Supplemental Figure 3 - Plos

4.00E+12

Particle Concentration / mL

Particle Concentration / mL

Supplemental Figure 3

3.00E+12 2.00E+12 1.00E+12 0.00E+00

6.00E+12

4.00E+12

2.00E+12

0.00E+00

4.00E+12

0 50 100 150 200 250 300 350 400 450 Particle Size (nm)

Particle Concentration / mL

Particle Concentration / mL

0 50 100150200250300350400450 Particle Size (nm)

3.00E+12 2.00E+12 1.00E+12 0.00E+00

3.00E+12

2.00E+12

1.00E+12

0.00E+00

2.00E+12

0 50 100 150 200 250 300 350 400 450 Particle Size (nm)

Particle Concentration / mL

Particle Concentration / mL

0 50 100 150 200 250 300 350 400 450 Particle Size (nm)

1.50E+12 1.00E+12

5.00E+11 0.00E+00 0 50 100 150 200 250 300 350 400 450 Particle Size (nm)

3.00E+12

2.00E+12

1.00E+12

0.00E+00 0

50 100 150 200 250 300 350 400 450 Particle Size (nm)

Supplemental Figure 3: Nanoparticle Tracking Analysis traces of the distribution of particles from each of the 6 ARCADIA patients. Each patient shows a considerable increase in particles of exosomal size following surgery. Red line: before the operation; blue line: during the operation, before initiation of CPB; black line: 24 hours post-surgery; Green line: 48 hours post-surgery. The 48h post-operation sample for one patient (E) was missing