
405.2
308.6 (M:308.6)
6
20.9
15.6
36.9
6.4
331.2 (M:331.2)
5
16.2
71.9
69.4 (M:69.4)
2
7.5
39.1
85.1
4.7
167.9 (M:167.9)
4
6
15.2
33.6
4.8
445.6 (M:445.6)
8
26.1
31.3
45.6
5.3
388.7 (M:388.7)
7
24.6
32.0
700.0 (M:700.0)
12
31.7
60.7
32
131 HNRPK_HUMAN
132 HNRPM_HUMAN
133 HNRPQ_HUMAN
134 HNRPR_HUMAN
135 HNRPU_HUMAN
136 HS90A_HUMAN
137 HS90B_HUMAN 138 HSP71_HUMAN 139 HSP7C_HUMAN 140 HSPB1_HUMAN 141 IDH3A_HUMAN
142 IF2A_HUMAN
143 IF2B_HUMAN
144 IF2B3_HUMAN
145 IF2G_HUMAN
Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens GN=HNRNPK PE=1 SV=1 Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens GN=HNRNPM PE=1 SV=3 Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens GN=SYNCRIP PE=1 SV=2 Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens GN=HNRNPR PE=1 SV=1 Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens GN=HNRNPU PE=1 SV=6 Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4 Heat shock 70 kDa protein 1A/1B OS=Homo sapiens GN=HSPA1A PE=1 SV=5 Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 Heat shock protein beta-1 OS=Homo sapiens GN=HSPB1 PE=1 SV=2 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens GN=IDH3A PE=1 SV=1 Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens GN=EIF2S1 PE=1 SV=3 Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens GN=EIF2S2 PE=1 SV=2 Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens GN=IGF2BP3 PE=1 SV=2 Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens GN=EIF2S3 PE=1 SV=3
50.9
5.3
199.0 (M:199.0)
4
11.4
340.8
77.5
9.6
376.4 (M:376.4)
7
14.9
27.9
69.6
9.1
474.8 (M:474.8)
10
14.9
29.1
70.9
8.8
247.7 (M:247.7)
3
6
27.2
283.5 (M:283.5)
6
11.7
26.7
90.5
5.7
1142.2 (M:1142.2)
11
12.6
64.9
1106.5 (M:1106.5)
18
18.1
26.5
84.6
4.8
1731.9 (M:1731.9)
10
15
47.3
83.2
4.8
1914.7 (M:1914.7)
27
37.4
68.9
160.8 (M:160.8) 535.7 (M:535.7) 733.0 (M:733.0) 168.2 (M:168.2)
3
4.8
29.3
70
5.4
6
11.5
34.9
70.9
5.2
15
25.4
25.9
22.8
6
4
20
47.5
39.6
6.5
36.1
4.9
241.4 (M:241.4)
5
15.6
38.7
38.4
5.5
302.6 (M:302.6)
5
18.9
68.7
63.7
9.6
102.6 (M:102.6)
3
8.5
40.9
51.1
9.5
124.0 (M:124.0)
3
5.7
325.2
123.4 (M:123.4)
2
4.2
66.2
474.1 (M:474.1) 303.3 (M:303.3) 181.9 (M:181.9)
6
10.7
67.7
6
31.2
55.4
3
9
21.4
105.6 (M:105.6)
2
7
36.0
33
146 IF2P_HUMAN 147 IF4A1_HUMAN 148 IF4A3_HUMAN 149 IF6_HUMAN 150 ILF2_HUMAN 151 ILF3_HUMAN 152 IMA1_HUMAN 153 IMB1_HUMAN 154 IPO5_HUMAN 155 IQGA1_HUMAN 156 K1C10_HUMAN 157 K1C14_HUMAN 158 K1C16_HUMAN 159 K1C17_HUMAN 160 K1C18_HUMAN 161 K1C28_HUMAN 162 K1C9_HUMAN 163 K22E_HUMAN 164 K2C1_HUMAN 165 K2C1B_HUMAN
Eukaryotic translation initiation factor 5B OS=Homo sapiens GN=EIF5B PE=1 SV=4 Eukaryotic initiation factor 4A-I OS=Homo sapiens GN=EIF4A1 PE=1 SV=1 Eukaryotic initiation factor 4A-III OS=Homo sapiens GN=EIF4A3 PE=1 SV=4 Eukaryotic translation initiation factor 6 OS=Homo sapiens GN=EIF6 PE=1 SV=1 Interleukin enhancer-binding factor 2 OS=Homo sapiens GN=ILF2 PE=1 SV=2 Interleukin enhancer-binding factor 3 OS=Homo sapiens GN=ILF3 PE=1 SV=3 Importin subunit alpha-1 OS=Homo sapiens GN=KPNA2 PE=1 SV=1 Importin subunit beta-1 OS=Homo sapiens GN=KPNB1 PE=1 SV=2 Importin-5 OS=Homo sapiens GN=IPO5 PE=1 SV=4 Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens GN=IQGAP1 PE=1 SV=1 Keratin, type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 Keratin, type I cytoskeletal 16 OS=Homo sapiens GN=KRT16 PE=1 SV=4 Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 Keratin, type I cytoskeletal 18 OS=Homo sapiens GN=KRT18 PE=1 SV=2 Keratin, type I cytoskeletal 28 OS=Homo sapiens GN=KRT28 PE=1 SV=2 Keratin, type I cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 Keratin, type II cytoskeletal 1b OS=Homo sapiens GN=KRT77 PE=2 SV=3
138.7
5.3
46.1
5.2
46.8
6.3
26.6
4.4
43
5
95.3
9.3
57.8
5.1
97.1
4.5
123.5
4.7
189.1
6.1
58.8
5
51.5
4.9
51.2
4.8
48.1
4.8
48
5.2
50.5
5.2
62
5
65.4
8.9
66
8.8
61.9
5.6
57.8 (M:57.8)
2
2.3
86.6
168.1 (M:168.1)
4
10.8
37.1
1167.2 (M:1167.2) 223.7 (M:223.7) 94.6 (M:94.6)
19
32
83.3
3
10.9
523.7
2
9.8
21.8
89.5 (M:89.5)
2
11.8
70.6
103.3 (M:103.3)
2
7.2
69.5
364.6 (M:364.6) 265.3 (M:265.3) 85.9 (M:85.9)
8
23.1
40.3
6
8.7
21.9
2
6.2
42.1
153.0 (M:153.0) 915.9 (M:915.9) 165.8 (M:165.8) 539.4 (M:539.4) 898.4 (M:898.4) 834.4 (M:834.4)
3
2.7
86.7
18
25.5
27.3
4
11.9
383.4
7
20.5
33.0
21
41.9
30.4
15
40.2
20.8
1031.6 (M:1031.6) 1021.2 (M:1021.2) 1341.7 (M:1341.7) 87.1 (M:87.1)
17
30.8
28.8
21
39.4
29.1
24
40.2
36.2
2
3.8
47.8
334.1 (M:334.1) 144.0 (M:144.0) 297.8 (M:297.8)
285.9 (M:285.9) 824.7 (M:824.7) 182.4 (M:182.4) 2671.0 (M:2671.0) 1875.1 (M:1875.1) 364.5 (M:364.5) 1178.4 (M:1178.4) 885.4 (M:885.4) 1028.7 (M:1028.7)
4
11.2
37.1
2
3
75.5
4
6.3
49.4
5
9.8
94.2
6
14.8
56.3
4
7.8
59.0
44
65.7
79.4
28
48.6
58.5
3
2.6
118.6
14
35.2
70.8
12
20.7
42.0
13
23.1
76.3
34
166 K2C5_HUMAN 167 K2C6A_HUMAN 168 K2C6B_HUMAN 169 K2C6C_HUMAN 170 K2C7_HUMAN 171 K2C8_HUMAN 172 KCD12_HUMAN
173 KPYM_HUMAN 174 LAP2B_HUMAN
175 LARP1_HUMAN 176 LC7L2_HUMAN 177 LC7L3_HUMAN 178 LEG1_HUMAN 179 LMNA_HUMAN 180 LMNB1_HUMAN 181 LPPRC_HUMAN
182 LRC59_HUMAN 183 LYRIC_HUMAN
Keratin, type II cytoskeletal 5 OS=Homo sapiens GN=KRT5 PE=1 SV=3 Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 Keratin, type II cytoskeletal 6C OS=Homo sapiens GN=KRT6C PE=1 SV=3 Keratin, type II cytoskeletal 7 OS=Homo sapiens GN=KRT7 PE=1 SV=5 Keratin, type II cytoskeletal 8 OS=Homo sapiens GN=KRT8 PE=1 SV=7 BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens GN=KCTD12 PE=1 SV=1 Pyruvate kinase PKM OS=Homo sapiens GN=PKM PE=1 SV=4 Lamina-associated polypeptide 2, isoforms beta/gamma OS=Homo sapiens GN=TMPO PE=1 SV=2 La-related protein 1 OS=Homo sapiens GN=LARP1 PE=1 SV=2 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens GN=LUC7L2 PE=1 SV=2 Luc7-like protein 3 OS=Homo sapiens GN=LUC7L3 PE=1 SV=2 Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 Prelamin-A/C OS=Homo sapiens GN=LMNA PE=1 SV=1 Lamin-B1 OS=Homo sapiens GN=LMNB1 PE=1 SV=2 Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens GN=LRPPRC PE=1 SV=3 Leucine-rich repeat-containing protein 59 OS=Homo sapiens GN=LRRC59 PE=1 SV=1 Protein LYRIC OS=Homo sapiens GN=MTDH PE=1 SV=2
62.3
8.6
389.5 (M:389.5) 262.3 (M:262.3) 169.2 (M:169.2) 552.4 (M:552.4) 1049.5 (M:1049.5) 1038.2 (M:1038.2)
4
7.5
75.3
60
8.9
4
8.7
36.5
60
8.9
2
5.9
39.7
60
8.9
8
15.4
35.8
51.4
5.3
22
43.9
26.2
53.7
5.4
17
37.9
26.0
35.7
5.4
57.9
9
262.0 (M:262.0)
5
9
242.9
50.6
9.8
123.4
9.4
3
3.9
61.4
10.8
125.7 (M:125.7) 83.0 (M:83.0)
46.5
2
5.9
48.3
51.4
10.5
75.8 (M:75.8)
2
7.4
116.9
14.7
5.2
74.1
6.6
420.6 (M:420.6)
8
14.5
15.4
66.4
5
157.8
5.8
131.2 (M:131.2)
2
2.1
7.1
34.9
10.4
74.4 (M:74.4)
2
10.1
67.5
63.8
9.8
72.0 (M:72.0)
2
5.2
31.0
270.7 (M:270.7) 264.5 (M:264.5) 188.8 (M:188.8) 2050.8 (M:2050.8) 3575.8 (M:3575.8) 152.7 (M:152.7)
2
3.5
842.4
2
3.9
100.2
2
4.3
54.1
24
45.4
62.7
55
59.8
56.2
2
10.2
32.0
310.9 (M:310.9) 131.3 (M:131.3)
3
5.5
108.7
3
12.8
32.1
130.3 (M:130.3) 2047.7 (M:2047.7) 755.5 (M:755.5)
2
17.8
66.8
30
38.9
74.8
11
22.7
103.8
35
184 MATR3_HUMAN
Matrin-3 OS=Homo sapiens GN=MATR3 PE=1 SV=2 185 MBB1A_HUMAN Myb-binding protein 1A OS=Homo sapiens GN=MYBBP1A PE=1 SV=2 186 MCM2_HUMAN DNA replication licensing factor MCM2 OS=Homo sapiens GN=MCM2 PE=1 SV=4 187 MCM3_HUMAN DNA replication licensing factor MCM3 OS=Homo sapiens GN=MCM3 PE=1 SV=3 188 MCM4_HUMAN DNA replication licensing factor MCM4 OS=Homo sapiens GN=MCM4 PE=1 SV=5 189 MCM6_HUMAN DNA replication licensing factor MCM6 OS=Homo sapiens GN=MCM6 PE=1 SV=1 190 MCM7_HUMAN DNA replication licensing factor MCM7 OS=Homo sapiens GN=MCM7 PE=1 SV=4 191 MCMBP_HUMAN Mini-chromosome maintenance complexbinding protein OS=Homo sapiens GN=MCMBP PE=1 SV=2 192 METK2_HUMAN S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens GN=MAT2A PE=1 SV=1 193 MK67I_HUMAN MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens GN=MKI67IP PE=1 SV=1 194 ML12B_HUMAN Myosin regulatory light chain 12B OS=Homo sapiens GN=MYL12B PE=1 SV=2 195 MLEC_HUMAN Malectin OS=Homo sapiens GN=MLEC PE=1 SV=1 196 MUC16_HUMAN Mucin-16 OS=Homo sapiens GN=MUC16 PE=1 SV=2 197 MYL6_HUMAN Myosin light polypeptide 6 OS=Homo sapiens GN=MYL6 PE=1 SV=2 198 NACA_HUMAN Nascent polypeptide-associated complex subunit alpha OS=Homo sapiens GN=NACA PE=1 SV=1 199 NASP_HUMAN Nuclear autoantigenic sperm protein OS=Homo sapiens GN=NASP PE=1 SV=2 200 NAT10_HUMAN N-acetyltransferase 10 OS=Homo sapiens GN=NAT10 PE=1 SV=2 201 NOG1_HUMAN Nucleolar GTP-binding protein 1 OS=Homo sapiens GN=GTPBP4 PE=1 SV=3
94.6
5.8
148.8
10
101.8
5.2
90.9
5.4
96.5
6.3
92.8
5.2
81.3
6.1
72.9
5.5
43.6
6
34.2
10.4
19.8
4.5
32.2
5.2
2353
5.6
16.9
4.4
23.4
4.4
85.2
4.1
115.7
9.2
73.9
10
261.9 (M:261.9)
492.1 (M:492.1)
140.7 (M:140.7)
236.3 (M:236.3) 112.7 (M:112.7)
321.0 (M:321.0) 215.5 (M:215.5)
225.6 (M:225.6)
4
7
2
5.7
11.5
2.8
64.1
277.6
17.4
89.3
2
8.6
57.8
6
39.1
53.0
2
13.5
36.1
4.2
3
3.9
20.1
7
6.6
41.7
28
29.3
32.9
3
5.8
47.3
25
32
24.6
22
27.4
32.7
18
26.6
21.0
2
5
50.5
86.6 (M:86.6)
2
10.9
43.9
90.1 (M:90.1)
2
0.1
547.5
142.9 (M:142.9) 266.7 (M:266.7)
3
22.5
44.8
3
19.5
22.4
799.7 (M:799.7)
13
28.7
30.0
95.8 (M:95.8)
2
3.2
33.6
76.1
3
4
107.4 (M:107.4) 499.2 (M:499.2) 1459.9 (M:1459.9) 149.0 (M:149.0) 1232.7 (M:1232.7) 970.6 (M:970.6) 827.2 (M:827.2) 65.9 (M:65.9)
40.9
36
202 NONO_HUMAN
203 NOP16_HUMAN 204 NOP2_HUMAN
205 NOP56_HUMAN 206 NOP58_HUMAN 207 NP1L1_HUMAN 208 NP1L4_HUMAN 209 NPM_HUMAN 210 NSUN2_HUMAN
211 NUCL_HUMAN 212 NUDC_HUMAN 213 NUP93_HUMAN 214 ODPB_HUMAN
215 OST48_HUMAN
216 PABP1_HUMAN 217 PAIRB_HUMAN
218 PARP1_HUMAN
Non-POU domain-containing octamerbinding protein OS=Homo sapiens GN=NONO PE=1 SV=4 Nucleolar protein 16 OS=Homo sapiens GN=NOP16 PE=1 SV=2 Putative ribosomal RNA methyltransferase NOP2 OS=Homo sapiens GN=NOP2 PE=1 SV=2 Nucleolar protein 56 OS=Homo sapiens GN=NOP56 PE=1 SV=4 Nucleolar protein 58 OS=Homo sapiens GN=NOP58 PE=1 SV=1 Nucleosome assembly protein 1-like 1 OS=Homo sapiens GN=NAP1L1 PE=1 SV=1 Nucleosome assembly protein 1-like 4 OS=Homo sapiens GN=NAP1L4 PE=1 SV=1 Nucleophosmin OS=Homo sapiens GN=NPM1 PE=1 SV=2 tRNA (cytosine(34)-C(5))methyltransferase OS=Homo sapiens GN=NSUN2 PE=1 SV=2 Nucleolin OS=Homo sapiens GN=NCL PE=1 SV=3 Nuclear migration protein nudC OS=Homo sapiens GN=NUDC PE=1 SV=1 Nuclear pore complex protein Nup93 OS=Homo sapiens GN=NUP93 PE=1 SV=2 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens GN=PDHB PE=1 SV=3 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit OS=Homo sapiens GN=DDOST PE=1 SV=4 Polyadenylate-binding protein 1 OS=Homo sapiens GN=PABPC1 PE=1 SV=2 Plasminogen activator inhibitor 1 RNAbinding protein OS=Homo sapiens GN=SERBP1 PE=1 SV=2 Poly [ADP-ribose] polymerase 1 OS=Homo sapiens GN=PARP1 PE=1 SV=4
54.2
9.6
451.0 (M:451.0)
7
16.3
62.7
21.2
10.4
5
24.2
74.1
89.2
9.8
262.2 (M:262.2) 278.0 (M:278.0)
3
5.4
46.7
66
9.8
3
4.7
23.8
59.5
9.7
331.3 (M:331.3) 448.2 (M:448.2)
6
10.6
61.6
45.3
4.2
42.8
4.4
32.6
4.5
86.4
6.3
76.6
4.4
38.2
5.1
93.4
5.4
39.2
330.3 (M:330.3)
6
17.7
88.6
717.7 (M:717.7) 136.8 (M:136.8) 84.3 (M:84.3)
11
16.3
78.0
2
7.9
67.2
2
3.3
67.1
6.2
209.3 (M:209.3)
5
15.9
65.7
50.8
6.1
94.0 (M:94.0)
2
4.8
123.4
70.6
10
44.9
9.3
113
9.6
668.1 (M:668.1)
10
10.4
79.4
205.1 (M:205.1)
5
14.2
27.8
399.0 (M:399.0)
6
9.6
20.8
408.3 (M:408.3) 341.2 (M:341.2) 367.9 (M:367.9) 276.1 (M:276.1)
9
26.1
18.6
6
18.1
16.6
7
21.4
34.7
7
11.6
30.9
966.5 (M:966.5)
21
27.6
30.8
280.5 (M:280.5) 514.9 (M:514.9)
6
10.4
25.7
10
29.4
31.4
724.4 (M:724.4)
14
17.3
38.4
37
219 PCBP1_HUMAN 220 PCBP2_HUMAN 221 PCDBF_HUMAN 222 PCH2_HUMAN 223 PDS5A_HUMAN
224 PELP1_HUMAN
225 PERQ2_HUMAN
226 PHB_HUMAN 227 PHB2_HUMAN 228 PLEC_HUMAN 229 PM14_HUMAN 230 PNM6C_HUMAN
231 PPIA_HUMAN 232 PPIB_HUMAN 233 PPM1G_HUMAN 234 PRDX1_HUMAN 235 PRKDC_HUMAN
236 PRP19_HUMAN
Poly(rC)-binding protein 1 OS=Homo sapiens GN=PCBP1 PE=1 SV=2 Poly(rC)-binding protein 2 OS=Homo sapiens GN=PCBP2 PE=1 SV=1 Protocadherin beta-15 OS=Homo sapiens GN=PCDHB15 PE=1 SV=1 Pachytene checkpoint protein 2 homolog OS=Homo sapiens GN=TRIP13 PE=1 SV=2 Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens GN=PDS5A PE=1 SV=1 Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens GN=PELP1 PE=1 SV=2 PERQ amino acid-rich with GYF domaincontaining protein 2 OS=Homo sapiens GN=GIGYF2 PE=1 SV=1 Prohibitin OS=Homo sapiens GN=PHB PE=1 SV=1 Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2 Plectin OS=Homo sapiens GN=PLEC PE=1 SV=3 Pre-mRNA branch site protein p14 OS=Homo sapiens GN=SF3B14 PE=1 SV=1 Paraneoplastic antigen-like protein 6C OS=Homo sapiens GN=PNMA6C PE=2 SV=1 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens GN=PPIA PE=1 SV=2 Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens GN=PPIB PE=1 SV=2 Protein phosphatase 1G OS=Homo sapiens GN=PPM1G PE=1 SV=1 Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 DNA-dependent protein kinase catalytic subunit OS=Homo sapiens GN=PRKDC PE=1 SV=3 Pre-mRNA-processing factor 19 OS=Homo sapiens GN=PRPF19 PE=1 SV=1
37.5
6.8
38.6
6.4
86.3
4.6
48.5
5.7
150.7
333.3 (M:333.3) 242.4 (M:242.4)
5
13.5
51.7
4
8.5
46.7 76.8 (M:76.8)
2
2.5
319.1
9
78.6 (M:78.6)
2
1.6
372.9
119.6
4.1
324.6 (M:324.6)
6
8.7
13.6
150
5.3
58.7 (M:58.7)
2
2.5
408.9
29.8
5.5
33.3
10.2
531.5
5.7
99.0 (M:99.0)
3
1
470.9
14.6
0
43.8
5.1
37.6 (M:37.6)
2
5.3
476.6
18
9
74.7 (M:74.7)
2
12.1
70.9
23.7
9.9
3
17.1
30.0
59.2
4.1
8
22.5
27.5
22.1
9.2
7
36.2
24.7
468.8
6.8
215.8 (M:215.8) 413.4 (M:413.4) 291.1 (M:291.1) 1324.9 (M:1324.9)
29
8.4
35.5
55.1
6.1
191.3 (M:191.3)
414.9 (M:414.9) 474.0 (M:474.0) 218.9 (M:218.9) 193.9 (M:193.9)
417.1 (M:417.1)
207.9 (M:207.9)
3
8.1
57.9
6
24.3
62.8
9
27.8
83.5
3
1
80.6
2
16.8
87.8
7
3
22.2
9.7
44.1
67.7
38
237 PRS7_HUMAN 238 PRS8_HUMAN 239 PSA7_HUMAN 240 PSD13_HUMAN
241 PSME3_HUMAN 242 PTPRA_HUMAN
243 PTRF_HUMAN 244 QCR2_HUMAN
245 RAB1C_HUMAN 246 RAD50_HUMAN 247 RAE1L_HUMAN 248 RALY_HUMAN 249 RAN_HUMAN 250 RBBP4_HUMAN 251 RBBP7_HUMAN 252 RBM26_HUMAN 253 RBM28_HUMAN 254 RBM39_HUMAN
26S protease regulatory subunit 7 OS=Homo sapiens GN=PSMC2 PE=1 SV=3 26S protease regulatory subunit 8 OS=Homo sapiens GN=PSMC5 PE=1 SV=1 Proteasome subunit alpha type-7 OS=Homo sapiens GN=PSMA7 PE=1 SV=1 26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens GN=PSMD13 PE=1 SV=2 Proteasome activator complex subunit 3 OS=Homo sapiens GN=PSME3 PE=1 SV=1 Receptor-type tyrosine-protein phosphatase alpha OS=Homo sapiens GN=PTPRA PE=1 SV=2 Polymerase I and transcript release factor OS=Homo sapiens GN=PTRF PE=1 SV=1 Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens GN=UQCRC2 PE=1 SV=3 Putative Ras-related protein Rab-1C OS=Homo sapiens GN=RAB1C PE=5 SV=2 DNA repair protein RAD50 OS=Homo sapiens GN=RAD50 PE=1 SV=1 mRNA export factor OS=Homo sapiens GN=RAE1 PE=1 SV=1 RNA-binding protein Raly OS=Homo sapiens GN=RALY PE=1 SV=1 GTP-binding nuclear protein Ran OS=Homo sapiens GN=RAN PE=1 SV=3 Histone-binding protein RBBP4 OS=Homo sapiens GN=RBBP4 PE=1 SV=3 Histone-binding protein RBBP7 OS=Homo sapiens GN=RBBP7 PE=1 SV=1 RNA-binding protein 26 OS=Homo sapiens GN=RBM26 PE=1 SV=3 RNA-binding protein 28 OS=Homo sapiens GN=RBM28 PE=1 SV=3 RNA-binding protein 39 OS=Homo sapiens GN=RBM39 PE=1 SV=2
48.6
5.6
144.1 (M:144.1) 118.0 (M:118.0) 151.4 (M:151.4) 115.4 (M:115.4)
2
7.4
98.9
45.6
7.8
2
6.2
495.9
27.9
9.3
2
11.7
56.7
42.9
5.5
2
5.9
13.4
29.5
5.6
223.6 (M:223.6)
3
15.7
53.2
90.5
6.3
43.4
5.4
48.4
9.3
22
5.1
153.8
6.5
40.9
9.1
80.6 (M:80.6)
2
6
36.5
32.4
9.6
5
18.6
59.2
24.4
7.8
264.4 (M:264.4) 156.0 (M:156.0)
3
14.8
11.8
47.6
4.6
47.8
4.8
113.5
9.7
85.7
9.9
59.3
10.7
386.1 (M:386.1) 221.8 (M:221.8)
3
14.1
44.0
3
11.5
20.1
171.9 (M:171.9)
3
21.4
79.1
186.3 (M:186.3)
2
9.4
31.2
73.3 (M:73.3)
2
2.4
823.0
173.7 (M:173.7)
3
12.8
359.8
89.9 (M:89.9)
3
2
216.1
257.8 (M:257.8)
7
24.8
42.5
320.4 (M:320.4) 618.2 (M:618.2) 109.1 (M:109.1) 74.1 (M:74.1)
3
10.4
32.2
13
26.8
29.1
2
2.9
62.6
2
3.7
17.2
166.2 (M:166.2)
3
7.5
33.7
39
255 RBM8A_HUMAN 256 RBMX_HUMAN 257 RBPMS_HUMAN 258 RCL1_HUMAN
259 REV1_HUMAN 260 RFC2_HUMAN 261 RFC3_HUMAN 262 RL10_HUMAN 263 RL10A_HUMAN 264 RL11_HUMAN 265 RL12_HUMAN 266 RL13_HUMAN 267 RL13A_HUMAN 268 RL14_HUMAN 269 RL15_HUMAN 270 RL17_HUMAN 271 RL18_HUMAN 272 RL18A_HUMAN 273 RL19_HUMAN
RNA-binding protein 8A OS=Homo sapiens GN=RBM8A PE=1 SV=1 RNA-binding motif protein, X chromosome OS=Homo sapiens GN=RBMX PE=1 SV=3 RNA-binding protein with multiple splicing OS=Homo sapiens GN=RBPMS PE=1 SV=1 RNA 3'-terminal phosphate cyclase-like protein OS=Homo sapiens GN=RCL1 PE=1 SV=3 DNA repair protein REV1 OS=Homo sapiens GN=REV1 PE=1 SV=1 Replication factor C subunit 2 OS=Homo sapiens GN=RFC2 PE=1 SV=3 Replication factor C subunit 3 OS=Homo sapiens GN=RFC3 PE=1 SV=2 60S ribosomal protein L10 OS=Homo sapiens GN=RPL10 PE=1 SV=4 60S ribosomal protein L10a OS=Homo sapiens GN=RPL10A PE=1 SV=2 60S ribosomal protein L11 OS=Homo sapiens GN=RPL11 PE=1 SV=2 60S ribosomal protein L12 OS=Homo sapiens GN=RPL12 PE=1 SV=1 60S ribosomal protein L13 OS=Homo sapiens GN=RPL13 PE=1 SV=4 60S ribosomal protein L13a OS=Homo sapiens GN=RPL13A PE=1 SV=2 60S ribosomal protein L14 OS=Homo sapiens GN=RPL14 PE=1 SV=4 60S ribosomal protein L15 OS=Homo sapiens GN=RPL15 PE=1 SV=2 60S ribosomal protein L17 OS=Homo sapiens GN=RPL17 PE=1 SV=3 60S ribosomal protein L18 OS=Homo sapiens GN=RPL18 PE=1 SV=2 60S ribosomal protein L18a OS=Homo sapiens GN=RPL18A PE=1 SV=2 60S ribosomal protein L19 OS=Homo sapiens GN=RPL19 PE=1 SV=1
19.9
5.4
42.3
0
21.8
8.9
40.8
10.1
138.2
9.5
39.1
6
40.5
9.6
24.6
11
24.8
10.5
20.2
10.3
17.8
10.3
24.2
12.2
23.6
11.5
23.4
11.6
24.1
12.2
21.4
10.9
21.6
12.3
20.7
11.7
23.5
12.1
129.6 (M:129.6) 820.6 (M:820.6)
158.4 (M:158.4)
110.7 (M:110.7) 142.9 (M:142.9) 440.6 (M:440.6) 283.5 (M:283.5) 214.2 (M:214.2)
329.2 (M:329.2) 288.2 (M:288.2) 212.0 (M:212.0) 308.4 (M:308.4) 168.1 (M:168.1) 317.2 (M:317.2)
413.7 (M:413.7)
2
10.9
54.8
19
41.7
58.4
3
7.2
8.5
70.1
2
7.9
3.4
6
15
47.6
6
21.2
62.2
4
19.1
67.3
8
34.1
71.7
8
28.6
50.5
4
9.8
77.4
8
41.2
74.0
3
17.9
84.3
6
29.8
79.6
17.9
8
24
35.6
2
18.4
229.2
67.1 (M:67.1)
2
2.1
555.0
158.4 (M:158.4) 153.4 (M:153.4) 174.0 (M:174.0) 71.4 (M:71.4)
3
14.5
26.5
3
13.4
35.5
3
16.9
41.8
2
15.2
36.4
288.5 (M:288.5) 192.0 (M:192.0) 156.0 (M:156.0) 91.3 (M:91.3)
7
34.1
43.5
6
25.1
43.2
4
18.1
55.4
3
11.3
68.1
205.1 (M:205.1) 234.7 (M:234.7) 97.4 (M:97.4)
5
27.7
47.7
5
23.4
33.0
3
14.8
31.8
179.7 (M:179.7)
3
16.3
41.9
54.7
2
7
435.6 (M:435.6) 58.7 (M:58.7)
50.5
40
274 RL1D1_HUMAN 275 RL21_HUMAN 276 RL22_HUMAN 277 RL23_HUMAN 278 RL23A_HUMAN 279 RL24_HUMAN 280 RL26_HUMAN 281 RL27_HUMAN 282 RL27A_HUMAN 283 RL28_HUMAN 284 RL29_HUMAN 285 RL3_HUMAN 286 RL30_HUMAN 287 RL31_HUMAN 288 RL34_HUMAN 289 RL35_HUMAN 290 RL35A_HUMAN 291 RL36_HUMAN 292 RL36A_HUMAN 293 RL37A_HUMAN
Ribosomal L1 domain-containing protein 1 OS=Homo sapiens GN=RSL1D1 PE=1 SV=3 60S ribosomal protein L21 OS=Homo sapiens GN=RPL21 PE=1 SV=2 60S ribosomal protein L22 OS=Homo sapiens GN=RPL22 PE=1 SV=2 60S ribosomal protein L23 OS=Homo sapiens GN=RPL23 PE=1 SV=1 60S ribosomal protein L23a OS=Homo sapiens GN=RPL23A PE=1 SV=1 60S ribosomal protein L24 OS=Homo sapiens GN=RPL24 PE=1 SV=1 60S ribosomal protein L26 OS=Homo sapiens GN=RPL26 PE=1 SV=1 60S ribosomal protein L27 OS=Homo sapiens GN=RPL27 PE=1 SV=2 60S ribosomal protein L27a OS=Homo sapiens GN=RPL27A PE=1 SV=2 60S ribosomal protein L28 OS=Homo sapiens GN=RPL28 PE=1 SV=3 60S ribosomal protein L29 OS=Homo sapiens GN=RPL29 PE=1 SV=2 60S ribosomal protein L3 OS=Homo sapiens GN=RPL3 PE=1 SV=2 60S ribosomal protein L30 OS=Homo sapiens GN=RPL30 PE=1 SV=2 60S ribosomal protein L31 OS=Homo sapiens GN=RPL31 PE=1 SV=1 60S ribosomal protein L34 OS=Homo sapiens GN=RPL34 PE=1 SV=3 60S ribosomal protein L35 OS=Homo sapiens GN=RPL35 PE=1 SV=2 60S ribosomal protein L35a OS=Homo sapiens GN=RPL35A PE=1 SV=2 60S ribosomal protein L36 OS=Homo sapiens GN=RPL36 PE=1 SV=3 60S ribosomal protein L36a OS=Homo sapiens GN=RPL36A PE=1 SV=2 60S ribosomal protein L37a OS=Homo sapiens GN=RPL37A PE=1 SV=2
54.9
10.7
18.6
11
14.8
9.7
14.9
11.2
17.7
10.9
17.8
12
17.2
11
15.8
11
16.6
11.8
15.7
12.6
17.7
12.3
46.1
10.8
12.8
10.2
14.5
11
13.3
12.4
14.5
11.5
12.5
11.7
12.2
12.2
12.4
11.7
10.3
11.5
306.3 (M:306.3) 283.2 (M:283.2) 371.4 (M:371.4) 361.4 (M:361.4)
205.8 (M:205.8) 173.5 (M:173.5) 113.4 (M:113.4) 159.8 (M:159.8) 509.7 (M:509.7) 263.0 (M:263.0) 160.6 (M:160.6) 119.3 (M:119.3) 138.1 (M:138.1) 199.1 (M:199.1) 272.1 (M:272.1)
235.3 (M:235.3)
6
15
10.1
4
32
55.0
4
17.9
47.4
6
28.8
63.5
272.4 (M:272.4) 162.4 (M:162.4) 152.8 (M:152.8) 147.2 (M:147.2) 225.7 (M:225.7) 177.4 (M:177.4) 329.9 (M:329.9) 217.4 (M:217.4)
5
12
77.9
2
16.2
21.2
2
18.8
39.1
3
23.6
10.2
6
20.5
33.0
3
13.4
60.0
9
50.3
37.4
6
42.6
30.0
5
40.4
56.0
2
8.8
92.7
3
20.4
53.4
2
14.5
53.5
86.6 (M:86.6)
2
14.5
70.8
10
11.9
81.6
15
23.3
39.6
5
22.6
87.8
5
28.7
21.1
3
21.6
50.1
2
15.2
24.2
2
14.5
85.3
4
21.4
33.5
3
22.8
60.7
3
15.4
44.3
6
37.3
94.9
4
30
30.6
5
24.8
48.8
615.4 (M:615.4) 220.2 (M:220.2) 120.9 (M:120.9) 150.8 (M:150.8) 143.9 (M:143.9) 131.8 (M:131.8) 125.6 (M:125.6) 119.7 (M:119.7) 121.5 (M:121.5)
2
19
27.4
3
17
19.1
4
23.9
32.5
6
44.6
66.3
41
294 RL4_HUMAN 295 RL40_HUMAN 296 RL5_HUMAN 297 RL6_HUMAN 298 RL7_HUMAN 299 RL7A_HUMAN 300 RL8_HUMAN 301 RL9_HUMAN 302 RLA0_HUMAN 303 RLA1_HUMAN 304 RLA2_HUMAN 305 RLP24_HUMAN
306 RM11_HUMAN 307 RM14_HUMAN 308 RM39_HUMAN 309 RM46_HUMAN 310 RM47_HUMAN 311 RM49_HUMAN 312 ROA0_HUMAN
60S ribosomal protein L4 OS=Homo sapiens GN=RPL4 PE=1 SV=5 Ubiquitin-60S ribosomal protein L40 OS=Homo sapiens GN=UBA52 PE=1 SV=2 60S ribosomal protein L5 OS=Homo sapiens GN=RPL5 PE=1 SV=3 60S ribosomal protein L6 OS=Homo sapiens GN=RPL6 PE=1 SV=3 60S ribosomal protein L7 OS=Homo sapiens GN=RPL7 PE=1 SV=1 60S ribosomal protein L7a OS=Homo sapiens GN=RPL7A PE=1 SV=2 60S ribosomal protein L8 OS=Homo sapiens GN=RPL8 PE=1 SV=2 60S ribosomal protein L9 OS=Homo sapiens GN=RPL9 PE=1 SV=1 60S acidic ribosomal protein P0 OS=Homo sapiens GN=RPLP0 PE=1 SV=1 60S acidic ribosomal protein P1 OS=Homo sapiens GN=RPLP1 PE=1 SV=1 60S acidic ribosomal protein P2 OS=Homo sapiens GN=RPLP2 PE=1 SV=1 Probable ribosome biogenesis protein RLP24 OS=Homo sapiens GN=RSL24D1 PE=1 SV=1 39S ribosomal protein L11, mitochondrial OS=Homo sapiens GN=MRPL11 PE=1 SV=1 39S ribosomal protein L14, mitochondrial OS=Homo sapiens GN=MRPL14 PE=1 SV=1 39S ribosomal protein L39, mitochondrial OS=Homo sapiens GN=MRPL39 PE=1 SV=3 39S ribosomal protein L46, mitochondrial OS=Homo sapiens GN=MRPL46 PE=1 SV=1 39S ribosomal protein L47, mitochondrial OS=Homo sapiens GN=MRPL47 PE=1 SV=2 39S ribosomal protein L49, mitochondrial OS=Homo sapiens GN=MRPL49 PE=1 SV=1 Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens GN=HNRNPA0 PE=1 SV=1
47.7
11.8
14.7
10.7
34.3
10.2
32.7
11.1
29.2
11.1
30
11.3
28
11.9
21.8
10.5
34.3
5.6
11.5
4
11.7
4.2
19.6
10.7
20.7
10.5
15.9
11.3
38.7
317.6 (M:317.6)
449.5 (M:449.5) 157.6 (M:157.6) 324.4 (M:324.4) 537.8 (M:537.8) 479.5 (M:479.5) 235.2 (M:235.2) 252.4 (M:252.4) 125.9 (M:125.9) 582.0 (M:582.0) 254.6 (M:254.6) 349.4 (M:349.4)
9
21.3
27.5
3
24.2
21.3
8
23.2
29.4
13
34.4
34.8
12
35.5
23.4
5
15.4
37.5
7
24.9
26.9
3
8.9
39.4
10
37.2
22.0
4
38.6
31.3
6
58.3
25.2
107.0 (M:107.0)
2
10.4
45.6
8.7
74.4 (M:74.4)
2
6.8
43.5
31.7
6.7
2
9.7
20.8
29.4
11.1
111.2 (M:111.2) 73.8 (M:73.8)
2
8
44.2
19.2
9.9
30.8
9.8
95.2 (M:95.2)
2
14.4
58.9
408.3 (M:408.3) 649.0 (M:649.0) 551.8 (M:551.8) 528.8 (M:528.8) 336.9 (M:336.9) 300.2 (M:300.2) 181.7 (M:181.7) 144.4 (M:144.4) 438.9 (M:438.9) 165.6 (M:165.6)
170.1 (M:170.1)
111.2 (M:111.2) 199.4 (M:199.4)
6
11.5
80.5
9
23.6
72.4
14
37.8
170.7
12
32.7
58.0
11
28.9
47.6
7
22.6
57.2
5
17.2
40.0
3
9.5
71.0
2
14.9
18.4
5
67.8
49.6
2
16.6
58.0
4
22.8
308.2
2
16.3
15.1
3
20
296.7
42
313 ROA1_HUMAN
314 ROA2_HUMAN
315 ROA3_HUMAN
316 ROAA_HUMAN
317 ROS1_HUMAN
318 RPAB1_HUMAN
319 RPAC1_HUMAN
320 RPN1_HUMAN
321 RRP12_HUMAN 322 RRS1_HUMAN
323 RS10_HUMAN 324 RS11_HUMAN 325 RS12_HUMAN 326 RS13_HUMAN 327 RS14_HUMAN 328 RS15A_HUMAN
Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens GN=HNRNPA1 PE=1 SV=5 Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens GN=HNRNPA2B1 PE=1 SV=2 Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens GN=HNRNPA3 PE=1 SV=2 Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens GN=HNRNPAB PE=1 SV=2 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens GN=POLR2E PE=1 SV=4 DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens GN=POLR1C PE=1 SV=1 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 OS=Homo sapiens GN=RPN1 PE=1 SV=1 RRP12-like protein OS=Homo sapiens GN=RRP12 PE=1 SV=2 Ribosome biogenesis regulatory protein homolog OS=Homo sapiens GN=RRS1 PE=1 SV=2 40S ribosomal protein S10 OS=Homo sapiens GN=RPS10 PE=1 SV=1 40S ribosomal protein S11 OS=Homo sapiens GN=RPS11 PE=1 SV=3 40S ribosomal protein S12 OS=Homo sapiens GN=RPS12 PE=1 SV=3 40S ribosomal protein S13 OS=Homo sapiens GN=RPS13 PE=1 SV=2 40S ribosomal protein S14 OS=Homo sapiens GN=RPS14 PE=1 SV=3 40S ribosomal protein S15a OS=Homo sapiens GN=RPS15A PE=1 SV=2
38.7
9.6
449.1 (M:449.1)
5
15.9
84.2
612.3 (M:612.3)
12
31.7
27.3
37.4
9.3
726.1 (M:726.1)
12
33.7
60.8
307.8 (M:307.8)
7
22.7
45.0
39.6
9.6
373.4 (M:373.4)
6
15.1
16.2
36.2
8.8
68.4 (M:68.4)
2
7.5
19.5
263.7
5.7
82.4 (M:82.4)
2
0.8
134.1
24.5
5.6
69.4 (M:69.4)
2
11
13.6
39.2
5.2
127.6 (M:127.6)
2
8.4
28.8
68.5
5.9
75.8 (M:75.8)
2
4
41.7
143.6
9.8
368.4 (M:368.4)
8
9.3
20.2
41.2
11.2
84.5 (M:84.5)
2
8.5
69.5
18.9
10.5
2
13.9
78.4
9.1
7.0
11
8
33.5
78.1
6
22.8
34.9
14.5
7.7
2
13.6
56.9
196.7 (M:196.7) 189.3 (M:189.3) 80.3 (M:80.3)
2
18.4
2
13.6
26.8
17.2
11
4
19.9
59.6
16.3
10.9
7
33.8
54.8
29.8
32.1
10.9
6
35.4
33.6
307.3 (M:307.3) 170.6 (M:170.6)
6
14.8
125.5 (M:125.5) 369.7 (M:369.7) 107.5 (M:107.5) 208.8 (M:208.8) 297.0 (M:297.0) 263.2 (M:263.2)
4
30.8
68.5
43
329 RS16_HUMAN 330 RS17L_HUMAN 331 RS18_HUMAN 332 RS19_HUMAN 333 RS2_HUMAN 334 RS20_HUMAN 335 RS23_HUMAN 336 RS25_HUMAN 337 RS26_HUMAN 338 RS27_HUMAN 339 RS3_HUMAN 340 RS3A_HUMAN 341 RS4X_HUMAN 342 RS5_HUMAN 343 RS6_HUMAN 344 RS7_HUMAN 345 RS8_HUMAN 346 RS9_HUMAN 347 RSF1_HUMAN 348 RSMB_HUMAN
40S ribosomal protein S16 OS=Homo sapiens GN=RPS16 PE=1 SV=2 40S ribosomal protein S17-like OS=Homo sapiens GN=RPS17L PE=1 SV=1 40S ribosomal protein S18 OS=Homo sapiens GN=RPS18 PE=1 SV=3 40S ribosomal protein S19 OS=Homo sapiens GN=RPS19 PE=1 SV=2 40S ribosomal protein S2 OS=Homo sapiens GN=RPS2 PE=1 SV=2 40S ribosomal protein S20 OS=Homo sapiens GN=RPS20 PE=1 SV=1 40S ribosomal protein S23 OS=Homo sapiens GN=RPS23 PE=1 SV=3 40S ribosomal protein S25 OS=Homo sapiens GN=RPS25 PE=1 SV=1 40S ribosomal protein S26 OS=Homo sapiens GN=RPS26 PE=1 SV=3 40S ribosomal protein S27 OS=Homo sapiens GN=RPS27 PE=1 SV=3 40S ribosomal protein S3 OS=Homo sapiens GN=RPS3 PE=1 SV=2 40S ribosomal protein S3a OS=Homo sapiens GN=RPS3A PE=1 SV=2 40S ribosomal protein S4, X isoform OS=Homo sapiens GN=RPS4X PE=1 SV=2 40S ribosomal protein S5 OS=Homo sapiens GN=RPS5 PE=1 SV=4 40S ribosomal protein S6 OS=Homo sapiens GN=RPS6 PE=1 SV=1 40S ribosomal protein S7 OS=Homo sapiens GN=RPS7 PE=1 SV=1 40S ribosomal protein S8 OS=Homo sapiens GN=RPS8 PE=1 SV=2 40S ribosomal protein S9 OS=Homo sapiens GN=RPS9 PE=1 SV=3 Remodeling and spacing factor 1 OS=Homo sapiens GN=RSF1 PE=1 SV=2 Small nuclear ribonucleoproteinassociated proteins B and B' OS=Homo
16.4
10.8
15.5
10.4
17.7
11.5
16.1
10.7
31.3
11
13.4
10.7
15.8
11.3
13.7
10.6
13
12.2
9.5
10.7
26.7
10.3
29.9
10.4
29.6
10.8
22.9
10.4
28.7
11.5
22.1
10.6
24.2
11
22.6
11.2
163.7
4.8
24.6
12.1
317.4 (M:317.4) 214.5 (M:214.5) 717.7 (M:717.7) 154.9 (M:154.9) 356.3 (M:356.3) 144.0 (M:144.0)
211.8 (M:211.8) 208.4 (M:208.4) 198.3 (M:198.3) 650.9 (M:650.9) 628.4 (M:628.4) 423.7 (M:423.7)
465.3 (M:465.3) 113.7 (M:113.7) 197.4 (M:197.4) 308.7 (M:308.7)
113.7 (M:113.7)
6
37
56.5
3
19.3
300.5
12
44.7
68.2
4
23.4
474.4
8
21.2
50.4
3
22.7
56.7
4
29.6
74.1
4
40
65.5
4
29.8
30.2
15
46.9
58.8
13
39.4
58.3
10
30
84.1
8
26.1
60.7
3
19.1
78.2
4
19.2
78.4
8
30.4
97.3
2
8.8
7.5
506.4 (M:506.4)
12
54.1
32.2
413.2 (M:413.2) 281.7 (M:281.7) 213.6 (M:213.6) 115.5 (M:115.5) 233.0 (M:233.0) 300.3 (M:300.3) 110.2 (M:110.2) 135.1 (M:135.1) 552.3 (M:552.3) 305.9 (M:305.9) 524.9 (M:524.9) 91.7 (M:91.7)
9
44.1
27.0
6
27.6
32.1
6
19.1
22.4
3
22.7
12.9
5
21.7
75.1
6
29.6
15.2
3
27
37.3
3
28.6
37.9
12
44.4
26.1
7
26.9
31.1
15
43
32.0
3
8.8
25.1
242.6 (M:242.6) 86.9 (M:86.9)
4
13.7
26.0
2
8.8
47.5
220.7 (M:220.7) 335.6 (M:335.6) 95.9 (M:95.9)
4
23.1
28.0
9
37.6
38.3
3
2.6
17.3
116.6 (M:116.6)
2
9.6
38.8
44
349 RSSA_HUMAN 350 RT09_HUMAN 351 RT22_HUMAN 352 RT23_HUMAN 353 RT27_HUMAN 354 RT29_HUMAN 355 RT31_HUMAN 356 RU17_HUMAN
357 RU1C_HUMAN 358 RU2A_HUMAN 359 RUVB1_HUMAN 360 RUVB2_HUMAN 361 RUXF_HUMAN 362 SC22B_HUMAN 363 SEPT2_HUMAN 364 SERA_HUMAN 365 SERPH_HUMAN 366 SET_HUMAN 367 SF3A1_HUMAN
sapiens GN=SNRPB PE=1 SV=2 40S ribosomal protein SA OS=Homo sapiens GN=RPSA PE=1 SV=4 28S ribosomal protein S9, mitochondrial OS=Homo sapiens GN=MRPS9 PE=1 SV=2 28S ribosomal protein S22, mitochondrial OS=Homo sapiens GN=MRPS22 PE=1 SV=1 28S ribosomal protein S23, mitochondrial OS=Homo sapiens GN=MRPS23 PE=1 SV=2 28S ribosomal protein S27, mitochondrial OS=Homo sapiens GN=MRPS27 PE=1 SV=3 28S ribosomal protein S29, mitochondrial OS=Homo sapiens GN=DAP3 PE=1 SV=1 28S ribosomal protein S31, mitochondrial OS=Homo sapiens GN=MRPS31 PE=1 SV=3 U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens GN=SNRNP70 PE=1 SV=2 U1 small nuclear ribonucleoprotein C OS=Homo sapiens GN=SNRPC PE=1 SV=1 U2 small nuclear ribonucleoprotein A' OS=Homo sapiens GN=SNRPA1 PE=1 SV=2 RuvB-like 1 OS=Homo sapiens GN=RUVBL1 PE=1 SV=1 RuvB-like 2 OS=Homo sapiens GN=RUVBL2 PE=1 SV=3 Small nuclear ribonucleoprotein F OS=Homo sapiens GN=SNRPF PE=1 SV=1 Vesicle-trafficking protein SEC22b OS=Homo sapiens GN=SEC22B PE=1 SV=4 Septin-2 OS=Homo sapiens GN=SEPT2 PE=1 SV=1 D-3-phosphoglycerate dehydrogenase OS=Homo sapiens GN=PHGDH PE=1 SV=4 Serpin H1 OS=Homo sapiens GN=SERPINH1 PE=1 SV=2 Protein SET OS=Homo sapiens GN=SET PE=1 SV=3 Splicing factor 3A subunit 1 OS=Homo sapiens GN=SF3A1 PE=1 SV=1
32.8
4.6
45.8
10.1
41.3
8.7
21.8
9.5
47.6
5.8
45.5
9.7
45.3
9.8
51.5
403.6 (M:403.6)
350.2 (M:350.2) 81.5 (M:81.5)
6
23.4
47.5
2
7.8
44.5
312.6 (M:312.6) 82.1 (M:82.1)
6
17.5
32.7
2
10.5
86.7
135.8 (M:135.8) 140.7 (M:140.7)
3
8.2
82.1
3
8.8
33.9
10.3
207.6 (M:207.6)
6
13.7
34.8
17.4
10.4
96.8 (M:96.8)
2
13.2
30.1
28.4
9.4
5
22.7
45.0
50.2
6
2
5.5
82.2
51.1
5.4
221.6 (M:221.6) 126.0 (M:126.0) 71.8 (M:71.8)
2
5.6
562.2
9.7
4.5
24.6
6.5
41.5
6.1
56.6
6.3
46.4
9.3
3
8.9
81.4
33.5
4.1
6
30
11.1
88.8
5
102.8 (M:102.8) 387.2 (M:387.2) 73.4 (M:73.4)
2
3.9
312.1
176.8 (M:176.8) 101.1 (M:101.1)
187.4 (M:187.4)
280.2 (M:280.2) 139.1 (M:139.1) 442.4 (M:442.4) 200.3 (M:200.3) 320.2 (M:320.2) 113.9 (M:113.9)
149.9 (M:149.9)
6
18.6
41.6
2
6.3
28.2
2
8.4
50.1
3
14.5
463.5
4
9.3
40.5
2
15.1
1.7
5
20
41.3
3
9.7
106.6
4
9.6
89.9
2
5.5
99.1
4
9.2
178.0
45
368 SF3B1_HUMAN 369 SF3B2_HUMAN 370 SF3B3_HUMAN 371 SFPQ_HUMAN 372 SFXN1_HUMAN 373 SGSM1_HUMAN 374 SK2L2_HUMAN 375 SMC4_HUMAN
376 SMCA5_HUMAN
377 SMD1_HUMAN 378 SMD2_HUMAN 379 SMD3_HUMAN 380 SND1_HUMAN
381 SP16H_HUMAN 382 SPB1_HUMAN 383 SPT6H_HUMAN 384 SPTB1_HUMAN 385 SRPK1_HUMAN
Splicing factor 3B subunit 1 OS=Homo sapiens GN=SF3B1 PE=1 SV=3 Splicing factor 3B subunit 2 OS=Homo sapiens GN=SF3B2 PE=1 SV=2 Splicing factor 3B subunit 3 OS=Homo sapiens GN=SF3B3 PE=1 SV=4 Splicing factor, proline- and glutamine-rich OS=Homo sapiens GN=SFPQ PE=1 SV=2 Sideroflexin-1 OS=Homo sapiens GN=SFXN1 PE=1 SV=4 Small G protein signaling modulator 1 OS=Homo sapiens GN=SGSM1 PE=1 SV=2 Superkiller viralicidic activity 2-like 2 OS=Homo sapiens GN=SKIV2L2 PE=1 SV=3 Structural maintenance of chromosomes protein 4 OS=Homo sapiens GN=SMC4 PE=1 SV=2 SWI/SNF-related matrix-associated actindependent regulator of chromatin subfamily A member 5 OS=Homo sapiens GN=SMARCA5 PE=1 SV=1 Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens GN=SNRPD1 PE=1 SV=1 Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens GN=SNRPD2 PE=1 SV=1 Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens GN=SNRPD3 PE=1 SV=1 Staphylococcal nuclease domaincontaining protein 1 OS=Homo sapiens GN=SND1 PE=1 SV=1 FACT complex subunit SPT16 OS=Homo sapiens GN=SUPT16H PE=1 SV=1 pre-rRNA processing protein FTSJ3 OS=Homo sapiens GN=FTSJ3 PE=1 SV=2 Transcription elongation factor SPT6 OS=Homo sapiens GN=SUPT6H PE=1 SV=2 Spectrin beta chain, erythrocytic OS=Homo sapiens GN=SPTB PE=1 SV=5 SRSF protein kinase 1 OS=Homo sapiens GN=SRPK1 PE=1 SV=2
145.7
6.7
81.4 (M:81.4)
2
1.8
113.4
100.2
5.4
3
4.1
50.5
135.5
5
4
4.2
46.6
76.1
9.9
136.5 (M:136.5) 166.8 (M:166.8) 269.8 (M:269.8)
5
8.3
28.4
35.6
10
129.6
5.3
56.1 (M:56.1)
2
2.2
1011.6
117.7
6.1
5
5.6
30.6
147.1
6.4
233.6 (M:233.6) 96.5 (M:96.5)
2
1.8
18.5
121.8
9
396.2 (M:396.2)
8
9
30.4
13.3
12.1
88.8 (M:88.8)
2
26.9
42.3
13.5
10.6
5
32.2
22.7
114.6 (M:114.6)
3
22
16.5
13.9
11.1
321.2 (M:321.2) 84.9 (M:84.9)
2
15.1
67.9
101.9
6.8
652.0 (M:652.0)
8
12.1
53.4
303.0 (M:303.0)
8
10.2
46.4
119.8
5.4
47
34.7
25.1
96.5
9.2
2315.8 (M:2315.8) 87.7 (M:87.7)
2
4.3
456.6
198.9
4.7
401.6 (M:401.6)
8
6.1
33.9
246.3
5
74.3
5.8
105.0 (M:105.0)
3
5.2
25.8
371.7 (M:371.7) 301.1 (M:301.1)
152.0 (M:152.0)
80.0 (M:80.0)
5
10.3
94.8
4
13
17.6
3
2
7.8
0.9
34.4
362.3
46
386 SRPRB_HUMAN
387 SRSF1_HUMAN 388 SRSF2_HUMAN 389 SRSF3_HUMAN 390 SRSF5_HUMAN 391 SRSF7_HUMAN 392 SRSF9_HUMAN 393 SSBP_HUMAN
394 SSRA_HUMAN
395 SSRP1_HUMAN 396 STML2_HUMAN 397 STOM_HUMAN
398 STRAP_HUMAN
399 TBA1A_HUMAN 400 TBA1C_HUMAN 401 TBA4A_HUMAN 402 TBB4B_HUMAN 403 TBB5_HUMAN
Signal recognition particle receptor subunit beta OS=Homo sapiens GN=SRPRB PE=1 SV=3 Serine/arginine-rich splicing factor 1 OS=Homo sapiens GN=SRSF1 PE=1 SV=2 Serine/arginine-rich splicing factor 2 OS=Homo sapiens GN=SRSF2 PE=1 SV=4 Serine/arginine-rich splicing factor 3 OS=Homo sapiens GN=SRSF3 PE=1 SV=1 Serine/arginine-rich splicing factor 5 OS=Homo sapiens GN=SRSF5 PE=1 SV=1 Serine/arginine-rich splicing factor 7 OS=Homo sapiens GN=SRSF7 PE=1 SV=1 Serine/arginine-rich splicing factor 9 OS=Homo sapiens GN=SRSF9 PE=1 SV=1 Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens GN=SSBP1 PE=1 SV=1 Translocon-associated protein subunit alpha OS=Homo sapiens GN=SSR1 PE=1 SV=3 FACT complex subunit SSRP1 OS=Homo sapiens GN=SSRP1 PE=1 SV=1 Stomatin-like protein 2, mitochondrial OS=Homo sapiens GN=STOML2 PE=1 SV=1 Erythrocyte band 7 integral membrane protein OS=Homo sapiens GN=STOM PE=1 SV=3 Serine-threonine kinase receptorassociated protein OS=Homo sapiens GN=STRAP PE=1 SV=1 Tubulin alpha-1A chain OS=Homo sapiens GN=TUBA1A PE=1 SV=1 Tubulin alpha-1C chain OS=Homo sapiens GN=TUBA1C PE=1 SV=1 Tubulin alpha-4A chain OS=Homo sapiens GN=TUBA4A PE=1 SV=1 Tubulin beta-4B chain OS=Homo sapiens GN=TUBB4B PE=1 SV=1 Tubulin beta chain OS=Homo sapiens GN=TUBB PE=1 SV=2
29.7
9.9
185.8 (M:185.8)
3
14.8
72.5
27.7
10.8
8
22.2
63.2
25.5
12.4
5
11.3
70.7
19.3
12.3
5
30.5
257.4
31.2
12.2
322.8 (M:322.8) 465.6 (M:465.6) 311.3 (M:311.3) 98.0 (M:98.0)
2
11.8
8.1
27.4
12.4
3
19.7
53.4
25.5
9.2
3
15.4
40.8
17.2
9.9
145.7 (M:145.7) 154.2 (M:154.2) 155.8 (M:155.8)
3
23.6
83.5
32.2
4.2
149.2 (M:149.2)
2
9.1
112.9
81
6.5
38.5
7.7
31.7
8.9
38.4
379.0 (M:379.0) 105.5 (M:105.5)
5
16.9
44.7
2
9.7
673.9
4.8
195.2 (M:195.2)
2
10.3
30.0
50.1
4.8
10
31.7
79.4
49.9
4.8
6
15.1
34.5
49.9
4.8
3
7.6
28.2
49.8
4.6
12
22
67.4
49.6
4.6
812.8 (M:812.8) 419.8 (M:419.8) 390.2 (M:390.2) 788.0 (M:788.0) 555.6 (M:555.6)
9
17.8
51.5
160.7 (M:160.7) 133.4 (M:133.4) 78.5 (M:78.5)
5
19.4
34.6
2
11.3
11.5
2
12.8
70.8
132.6 (M:132.6) 87.2 (M:87.2)
3
13.2
38.8
2
10.9
24.4
242.2 (M:242.2)
5
35.1
39.3
1103.0 (M:1103.0)
22
27.2
21.2
169.0 (M:169.0) 471.5 (M:471.5) 308.9 (M:308.9) 199.4 (M:199.4) 394.4 (M:394.4)
3
8.4
32.4
10
26.5
30.9
2
4.2
38.8
4
11
18.8
10
29.1
31.1
47
404 TCP4_HUMAN
405 TCPA_HUMAN 406 TCPB_HUMAN 407 TCPD_HUMAN 408 TCPH_HUMAN 409 TCPQ_HUMAN 410 TFAM_HUMAN 411 TFG_HUMAN 412 THIO_HUMAN 413 THOC4_HUMAN 414 TIM50_HUMAN
415 TITIN_HUMAN 416 TKT_HUMAN 417 TLN2_HUMAN 418 TOM20_HUMAN
419 TOM22_HUMAN
420 TOM40_HUMAN
Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens GN=SUB1 PE=1 SV=3 T-complex protein 1 subunit alpha OS=Homo sapiens GN=TCP1 PE=1 SV=1 T-complex protein 1 subunit beta OS=Homo sapiens GN=CCT2 PE=1 SV=4 T-complex protein 1 subunit delta OS=Homo sapiens GN=CCT4 PE=1 SV=4 T-complex protein 1 subunit eta OS=Homo sapiens GN=CCT7 PE=1 SV=2 T-complex protein 1 subunit theta OS=Homo sapiens GN=CCT8 PE=1 SV=4 Transcription factor A, mitochondrial OS=Homo sapiens GN=TFAM PE=1 SV=1 Protein TFG OS=Homo sapiens GN=TFG PE=1 SV=2 Thioredoxin OS=Homo sapiens GN=TXN PE=1 SV=3 THO complex subunit 4 OS=Homo sapiens GN=ALYREF PE=1 SV=3 Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens GN=TIMM50 PE=1 SV=2 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens GN=TOMM20 PE=1 SV=1 Mitochondrial import receptor subunit TOM22 homolog OS=Homo sapiens GN=TOMM22 PE=1 SV=3 Mitochondrial import receptor subunit TOM40 homolog OS=Homo sapiens GN=TOMM40 PE=1 SV=1
14.4
10.1
148.4 (M:148.4)
60.3
5.7
57.5
6
57.9
9
59.3
8.6
59.6
5.3
29.1
10.3
43.4
4.8
11.7
4.7
26.9
11.6
39.6
9.3
3814
6
67.8
8.5
271.4
5.3
16.3
9.7
139.3 (M:139.3)
2
17.2
49.0
15.5
4.1
120.9 (M:120.9)
2
26.1
9.7
37.9
7
337.6 (M:337.6)
5
18
66.9
254.1 (M:254.1) 361.6 (M:361.6) 124.5 (M:124.5) 411.0 (M:411.0) 160.2 (M:160.2)
3
26.8
73.9
3
8
86.5
4
8.2
53.5
2
5.3
79.5
6
13.7
36.1
3
13.8
29.3
167.6 (M:167.6) 176.2 (M:176.2)
2
11.3
10.6
3
9.3
11.5
180.3 (M:180.3) 117.7 (M:117.7)
2
0
101.3
2
4.3
56.9
154.1 (M:154.1)
4
35.4
53.6
145.2 (M:145.2)
3
7.4
43.4
535.2 (M:535.2) 144.9 (M:144.9) 162.8 (M:162.8)
12
34.8
36.9
2
22.9
22.7
3
14
32.8
208.1 (M:208.1)
6
0.2
96.9
63.0 (M:63.0)
2
1.3
56.1
48
421 TOM6_HUMAN
422 TOP1_HUMAN 423 TOP2A_HUMAN 424 TPM4_HUMAN 425 TR112_HUMAN
426 TRA2B_HUMAN 427 TSR1_HUMAN
428 U2AF1_HUMAN 429 U2AF2_HUMAN 430 U5S1_HUMAN
431 UBE2S_HUMAN 432 UHRF1_HUMAN 433 VA0D1_HUMAN
434 VDAC1_HUMAN
435 VDAC2_HUMAN
436 VDAC3_HUMAN
Mitochondrial import receptor subunit TOM6 homolog OS=Homo sapiens GN=TOMM6 PE=1 SV=1 DNA topoisomerase 1 OS=Homo sapiens GN=TOP1 PE=1 SV=2 DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3 Tropomyosin alpha-4 chain OS=Homo sapiens GN=TPM4 PE=1 SV=3 tRNA methyltransferase 112 homolog OS=Homo sapiens GN=TRMT112 PE=1 SV=1 Transformer-2 protein homolog beta OS=Homo sapiens GN=TRA2B PE=1 SV=1 Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens GN=TSR1 PE=1 SV=1 Splicing factor U2AF 35 kDa subunit OS=Homo sapiens GN=U2AF1 PE=1 SV=3 Splicing factor U2AF 65 kDa subunit OS=Homo sapiens GN=U2AF2 PE=1 SV=4 116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens GN=EFTUD2 PE=1 SV=1 Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens GN=UBE2S PE=1 SV=2 E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens GN=UHRF1 PE=1 SV=1 V-type proton ATPase subunit d 1 OS=Homo sapiens GN=ATP6V0D1 PE=1 SV=1 Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens GN=VDAC1 PE=1 SV=2 Voltage-dependent anion-selective channel protein 2 OS=Homo sapiens GN=VDAC2 PE=1 SV=2 Voltage-dependent anion-selective channel protein 3 OS=Homo sapiens GN=VDAC3 PE=1 SV=1
8
4.5
126.1 (M:126.1)
2
18.9
43.8
90.7
9.9
119.2 (M:119.2)
2
3.7
76.9
174.3
9.4
28.5
4.5
87.9 (M:87.9)
2
11.3
42.1
14.2
5.1
193.1 (M:193.1)
3
22.4
405.0
33.6
11.8
242.9 (M:242.9)
3
13.9
41.9
91.8
7.1
27.9
10.1
53.5
9.8
109.4
4.7
237.3 (M:237.3)
5
10.2
206.2
23.8
9.3
118.7 (M:118.7)
2
11.7
30.6
89.8
8.7
40.3
4.7
109.3 (M:109.3)
2
6.6
576.1
30.8
9.2
862.6 (M:862.6)
13
32.2
46.8
31.5
8.7
204.3 (M:204.3)
3
11.2
106.1
30.6
9.5
82.1 (M:82.1)
2
3.9
546.9
111.8 (M:111.8)
2
8.8
103.4
502.6 (M:502.6)
10
9.1
28.2
120.4 (M:120.4)
2
22.4
30.5
253.7 (M:253.7)
5
8.2
18.8
91.2 (M:91.2)
2
8.8
60.3
80.1 (M:80.1)
2
3.8
46.5
64.5 (M:64.5)
2
2.3
46.6
157.8 (M:157.8)
3
4.5
49.5
49
437 VIME_HUMAN 438 WDR11_HUMAN 439 WDR12_HUMAN 440 WDR18_HUMAN 441 XPO1_HUMAN 442 XPO2_HUMAN 443 XRCC5_HUMAN 444 XRCC6_HUMAN 445 YBOX1_HUMAN
446 ZFR_HUMAN
Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 WD repeat-containing protein 11 OS=Homo sapiens GN=WDR11 PE=1 SV=1 Ribosome biogenesis protein WDR12 OS=Homo sapiens GN=WDR12 PE=1 SV=2 WD repeat-containing protein 18 OS=Homo sapiens GN=WDR18 PE=1 SV=2 Exportin-1 OS=Homo sapiens GN=XPO1 PE=1 SV=1 Exportin-2 OS=Homo sapiens GN=CSE1L PE=1 SV=3 X-ray repair cross-complementing protein 5 OS=Homo sapiens GN=XRCC5 PE=1 SV=3 X-ray repair cross-complementing protein 6 OS=Homo sapiens GN=XRCC6 PE=1 SV=2 Nuclease-sensitive element-binding protein 1 OS=Homo sapiens GN=YBX1 PE=1 SV=3 Zinc finger RNA-binding protein OS=Homo sapiens GN=ZFR PE=1 SV=2
53.6
4.9
136.6
6.5
47.7
5.5
47.4
6.2
123.3
5.7
110.3
5.4
82.7
5.5
69.8
6.2
35.9
0
116.9
9.8
2342.6 (M:2342.6)
141.7 (M:141.7)
344.2 (M:344.2) 334.0 (M:334.0)
239.0 (M:239.0) 601.0 (M:601.0)
35
2
50.9
5.4
70.2
270.8 (M:270.8) 84.4 (M:84.4)
4
8.8
45.3
2
2.9
40.2
259.9 (M:259.9)
7
16.4
60.5
1010.8 (M:1010.8) 973.4 (M:973.4) 909.2 (M:909.2)
19
34
29.3
20
37.4
26.4
14
43.5
19.1
295.8 (M:295.8)
6
7.8
28.4
49.3
5
5.8
79.3
5
5.4
62.4
3
6.4
79.7
8
38.9
74.1
1
,IP proteomes of biological replicates
50
Table S3. List of the 20 most abundant SMM proteins, estimated using the exponentially modified protein abundance index (emPAI) approach (10). Protein abundance is displayed as average values. ID
Accession Protein description UniProtAC human
Protein abundance
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 29
ACTS_HUMAN ARF4_HUMAN CN166_HUMAN ATPO_HUMAN RAB5C_HUMAN NDUS3_HUMAN ACTN1_HUMAN RAB10_HUMAN TPM3_HUMAN SPTN1_HUMAN LAP2A_HUMAN ADT3_HUMAN CALX_HUMAN SNAA_HUMAN MYH9_HUMAN AT5F1_HUMAN 4F2_HUMAN PP1A_HUMAN FLNA_HUMAN NB5R3_HUMAN
2.10 1.34 1.31 0.97 0.86 0.83 0.70 0.63 0.61 0.57 0.56 0.55 0.50 0.49 0.47 0.47 0.46 0.46 0.46 0.46
Actin ADP-ribosylation factor 4 UPF0568 protein C14orf166 ATP synthase subunit O, mitochondrial Ras-related protein Rab-5C NADH dehydrogenase iron-sulfur protein 3, mitochondrial Alpha-actinin-1 Ras-related protein Rab-10 Tropomyosin alpha-3 chain Spectrin alpha chain Lamina-associated polypeptide 2 ADP/ATP translocase Calnexin Alpha-soluble NSF attachment protein Myosin ATP synthase subunit b, mitochondrial 4F2 cell-surface antigen heavy chain Serine/threonine-protein phosphatase Filamin-A NADH-cytochrome b5 reductase 3
51
Table S4. MS-identified proteins observed in Legionella containing vacuoles (LCV) and Salmonella-modified membranes (SMM). ID
Accession Protein description UniProtAC human
Accession UniProtID 1 human
Accession Accession UniProtID UniProtID 2 3 mouse dicti
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48
2AAA_HUMAN ACLY_HUMAN ACTS_HUMAN ALDOA_HUMAN ARPC4_HUMAN C1TM_HUMAN CAPZB_HUMAN DESP_HUMAN DHB4_HUMAN DHX30_HUMAN EF1B_HUMAN EF1G_HUMAN EF2_HUMAN GLSK_HUMAN GPDM_HUMAN H2B3B_HUMAN IMDH2_HUMAN MYH9_HUMAN PSMD2_HUMAN PUR9_HUMAN RM04_HUMAN RM12_HUMAN RM13_HUMAN RM19_HUMAN RM20_HUMAN RM22_HUMAN RM43_HUMAN RM48_HUMAN RRP1_HUMAN SLIRP_HUMAN SMC1A_HUMAN SMC3_HUMAN SRP72_HUMAN SYRC_HUMAN TBRG4_HUMAN TCPE_HUMAN TCPG_HUMAN TCPZ_HUMAN TERA_HUMAN TIF1B_HUMAN BAG2_HUMAN P5CR2_HUMAN ACTN1_HUMAN COR1C_HUMAN DDX3X_HUMAN MYO1C_HUMAN ANXA1_HUMAN AP2A1_HUMAN
P30153 P53396 P68133 P04075 P59998 Q6UB35 P47756 P15924 P51659 Q7L2E3 P24534 P26641 P13639 O94925 P43304 Q8N257 P12268 P35579 Q13200 P31939 Q9BYD3 P52815 Q9BYD1 P49406 Q9BYC9 Q9NWU5 Q8N983 Q96GC5 P56182 Q9GZT3 Q14683 Q9UQE7 O76094 P54136 Q969Z0 P48643 P49368 P40227 P55072 Q13263 O95816 Q96C36 P12814 Q9ULV4 O00571 O00159 P04083 O95782
Q76MZ3
Serine/threonine-protein phosphatase 2A 65 kDa ATP-citrate synthase Actin Fructose-bisphosphate aldolase A Actin-related protein 2/3 complex subunit 4 Monofunctional C1-tetrahydrofolate synthase F-actin-capping protein subunit beta Desmoplakin Peroxisomal multifunctional enzyme type 2 Putative ATP-dependent RNA helicase DHX30 Elongation factor 1-beta Elongation factor 1-gamma Elongation factor 2 Glutaminase kidney isoform, mitochondrial Glycerol-3-phosphate dehydrogenase, mitochondrial Histone H2B type 3-B Inosine-5'-monophosphate dehydrogenase 2 Myosin-9 26S proteasome non-ATPase regulatory subunit 2 Bifunctional purine biosynthesis protein PURH 39S ribosomal protein L4, mitochondrial 39S ribosomal protein L12, mitochondrial 39S ribosomal protein L13, mitochondrial 39S ribosomal protein L19, mitochondrial 39S ribosomal protein L20, mitochondrial 39S ribosomal protein L22, mitochondrial 39S ribosomal protein L43, mitochondrial 39S ribosomal protein L48, mitochondrial Ribosomal RNA processing protein 1 homolog A SRA stem-loop-interacting RNA-binding protein Structural maintenance of chromosomes protein 1A Structural maintenance of chromosomes protein 3 Signal recognition particle subunit SRP72 Arginine-tRNA ligase, cytoplasmic Protein TBRG4 T-complex protein 1 subunit epsilon T-complex protein 1 subunit gamma T-complex protein 1 subunit zeta Transitional endoplasmic reticulum ATPase Transcription intermediary factor 1-beta BAG family molecular chaperone regulator 2 Pyrroline-5-carboxylate reductase 2 Alpha-actinin-1 Coronin-1C ATP-dependent RNA helicase DDX3X Unconventional myosin-Ic Annexin A1 AP-2 complex subunit alpha-1
P60710 P59999 Q3V3R1 P47757 E9Q557 P51660 Q99PU8 O70251 Q9D8N0 P58252 D3Z7P3 Q64521
Q54YA0 P07830 Q86A67 O96625
Q9NKW1 Q9GRF8 P15112
Q54LP8 P24547 Q8VDD5 Q8VDM4 Q9DCU6 Q9DB15 Q9D1P0 Q9D338 Q9CQL4 Q8BU88 Q5RL20 Q8JZS9 P56183
Q86L14 Q54RB5 Q86KA1
Q556W7
Q86I71 Q9CU62 Q9CW03 F8VQC1 Q9D0I9 Q91YM4 P80316 P80318 P80317 Q01853 Q62318 Q91YN9 Q922Q4
Q62167 Q9WTI7 P10107 P17426
Q54JT6
P90532
P05095 P27133 Q54QS3
52
49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69
AT5F1_HUMAN ATD3A_HUMAN ATPG_HUMAN ATPO_HUMAN BAP31_HUMAN CALX_HUMAN CMC2_HUMAN COPA_HUMAN COPG1_HUMAN DHB12_HUMAN EHD4_HUMAN ENPL_HUMAN HYOU1_HUMAN IMMT_HUMAN LMNB2_HUMAN M2OM_HUMAN MPCP_HUMAN MTCH2_HUMAN MYH10_HUMAN NB5R3_HUMAN NDUA9_HUMAN
70 71 72 73 74 75
NDUS1_HUMAN NDUS3_HUMAN NDUV2_HUMAN NU107_HUMAN NU155_HUMAN NU160_HUMAN
76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92
ODO1_HUMAN ODPA_HUMAN OPA1_HUMAN PCNA_HUMAN PDIA1_HUMAN PDIA3_HUMAN PDIA6_HUMAN PGAM5_HUMAN PRDX3_HUMAN RAB10_HUMAN RAB14_HUMAN RAB2A_HUMAN RAB5C_HUMAN RAB7A_HUMAN RAP1B_HUMAN RB11A_HUMAN RPN2_HUMAN
93 94 95 96 97 98 99 100
SAR1A_HUMAN SNAA_HUMAN SRPR_HUMAN TFR1_HUMAN TMED9_HUMAN TMEDA_HUMAN TMM43_HUMAN TOP2B_HUMAN
ATP synthase subunit b, mitochondrial ATPase family AAA domain-containing protein 3A ATP synthase subunit gamma, mitochondrial ATP synthase subunit O, mitochondrial B-cell receptor-associated protein 31 Calnexin Calcium-binding mitochondrial carrier protein Aralar2 Coatomer subunit alpha Coatomer subunit gamma-1 Estradiol 17-beta-dehydrogenase 12 EH domain-containing protein 4 Endoplasmin Hypoxia up-regulated protein 1 Mitochondrial inner membrane protein Lamin-B2 Mitochondrial 2-oxoglutarate/malate carrier protein Phosphate carrier protein, mitochondrial Mitochondrial carrier homolog 2 Myosin-10 NADH-cytochrome b5 reductase 3 NADH dehydrogenase [ubiquinone] 1a sub-complex subunit 9 NADH-ubiquinone oxidoreductase 75 kDa subunit NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 NADH dehydrogenase [ubiquinone] flavoprotein 2 Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup160
P24539 Q9NVI7 P36542 P48047 P51572 P27824 Q9UJS0 P53621 Q9Y678 Q53GQ0 Q9H223 P14625 Q9Y4L1 Q16891 Q03252 Q02978 Q00325 Q9Y6C9 P35580 P00387 Q16795
Q9CQQ7 Q925I1 Q91VR2 Q9DB20 Q61335 P35564 Q9QXX4 Q8CIE6 Q9QZE5 O70503 Q9EQP2 P08113 Q9JKR6 Q8CAQ8 P21619 Q9CR62 Q8VEM8 Q791V5
P28331 O75489 P19404 P57740 O75694 Q12769
Q91VD9 Q9DCT2 Q9D6J6 Q8BH74 Q99P88 Q9Z0W3
Q34312 P22237
2-oxoglutarate dehydrogenase, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha Dynamin-like 120 kDa protein, mitochondrial Proliferating cell nuclear antigen Protein disulfide-isomerase Protein disulfide-isomerase A3 Protein disulfide-isomerase A6 Serine/threonine-protein phosphatase PGAM5 Thioredoxin-dependent peroxide reductase Ras-related protein Rab-10 Ras-related protein Rab-14 Ras-related protein Rab-2A Ras-related protein Rab-5C Ras-related protein Rab-7a Ras-related protein Rap-1b Ras-related protein Rab-11A Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2 GTP-binding protein SAR1a Alpha-soluble NSF attachment protein Signal recognition particle receptor subunit alpha Transferrin receptor protein 1 Transmembrane emp24 domain-containing protein 9 Transmembrane emp24 domain-containing protein 10 Transmembrane protein 43 DNA topoisomerase 2-beta
Q02218 P08559 O60313 P12004 P07237 P30101 Q15084 Q96HS1 P30048 P61026 P61106 P61019 P51148 P51149 P61224 P62491 P04844
Q60597 P35486 P58281 P17918 P09103 P27773
Q54JE4 Q54C70
Q9NR31 P54920 P08240 P02786 Q9BVK6 P49755 Q9BTV4 Q02880
Q54DF1 Q54RA8 Q55BA8
Q556U6
Q54BF6 P08799
Q9DCN2 Q559Z0
Q8BX10 P20108 P61027 Q91V41 P53994 P35278 P51150
Q54EN4 Q869Z0
P36410 P36409 P36411 P18613
P62492 Q9DBG6 Q559R0 Q9DB05 Q9DBG7 Q62351 Q99KF1 Q9D1D4 Q9DBS1
Q54ZR7 Q769F7 Q769F6 Q55BP5
53
101 102 103 104 105 106 107 108 109
TRAP1_HUMAN TXTP_HUMAN VAPA_HUMAN VAPB_HUMAN VIGLN_HUMAN 4F2_HUMAN PGRC2_HUMAN K6PP_HUMAN UBA1_HUMAN
Heat shock protein 75 kDa, mitochondrial Tricarboxylate transport protein, mitochondrial Vesicle-associated membrane protein A Vesicle-associated membrane protein B/C Vigilin 4F2 cell-surface antigen heavy chain Membrane-associated progesterone receptor component 2 6-phosphofructokinase type C Ubiquitin-like modifier-activating enzyme 1
Q12931 P53007 Q9P0L0 O95292 Q00341 P08195 O15173 Q01813 P22314
Q9CQN1 Q8JZU2 Q9WV55 Q8BH80 Q8VDJ3 P10852 Q80UU9 Q9WUA3 Q02053
Q86L04
1
,SMM proteins isolated from HeLa (data set: this study); 2,LCV proteins isolated from RAW macrophages (data set: (11); 3,LCV proteins isolated from Dictyostelium strains (combined data sets: (11, 12)).
References 1. Hensel, M., Shea, J. E., Waterman, S. R., Mundy, R., Nikolaus, T., Banks, G., Vazquez-Torres, A., Gleeson, C., Fang, F. C., and Holden, D. W. (1998) Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages. Mol. Microbiol 30, 163-174 2. Shea, J. E., Hensel, M., Gleeson, C., and Holden, D. W. (1996) Identification of a virulence locus encoding a second type III secretion system in Salmonella Typhimurium. Proc. Natl. Acad. Sci 93, 2593-2597 3. Wang, R. F., and Kushner, S. R. (1991) Construction of versatile low-copy-number vectors for cloning, sequencing and gene expression in Escherichia coli. Gene 100, 195-199 4. Husseiny, M. I., Wartha, F., and Hensel, M. (2007) Recombinant vaccines based on translocated effector proteins of Salmonella Pathogenicity Island 2. Vaccine 25, 185-193 5. Lorkowski, M. F.-L., A., Danzer, C., Hansmeier, N., and Hensel, M. (2014) Salmonella enterica invasion of polarized epithelial cells is a highly cooperative effort. Infect. Immun 82, 2657-67 6. Drecktrah, D., Levine-Wilkinson, S., Dam, T., Winfree, S., Knodler, L. A., Schroer, T. A., and Steele-Mortimer, O. (2008) Dynamic behavior of Salmonella-induced membrane tubules in epithelial cells. Traffic 9, 2117-2129 7. Burkel, B. M., von Dassow, G., and Bement, W. M. (2007) Versatile fluorescent probes for actin filaments based on the actin-binding domain of utrophin. Cell Motil. Cytoskeleton 64, 822-832 8. Goedhart, J., von Stetten, D., Noirclerc-Savoye, M., Lelimousin, M., Joosen, L., Hink, M. A., van Weeren, L., Gadella, T. W., Jr., and Royant, A. (2012) Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%. Nat. Commun 3, 751 9. Obert, S., O'Connor, R. J., Schmid, S., and Hearing, P. (1994) The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex. Mol. Cell. Biol 14, 1333-1346 10. Ishihama, Y., Oda, Y., Tabata, T., Sato, T., Nagasu, T., Rappsilber, J., and Mann, M. (2005) Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol. Cell. Proteomics 4, 1265-1272 11. Hoffmann, C., Finsel, I., Otto, A., Pfaffinger, G., Rothmeier, E., Hecker, M., Becher, D., and Hilbi, H. (2013) Functional analysis of novel Rab GTPases identified in the proteome of purified Legionella-containing vacuoles from macrophages. Cell. Microbiol 16, 1034-52 12. Shevchuk, O., Batzilla, C., Hagele, S., Kusch, H., Engelmann, S., Hecker, M., Haas, A., Heuner, K., Glockner, G., and Steinert, M. (2009) Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium. Int. J. Med. Microbiol 299, 489-508
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