Supplemental Figure 1 - PLOS

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1. 0-6. -. 1. 0-5. 1. 0-6. -. mSF-1. StAR-Luc. -. 1. 0-5. 1. 0-6. -. 1. 0-5. 1. 0-6. -. mSF-1. HSD3B-Luc. -. 1. 0-5. 1. 0-6. -. 1. 0-5. 1. 0-6. -. mSF-1. -. 1. 0-5. 1. 0-6. -. mSF- ...
Supplemental Figure 1

A

HSD3B-Luc

StAR-Luc

-

-

mSF-1

mSF-1

-

10-5

-

10-6

10-5

-

10-6

10-5

-

10-6

10-5

10-6

10-5

-

mSF-1

A2BP1-Luc A. Luciferase Activity is shown for different reporters, as indicated above bar graphs with or without SF-1 and with increasing concentrations of ATR added.

-

mSF-1

-

10-5

-

10-6

10-5

-

10-6

-

10-5

B. Luciferase activity is shown with a hypothalamic SF-1 target gene using a wild type and mutant promoter. The SF-1 binding site is mutated in the mutant promoter (mutant SF-1 RE). The promoter is ataxin 2 binding protein. 10-5

ATR (M) -

Mutant SF-1RE

WT SF-1RE

10-6

Relative Activity (RLU)

B

10-6

-

10-6

-

10-5

ATR (M)

10-6

Relative Activity (RLU)

MIS-Luc

mSF-1